{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:50:26Z","timestamp":1793242226826,"version":"4.5.0"},"reference-count":262,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.nbd.2024.106663","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T18:52:22Z","timestamp":1725735142000},"page":"106663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Brain incoming call from glia during neuroinflammation: Roles of extracellular vesicles"],"prefix":"10.1016","volume":"201","author":[{"given":"Francesco","family":"D'Egidio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Castelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"d'Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Ammannito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Quintiliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Cimini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2024.106663_bb0005","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3390\/ijms24010894","article-title":"Myelin basic protein in oligodendrocyte-derived extracellular vesicles as a diagnostic and prognostic biomarker in multiple sclerosis: A pilot study","volume":"24","author":"Agliardi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0010","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.3390\/ijms22115904","article-title":"Astrocytes in multiple sclerosis\u2014essential constituents with diverse multifaceted functions","volume":"22","author":"Aharoni","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.844194","article-title":"Role of extracellular vesicles in glia-neuron intercellular communication","volume":"15","author":"Ahmad","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0020","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.aat0473","article-title":"Glia as architects of central nervous system formation and function","volume":"362","author":"Allen","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.nbd.2024.106663_bb0025","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.3390\/ijms23105598","article-title":"Huntingtin co-isolates with small extracellular vesicles from blood plasma of TgHD and KI-HD pig models of Huntington's disease and human blood plasma","volume":"23","author":"Ananbeh","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0030","article-title":"Huntington's Disease: A Clinical Review","volume":"14","author":"Andhale","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.nbd.2024.106663_bb0035","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/emboj.2011.489","article-title":"Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism","volume":"31","author":"Antonucci","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2024.106663_bb0040","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0045","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cell.2017.12.022","article-title":"Retrovirus-like gag protein Arc1 binds RNA and traffics across synaptic boutons","volume":"172","author":"Ashley","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2024.106663_bb0050","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1074\/jbc.M110.190009","article-title":"Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles","volume":"286","author":"Bakhti","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2024.106663_bb0055","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.neuron.2008.10.013","article-title":"The mystery and magic of glia: a perspective on their roles in health and disease","volume":"60","author":"Barres","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106663_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0257372","article-title":"Biomarkers of neurodegeneration and glial activation validated in Alzheimer\u2019s disease assessed in longitudinal cerebrospinal fluid samples of Parkinson\u2019s disease","volume":"16","author":"Bartl","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2024.106663_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.nbd.2024.106663_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.00209","article-title":"Glia crosstalk in Neuroinflammatory diseases","volume":"14","author":"Bernaus","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0075","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/1352458520924590","article-title":"Synaptic and complement markers in extracellular vesicles in multiple sclerosis","volume":"27","author":"Bhargava","year":"2021","journal-title":"Mult. Scler."},{"key":"10.1016\/j.nbd.2024.106663_bb0080","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1136\/ard.2006.061309","article-title":"Activated complement components and complement activator molecules on the surface of cell-derived microparticles in patients with rheumatoid arthritis and healthy individuals","volume":"66","author":"Bir\u00f3","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.nbd.2024.106663_bb0085","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.4103\/1673-5374.342678","article-title":"Not only myelination: the immune-inflammatory functions of oligodendrocytes","volume":"17","author":"Boccazzi","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.nbd.2024.106663_bb0090","doi-asserted-by":"crossref","DOI":"10.1002\/alz.13134","article-title":"Alzheimer\u2019s disease brain-derived extracellular vesicles reveal altered synapse-related proteome and induce cognitive impairment in mice","author":"Bodart-Santos","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2024.106663_bb0095","doi-asserted-by":"crossref","first-page":"22480","DOI":"10.1073\/pnas.0911503106","article-title":"Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms","volume":"106","author":"Bradford","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106663_bb0100","doi-asserted-by":"crossref","first-page":"5681036","DOI":"10.1155\/2016\/5681036","article-title":"Nitric oxide-mediated posttranslational modifications: impacts at the synapse","volume":"2016","author":"Bradley","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.nbd.2024.106663_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-023-05672-9","article-title":"Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction","volume":"14","author":"Calabresi","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2024.106663_bb0110","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12974-017-0802-0","article-title":"Aging and amyloid \u03b2 oligomers enhance TLR4 expression, LPS-induced Ca2+ responses, and neuron cell death in cultured rat hippocampal neurons","volume":"14","author":"Calvo-Rodr\u00edguez","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2024.106663_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1214210","article-title":"Intercellular crosstalk mediated by tunneling nanotubes between central nervous system cells. What we need to advance","volume":"14","author":"Capobianco","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.nbd.2024.106663_bb0120","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1016\/j.neuron.2021.08.011","article-title":"Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2","volume":"109","author":"Chamberlain","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106663_bb0125","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41419-018-0369-4","article-title":"TNF\u03b1 and IL-1\u03b2 modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons","volume":"9","author":"Chaudhuri","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2024.106663_bb0130","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3390\/brainsci12010075","article-title":"Neuronal glial crosstalk: specific and shared mechanisms in Alzheimer\u2019s disease","volume":"12","author":"Chavda","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fnins.2015.00003","article-title":"Response of the nitrergic system to activation of the neuroendocrine stress axis","volume":"9","author":"Chen","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0140","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.1245296","article-title":"Identification and rescue of \u03b1-synuclein toxicity in Parkinson patient-derived neurons","volume":"342","author":"Chung","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.nbd.2024.106663_bb0145","doi-asserted-by":"crossref","first-page":"E1896","DOI":"10.1073\/pnas.1800165115","article-title":"Normal aging induces A1-like astrocyte reactivity","volume":"115","author":"Clarke","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106663_bb0150","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13024-021-00440-9","article-title":"Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model","volume":"16","author":"Clayton","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2024.106663_bb0155","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.nbd.2024.106663_bb0160","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s13311-019-00782-9","article-title":"Cell-autonomous and non-cell-autonomous pathogenic mechanisms in Huntington\u2019s disease: insights from in vitro and in vivo models","volume":"16","author":"Creus-Muncunill","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2024.106663_bb0165","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nn.3668","article-title":"Mutant huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors","volume":"17","author":"Crotti","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0170","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1682\/JRRD.2004.08.0111","article-title":"Oligodendrocyte cell death in pathogenesis of multiple sclerosis: protection of oligodendrocytes from apoptosis by complement","volume":"43","author":"Cudrici","year":"2006","journal-title":"J. Rehabil. Res. Dev."