{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:58:37Z","timestamp":1793066317563,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.nbd.2024.106609","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T15:52:49Z","timestamp":1721663569000},"page":"106609","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Immune landscape of the enteric nervous system differentiates Parkinson's disease patients from controls: The PADUA-CESNE cohort"],"prefix":"10.1016","volume":"200","author":[{"given":"Marta","family":"Campagnolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Weis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Sandre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Tushevski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Paolo","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Savarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miryam","family":"Carecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Stocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Macchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"De Caro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Parchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Bubacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Porzionato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Antonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Emmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.nbd.2024.106609_bb0005","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1007\/s00415-012-6557-8","article-title":"The progression of non-motor symptoms in Parkinson\u2019s disease and their contribution to motor disability and quality of life","volume":"259","author":"Antonini","year":"2012","journal-title":"J. Neurol."},{"issue":"5","key":"10.1016\/j.nbd.2024.106609_bb0010","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s10072-012-1112-z","article-title":"Validation of the Italian version of the movement disorder society\u2014unified Parkinson\u2019s disease rating scale","volume":"34","author":"Antonini","year":"2013","journal-title":"Neurol. Sci."},{"issue":"6","key":"10.1016\/j.nbd.2024.106609_bb0015","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1128\/JVI.02949-15","article-title":"Alpha-synuclein expression restricts RNA viral infections in the brain","volume":"90","author":"Beatman","year":"2016","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.nbd.2024.106609_bb0020","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1111\/ene.15607","article-title":"Intestinal histomorphological and molecular alterations in patients with Parkinson\u2019s disease","volume":"30","author":"Bellini","year":"2023","journal-title":"Eur. J. Neurol."},{"issue":"4","key":"10.1016\/j.nbd.2024.106609_bb0035","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.nbd.2024.106609_bb0045","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/mds.27862","article-title":"The movement disorder society nonmotor rating scale: initial validation study","volume":"35","author":"Chaudhuri","year":"2020","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.nbd.2024.106609_bb0050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.gtc.2016.09.007","article-title":"The microbiome-gut-brain axis in health and disease","volume":"46","author":"Dinan","year":"2017","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"10.1016\/j.nbd.2024.106609_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2021.663399","article-title":"3D reconstruction of the morpho-functional topography of the human vagal trigone","volume":"15","author":"Emmi","year":"2021","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.nbd.2024.106609_bb0060","series-title":"Covid-19, Nervous System Pathology, and Parkinson\u2019s Disease: Bench to Bedside","first-page":"17","author":"Emmi","year":"2022"},{"issue":"5","key":"10.1016\/j.nbd.2024.106609_bb0065","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/mds.29358","article-title":"Duodenal alpha-synuclein pathology and enteric gliosis in advanced Parkinson\u2019s disease","volume":"38","author":"Emmi","year":"2023","journal-title":"Mov. Disord."},{"issue":"2","key":"10.1016\/j.nbd.2024.106609_bb0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/mds.29678","article-title":"Brain dynamics complexity as a signature of cognitive decline in Parkinson\u2019s disease","volume":"39","author":"Fiorenzato","year":"2024","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2024.106609_bb0075","series-title":"Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease","first-page":"39","article-title":"The enteric nervous system and gastrointestinal innervation: integrated local and central control","author":"Furness","year":"2014"},{"key":"10.1016\/j.nbd.2024.106609_bb0080","doi-asserted-by":"crossref","DOI":"10.1007\/s00702-024-02746-6","article-title":"Validation of the Italian version of the Parkinson\u2019s disease- cognitive functional rating scale","author":"Garon","year":"2024","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"2","key":"10.1016\/j.nbd.2024.106609_bb0085","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3233\/JPD-202351","article-title":"T cells limit accumulation of aggregate pathology following intrastriatal injection of \u03b1-synuclein fibrils","volume":"11","author":"George","year":"2021","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nbd.2024.106609_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2023.105480","article-title":"Neutrophil-to-lymphocyte ratio and lymphocyte count reflect alterations in central neurodegeneration-associated proteins and clinical severity in Parkinson disease patients","volume":"112","author":"Grillo","year":"2023","journal-title":"Parkinsonism Relat. Disord."