{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:07:47Z","timestamp":1793416067453,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.nbd.2024.106670","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T02:12:48Z","timestamp":1726711968000},"page":"106670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Astrocyte TrkB promotes brain injury and edema formation in ischemic stroke"],"prefix":"10.1016","volume":"201","author":[{"given":"Emanuela","family":"Colombo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bacigaluppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Bartoccetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Triolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bassani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bergamaschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne C.","family":"Descamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia Serena","family":"Gullotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Henley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Piccoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Anastasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Newcombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianvito","family":"Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthia","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2024.106670_bb0005","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.nbd.2009.09.019","article-title":"Increased expression of glutamate transporters in subcortical white matter after transient focal cerebral ischemia","volume":"37","author":"Arranz","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106670_bb0010","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1523\/JNEUROSCI.1643-16.2016","article-title":"Neural stem cell transplantation induces stroke recovery by upregulating glutamate transporter GLT-1 in astrocytes","volume":"36","author":"Bacigaluppi","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106670_bb0015","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/jcbfm.2012.185","article-title":"Assessing post-stroke behavior in mouse models of focal ischemia","volume":"33","author":"Balkaya","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2024.106670_bb0020","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1161\/STROKEAHA.114.006884","article-title":"Brain edema predicts outcome after nonlacunar ischemic stroke","volume":"45","author":"Battey","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2024.106670_bb0025","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1161\/01.ATV.0000258979.92828.bc","article-title":"Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site","volume":"27","author":"Bonello","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.nbd.2024.106670_bb0030","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0140-6736(20)31179-X","article-title":"Stroke","volume":"396","author":"Campbell","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2024.106670_bb0035","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/glia.22675","article-title":"Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice","volume":"62","author":"Cekanaviciute","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2024.106670_bb0040","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/jnnp-2020-324283","article-title":"The future of neuroprotection in stroke","volume":"92","author":"Chamorro","year":"2021","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2024.106670_bb0045","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/NEN.0b013e3182779e96","article-title":"Brain-derived neurotrophic factor-transfected and nontransfected 3T3 fibroblasts enhance migratory neuroblasts and functional restoration in mice with intracerebral hemorrhage","volume":"71","author":"Chen","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2024.106670_bb0050","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.it.2016.06.006","article-title":"Astrocytes: key regulators of Neuroinflammation","volume":"37","author":"Colombo","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.nbd.2024.106670_bb0055","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1084\/jem.20110698","article-title":"Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration","volume":"209","author":"Colombo","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2024.106670_bb0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025804118","article-title":"Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes","volume":"118","author":"Colombo","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106670_bb0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neulet.2009.01.077","article-title":"Hypoxia-inducible factor-1alpha signaling in aquaporin upregulation after traumatic brain injury","volume":"453","author":"Ding","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2024.106670_bb0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1460-9568.2009.06814.x","article-title":"Inactivation of astroglial NF-kappa B promotes survival of retinal neurons following ischemic injury","volume":"30","author":"Dvoriantchikova","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106670_bb0075","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41590-023-01505-1","article-title":"Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology","volume":"24","author":"Gullotta","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.nbd.2024.106670_bb0080","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3171\/2010.6.JNS10207","article-title":"The role of hypoxia-inducible factor-1alpha, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury","volume":"114","author":"Higashida","year":"2011","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.nbd.2024.106670_bb0085","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/0271678X15623290","article-title":"Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice","volume":"37","author":"Hirt","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2024.106670_bb0090","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44667","article-title":"Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1","volume":"8","author":"Holt","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2024.106670_bb0095","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1096\/fj.05-5086com","article-title":"Calcium signaling stimulates translation of HIF-alpha during hypoxia","volume":"20","author":"Hui","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2024.106670_bb0100","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1096\/fj.02-1086fje","article-title":"Inhibition of glutamate release by delaying ATP fall accounts for neuroprotective effects of antioxidants in experimental stroke","volume":"17","author":"Hurtado","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2024.106670_bb0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1471-4159.2006.04036.x","article-title":"Interleukin-1beta induces the expression of aquaporin-4 through a nuclear factor-kappaB pathway in rat astrocytes","volume":"99","author":"Ito","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2024.106670_bb0110","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1038\/s41388-018-0182-7","article-title":"Astrocyte-derived CCL20 reinforces HIF-1-mediated hypoxic responses in glioblastoma by stimulating the CCR6-NF-kappaB signaling pathway","volume":"37","author":"Jin","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.nbd.2024.106670_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.866738","article-title":"Glutamate scavenging as a Neuroreparative strategy in ischemic stroke","volume":"13","author":"Kaplan-Arabaci","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.nbd.2024.106670_bb0120","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.cell.2020.03.037","article-title":"Targeting Aquaporin-4 subcellular localization to treat central nervous system edema","volume":"181","author":"Kitchen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2024.106670_bb0125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ymthe.2003.10.012","article-title":"BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model","volume":"9","author":"Kurozumi","year":"2004","journal-title":"Mol. Ther."