},{"key":"10.1016\/j.nbd.2024.106663_bb0175","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1750-1326-7-42","article-title":"Exosomal cell-to-cell transmission of alpha synuclein oligomers","volume":"7","author":"Danzer","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2024.106663_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12114","article-title":"Astrocytes-derived extracellular vesicles in motion at the neuron surface: involvement of the prion protein","volume":"10","author":"D'Arrigo","year":"2021","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.nbd.2024.106663_bb0185","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/s41593-018-0236-8","article-title":"Animal models of neurodegenerative diseases","volume":"21","author":"Dawson","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0190","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73062","article-title":"The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson\u2019s disease","volume":"10","author":"de Rus Jacquet","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.nbd.2024.106663_bb0195","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3390\/antiox12030571","article-title":"Cell rearrangement and oxidant\/antioxidant imbalance in Huntington's disease","volume":"12","author":"D'Egidio","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.nbd.2024.106663_bb0200","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.4103\/1673-5374.390969","article-title":"Therapeutic advances in neural regeneration for Huntington's disease","volume":"19","author":"D'Egidio","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.nbd.2024.106663_bb0205","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tins.2019.02.007","article-title":"Neuroimmune crosstalk through extracellular vesicles in health and disease","volume":"42","author":"Delpech","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0210","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/s41598-017-01115-6","article-title":"Neurons export extracellular vesicles enriched in cysteine string protein and misfolded protein cargo","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2024.106663_bb0215","doi-asserted-by":"crossref","first-page":"eaaw8546","DOI":"10.1126\/scitranslmed.aaw8546","article-title":"Astrocyte molecular signatures in Huntington\u2019s disease","volume":"11","author":"Diaz-Castro","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2024.106663_bb0220","doi-asserted-by":"crossref","first-page":"eaai7696","DOI":"10.1126\/scisignal.aai7696","article-title":"Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions","volume":"10","author":"Dickens","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.nbd.2024.106663_bb0225","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1152\/physrev.00036.2013","article-title":"Glial cells as progenitors and stem cells: new roles in the healthy and diseased brain","volume":"94","author":"Dimou","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.nbd.2024.106663_bb0230","doi-asserted-by":"crossref","first-page":"8653","DOI":"10.1523\/JNEUROSCI.1429-16.2016","article-title":"Neutral Sphingomyelinase-2 deficiency ameliorates Alzheimer\u2019s disease pathology and improves cognition in the 5XFAD mouse","volume":"36","author":"Dinkins","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0235","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41580-023-00576-0","article-title":"Context-specific regulation of extracellular vesicle biogenesis and cargo selection","volume":"24","author":"Dixson","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.nbd.2024.106663_bb0240","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.275.5300.661","article-title":"Regulation of neuronal survival by the serine-threonine protein kinase Akt","volume":"275","author":"Dudek","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.nbd.2024.106663_bb0245","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuroscience.2018.11.010","article-title":"Diversity and specificity of astrocyte-neuron communication","volume":"396","author":"Durkee","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2024.106663_bb0250","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/joa.13577","article-title":"R\u00edo-Hortega\u2019s drawings revisited with fluorescent protein defines a cytoplasm-filled channel system of CNS myelin","volume":"239","author":"Edgar","year":"2021","journal-title":"J. Anat."},{"key":"10.1016\/j.nbd.2024.106663_bb0255","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1074\/jbc.M111.293696","article-title":"NADPH oxidase is internalized by Clathrin-coated pits and localizes to a Rab27A\/B GTPase-regulated secretory compartment in activated macrophages","volume":"287","author":"Ejlerskov","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2024.106663_bb0260","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s40478-020-00981-y","article-title":"In vivo evidence of exosome-mediated A\u03b2 neurotoxicity","volume":"8","author":"Elsherbini","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2024.106663_bb0265","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1038\/s41591-018-0236-y","article-title":"Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis","volume":"24","author":"Falc\u00e3o","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2024.106663_bb0270","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00418-012-1045-x","article-title":"Astrocytes shed large membrane vesicles that contain mitochondria, lipid droplets and ATP","volume":"139","author":"Falchi","year":"2013","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.nbd.2024.106663_bb0275","doi-asserted-by":"crossref","first-page":"fcad170","DOI":"10.1093\/braincomms\/fcad170","article-title":"Microglial extracellular vesicles induce Alzheimer's disease-related cortico-hippocampal network dysfunction","volume":"5","author":"Falcicchia","year":"2023","journal-title":"Brain Commun"},{"key":"10.1016\/j.nbd.2024.106663_bb0280","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.coi.2019.05.008","article-title":"Reactive nitrogen species in host-bacterial interactions","volume":"60","author":"Fang","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.nbd.2024.106663_bb0285","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13064-018-0104-y","article-title":"Astrocytes, neurons, synapses: a tripartite view on cortical circuit development","volume":"13","author":"Farhy-Tselnicker","year":"2018","journal-title":"Neural Dev."},{"key":"10.1016\/j.nbd.2024.106663_bb0290","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biochi.2018.05.015","article-title":"Secretome from SH-SY5Y APPSwe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling","volume":"155","author":"Fernandes","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.nbd.2024.106663_bb0295","doi-asserted-by":"crossref","first-page":"9622","DOI":"10.1073\/pnas.1818042116","article-title":"Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease","volume":"116","author":"Ferrari Bardile","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106663_bb0300","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jalz.2014.06.008","article-title":"Identification of preclinical Alzheimer\u2019s disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study","volume":"11","author":"Fiandaca","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2024.106663_bb0305","first-page":"1","article-title":"Multiple sclerosis","volume":"4","author":"Filippi","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.nbd.2024.106663_bb0310","doi-asserted-by":"crossref","first-page":"9262","DOI":"10.1523\/JNEUROSCI.0146-18.2019","article-title":"NeuroEVs: characterizing extracellular vesicles generated in the neural domain","volume":"39","author":"Fowler","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0315","article-title":"Tau filaments are tethered within brain extracellular vesicles in Alzheimer\u2019s disease","volume":"2023.04.30.537820","author":"Fowler","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2024.106663_bb0320","doi-asserted-by":"crossref","first-page":"20130510","DOI":"10.1098\/rstb.2013.0510","article-title":"Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation","volume":"369","author":"Fr\u00f6hlich","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001604","article-title":"Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte\u2013Neuron