{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T14:03:18Z","timestamp":1793628198534,"version":"4.5.1"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG062840"],"award-info":[{"award-number":["R01AG062840"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG072896"],"award-info":[{"award-number":["R01AG072896"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 AA011999"],"award-info":[{"award-number":["P50 AA011999"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.nbd.2024.106570","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T11:39:36Z","timestamp":1718451576000},"page":"106570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's disease mice: Potential role in chronic heavy alcohol feeding"],"prefix":"10.1016","volume":"199","author":[{"given":"Devaraj V.","family":"Chandrashekar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Chuli","family":"Roules","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataraj","family":"Jagadeesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urvashi R.","family":"Panchal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adenike","family":"Oyegbesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oghenetega E.","family":"Imiruaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamaljit","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanda","family":"Win","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin A.","family":"Than","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Kaplowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moom R.","family":"Roosan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derick","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachita K.","family":"Sumbria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2024.106570_bb0005","series-title":"2023 Alzheimer's disease facts and figures","first-page":"1598","volume":"19","year":"2023"},{"key":"10.1016\/j.nbd.2024.106570_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.884170","article-title":"Adolescent binge alcohol enhances early Alzheimer's disease pathology in adulthood through Proinflammatory Neuroimmune activation","volume":"13","author":"Barnett","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.nbd.2024.106570_bb0015","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1186\/1471-2458-14-643","article-title":"Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis","volume":"14","author":"Beydoun","year":"2014","journal-title":"BMC Public Health"},{"key":"10.1016\/j.nbd.2024.106570_bb0020","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/ueg2.12370","article-title":"Influence of sex in alcohol-related liver disease: pre-clinical and clinical settings","volume":"11","author":"Bizzaro","year":"2023","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.nbd.2024.106570_bb0025","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0896-6273(00)80974-5","article-title":"Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins","volume":"19","author":"Borchelt","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106570_bb0030","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/hep4.1609","article-title":"High-fat diet modulates hepatic amyloid beta and Cerebrosterol metabolism in the triple transgenic mouse model of Alzheimer\u2019s disease","volume":"5","author":"Bosoi","year":"2021","journal-title":"Hepatol Commun."},{"key":"10.1016\/j.nbd.2024.106570_bb0035","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1111\/j.1460-9568.2006.05247.x","article-title":"Homeostatic plasticity during alcohol exposure promotes enlargement of dendritic spines","volume":"24","author":"Carpenter-Hyland","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106570_bb0040","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/gps.2470","article-title":"Association between alcohol consumption and cognitive impairment in southern Chinese older adults","volume":"25","author":"Chan","year":"2010","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.nbd.2024.106570_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24119492","article-title":"Alcohol as a modifiable risk factor for Alzheimer\u2019s disease-evidence from experimental studies","volume":"24","author":"Chandrashekar","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106570_bb0050","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1021\/acs.molpharmaceut.8b00594","article-title":"Brain penetrating bifunctional erythropoietin-transferrin receptor antibody fusion protein for Alzheimer's disease","volume":"15","author":"Chang","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.nbd.2024.106570_bb0055","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00401-023-02559-z","article-title":"Physiological \u03b2-amyloid clearance by the liver and its therapeutic potential for Alzheimer's disease","volume":"145","author":"Cheng","year":"2023","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2024.106570_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134306","article-title":"Peripheral versus central nervous system APOE in Alzheimer's disease: interplay across the blood-brain barrier","volume":"708","author":"Chernick","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2024.106570_bb0065","first-page":"377","article-title":"Alcohol-related neurodegeneration and recovery","volume":"31","author":"Crews","year":"2008","journal-title":"Alcohol Res. Health"},{"key":"10.1016\/j.nbd.2024.106570_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.732929","article-title":"Liver zonation - revisiting old questions with new technologies","volume":"12","author":"Cunningham","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.nbd.2024.106570_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105967","article-title":"Ethanol exposure alters Alzheimer\u2019s-related pathology, behavior, and metabolism in