{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:25:33Z","timestamp":1777627533544,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T00:00:00Z","timestamp":1720310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000095","name":"Savoy Foundation Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT153310"],"award-info":[{"award-number":["PJT153310"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT166178"],"award-info":[{"award-number":["PJT166178"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP130328"],"award-info":[{"award-number":["MOP130328"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.nbd.2024.106596","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T16:43:19Z","timestamp":1720456999000},"page":"106596","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Frequency-dependent seizure-suppressing effects of optogenetic activation of septal inhibitory cells in mesial temporal lobe epilepsy"],"prefix":"10.1016","volume":"199","author":[{"given":"Maxime","family":"L\u00e9vesque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Avoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2024.106596_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106097","article-title":"Ligand-gated mechanisms leading to ictogenesis in focal epileptic disorders","volume":"180","author":"Avoli","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106596_bb0010","doi-asserted-by":"crossref","first-page":"9308","DOI":"10.1523\/JNEUROSCI.17-23-09308.1997","article-title":"CA3-driven hippocampal-entorhinal loop controls rather than sustains in vitro limbic seizures","volume":"17","author":"Barbarosie","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106596_bb0015","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1046\/j.1528-1157.2002.17402.x","article-title":"Masking synchronous GABA-mediated potentials controls limbic seizures","volume":"43","author":"Barbarosie","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2024.106596_bb0020","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0306-4522(03)00262-8","article-title":"Involvement of amygdala networks in epileptiform synchronization in vitro","volume":"120","author":"Benini","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2024.106596_bb0025","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.aad5252","article-title":"Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation","volume":"352","author":"Boyce","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.nbd.2024.106596_bb0030","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1212\/WNL.43.6.1083","article-title":"Early childhood prolonged febrile convulsions, atrophy and sclerosis of mesial structures, and temporal lobe epilepsy: an MRI volumetric study","volume":"43","author":"Cendes","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2024.106596_bb0035","doi-asserted-by":"crossref","DOI":"10.1111\/epi.17326","article-title":"Evidence supporting deep brain stimulation of the medial septum in the treatment of temporal lobe epilepsy","author":"Cole","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2024.106596_bb0040","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0920-1211(96)00043-5","article-title":"Introduction to temporal lobe epilepsy","volume":"26","author":"Engel","year":"1996","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2024.106596_bb0045","series-title":"Optogenetic Frequency Scrambling of Hippocampal Theta Oscillations Dissociates Working Memory Retrieval from Hippocampal Spatiotemporal Codes","author":"Etter","year":"2022"},{"key":"10.1016\/j.nbd.2024.106596_bb0050","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrneurol.2014.59","article-title":"Electrical brain stimulation for epilepsy","volume":"10","author":"Fisher","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2024.106596_bb0055","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/ana.410340604","article-title":"Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination","volume":"34","author":"French","year":"1993","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2024.106596_bb0060","series-title":"The Temporal Lobe and Limbic System","author":"Gloor","year":"1997"},{"key":"10.1016\/j.nbd.2024.106596_bb0065","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1093\/brain\/awab042","article-title":"Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation","volume":"144","author":"Hristova","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2024.106596_bb0070","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.brs.2019.01.005","article-title":"Medial septal stimulation increases seizure threshold and improves cognition in epileptic rats","volume":"12","author":"Izadi","year":"2019","journal-title":"Brain Stimul."},{"key":"10.1016\/j.nbd.2024.106596_bb0075","series-title":"Jasper\u2019s Basic Mechanisms of the Epilepsies","article-title":"Limbic network synchronization and temporal lobe epilepsy","author":"Jefferys","year":"2012"},{"key":"10.1016\/j.nbd.2024.106596_bb0080","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.pneurobio.2012.02.005","article-title":"Mechanisms of physiological and epileptic HFO generation","volume":"98","author":"Jefferys","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106596_bb0085","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/epi.13830","article-title":"Update on the mechanisms and roles of high-frequency oscillations in seizures and epileptic disorders","volume":"58","author":"Jiruska","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2024.106596_bb0090","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1136\/jnnp.2004.045690","article-title":"The natural history of epilepsy: an epidemiological view","volume":"75","author":"Kwan","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2024.106596_bb0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.yebeh.2014.05.031","article-title":"The consequences of refractory epilepsy and its treatment","volume":"37","author":"Laxer","year":"2014","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nbd.2024.106596_bb0100","doi-asserted-by":"crossref","first-page":"13264","DOI":"10.1523\/JNEUROSCI.5086-11.2012","article-title":"Two seizure-onset types reveal specific patterns of high-frequency oscillations in a model of temporal lobe epilepsy","volume":"32","author":"L\u00e9vesque","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106596_bb0105","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/ana.25572","article-title":"Paradoxical effects of optogenetic stimulation in mesial temporal lobe epilepsy","volume":"86","author":"L\u00e9vesque","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2024.106596_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105794","article-title":"Bilateral optogenetic activation of inhibitory