Communication","volume":"11","author":"Fr\u00fchbeis","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.nbd.2024.106663_bb0330","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fncel.2013.00182","article-title":"Extracellular vesicles as mediators of neuron-glia communication","volume":"7","author":"Fr\u00fchbeis","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000621","article-title":"Oligodendrocytes support axonal transport and maintenance via exosome secretion","volume":"18","author":"Fr\u00fchbeis","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.nbd.2024.106663_bb0340","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature11007","article-title":"Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity","volume":"485","author":"F\u00fcnfschilling","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2024.106663_bb0345","doi-asserted-by":"crossref","first-page":"213","DOI":"10.15252\/embr.201439668","article-title":"Active endocannabinoids are secreted on extracellular membrane vesicles","volume":"16","author":"Gabrielli","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.nbd.2024.106663_bb0350","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1093\/brain\/awac083","article-title":"Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease","volume":"145","author":"Gabrielli","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2024.106663_bb0355","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.984690","article-title":"The multiple faces of extracellular vesicles released by microglia: Where are we 10 years after?","volume":"16","author":"Gabrielli","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Sig Transduct Target Ther"},{"key":"10.1016\/j.nbd.2024.106663_bb0365","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/1673-5374.343882","article-title":"Extracellular vesicles in Alzheimer\u2019s disease: from pathology to therapeutic approaches","volume":"18","author":"Garcia-Contreras","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.nbd.2024.106663_bb0370","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1007\/s12035-018-1393-1","article-title":"Laquinimod treatment improves myelination deficits at the transcriptional and ultrastructural levels in the YAC128 mouse model of Huntington disease","volume":"56","author":"Garcia-Miralles","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106663_bb0375","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.77019","article-title":"Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice","volume":"11","author":"Gargareta","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2024.106663_bb0380","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020537","article-title":"Origin of microglia: current concepts and past controversies","volume":"7","author":"Ginhoux","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.nbd.2024.106663_bb0385","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","article-title":"Mechanisms underlying inflammation in neurodegeneration","volume":"140","author":"Glass","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2024.106663_bb0390","article-title":"Impairment of the glial phagolysosomal system drives prion-like propagation in a <em>Drosophila<\/em> model of Huntington\u2019s disease","author":"Graham","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.nbd.2024.106663_bb0395","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/14789450.2017.1260450","article-title":"Proteomic insights into extracellular vesicle biology - defining exosomes and shed microvesicles","volume":"14","author":"Greening","year":"2017","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.nbd.2024.106663_bb0400","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1074\/jbc.M114.585703","article-title":"Acceleration of \u03b1-Synuclein aggregation by exosomes*","volume":"290","author":"Grey","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2024.106663_bb0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00702-009-0288-8","article-title":"Astrocytes and glioblastoma cells release exosomes carrying mtDNA","volume":"117","author":"Guescini","year":"2010","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.nbd.2024.106663_bb0410","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/glia.22963","article-title":"Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein","volume":"64","author":"Guitart","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2024.106663_bb0415","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbrc.2018.11.024","article-title":"Extracellular \u03b1B-crystallin modulates the inflammatory responses","volume":"508","author":"Guo","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2024.106663_bb0420","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1093\/brain\/awaa090","article-title":"Microglial exosomes facilitate \u03b1-synuclein transmission in Parkinson's disease","volume":"143","author":"Guo","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2024.106663_bb0425","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12964-021-00730-1","article-title":"The exosome journey: from biogenesis to uptake and intracellular signalling","volume":"19","author":"Gurung","year":"2021","journal-title":"Cell Communication and Signaling"},{"key":"10.1016\/j.nbd.2024.106663_bb0430","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s10571-018-0622-5","article-title":"Secretion and uptake of \u03b1-Synuclein via extracellular vesicles in cultured cells","volume":"38","author":"Gustafsson","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106663_bb0435","doi-asserted-by":"crossref","first-page":"9011","DOI":"10.3390\/ijms22169011","article-title":"Potential roles of extracellular vesicles as biomarkers and a novel treatment approach in multiple sclerosis","volume":"22","author":"Guti\u00e9rrez-Fern\u00e1ndez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0440","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41583-018-0055-7","article-title":"Inflammasome signalling in brain function and neurodegenerative disease","volume":"19","author":"Heneka","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0445","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/brain\/awad332","article-title":"Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signalling","volume":"147","author":"Hermann","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2024.106663_bb0450","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.tins.2018.03.006","article-title":"Extracellular vesicles: multimodal envoys in neural maintenance and repair","volume":"41","author":"Holm","year":"2018","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0455","doi-asserted-by":"crossref","first-page":"9550","DOI":"10.1523\/JNEUROSCI.1418-17.2017","article-title":"Mutant huntingtin inhibits \u03b1B-Crystallin expression and impairs exosome secretion from astrocytes","volume":"37","author":"Hong","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0460","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1083\/jcb.200911018","article-title":"Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A\u2013C","volume":"189","author":"Hsu","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2024.106663_bb0465","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s11481-019-09869-8","article-title":"HIV-1 tat-induced astrocytic extracellular vesicle miR-7 impairs synaptic architecture","volume":"15","author":"Hu","year":"2020","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.nbd.2024.106663_bb0470","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.neuron.2015.02.026","article-title":"Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes","volume":"85","author":"Huang","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106663_bb0475","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1096\/fj.201700673r","article-title":"Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons","volume":"32","author":"Huang","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2024.106663_bb0480","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12974-019-1529-x","article-title":"TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles","volume":"16","author":"Ib\u00e1\u00f1ez","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2024.106663_bb0485","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3390\/biom13010178","article-title":"Is glial dysfunction the key pathogenesis of LRRK2-linked Parkinson's disease?","volume":"13","author":"Iseki","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.nbd.2024.106663_bb0490","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/1073858421990001","article-title":"The two faces of exosomes in Parkinson's disease: from pathology to therapy","volume":"28","author":"Izco","year":"2022","journal-title":"Neuroscientist"},{"key":"10.1016\/j.nbd.2024.106663_bb0495","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s40478-023-01637-3","article-title":"Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer\u2019s disease","volume":"11","author":"Jang","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2024.106663_bb0500","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1582-4934.2010.01010.x","article-title":"Basic mechanisms of neurodegeneration: a critical update","volume":"14","author":"Jellinger","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.nbd.2024.106663_bb0505","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4110\/in.2012.12.2.41","article-title":"Glia as a link between Neuroinflammation and neuropathic pain","volume":"12","author":"Jha","year":"2012","journal-title":"Immune Netw."