APP\/PS1 mice","volume":"177","author":"Day","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106570_bb0085","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ebiom.2016.04.002","article-title":"Low-density lipoprotein receptor-related Protein-1 protects against hepatic insulin resistance and hepatic steatosis","volume":"7","author":"Ding","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.nbd.2024.106570_bb0090","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fnagi.2019.00174","article-title":"Liver dysfunction as a novel player in Alzheimer\u2019s progression: looking outside the brain","volume":"11","author":"Estrada","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2024.106570_bb0095","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1471-2377-10-87","article-title":"Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment","volume":"10","author":"Fernandez","year":"2010","journal-title":"BMC Neurol."},{"key":"10.1016\/j.nbd.2024.106570_bb0100","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/ana.410330306","article-title":"Risk factors for late-onset Alzheimer\u2019s disease: a population-based, case-control study","volume":"33","author":"Fratiglioni","year":"1993","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2024.106570_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.930402","article-title":"Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: potential link between liver steatosis and amyloid-beta","volume":"13","author":"Garcia","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.nbd.2024.106570_bb0110","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.nbd.2006.08.017","article-title":"Characterization of amyloid deposition in the APPswe\/PS1dE9 mouse model of Alzheimer disease","volume":"24","author":"Garcia-Alloza","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106570_bb0115","doi-asserted-by":"crossref","first-page":"45897","DOI":"10.1074\/jbc.M407668200","article-title":"Systemic catabolism of Alzheimer\u2019s Abeta40 and Abeta42","volume":"279","author":"Ghiso","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2024.106570_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112105","article-title":"Effects of alcohol intake on cognitive function and \u03b2-amyloid protein in APP\/PS1 transgenic mice","volume":"151","author":"Gong","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.nbd.2024.106570_bb0125","doi-asserted-by":"crossref","first-page":"16610","DOI":"10.1074\/jbc.M116.717744","article-title":"LRP1 protein deficiency exacerbates palmitate-induced steatosis and toxicity in hepatocytes","volume":"291","author":"Hamlin","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2024.106570_bb0130","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/syn.20559","article-title":"Elevated synaptophysin I in the prefrontal cortex of human chronic alcoholics","volume":"62","author":"Henriksson","year":"2008","journal-title":"Synapse"},{"key":"10.1016\/j.nbd.2024.106570_bb0135","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.2174\/1567205013666160603005035","article-title":"The association between alcohol use and the progression of Alzheimer's disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.nbd.2024.106570_bb0140","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/bs.irn.2019.10.017","article-title":"Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer\u2019s disease","volume":"148","author":"Hoffman","year":"2019","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106570_bb0145","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1007\/s12035-017-0703-3","article-title":"Ethanol alters APP processing and aggravates Alzheimer-associated phenotypes","volume":"55","author":"Huang","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106570_bb0150","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13024-019-0337-1","article-title":"Lack of hepatic apoE does not influence early A\u03b2 deposition: observations from a new APOE knock-in model","volume":"14","author":"Huynh","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2024.106570_bb0155","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s12967-024-05008-x","article-title":"Modulation of hippocampal protein expression by a brain penetrant biologic TNF-\u03b1 inhibitor in the 3xTg Alzheimer's disease mice","volume":"22","author":"Jagadeesan","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.nbd.2024.106570_bb0160","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","article-title":"Co-expression of multiple transgenes in mouse CNS: a comparison of strategies","volume":"17","author":"Jankowsky","year":"2001","journal-title":"Biomol. Eng."},{"key":"10.1016\/j.nbd.2024.106570_bb0165","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis","volume":"313","author":"Jansen","year":"2015","journal-title":"Jama"},{"key":"10.1016\/j.nbd.2024.106570_bb0170","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/j.neurobiolaging.2015.05.010","article-title":"Behavioral abnormalities in APPSwe\/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains","volume":"36","author":"Janus","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2024.106570_bb0175","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.54771","article-title":"Changes in alcohol consumption and risk of dementia in a Nationwide cohort in South Korea","volume":"6","author":"Jeon","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.nbd.2024.106570_bb0180","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jneumeth.2014.02.001","article-title":"Burrowing and nest building behavior as indicators of well-being in