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Bull."},{"key":"10.1016\/j.nbd.2024.106588_bb0810","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10548-016-0485-3","article-title":"Effects of dopamine and serotonin systems on modulating neural oscillations in hippocampus-prefrontal cortex pathway in rats","volume":"29","author":"Xu","year":"2016","journal-title":"Brain Topogr."},{"key":"10.1016\/j.nbd.2024.106588_bb0815","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1001\/jama.2017.17225","article-title":"Trends in self-reported and biochemically tested marijuana use among pregnant females in California from 2009-2016","volume":"318","author":"Young-Wolff","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.nbd.2024.106588_bb0820","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1016\/j.euroneuro.2015.09.021","article-title":"Cortical neuroinflammation contributes to long-term cognitive dysfunctions following adolescent delta-9-tetrahydrocannabinol treatment in female rats","volume":"25","author":"Zamberletti","year":"2015","journal-title":"Eur. 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