},{"key":"10.1016\/j.nbd.2024.106663_bb0510","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.0022-3042.2001.00678.x","article-title":"MEK and ERK protect hypoxic cortical neurons via phosphorylation of bad","volume":"80","author":"Jin","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2024.106663_bb0515","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1093\/hmg\/ddv016","article-title":"Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington\u2019s disease","volume":"24","author":"Jin","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2024.106663_bb0520","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/cdd.2013.180","article-title":"Microglia convert aggregated amyloid-\u03b2 into neurotoxic forms through the shedding of microvesicles","volume":"21","author":"Joshi","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.nbd.2024.106663_bb0525","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171418","article-title":"Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes","volume":"12","author":"Jovi\u010di\u0107","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2024.106663_bb0530","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/nm.2224","article-title":"The benefits and limitations of animal models for translational research in neurodegenerative diseases","volume":"16","author":"Jucker","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2024.106663_bb0535","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nature04302","article-title":"NMDA receptors are expressed in oligodendrocytes and activated in ischaemia","volume":"438","author":"K\u00e1rad\u00f3ttir","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2024.106663_bb0540","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/s41593-022-01104-7","article-title":"A shared disease-associated oligodendrocyte signature among multiple CNS pathologies","volume":"25","author":"Kenigsbuch","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0545","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nn.4043","article-title":"Diversity of astrocyte functions and phenotypes in neural circuits","volume":"18","author":"Khakh","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0550","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.nbd.2024.106663_bb0555","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.neuron.2013.01.013","article-title":"Regulation of postsynaptic retrograde signaling by presynaptic exosome release","volume":"77","author":"Korkut","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106663_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.02.015","article-title":"Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons","volume":"33","author":"Kraft","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2024.106663_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.134915","article-title":"Extracellular vesicles in the oligodendrocyte microenvironment","volume":"725","author":"Kr\u00e4mer-Albers","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2024.106663_bb0570","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1016\/j.neuron.2021.10.016","article-title":"Superfood for axons: glial exosomes boost axonal energetics by delivery of SIRT2","volume":"109","author":"Kr\u00e4mer-Albers","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106663_bb0575","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41583-023-00711-y","article-title":"Mechanisms of axonal support by oligodendrocyte-derived extracellular vesicles","volume":"24","author":"Kr\u00e4mer-Albers","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0580","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/prca.200700522","article-title":"Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: trophic support for axons?","volume":"1","author":"Kr\u00e4mer-Albers","year":"2007","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.nbd.2024.106663_bb0585","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12974-017-0819-4","article-title":"Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury","volume":"14","author":"Kumar","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2024.106663_bb0590","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1124\/pharmrev.122.000788","article-title":"Emergence of extracellular vesicles as \u201cliquid biopsy\u201d for neurological disorders: boom or bust","volume":"76","author":"Kumar","year":"2024","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.nbd.2024.106663_bb0595","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1007\/s12035-017-0529-z","article-title":"Prolonged dysfunction of astrocytes and activation of microglia accelerate degeneration of dopaminergic neurons in the rat substantia Nigra and block compensation of early motor dysfunction induced by 6-OHDA","volume":"55","author":"Kuter","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106663_bb0600","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Translational Neurodegeneration"},{"key":"10.1016\/j.nbd.2024.106663_bb0605","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.mcn.2010.11.004","article-title":"Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity","volume":"46","author":"Lachenal","year":"2011","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0610","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028936","article-title":"Multiple sclerosis pathology","volume":"8","author":"Lassmann","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.nbd.2024.106663_bb0615","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature11314","article-title":"Oligodendroglia metabolically support axons and contribute to neurodegeneration","volume":"487","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2024.106663_bb0620","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41573-022-00390-x","article-title":"Function and therapeutic value of astrocytes in neurological diseases","volume":"21","author":"Lee","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.nbd.2024.106663_bb0625","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1523\/JNEUROSCI.3206-12.2013","article-title":"Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt\/\u03b2-catenin dysregulation","volume":"33","author":"L\u2019Episcopo","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0630","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/stem.2827","article-title":"Neural stem cell grafts promote Astroglia-driven Neurorestoration in the aged parkinsonian brain via Wnt\/\u03b2-catenin signaling","volume":"36","author":"L\u2019Episcopo","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.nbd.2024.106663_bb0635","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1523\/JNEUROSCI.3995-07.2008","article-title":"Tumor necrosis factor \u03b1 mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present","volume":"28","author":"Li","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0640","doi-asserted-by":"crossref","first-page":"664","DOI":"10.14336\/AD.2018.0720","article-title":"Reactive astrocytes in neurodegenerative diseases","volume":"10","author":"Li","year":"2019","journal-title":"Aging Dis."