{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:47:11Z","timestamp":1790948831438,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006309","name":"American Parkinson Disease Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001595","name":"Dystonia Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.nbd.2024.106685","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T21:34:08Z","timestamp":1727472848000},"page":"106685","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Striatal cholinergic transmission in an inducible transgenic mouse model of paroxysmal non-kinesiogenic dyskinesia"],"prefix":"10.1016","volume":"201","author":[{"given":"Mariangela","family":"Scarduzio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Eskow Jaunarajs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Standaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"45","key":"10.1016\/j.nbd.2024.106685_bb0005","doi-asserted-by":"crossref","first-page":"18488","DOI":"10.1073\/pnas.1104807108","article-title":"Discovery of \u03b2-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy","volume":"108","author":"Allen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2024.106685_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105429","article-title":"Distinct patterns of dyskinetic and dystonic features following D1 or D2 receptor stimulation in a mouse model of parkinsonism","volume":"157","author":"Andreoli","year":"2021","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.nbd.2024.106685_bb0015","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1016\/j.celrep.2018.08.042","article-title":"Dual dopaminergic regulation of Corticostriatal plasticity by cholinergic interneurons and indirect pathway medium spiny neurons","volume":"24","author":"Augustin","year":"2018","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.nbd.2024.106685_bb0020","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1021\/acsptsci.8b00060","article-title":"Novel and potent dopamine D(2) receptor go-protein biased agonists","volume":"2","author":"Bonifazi","year":"2019","journal-title":"ACS Pharmacol. Transl. Sci."},{"issue":"7","key":"10.1016\/j.nbd.2024.106685_bb0025","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/iub.473","article-title":"Moonlighting characteristics of G protein-coupled receptors: focus on receptor heteromers and relevance for neurodegeneration","volume":"63","author":"Borroto-Escuela","year":"2011","journal-title":"IUBMB Life"},{"issue":"4","key":"10.1016\/j.nbd.2024.106685_bb0030","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s12311-022-01441-0","article-title":"Cerebellar dysfunction as a source of dystonic phenotypes in mice","volume":"22","author":"Brown","year":"2023","journal-title":"Cerebellum"},{"key":"10.1016\/j.nbd.2024.106685_bb0035","series-title":"Dopaminergic D2 Receptor Modulation of Striatal Cholinergic Interneurons Contributes to Sequence Learning","author":"Chancey","year":"2023"},{"key":"10.1016\/j.nbd.2024.106685_bb0040","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/bs.irn.2023.04.009","article-title":"Dystonia genes and their biological pathways","volume":"169","author":"Di Fonzo","year":"2023","journal-title":"Int. Rev. Neurobiol."},{"issue":"9","key":"10.1016\/j.nbd.2024.106685_bb0045","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1021\/acschemneuro.2c00817","article-title":"Within-mice comparison of microdialysis and fiber photometry-recorded dopamine biosensor during amphetamine response","volume":"14","author":"Ejdrup","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.nbd.2024.106685_bb0050","series-title":"GeneReviews(\u00ae)","article-title":"Familial paroxysmal nonkinesigenic dyskinesia","author":"Erro","year":"1993"},{"key":"10.1016\/j.nbd.2024.106685_bb0055","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pneurobio.2015.02.002","article-title":"Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia","volume":"127-128","author":"Eskow Jaunarajs","year":"2015","journal-title":"Prog. Neurobiol."},{"issue":"36","key":"10.1016\/j.nbd.2024.106685_bb0060","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.1523\/JNEUROSCI.0407-19.2019","article-title":"Diverse mechanisms Lead to common dysfunction of striatal cholinergic interneurons in distinct genetic mouse models of dystonia","volume":"39","author":"Eskow Jaunarajs","year":"2019","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2024.106685_bb0065","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41531-022-00301-2","article-title":"Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings","volume":"8","author":"Feldmann","year":"2022","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.nbd.2024.106685_bb0070","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fendo.2014.00071","article-title":"Diversity and bias through receptor-receptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization","volume":"5","author":"Fuxe","year":"2014","journal-title":"Front. Endocrinol."