cells favors ictogenesis","volume":"171","author":"L\u00e9vesque","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106596_bb0115","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1152\/jn.00111.2023","article-title":"Optogenetic activation of septal inhibitory cells abates focal seizures","volume":"129","author":"L\u00e9vesque","year":"2023","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2024.106596_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-08933-4","article-title":"KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition","volume":"10","author":"Magloire","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2024.106596_bb0125","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0920-1211(94)90040-X","article-title":"Anticonvulsant effects of the experimental induction of hippocampal theta activity","volume":"18","author":"Miller","year":"1994","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.nbd.2024.106596_bb0130","article-title":"Septo-hippocampal interaction","author":"M\u00fcller","year":"2017","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.nbd.2024.106596_bb0135","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54518","article-title":"Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy","volume":"9","author":"Paschen","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2024.106596_bb0140","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/brain\/awad299","article-title":"On-demand low-frequency stimulation for seizure control: efficacy and behavioural implications","volume":"147","author":"Paschen","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2024.106596_bb0145","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation: II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.nbd.2024.106596_bb0150","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1190-22.2023","article-title":"Involvement of GABAergic interneuron subtypes in 4-aminopyridine-induced seizure-like events in mouse entorhinal cortex in vitro","author":"Scalmani","year":"2023","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106596_bb0155","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/ana.24342","article-title":"Interneuron activity leads to initiation of low-voltage fast-onset seizures","volume":"77","author":"Shiri","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2024.106596_bb0160","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/ana.24570","article-title":"Activation of specific neuronal networks leads to different seizure onset types","volume":"79","author":"Shiri","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2024.106596_bb0165","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1523\/JNEUROSCI.2244-16.2017","article-title":"Optogenetic low-frequency stimulation of specific neuronal populations abates Ictogenesis","volume":"37","author":"Shiri","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106596_bb0170","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1111\/epi.17329","article-title":"Practical considerations in epilepsy neurostimulation","volume":"63","author":"Simpson","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2024.106596_bb0175","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.3390\/ijms23116034","article-title":"Deep brain stimulation of the medial septal area can modulate gene expression in the Hippocampus of rats under urethane anesthesia","volume":"23","author":"Spivak","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106596_bb0180","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3389\/fneur.2017.00712","article-title":"The burden of severely drug-refractory epilepsy: a comparative longitudinal evaluation of mortality, morbidity, resource use, and cost using German health insurance data","volume":"8","author":"Strzelczyk","year":"2017","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2024.106596_bb0185","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/brain\/awaa450","article-title":"Closed-loop stimulation of the medial septum terminates epileptic seizures","volume":"144","author":"Takeuchi","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2024.106596_bb0190","article-title":"The medial septum as a potential target for treating brain disorders associated with Oscillopathies","volume":"15","author":"Takeuchi","year":"2021","journal-title":"Front. Neural Circ."},{"key":"10.1016\/j.nbd.2024.106596_bb0195","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/WNP.0b013e31826b3ab7","article-title":"Mesial temporal lobe epilepsy","volume":"29","author":"Tatum","year":"2012","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.nbd.2024.106596_bb0200","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1152\/jn.00192.2022","article-title":"Modulation of in vitro epileptiform activity by optogenetic stimulation of parvalbumin-positive interneurons","volume":"128","author":"Wang","year":"2022","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2024.106596_bb0205","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1152\/jn.00244.2023","article-title":"CA3 principal cell activation triggers hypersynchronous-onset seizures in a mouse model of mesial temporal lobe epilepsy","volume":"130","author":"Wang","year":"2023","journal-title":"J. Neurophysiol."},{"issue":"120\u2013122","key":"10.1016\/j.nbd.2024.106596_bb0210","first-page":"126","article-title":"Effectiveness and safety of epilepsy surgery: what is the evidence?","volume":"9","author":"Wiebe","year":"2004","journal-title":"CNS Spectr."},{"key":"10.1016\/j.nbd.2024.106596_bb0215","article-title":"The induction of long-term potentiation by medial septum activation under urethane anesthesia can alter gene expression in the Hippocampus","volume":"24","author":"Yv","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106596_bb0220","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.eplepsyres.2009.03.026","article-title":"High frequency oscillations and seizure frequency in patients with focal epilepsy","volume":"85","author":"Zijlmans","year":"2009","journal-title":"Epilepsy Res."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124001967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124001967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T12:28:55Z","timestamp":1738585735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996124001967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":44,"alternative-id":["S0969996124001967"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106596","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frequency-dependent seizure-suppressing effects of optogenetic activation of septal inhibitory cells in mesial temporal lobe epilepsy","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106596","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106596"}}