},{"issue":"18","key":"10.1016\/j.nbd.2024.106609_bb0095","doi-asserted-by":"crossref","first-page":"e1944","DOI":"10.1212\/WNL.0000000000207147","article-title":"Misfolded \u03b1-synuclein assessment in the skin and CSF by RT-QuIC in isolated REM sleep behavior disorder","volume":"100","author":"Iranzo","year":"2023","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.nbd.2024.106609_bb0105","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/mds.29410","article-title":"International Parkinson and movement disorders society non-motor Parkinson disease study group. Levodopa dose equivalency in Parkinson\u2019s disease: updated systematic review and proposals","volume":"38","author":"Jost","year":"2023","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.nbd.2024.106609_bb0110","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/mds.28411","article-title":"Genetic and environmental factors in Parkinson\u2019s disease converge on immune function and inflammation","volume":"36","author":"Kline","year":"2021","journal-title":"Mov. Disord."},{"issue":"10","key":"10.1016\/j.nbd.2024.106609_bb0115","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.tins.2023.07.005","article-title":"The systemic immune response in Parkinson\u2019s disease: focus on the peripheral immune component","volume":"46","author":"Lauritsen","year":"2023","journal-title":"Trends Neurosci."},{"issue":"7","key":"10.1016\/j.nbd.2024.106609_bb0120","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.neuron.2022.12.029","article-title":"Virus exposure and neurodegenerative disease risk across national biobanks","volume":"111","author":"Levine","year":"2023","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.nbd.2024.106609_bb0130","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1093\/brain\/awac192","article-title":"Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue","volume":"145","author":"Monogue","year":"2022","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.nbd.2024.106609_bb0135","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3390\/ijms25021294","article-title":"From the gut to the brain: the role of enteric glial cells and their involvement in the pathogenesis of Parkinson\u2019s disease","volume":"25","author":"Montalb\u00e1n-Rodr\u00edguez","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.nbd.2024.106609_bb0140","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3390\/life11080732","article-title":"The baseline structure of the enteric nervous system and its role in Parkinson\u2019s disease","volume":"11","author":"Natale","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.nbd.2024.106609_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2017.00037","article-title":"Exploring Braak\u2019s hypothesis of Parkinson\u2019s disease","volume":"8","author":"Rietdijk","year":"2017","journal-title":"Front. Neurol."},{"issue":"s1","key":"10.1016\/j.nbd.2024.106609_bb0155","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.3233\/JPD-223418","article-title":"B lymphocytes in Parkinson\u2019s disease","volume":"12","author":"Scott","year":"2022","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nbd.2024.106609_bb0165","series-title":"Can Infections Trigger Alpha-Synucleinopathies?","first-page":"299","author":"Tulisiak","year":"2019"},{"key":"10.1016\/j.nbd.2024.106609_bb0170","first-page":"1","article-title":"Functions of macrophages in the maintenance of intestinal homeostasis","volume":"2019","author":"Wang","year":"2019","journal-title":"J Immunol Res"},{"issue":"1","key":"10.1016\/j.nbd.2024.106609_bb0175","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41531-022-00295-x","article-title":"Gastrointestinal involvement in Parkinson\u2019s disease: pathophysiology, diagnosis, and management","volume":"8","author":"Warnecke","year":"2022","journal-title":"Npj Parkinsons Dis."},{"issue":"7","key":"10.1016\/j.nbd.2024.106609_bb0180","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1093\/brain\/awab103","article-title":"CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson\u2019s disease","volume":"144","author":"Williams","year":"2021","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.nbd.2024.106609_bb0185","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.3390\/ijms23063394","article-title":"SARS-CoV-2 proteins interact with alpha synuclein and induce Lewy body-like pathology in vitro","volume":"23","author":"Wu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.nbd.2024.106609_bb0190","doi-asserted-by":"crossref","DOI":"10.14336\/AD.2022.01281","article-title":"Intestinal permeability, dysbiosis, inflammation and enteric glia cells: the intestinal etiology of Parkinson\u2019s disease","volume":"13","author":"Yang","year":"2022","journal-title":"Aging Dis."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124002092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124002092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T23:37:33Z","timestamp":1731368253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996124002092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":31,"alternative-id":["S0969996124002092"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106609","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune landscape of the enteric nervous system differentiates Parkinson's disease patients from controls: The PADUA-CESNE cohort","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106609","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106609"}}