},{"key":"10.1016\/j.nbd.2024.106663_bb0645","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bbrc.2019.07.084","article-title":"Extracellular microvesicles-derived from microglia treated with unaggregated \u03b1-synuclein attenuate mitochondrial fission and toxicity-induced by parkinsonian toxin MPP","volume":"517","author":"Li","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2024.106663_bb0650","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.765395","article-title":"Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases","volume":"13","author":"Li","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0655","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40035-023-00375-9","article-title":"Research progress on the role of extracellular vesicles in neurodegenerative diseases","volume":"12","author":"Li","year":"2023","journal-title":"Translational Neurodegeneration"},{"key":"10.1016\/j.nbd.2024.106663_bb0660","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2024.106663_bb0665","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1089\/ars.2016.6662","article-title":"Loss of NAD-dependent protein deacetylase Sirtuin-2 alters mitochondrial protein acetylation and dysregulates Mitophagy","volume":"26","author":"Liu","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2024.106663_bb0670","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00401-019-02049-1","article-title":"Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure","volume":"138","author":"Lombardi","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2024.106663_bb0675","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.654023","article-title":"Role of ATP in extracellular vesicle biogenesis and dynamics","volume":"12","author":"Lombardi","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.nbd.2024.106663_bb0680","doi-asserted-by":"crossref","first-page":"1331210","DOI":"10.3389\/fimmu.2024.1331210","article-title":"Extracellular vesicles released by microglia and macrophages carry endocannabinoids which foster oligodendrocyte differentiation","volume":"15","author":"Lombardi","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2024.106663_bb0685","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: an update on pathobiology and treatment strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2024.106663_bb0690","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12974-020-01761-0","article-title":"Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury","volume":"17","author":"Long","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2024.106663_bb0695","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3390\/cells9040930","article-title":"Astrocyte-derived small extracellular vesicles regulate dendritic complexity through miR-26a-5p activity","volume":"9","author":"Luarte","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.nbd.2024.106663_bb0700","doi-asserted-by":"crossref","DOI":"10.1016\/j.bionps.2023.100062","article-title":"Fluid biomarkers for the diagnosis of neurodegenerative diseases","volume":"8","author":"Luebke","year":"2023","journal-title":"Biomarkers in Neuropsychiatry"},{"key":"10.1016\/j.nbd.2024.106663_bb0705","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbi.2019.11.017","article-title":"Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling","volume":"84","author":"Madsen","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2024.106663_bb0710","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2018.00018","article-title":"Exosome-Based Cell-Cell Communication in the Tumor Microenvironment","volume":"6","author":"Maia","year":"2018","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1016\/j.nbd.2024.106663_bb0715","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s13238-015-0168-y","article-title":"Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2","volume":"6","author":"Mao","year":"2015","journal-title":"Protein Cell"},{"key":"10.1016\/j.nbd.2024.106663_bb0720","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3390\/ijms24010470","article-title":"Neuronal and glial communication via non-coding RNAs: messages in extracellular vesicles","volume":"24","author":"Marangon","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0725","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.tips.2005.08.007","article-title":"To be or not to be (inflamed) \u2013 is that the question in anti-inflammatory drug therapy of neurodegenerative disorders?","volume":"26","author":"Marchetti","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0730","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.3390\/jcm9061941","article-title":"Glia-derived extracellular vesicles in Parkinson's disease","volume":"9","author":"Marchetti","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.nbd.2024.106663_bb0735","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13101","article-title":"Parkinson\u2019s disease, aging and adult neurogenesis: Wnt\/\u03b2-catenin signalling as the key to unlock the mystery of endogenous brain repair","volume":"19","author":"Marchetti","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.nbd.2024.106663_bb0740","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fncel.2018.00268","article-title":"Interactions between neural progenitor cells and microglia in the subventricular zone: physiological implications in the neurogenic niche and after implantation in the injured brain","volume":"12","author":"Matarredona","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0745","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.nbd.2024.106663_bb0750","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13024-019-0329-1","article-title":"Alpha-synuclein structure and Parkinson\u2019s disease - lessons and emerging principles","volume":"14","author":"Meade","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2024.106663_bb0755","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1038\/s41467-019-11534-w","article-title":"Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS","volume":"10","author":"Men","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2024.106663_bb0760","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fimmu.2015.00262","article-title":"Complement system part I - molecular mechanisms of activation and regulation","volume":"6","author":"Merle","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2024.106663_bb0765","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1201982","article-title":"Microglia in Alzheimer's disease: pathogenesis, mechanisms, and therapeutic potentials","volume":"15","author":"Miao","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0770","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.expneurol.2015.10.006","article-title":"The molecular physiology of the axo-myelinic synapse","volume":"276","author":"Micu","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2024.106663_bb0775","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00018-023-04882-w","article-title":"Soluble mutant huntingtin drives early human pathogenesis in Huntington's disease","volume":"80","author":"Miguez","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0780","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.expneurol.2005.10.034","article-title":"Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys","volume":"197","author":"Miklossy","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2024.106663_bb0785","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0790","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jneuroim.2006.07.019","article-title":"Expression and distribution of toll-like receptors in the brain during murine neurocysticercosis","volume":"181","author":"Mishra","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.nbd.2024.106663_bb0795","doi-asserted-by":"crossref","first-page":"7933","DOI":"10.3390\/ijms22157933","article-title":"Differential proteomic analysis of astrocytes and astrocytes-derived extracellular vesicles from control and Rai knockout mice: insights into the mechanisms of neuroprotection","volume":"22","author":"Montecchi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0800","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.celrep.2018.03.037","article-title":"Neonatal subventricular zone neural stem cells release extracellular vesicles that act as a microglial morphogen","volume":"23","author":"Morton","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2024.106663_bb0805","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cmet.2020.05.019","article-title":"Oligodendrocytes provide antioxidant defense function for neurons by secreting ferritin heavy chain","volume":"32","author":"Mukherjee","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.nbd.2024.106663_bb0810","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/alz.12089","article-title":"Proteomic and biological profiling of extracellular vesicles from Alzheimer\u2019s disease human brain tissues","volume":"16","author":"Muraoka","year":"2020","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2024.106663_bb0815","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1021\/acs.jproteome.0c00934","article-title":"Enrichment of neurodegenerative microglia signature in brain-derived extracellular vesicles isolated from Alzheimer\u2019s disease mouse models","volume":"20","author":"Muraoka","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.nbd.2024.106663_bb0820","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0223-5","article-title":"Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking","volume":"51","author":"Murphy","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.nbd.2024.106663_bb0825","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3233\/JAD-170278","article-title":"Increased release of apolipoprotein E in extracellular vesicles following amyloid-\u03b2 Protofibril exposure of neuroglial co-cultures","volume":"60","author":"Nikitidou","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2024.106663_bb0830","doi-asserted-by":"crossref","first-page":"10236","DOI":"10.3390\/ijms221910236","article-title":"Emerging roles of astrocyte Kir4.1 channels in the pathogenesis and treatment of brain