mice","volume":"234","author":"Jirkof","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nbd.2024.106570_bb0185","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12974-018-1184-7","article-title":"Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis","volume":"15","author":"Kalinin","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2024.106570_bb0190","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnagi.2014.00093","article-title":"The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer's disease","volume":"6","author":"Kanekiyo","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2024.106570_bb0195","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/495156","article-title":"The effect of inflammatory cytokines in alcoholic liver disease","volume":"2013","author":"Kawaratani","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.nbd.2024.106570_bb0200","doi-asserted-by":"crossref","DOI":"10.1242\/bio.058678","article-title":"Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice","volume":"10","author":"Kiourtis","year":"2021","journal-title":"Biol Open."},{"key":"10.1016\/j.nbd.2024.106570_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001358","article-title":"Synthesis of human amyloid restricted to liver results in an Alzheimer disease-like neurodegenerative phenotype","volume":"19","author":"Lam","year":"2021","journal-title":"PLoS Biol."},{"key":"10.1016\/j.nbd.2024.106570_bb0210","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12883","article-title":"Adolescent binge-ethanol accelerates cognitive impairment and \u03b2-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP\/PSE mice","volume":"26","author":"Ledesma","year":"2021","journal-title":"Addict. Biol."},{"key":"10.1016\/j.nbd.2024.106570_bb0215","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2024.106570_bb0220","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/0960327118777869","article-title":"Molecular mechanism for the influence of gender dimorphism on alcoholic liver injury in mice","volume":"38","author":"Li","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.nbd.2024.106570_bb0225","doi-asserted-by":"crossref","first-page":"231S","DOI":"10.1111\/j.1530-0277.1998.tb04008.x","article-title":"Chronic ethanol consumption induces the production of tumor necrosis factor-alpha and related cytokines in liver and adipose tissue","volume":"22","author":"Lin","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.nbd.2024.106570_bb0230","series-title":"Secretases Related to Amyloid Precursor Protein Processing","first-page":"11","author":"Liu","year":"2021"},{"key":"10.1016\/j.nbd.2024.106570_bb0235","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/s41593-022-01127-0","article-title":"Peripheral apoE4 enhances Alzheimer\u2019s pathology and impairs cognition by compromising cerebrovascular function","volume":"25","author":"Liu","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106570_bb0240","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.nbd.2024.106570_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203659","article-title":"Impaired hepatic amyloid-beta degradation in Alzheimer\u2019s disease","volume":"13","author":"Maarouf","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2024.106570_bb0250","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1212\/WNL.56.1.127","article-title":"Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease","volume":"56","author":"Masliah","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2024.106570_bb0255","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41587-020-0472-9","article-title":"Multiplex digital spatial profiling of proteins and RNA in fixed tissue","volume":"38","author":"Merritt","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.nbd.2024.106570_bb0260","series-title":"Alcohol Use Disorder (AUD) in the United States: Age Groups and Demographic Characteristics","author":"NIAAA","year":"2023"},{"key":"10.1016\/j.nbd.2024.106570_bb0265","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.3390\/pharmaceutics14102200","article-title":"Efficacy and safety of a brain-penetrant biologic TNF-\u03b1 inhibitor in aged APP\/PS1 mice","volume":"14","author":"Ou","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.nbd.2024.106570_bb0275","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0896-6273(00)80187-7","article-title":"Microglial cells internalize aggregates of the Alzheimer\u2019s disease amyloid beta-protein via a scavenger receptor","volume":"17","author":"Paresce","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106570_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114707","article-title":"Apathy-like behaviour in tau mouse models of Alzheimer's disease and frontotemporal dementia","volume":"456","author":"Robinson","year":"2024","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2024.106570_bb0285","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.15252\/embj.201797397","article-title":"APP mouse models for Alzheimer's disease preclinical studies","volume":"36","author":"Sasaguri","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2024.106570_bb0290","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1073\/pnas.1112209109","article-title":"Withania somnifera reverses Alzheimer\u2019s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver","volume":"109","author":"Sehgal","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106570_bb0295","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.nbd.2024.106570_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134531","article-title":"Obesity and hepatic steatosis are associated with elevated serum amyloid Beta in metabolically stressed APPswe\/PS1dE9 mice","volume":"10","author":"Shie","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2024.106570_bb0305","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1194\/jlr.R075796","article-title":"Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies","volume":"58","author":"Shinohara","year":"2017","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.nbd.2024.106570_bb0315","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbi.2018.07.017","article-title":"The