},{"key":"10.1016\/j.nbd.2024.106670_bb0130","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1073\/pnas.061020198","article-title":"Activation of Trk neurotrophin receptors in the absence of neurotrophins","volume":"98","author":"Lee","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106670_bb0135","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/sj.jcbfm.9600546","article-title":"Protective role of reactive astrocytes in brain ischemia","volume":"28","author":"Li","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2024.106670_bb0140","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/01.STR.24.1.117","article-title":"Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats","volume":"24","author":"Lin","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2024.106670_bb0145","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/sj.jcbfm.9600108","article-title":"Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet","volume":"25","author":"Lo","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2024.106670_bb0150","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20212224","article-title":"TNF-alpha induces AQP4 overexpression in astrocytes through the NF-kappaB pathway causing cellular edema and apoptosis","volume":"42","author":"Lu","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.nbd.2024.106670_bb0155","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.canlet.2014.09.011","article-title":"2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2","volume":"355","author":"Ma","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.nbd.2024.106670_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110686","article-title":"Animal models of cerebral ischemia: a review","volume":"131","author":"Ma","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.nbd.2024.106670_bb0165","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/72256","article-title":"Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke","volume":"6","author":"Manley","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2024.106670_bb0170","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1523\/JNEUROSCI.3353-16.2017","article-title":"Truncated TrkB.T1-mediated astrocyte dysfunction contributes to impaired motor function and neuropathic pain after spinal cord injury","volume":"37","author":"Matyas","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106670_bb0175","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12028-021-01341-x","article-title":"Midline shift greater than 3 mm independently predicts outcome after ischemic stroke","volume":"36","author":"McKeown","year":"2022","journal-title":"Neurocrit. Care."},{"key":"10.1016\/j.nbd.2024.106670_bb0180","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1523\/JNEUROSCI.23-18-07176.2003","article-title":"Functional changes of glial glutamate transporter GLT-1 during ischemia: an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1","volume":"23","author":"Mitani","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106670_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.703084","article-title":"Hypoxia-inducible factor (HIF) in ischemic stroke and neurodegenerative disease","volume":"9","author":"Mitroshina","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.nbd.2024.106670_bb0190","first-page":"751","article-title":"The HIF-1 inhibitor YC-1 decreases reactive astrocyte formation in a rodent ischemia model","volume":"7","author":"Na","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.nbd.2024.106670_bb0195","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.2174\/1570159X18666200528143301","article-title":"The stroke-induced blood-brain barrier disruption: current Progress of inspection technique, mechanism, and therapeutic target","volume":"18","author":"Okada","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.nbd.2024.106670_bb0200","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1073\/pnas.1204386109","article-title":"A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke","volume":"109","author":"Overman","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106670_bb0205","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.4103\/1673-5374.339481","article-title":"Astrocytic aquaporin 4 subcellular translocation as a therapeutic target for cytotoxic edema in ischemic stroke","volume":"17","author":"Patabendige","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.nbd.2024.106670_bb0210","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00031.2020","article-title":"Fluid transport in the brain","volume":"102","author":"Rasmussen","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.nbd.2024.106670_bb0215","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1161\/01.STR.31.9.2212","article-title":"Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia","volume":"31","author":"Schabitz","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2024.106670_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.755955","article-title":"Activation and role of astrocytes in ischemic stroke","volume":"15","author":"Shen","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2024.106670_bb0225","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.add6364","article-title":"Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke","volume":"16","author":"Stokum","year":"2023","journal-title":"Sci. Signal."},{"key":"10.1016\/j.nbd.2024.106670_bb0230","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/carcin\/bgh227","article-title":"Hepatocyte growth factor-activated NF-kappaB regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines","volume":"25","author":"Tacchini","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.nbd.2024.106670_bb0235","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1042\/BJ20080476","article-title":"Regulation of hypoxia-inducible factor-1alpha by NF-kappaB","volume":"412","author":"van Uden","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2024.106670_bb0240","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40035-021-00278-7","article-title":"Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration","volume":"11","author":"Verma","year":"2022","journal-title":"Transl. Neurodegen."},{"key":"10.1016\/j.nbd.2024.106670_bb0245","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1038\/s41598-022-06773-9","article-title":"Inhibition of HIF-1alpha-AQP4 axis ameliorates brain edema and neurological functional deficits in a rat controlled cortical injury (CCI) model","volume":"12","author":"Xiong","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2024.106670_bb0250","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s12975-021-00916-2","article-title":"Four decades of ischemic penumbra and its implication for ischemic stroke","volume":"12","author":"Yang","year":"2021","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.nbd.2024.106670_bb0255","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.neulet.2014.10.040","article-title":"Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia","volume":"584","author":"Yao","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2024.106670_bb0260","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1750-3639.2010.00443.x","article-title":"Selective inhibition of early--but not late--expressed HIF-1alpha is neuroprotective in rats after focal ischemic brain damage","volume":"21","author":"Yeh","year":"2011","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nbd.2024.106670_bb0265","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1124\/mol.107.036418","article-title":"Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression","volume":"72","author":"Yeh","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.nbd.2024.106670_bb0270","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.neuroscience.2009.12.076","article-title":"Hypertonic saline ameliorates cerebral edema through downregulation of aquaporin-4 expression in the astrocytes","volume":"166","author":"Zeng","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2024.106670_bb0275","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.brainres.2006.07.005","article-title":"Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion","volume":"1111","author":"Zhang","year":"2006","journal-title":"Brain Res."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124002705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124002705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T15:09:01Z","timestamp":1729782541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996124002705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":55,"alternative-id":["S0969996124002705"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106670","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astrocyte TrkB promotes brain injury and edema formation in ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106670","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106670"}}