},{"issue":"12","key":"10.1016\/j.nbd.2024.106685_bb0075","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.tins.2013.09.003","article-title":"New genetic insights highlight \u2018old\u2019 ideas on motor dysfunction in dystonia","volume":"36","author":"Goodchild","year":"2013","journal-title":"Trends Neurosci."},{"issue":"10","key":"10.1016\/j.nbd.2024.106685_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ph16101427","article-title":"Modulation of neuron and astrocyte dopamine receptors via receptor-receptor interactions","volume":"16","author":"Guidolin","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.nbd.2024.106685_bb0085","first-page":"8","article-title":"Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement","author":"Howe","year":"2019","journal-title":"Elife"},{"issue":"11","key":"10.1016\/j.nbd.2024.106685_bb0090","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/s41592-020-0953-2","article-title":"An optimized acetylcholine sensor for monitoring in vivo cholinergic activity","volume":"17","author":"Jing","year":"2020","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.nbd.2024.106685_bb0095","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/1531-8257(200005)15:3<542::AID-MDS1019>3.0.CO;2-2","article-title":"Calcium channel agonists and dystonia in the mouse","volume":"15","author":"Jinnah","year":"2000","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.nbd.2024.106685_bb0100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuron.2016.06.014","article-title":"Parkinsonism driven by antipsychotics originates from dopaminergic control of striatal cholinergic interneurons","volume":"91","author":"Kharkwal","year":"2016","journal-title":"Neuron"},{"issue":"7979","key":"10.1016\/j.nbd.2024.106685_bb0105","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41586-023-05995-9","article-title":"Intrinsic dopamine and acetylcholine dynamics in the striatum of mice","volume":"621","author":"Krok","year":"2023","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.nbd.2024.106685_bb0110","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1172\/JCI58470","article-title":"Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia","volume":"122","author":"Lee","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.nbd.2024.106685_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107527","article-title":"Dopaminergic control of striatal cholinergic interneurons underlies cocaine-induced Psychostimulation","volume":"31","author":"Lewis","year":"2020","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.nbd.2024.106685_bb0120","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.expneurol.2005.02.002","article-title":"Pharmacological validation of a mouse model of l-DOPA-induced dyskinesia","volume":"194","author":"Lundblad","year":"2005","journal-title":"Exp. Neurol."},{"issue":"10","key":"10.1016\/j.nbd.2024.106685_bb0125","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1021\/acschembio.7b00493","article-title":"Structure-guided screening for functionally selective D(2) dopamine receptor ligands from a virtual chemical library","volume":"12","author":"M\u00e4nnel","year":"2017","journal-title":"ACS Chem. Biol."},{"issue":"7","key":"10.1016\/j.nbd.2024.106685_bb0130","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/mdc3.13524","article-title":"The prevalence of idiopathic or inherited isolated dystonia: a systematic review and meta-analysis","volume":"9","author":"Medina","year":"2022","journal-title":"Mov. Disord. Clin. Pract."},{"key":"10.1016\/j.nbd.2024.106685_bb0135","article-title":"Enhancement of adenosine a(2A) signaling improves dopamine D(2) receptor antagonist-induced dyskinesia via \u03b2-arrestin signaling","volume":"16","author":"Nagaoka","year":"2022","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2024.106685_bb0140","doi-asserted-by":"crossref","first-page":"652","DOI":"10.2174\/1871527315666161107091149","article-title":"Caffeine; the forgotten potential for Parkinson\u2019s disease","volume":"16","author":"Negida","year":"2017","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"13","key":"10.1016\/j.nbd.2024.106685_bb0145","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1523\/JNEUROSCI.1614-20.2022","article-title":"Striatal indirect pathway dysfunction underlies motor deficits in a mouse model of paroxysmal dyskinesia","volume":"42","author":"Nelson","year":"2022","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2024.106685_bb0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.nbd.2011.01.026","article-title":"The functional neuroanatomy of dystonia","volume":"42","author":"Neychev","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.nbd.2024.106685_bb0155","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.nbd.2006.07.006","article-title":"Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia","volume":"24","author":"Pisani","year":"2006","journal-title":"Neurobiol. Dis."