diseases","volume":"22","author":"Ohno","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0835","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1007\/s00018-019-03111-7","article-title":"Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms","volume":"76","author":"Oksanen","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb0840","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/1348-0421.12162","article-title":"Review of studies that have used knockout mice to assess normal function of prion protein under immunological or pathophysiological stress","volume":"58","author":"Onodera","year":"2014","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.nbd.2024.106663_bb0845","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.arcmed.2014.11.013","article-title":"Role of the blood-brain barrier in multiple sclerosis","volume":"45","author":"Ortiz","year":"2014","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.nbd.2024.106663_bb0850","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/ana.20338","article-title":"Microglial activation and dopamine terminal loss in early Parkinson's disease","volume":"57","author":"Ouchi","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2024.106663_bb0855","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0165-3806(02)00606-5","article-title":"Disturbance of oligodendrocyte development, hypomyelination and white matter injury in the neonatal rat brain after intracerebral injection of lipopolysaccharide","volume":"140","author":"Pang","year":"2003","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.nbd.2024.106663_bb0860","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: A field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106663_bb0865","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3389\/fncel.2018.00526","article-title":"Extracellular vesicles secreted by Astroglial cells transport apolipoprotein D to neurons and mediate neuronal survival upon oxidative stress","volume":"12","author":"Pascua-Maestro","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0870","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2017.12.024","article-title":"The neuronal gene arc encodes a repurposed retrotransposon gag protein that mediates intercellular RNA transfer","volume":"172","author":"Pastuzyn","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2024.106663_bb0875","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108829","article-title":"Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-\u03b2 signaling","volume":"34","author":"Patel","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2024.106663_bb0880","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.3390\/cells9102277","article-title":"The impact of the CX3CL1\/CX3CR1 Axis in neurological disorders","volume":"9","author":"Pawelec","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.nbd.2024.106663_bb0885","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/imm.12163","article-title":"Oligodendrocyte-microglia cross-talk in the central nervous system","volume":"141","author":"Peferoen","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.nbd.2024.106663_bb0890","doi-asserted-by":"crossref","first-page":"6328","DOI":"10.1073\/pnas.0914843107","article-title":"Functional delivery of viral miRNAs via exosomes","volume":"107","author":"Pegtel","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106663_bb0895","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.06.019","article-title":"Astrocyte-derived exosomes suppress autophagy and ameliorate neuronal damage in experimental ischemic stroke","volume":"382","author":"Pei","year":"2019","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.nbd.2024.106663_bb0900","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41582-020-0333-7","article-title":"Protein transmission in neurodegenerative disease","volume":"16","author":"Peng","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2024.106663_bb0905","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.1523\/JNEUROSCI.3351-16.2017","article-title":"Astrocyte transforming growth factor Beta 1 protects synapses against A\u03b2 oligomers in Alzheimer\u2019s disease model","volume":"37","author":"Pereira Diniz","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0910","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3390\/antiox10020172","article-title":"Novel and converging ways of NOX2 and SOD3 in trafficking and redox signaling in macrophages","volume":"10","author":"Petersen","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.nbd.2024.106663_bb0915","volume":"8","author":"Pistono","year":"2021","journal-title":"Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease. Frontiers in Cell and Developmental Biology"},{"issue":"2","key":"10.1016\/j.nbd.2024.106663_bb0920","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/sclerosis1020011","article-title":"Roles of extracellular vesicles in multiple sclerosis: from pathogenesis to potential tools as biomarkers and therapeutics","volume":"1","author":"Pistono","year":"2023","journal-title":"Sclerosis"},{"key":"10.1016\/j.nbd.2024.106663_bb0925","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.nbd.2024.106663_bb0930","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40478-018-0514-4","article-title":"Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons","volume":"6","author":"Polanco","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2024.106663_bb0935","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/hbm.21008","article-title":"Microglial activation in regions related to cognitive function predicts disease onset in Huntington\u2019s disease: a multimodal imaging study","volume":"32","author":"Politis","year":"2011","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nbd.2024.106663_bb0940","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cmet.2019.03.004","article-title":"Metabolic reprogramming in astrocytes distinguishes region-specific neuronal susceptibility in Huntington mice","volume":"29","author":"Polyzos","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.nbd.2024.106663_bb0945","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3389\/fimmu.2018.00217","article-title":"The role of astrocytes in multiple sclerosis","volume":"9","author":"Ponath","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2024.106663_bb0950","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00401-017-1803-x","article-title":"Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations","volume":"135","author":"Prada","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2024.106663_bb0955","first-page":"63","article-title":"Astrocytes shed extracellular vesicles that contain fibroblast growth factor-2 and vascular endothelial growth factor","volume":"21","author":"Proia","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.nbd.2024.106663_bb0960","doi-asserted-by":"crossref","first-page":"1061076","DOI":"10.3389\/fnmol.2022.1061076","article-title":"Extracellular vesicles in neurodegenerative diseases: A systematic review","volume":"15","author":"Raghav","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0965","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1074\/jbc.M608328200","article-title":"The macrophage cell surface Glyceraldehyde-3-phosphate dehydrogenase is a novel transferrin receptor*","volume":"282","author":"Raje","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2024.106663_bb0970","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1172\/JCI58644","article-title":"Innate immunity in the central nervous system","volume":"122","author":"Ransohoff","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2024.106663_bb0975","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41583-020-00406-8","article-title":"Mechanisms of node of Ranvier assembly","volume":"22","author":"Rasband","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb0980","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105445","article-title":"Extracellular vesicles in the treatment of neurological disorders","volume":"157","author":"Reed","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106663_bb0985","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/628192","article-title":"Insights into Neuroinflammation in Parkinson\u2019s disease: from biomarkers to anti-inflammatory based therapies","volume":"2015","author":"Rocha","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.nbd.2024.106663_bb0990","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/glia.24385","article-title":"Microglia-specific knock-out of NF-\u03baB\/IKK2 increases the accumulation of misfolded \u03b1-synuclein through the inhibition of p62\/sequestosome-1-dependent autophagy in the rotenone model of Parkinson\u2019s disease","volume":"71","author":"Rocha","year":"2023","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2024.106663_bb0995","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/816460","article-title":"Understanding the mysterious M2 macrophage through activation markers