concerted amyloid-beta clearance of LRP1 and ABCB1\/P-gp across the blood-brain barrier is linked by PICALM","volume":"73","author":"Storck","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2024.106570_bb0320","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1161\/ATVBAHA.115.306895","article-title":"LRP in endothelial cells: a little Goes a long way","volume":"36","author":"Strickland","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.nbd.2024.106570_bb0325","doi-asserted-by":"crossref","first-page":"13287","DOI":"10.1073\/pnas.94.24.13287","article-title":"Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology","volume":"94","author":"Sturchler-Pierrat","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106570_bb0330","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s11095-006-0208-7","article-title":"Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver","volume":"23","author":"Tamaki","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.nbd.2024.106570_bb0335","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/hep.1840050212","article-title":"Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet","volume":"5","author":"Tsukamoto","year":"1985","journal-title":"Hepatology"},{"key":"10.1016\/j.nbd.2024.106570_bb0340","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1530-0277.1985.tb05046.x","article-title":"Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats","volume":"9","author":"Tsukamoto","year":"1985","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.nbd.2024.106570_bb0345","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40478-022-01324-9","article-title":"Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling","volume":"10","author":"Walker","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2024.106570_bb0350","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.14336\/AD.2022.0219","article-title":"Locomotor hyperactivity in the early-stage Alzheimer's disease-like pathology of APP\/PS1 mice: associated with impaired polarization of astrocyte aquaporin 4","volume":"13","author":"Wang","year":"2022","journal-title":"Aging Dis."},{"key":"10.1016\/j.nbd.2024.106570_bb0355","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/01480545.2019.1681444","article-title":"Long-term consumption of alcohol exacerbates neural lesions by destroying the functional integrity of the blood-brain barrier","volume":"45","author":"Wei","year":"2022","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.nbd.2024.106570_bb0360","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1172\/JCI128289","article-title":"Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury","volume":"129","author":"Win","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2024.106570_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106433","article-title":"Depression-like phenotypes in mice following common bile duct ligation: insights into the gut-liver-brain axis via the vagus nerve","volume":"192","author":"Yang","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106570_bb0370","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jad.2023.10.142","article-title":"Depression-like phenotypes in mice with hepatic ischemia\/reperfusion injury: a role of gut-microbiota-liver-brain axis via vagus nerve","volume":"345","author":"Yang","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.nbd.2024.106570_bb0375","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuron.2021.10.030","article-title":"Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research","volume":"110","author":"Yu","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106570_bb0380","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3389\/fimmu.2016.00538","article-title":"Critical roles of Kupffer cells in the pathogenesis of alcoholic liver disease: from basic science to clinical trials","volume":"7","author":"Zeng","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2024.106570_bb0385","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12974-023-02932-5","article-title":"Erythrocyte\u2013brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo","volume":"20","author":"Zhang","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2024.106570_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2021.111380","article-title":"Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis","volume":"317","author":"Zhornitsky","year":"2021","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.nbd.2024.106570_bb0395","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/j.1471-4159.2010.07002.x","article-title":"Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer\u2019s amyloid \u03b2-peptide elimination from the brain","volume":"115","author":"Zlokovic","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2024.106570_bb0310","first-page":"1097","article-title":"Gut microbiome-brain-cirrhosis axis","volume":"10","author":"Smith","year":"2023","journal-title":"Hepatology"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124001700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124001700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:55:54Z","timestamp":1778576154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996124001700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":77,"alternative-id":["S0969996124001700"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106570","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4110239\/v1","asserted-by":"object"}]},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's disease mice: Potential role in chronic heavy alcohol feeding","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106570","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106570"}}