{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:28:54Z","timestamp":1785338934145,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.nbd.2024.106576","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T15:58:48Z","timestamp":1719071928000},"page":"106576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Sunitinib-mediated inhibition of STAT3 in skeletal muscle and spinal cord does not affect the disease in a mouse model of ALS"],"prefix":"10.1016","volume":"199","author":[{"given":"Massimo","family":"Tortarolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea David","family":"Re Cecconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Camporeale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Margotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Nardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pasetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bonetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarita","family":"Galbiati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Crippa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Poletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Piccirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Bendotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.nbd.2024.106576_bb0005","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1093\/brain\/awac394","article-title":"Neurofilament light chain in drug development for amyotrophic lateral sclerosis: a critical appraisal","volume":"146","author":"Benatar","year":"2023","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.nbd.2024.106576_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150748","article-title":"The mdx mutation in the 129\/Sv background results in a milder phenotype: transcriptome comparative analysis searching for the protective factors","volume":"11","author":"Calyjur","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.nbd.2024.106576_bb0015","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.3390\/ijms21031092","article-title":"Displaced Myonuclei in cancer Cachexia suggest altered innervation","volume":"21","author":"Daou","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.nbd.2024.106576_bb0020","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1093\/hmg\/ddz044","article-title":"Sunitinib promotes myogenic regeneration and mitigates disease progression in the mdx mouse model of Duchenne muscular dystrophy","volume":"28","author":"Fontelonga","year":"2019","journal-title":"Hum. Mol. Genet."},{"issue":"8","key":"10.1016\/j.nbd.2024.106576_bb0025","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.3390\/ijms19082265","article-title":"STAT3 in skeletal muscle function and disorders","volume":"19","author":"Guadagnin","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.nbd.2024.106576_bb0030","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/17482968.2010.550626","article-title":"Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: a window of opportunity in the search for genetic modifiers","volume":"12","author":"Heiman-Patterson","year":"2011","journal-title":"Amyotroph. Lateral Scler."},{"issue":"5","key":"10.1016\/j.nbd.2024.106576_bb0035","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neuron.2010.11.036","article-title":"Exome sequencing reveals VCP mutations as a cause of familial ALS","volume":"68","author":"Johnson","year":"2010","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.nbd.2024.106576_bb0040","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.bbadis.2008.09.003","article-title":"VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: review of a unique disorder","volume":"1782","author":"Kimonis","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"issue":"Pt 4","key":"10.1016\/j.nbd.2024.106576_bb0045","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/brain\/awv005","article-title":"Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes","volume":"138","author":"Lauranzano","year":"2015","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.nbd.2024.106576_bb0050","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1096\/fj.03-0610com","article-title":"Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression","volume":"18","author":"Lecker","year":"2004","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.nbd.2024.106576_bb0055","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/cne.20140","article-title":"STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: potential role for STAT3 as a retrograde signaling transcription factor","volume":"474","author":"Lee","year":"2004","journal-title":"J. Comp. Neurol."},{"issue":"8","key":"10.1016\/j.nbd.2024.106576_bb0060","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/s41556-018-0151-y","article-title":"Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis","volume":"20","author":"Madaro","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.nbd.2024.106576_bb0065","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s41232-023-00276-4","article-title":"Correction: immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models","volume":"43","author":"Margotta","year":"2023","journal-title":"Inflamm. Regener."},{"issue":"1","key":"10.1016\/j.nbd.2024.106576_bb0070","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.neurobiolaging.2014.06.026","article-title":"Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis","volume":"36","author":"Marino","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.nbd.2024.106576_bb0075","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/bpa.12351","article-title":"New insights on the mechanisms of disease course variability in ALS from mutant SOD1 mouse models","volume":"26","author":"Nardo","year":"2016","journal-title":"Brain Pathol. (Zurich, Switzerland)"},{"issue":"4","key":"10.1016\/j.nbd.2024.106576_bb0080","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1111\/ejn.13650","article-title":"Differential activation of neuronal and glial STAT3 in the spinal cord of the SOD1G93A mouse model of amyotrophic lateral sclerosis","volume":"46","author":"Ohgomori","year":"2017","journal-title":"Eur. J. Neurosci."},{"issue":"7","key":"10.1016\/j.nbd.2024.106576_bb0085","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nm1425","article-title":"Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury","volume":"12","author":"Okada","year":"2006","journal-title":"Nat. Med."},{"issue":"15","key":"10.1016\/j.nbd.2024.106576_bb0090","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1038\/emboj.2012.178","article-title":"The p97\/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins","volume":"31","author":"Piccirillo","year":"2012","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.nbd.2024.106576_bb0095","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.18632\/oncotarget.2812","article-title":"Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle","volume":"6","author":"Pretto","year":"2015","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.nbd.2024.106576_bb0100","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1523\/JNEUROSCI.3269-04.2005","article-title":"Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation","volume":"25","author":"Qiu","year":"2005","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.nbd.2024.106576_bb0105","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1002\/jcsm.13011","article-title":"The p97-Nploc4 ATPase complex plays a role in muscle atrophy during cancer and amyotrophic lateral sclerosis","volume":"13","author":"Re Cecconi","year":"2022","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.nbd.2024.106576_bb0110","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40035-023-00380-y","article-title":"Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis","volume":"12","author":"Richardson","year":"2023","journal-title":"Transl. Neurodegener."},{"issue":"605","key":"10.1016\/j.nbd.2024.106576_bb0115","doi-asserted-by":"crossref","first-page":"eaay9592","DOI":"10.1126\/scitranslmed.aay9592","article-title":"Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia","volume":"13","author":"Sartori","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.nbd.2024.106576_bb0120","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1046\/j.1460-9568.2000.00005.x","article-title":"Peripheral but not central axotomy induces changes in Janus kinases (JAK) and signal transducers and activators of transcription (STAT)","volume":"12","author":"Schwaiger","year":"2000","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2024.106576_bb0125","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000213762","article-title":"Activation of signal transducer and activator of transcription-3 in the spinal cord of sporadic amyotrophic lateral sclerosis patients","volume":"6","author":"Shibata","year":"2009","journal-title":"Neurodegener. Dis."},{"issue":"4","key":"10.1016\/j.nbd.2024.106576_bb0130","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1440-1789.2009.01078.x","article-title":"Activation of STAT3 and inhibitory effects of pioglitazone on STAT3 activity in a mouse model of SOD1-mutated amyotrophic lateral sclerosis. Neuropathology: official journal of the Japanese society of","volume":"30","author":"Shibata","year":"2010","journal-title":"Neuropathology"},{"issue":"10","key":"10.1016\/j.nbd.2024.106576_bb0135","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/nm.3656","article-title":"STAT3 signaling controls satellite cell expansion and skeletal muscle repair","volume":"20","author":"Tierney","year":"2014","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.nbd.2024.106576_bb0140","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1016\/j.ymthe.2022.04.018","article-title":"Boosting the peripheral immune response in the skeletal muscles improved motor function in ALS transgenic mice","volume":"30","author":"Trolese","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.nbd.2024.106576_bb0145","doi-asserted-by":"crossref","first-page":"1160719","DOI":"10.3389\/fimmu.2023.1160719","article-title":"Advances in the role of STAT3 in macrophage polarization","volume":"14","author":"Xia","year":"2023","journal-title":"Front. Immunol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124001761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124001761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T12:27:42Z","timestamp":1738585662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996124001761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":29,"alternative-id":["S0969996124001761"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106576","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sunitinib-mediated inhibition of STAT3 in skeletal muscle and spinal cord does not affect the disease in a mouse model of ALS","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106576","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106576"}}