and effector mechanisms","volume":"2015","author":"R\u0151szer","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.nbd.2024.106663_bb1000","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature09611","article-title":"Developmental genetics of vertebrate glial-cell specification","volume":"468","author":"Rowitch","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2024.106663_bb1005","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13024-020-00396-2","article-title":"P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice","volume":"15","author":"Ruan","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2024.106663_bb1010","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.neuron.2022.03.008","article-title":"Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer\u2019s disease","volume":"110","author":"Sadick","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106663_bb1015","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2022.103749","article-title":"Functions of astrocytes in multiple sclerosis: A review","volume":"60","author":"Salles","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.nbd.2024.106663_bb1020","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nm.4397","article-title":"Microglia emerge as central players in brain disease","volume":"23","author":"Salter","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2024.106663_bb1025","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-020-03116-4","article-title":"Gut-licensed IFN\u03b3+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes","volume":"590","author":"Sanmarco","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2024.106663_bb1030","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00401-018-1868-1","article-title":"Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers","volume":"136","author":"Sardar Sinha","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2024.106663_bb1035","doi-asserted-by":"crossref","first-page":"eaat9900","DOI":"10.1126\/scisignal.aat9900","article-title":"Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells","volume":"12","author":"Sarkar","year":"2019","journal-title":"Sci. Signal."},{"key":"10.1016\/j.nbd.2024.106663_bb1040","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s11064-020-02977-5","article-title":"Astrocyte-derived Exosomal microRNA miR-200a-3p prevents MPP+-induced apoptotic cell death through Down-regulation of MKK4","volume":"45","author":"Shakespear","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2024.106663_bb1045","doi-asserted-by":"crossref","first-page":"16086","DOI":"10.1073\/pnas.1902513116","article-title":"Exosomes regulate neurogenesis and circuit assembly","volume":"116","author":"Sharma","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb1050","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4049\/jimmunol.175.1.155","article-title":"Acute lipopolysaccharide-mediated injury in neonatal white matter glia: role of TNF-alpha, IL-1beta, and calcium","volume":"175","author":"Sherwin","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2024.106663_bb1055","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1042\/BST20220204","article-title":"Propagation of Parkinson\u2019s disease by extracellular vesicle production and secretion","volume":"50","author":"Shippey","year":"2022","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.nbd.2024.106663_bb1060","article-title":"Oligodendrocytes: myelination and axonal support","volume":"8","author":"Simons","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.nbd.2024.106663_bb1065","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.3390\/ijms22042153","article-title":"Regenerative stem cell therapy for neurodegenerative diseases: an overview","volume":"22","author":"Sivandzade","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb1070","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s41232-023-00277-3","article-title":"Neuroinflammation in Alzheimer's disease: microglial signature and their relevance to disease","volume":"43","author":"Sobue","year":"2023","journal-title":"Inflamm Regen"},{"key":"10.1016\/j.nbd.2024.106663_bb1075","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13024-016-0098-z","article-title":"Accumulation of amyloid-\u03b2 by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons","volume":"11","author":"S\u00f6llvander","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2024.106663_bb1080","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.7150\/thno.30879","article-title":"M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124","volume":"9","author":"Song","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.nbd.2024.106663_bb1085","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s12017-022-08704-3","article-title":"Neuroinflammatory modulation of extracellular vesicle biogenesis and cargo loading","volume":"24","author":"Spiers","year":"2022","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.nbd.2024.106663_bb1090","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12974-023-02963-y","article-title":"Na\u00efve Huntington's disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1","volume":"20","author":"Steinberg","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2024.106663_bb1095","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019101997","article-title":"Microglial subtypes: diversity within the microglial community","volume":"38","author":"Stratoulias","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2024.106663_bb1100","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3233\/JAD-190497","article-title":"Changes in the morphology, number, and pathological protein levels of plasma exosomes may help diagnose Alzheimer's disease","volume":"73","author":"Sun","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2024.106663_bb1105","doi-asserted-by":"crossref","first-page":"7470","DOI":"10.3390\/ijms24087470","article-title":"Astrocyte-derived exosomes differentially shape T Cells' immune response in MS patients","volume":"24","author":"Szpakowski","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb1110","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/brain\/awm044","article-title":"Microglial activation in presymptomatic Huntington\u2019s disease gene carriers","volume":"130","author":"Tai","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2024.106663_bb1115","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.imlet.2015.08.002","article-title":"Extracellular ATP induces unconventional release of glyceraldehyde-3-phosphate dehydrogenase from microglial cells","volume":"167","author":"Takenouchi","year":"2015","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.nbd.2024.106663_bb1120","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3390\/genes10070510","article-title":"Insight into the role of extracellular vesicles in lysosomal storage disorders","volume":"10","author":"Tancini","year":"2019","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.nbd.2024.106663_bb1125","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nn.4547","article-title":"A new fate mapping system reveals context-dependent random or clonal expansion of microglia","volume":"20","author":"Tay","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb1130","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/dneu.20559","article-title":"Regulation of heat shock protein 70 release in astrocytes: role of signaling kinases","volume":"67","author":"Taylor","year":"2007","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106663_bb1135","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2015.06.021","article-title":"Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease","volume":"88","author":"Tebay","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nbd.2024.106663_bb1140","first-page":"2621","article-title":"Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease","volume":"25","author":"Teo","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2024.106663_bb1145","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"Journal of Extracellular Vesicles"},{"key":"10.1016\/j.nbd.2024.106663_bb1150","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nn.3691","article-title":"Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington\u2019s disease model mice","volume":"17","author":"Tong","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb1155","doi-asserted-by":"crossref","first-page":"480","DOI":"10.4049\/jimmunol.1502063","article-title":"The adaptor protein Rai\/ShcC promotes astrocyte-dependent inflammation during experimental autoimmune encephalomyelitis","volume":"197","author":"Ulivieri","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2024.106663_bb1160","doi-asserted-by":"crossref","first-page":"jcs243139","DOI":"10.1242\/jcs.243139","article-title":"Extracellular vesicles \u2013 propagators of neuropathology and sources of potential biomarkers and therapeutics for neurodegenerative