},{"issue":"17","key":"10.1016\/j.nbd.2024.106685_bb0160","doi-asserted-by":"crossref","first-page":"7825","DOI":"10.1523\/JNEUROSCI.22-17-07825.2002","article-title":"Abnormal cerebellar signaling induces dystonia in mice","volume":"22","author":"Pizoli","year":"2002","journal-title":"J. Neurosci."},{"issue":"255","key":"10.1016\/j.nbd.2024.106685_bb0165","doi-asserted-by":"crossref","first-page":"pe50","DOI":"10.1126\/stke.2552004pe50","article-title":"Coactivation of D1 and D2 dopamine receptors: in marriage, a case of his, hers, and theirs","volume":"2004","author":"Pollack","year":"2004","journal-title":"Sci. STKE"},{"key":"10.1016\/j.nbd.2024.106685_bb0170","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.nbd.2012.07.019","article-title":"Limited regional cerebellar dysfunction induces focal dystonia in mice","volume":"49","author":"Raike","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106685_bb0175","doi-asserted-by":"crossref","DOI":"10.1177\/17590914221102075","article-title":"Dopamine D(2) and adenosine a(2A) receptors interaction on ca(2+) current modulation in a rodent model of parkinsonism","volume":"14","author":"Rend\u00f3n-Ochoa","year":"2022","journal-title":"ASN Neuro"},{"issue":"Pt 10","key":"10.1016\/j.nbd.2024.106685_bb0180","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1093\/brain\/awv212","article-title":"A new knock-in mouse model of l-DOPA-responsive dystonia","volume":"138","author":"Rose","year":"2015","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.nbd.2024.106685_bb0185","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1007\/s12035-017-0696-y","article-title":"Antipsychotic-like efficacy of dopamine D(2) receptor-biased ligands is dependent on adenosine a(2A) receptor expression","volume":"55","author":"Sahlholm","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2024.106685_bb0190","first-page":"2","article-title":"Piecing together a complex puzzle: 5 key challenges in basic dystonia research","author":"Scarduzio","year":"2023","journal-title":"Dystonia"},{"key":"10.1016\/j.nbd.2024.106685_bb0195","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.expneurol.2017.06.005","article-title":"Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia","volume":"295","author":"Scarduzio","year":"2017","journal-title":"Exp. Neurol."},{"issue":"10","key":"10.1016\/j.nbd.2024.106685_bb0200","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1073\/pnas.1501364112","article-title":"Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis","volume":"112","author":"Shen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.nbd.2024.106685_bb0205","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1038\/s41467-023-39497-z","article-title":"Striatal cholinergic interneuron membrane voltage tracks locomotor rhythms in mice","volume":"14","author":"Shroff","year":"2023","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.nbd.2024.106685_bb0210","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00004714-198210000-00008","article-title":"The neuropharmacology of tardive dyskinesia, spontaneous dyskinesia, and other dystonias","volume":"2","author":"Stahl","year":"1982","journal-title":"J. Clin. Psychopharmacol."},{"issue":"2","key":"10.1016\/j.nbd.2024.106685_bb0215","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.nbd.2011.01.012","article-title":"Update on the pathology of dystonia","volume":"42","author":"Standaert","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.nbd.2024.106685_bb0220","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S1474-4422(20)30366-5","article-title":"Dystonia: genetics, phenomenology, and pathophysiology","volume":"19","author":"Vidailhet","year":"2020","journal-title":"Lancet Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124002857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124002857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T14:16:27Z","timestamp":1731507387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996124002857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":44,"alternative-id":["S0969996124002857"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106685","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Striatal cholinergic transmission in an inducible transgenic mouse model of paroxysmal non-kinesiogenic dyskinesia","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106685","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106685"}}