diseases","volume":"133","author":"Vassileff","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb1165","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s12035-021-02603-7","article-title":"Insights of extracellular vesicles of mesenchymal stem cells: a prospective cell-free regenerative medicine for neurodegenerative disorders","volume":"59","author":"Vatsa","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106663_bb1170","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fncel.2019.00109","article-title":"Phenotypic effects of wild-type and mutant SOD1 expression in N9 murine microglia at steady state, inflammatory and immunomodulatory conditions","volume":"13","author":"Vaz","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2024.106663_bb1175","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/ana.23627","article-title":"Myeloid microvesicles are a marker and therapeutic target for neuroinflammation","volume":"72","author":"Verderio","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2024.106663_bb1180","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2210719120","article-title":"Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington\u2019s disease","volume":"120","author":"Villanueva","year":"2023","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nbd.2024.106663_bb1185","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1002\/cne.24040","article-title":"The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting","volume":"524","author":"von Bartheld","year":"2016","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2024.106663_bb1190","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington\u2019s disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2024.106663_bb1195","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3233\/JHD-210502","article-title":"Diminished LC3-associated phagocytosis by Huntington\u2019s disease striatal astrocytes","volume":"11","author":"Wakida","year":"2022","journal-title":"J Huntingtons Dis"},{"key":"10.1016\/j.nbd.2024.106663_bb1200","first-page":"136","article-title":"Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease","volume":"3","author":"Wang","year":"2015","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.nbd.2024.106663_bb1205","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-016-0143-y","article-title":"The release and trans-synaptic transmission of tau via exosomes","volume":"12","author":"Wang","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2024.106663_bb1210","doi-asserted-by":"crossref","first-page":"3232869","DOI":"10.1155\/2020\/3232869","article-title":"The role of Exosomal microRNAs and oxidative stress in neurodegenerative diseases","volume":"2020","author":"Wang","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.nbd.2024.106663_bb1215","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40035-023-00372-y","article-title":"\u03b1-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis","volume":"12","author":"Wang","year":"2023","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.nbd.2024.106663_bb1220","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/acn3.50862","article-title":"Environmental and genetic risk factors for MS: an integrated review","volume":"6","author":"Waubant","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.nbd.2024.106663_bb1225","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"Journal of Extracellular Vesicles"},{"key":"10.1016\/j.nbd.2024.106663_bb1230","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/s41598-020-57663-x","article-title":"Astrocyte support for oligodendrocyte differentiation can be conveyed via extracellular vesicles but diminishes with age","volume":"10","author":"Willis","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2024.106663_bb1235","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1038\/s41591-023-02566-3","article-title":"Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington\u2019s disease","volume":"29","author":"Wilton","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2024.106663_bb1240","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev-physiol-022516-034406","article-title":"Microglia in physiology and disease","volume":"79","author":"Wolf","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.nbd.2024.106663_bb1245","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41419-019-1404-9","article-title":"Microglia as modulators of exosomal alpha-synuclein transmission","volume":"10","author":"Xia","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2024.106663_bb1250","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40035-022-00330-0","article-title":"Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases","volume":"11","author":"Xia","year":"2022","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.nbd.2024.106663_bb1255","doi-asserted-by":"crossref","first-page":"608","DOI":"10.4103\/1673-5374.320999","article-title":"Profile of the RNA in exosomes from astrocytes and microglia using deep sequencing: implications for neurodegeneration mechanisms","volume":"17","author":"Xie","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.nbd.2024.106663_bb1260","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.4103\/1673-5374.390961","article-title":"The functions of exosomes targeting astrocytes and astrocyte-derived exosomes targeting other cell types","volume":"19","author":"Xu","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.nbd.2024.106663_bb1265","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/glia.23571","article-title":"Neuroinflammation in the central nervous system: symphony of glial cells","volume":"67","author":"Yang","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2024.106663_bb1270","doi-asserted-by":"crossref","first-page":"1238306","DOI":"10.3389\/fnins.2023.1238306","article-title":"Mutant HTT does not affect glial development but impairs myelination in the early disease stage","volume":"17","author":"Yang","year":"2023","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2024.106663_bb1275","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41423-019-0223-3","article-title":"The benefits of neuroinflammation for the repair of the injured central nervous system","volume":"16","author":"Yong","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.nbd.2024.106663_bb1280","doi-asserted-by":"crossref","first-page":"1706801","DOI":"10.1080\/20013078.2019.1706801","article-title":"Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing","volume":"9","author":"You","year":"2020","journal-title":"Journal of Extracellular Vesicles"},{"key":"10.1016\/j.nbd.2024.106663_bb1285","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.neuron.2018.08.015","article-title":"Reducing astrocyte calcium signaling in vivo alters striatal microcircuits and causes repetitive behavior","volume":"99","author":"Yu","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106663_bb1290","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1128\/MMBR.00043-14","article-title":"JNK signaling: regulation and functions based on complex protein-protein partnerships","volume":"80","author":"Zeke","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.nbd.2024.106663_bb1295","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s10571-016-0350-7","article-title":"Potential transfer of Polyglutamine and CAG-repeat RNA in extracellular vesicles in Huntington\u2019s disease: background and evaluation in cell culture","volume":"36","author":"Zhang","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106663_bb1300","doi-asserted-by":"crossref","first-page":"74","DOI":"10.7150\/thno.35841","article-title":"Microglia exacerbate white matter injury via complement C3\/C3aR pathway after hypoperfusion","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.nbd.2024.106663_bb1305","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40001-023-01606-5","article-title":"Current progression in application of extracellular vesicles in central nervous system diseases","volume":"29","author":"Zhang","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.nbd.2024.106663_bb1310","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/brain\/awx113","article-title":"Loss of \u201chomeostatic\u201d microglia and patterns of their activation in active multiple sclerosis","volume":"140","author":"Zrzavy","year":"2017","journal-title":"Brain"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124002638?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124002638?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T15:09:37Z","timestamp":1729782577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996124002638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":262,"alternative-id":["S0969996124002638"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106663","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain incoming call from glia during neuroinflammation: Roles of extracellular vesicles","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106663","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106663"}}