{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:10:46Z","timestamp":1782169846297,"version":"3.54.5"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson's","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"US Office of Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.nbd.2024.106702","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T17:27:41Z","timestamp":1728840461000},"page":"106702","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["\u03b1-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice"],"prefix":"10.1016","volume":"202","author":[{"given":"Wei","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Menard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha L.","family":"Escobar Galvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yuan","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2024.106702_bb0005","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1007\/s43440-023-00530-z","article-title":"Investigating the potential effects of alpha-synuclein aggregation on susceptibility to chronic stress in a mouse Parkinson\u2019s disease model","volume":"75","author":"Alwani","year":"2023","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.nbd.2024.106702_bb0010","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41593-022-01076-8","article-title":"Adolescent sleep shapes social novelty preference in mice","volume":"25","author":"Bian","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106702_bb0015","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1093\/brain\/awl301","article-title":"Startling facts about emotion in Parkinson\u2019s disease: blunted reactivity to aversive stimuli","volume":"129","author":"Bowers","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2024.106702_bb0020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2024.106702_bb0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2019.08.007","article-title":"Chronic corticosterone aggravates behavioural and neuronal symptomatology in a mouse model of alpha-synuclein pathology","volume":"83","author":"Burtscher","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2024.106702_bb0030","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3233\/JPD-191590","article-title":"Loss of one Engrailed1 allele enhances induced \u03b1-synucleinopathy","volume":"9","author":"Chatterjee","year":"2019","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nbd.2024.106702_bb0035","first-page":"11","article-title":"Synaptic location is a determinant of the detrimental effects of \u03b1-Synuclein pathology to glutamatergic transmission in the basolateral amygdala","author":"Chen","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2024.106702_bb0040","article-title":"Motor cortical neuronal hyperexcitability associated with \u03b1-synuclein aggregation","author":"Chen","year":"2024","journal-title":"Biorxiv"},{"key":"10.1016\/j.nbd.2024.106702_bb0045","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1523\/JNEUROSCI.4257-13.2014","article-title":"Amygdala inputs to the ventral Hippocampus bidirectionally modulate social behavior","volume":"34","author":"Felix-Ortiz","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106702_bb0050","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/jnen\/nlx054","article-title":"\u03b1-Synucleinopathy in the human amygdala in Parkinson disease: differential vulnerability of somatostatin- and Parvalbumin-expressing neurons","volume":"76","author":"Flores-Cuadrado","year":"2017","journal-title":"J Neuropathology Exp Neurology"},{"key":"10.1016\/j.nbd.2024.106702_bb0055","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40478-018-0537-x","article-title":"\u03b1-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons","volume":"6","author":"Froula","year":"2018","journal-title":"Acta Neuropathologica Commun"},{"key":"10.1016\/j.nbd.2024.106702_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106595","article-title":"Excitatory synaptic structural abnormalities produced by templated aggregation of alpha-syn in the basolateral amygdala","volume":"199","author":"Gcwensa","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106702_bb0065","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41531-024-00672-8","article-title":"A topographical atlas of alpha-synuclein dosage and cell type-specific expression in adult mouse brain and peripheral organs","volume":"10","author":"Geertsma","year":"2024","journal-title":"NPJ Parkinsons Dis"},{"key":"10.1016\/j.nbd.2024.106702_bb0070","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3389\/fneur.2018.00295","article-title":"Alpha-Synuclein: from early synaptic dysfunction to neurodegeneration","volume":"9","author":"Ghiglieri","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2024.106702_bb0075","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0006-8993(96)00517-3","article-title":"5-HT1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-maze","volume":"732","author":"Gonzalez","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2024.106702_bb0080","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1096\/fj.10-173625","article-title":"Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson\u2019s disease","volume":"25","author":"Good","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2024.106702_bb0085","doi-asserted-by":"crossref","first-page":"eaav8736","DOI":"10.1126\/science.aav8736","article-title":"Amygdala ensembles encode behavioral states","volume":"364","author":"Gr\u00fcndemann","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.nbd.2024.106702_bb0090","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.expneurol.2016.10.009","article-title":"Functional alterations of the dopaminergic and glutamatergic systems in spontaneous \u03b1-synuclein overexpressing rats","volume":"287","author":"Guatteo","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2024.106702_bb0095","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1093\/brain\/awf251","article-title":"Clinical correlates of selective pathology in the amygdala of patients with Parkinson\u2019s disease","volume":"125","author":"Harding","year":"2002","journal-title":"Brain J Neurology"},{"key":"10.1016\/j.nbd.2024.106702_bb0100","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/s41593-019-0457-5","article-title":"Spread of \u03b1-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis","volume":"22","author":"Henderson","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106702_bb0105","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/mds.26087","article-title":"Abnormal functional connectivity of the amygdala is associated with depression in Parkinson\u2019s disease","volume":"30","author":"Hu","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2024.106702_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107899","article-title":"Social behavior is modulated by valence-encoding mPFC-amygdala sub-circuitry","volume":"32","author":"Huang","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2024.106702_bb0115","doi-asserted-by":"crossref","first-page":"E4016","DOI":"10.1073\/pnas.1309143110","article-title":"Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model","volume":"110","author":"Janezic","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nbd.2024.106702_bb0120","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/mds.29269","article-title":"Morpho-functional changes of Nigral dopamine neurons in an \u03b1-Synuclein model of Parkinson\u2019s disease","volume":"38","author":"Ledonne","year":"2023","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2024.106702_bb0125","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nn.3582","article-title":"Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety","volume":"17","author":"Likhtik","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106702_bb0130","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1227157","article-title":"Pathological \u03b1-Synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.nbd.2024.106702_bb0135","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1073\/pnas.1200575109","article-title":"Impaired neurotransmission caused by overexpression of \u03b1-synuclein in nigral dopamine neurons","volume":"109","author":"Lundblad","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2024.106702_bb0140","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1073\/pnas.1913904117","article-title":"The process of Lewy body formation, rather than simply \u03b1-synuclein fibrillization, is one of the major drivers of neurodegeneration","volume":"117","author":"Mahul-Mellier","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2024.106702_bb0145","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S1353-8020(13)70017-8","article-title":"\u03b1-Synucleinopathy phenotypes","volume":"20","author":"McCann","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2024.106702_bb0150","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.celrep.2017.10.046","article-title":"Prefrontal cortex drives distinct projection neurons in the basolateral amygdala","volume":"21","author":"McGarry","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2024.106702_bb0155","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/s41593-020-0661-3","article-title":"Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys","volume":"23","author":"Nagai","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2024.106702_bb0160","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/jnen\/nlx099","article-title":"The amygdala as a locus of pathologic misfolding in neurodegenerative diseases","volume":"77","author":"Nelson","year":"2017","journal-title":"J Neuropathology Exp Neurology"},{"key":"10.1016\/j.nbd.2024.106702_bb0165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.parkreldis.2018.06.025","article-title":"Evidence for dopaminergic axonal degeneration as an early pathological process in Parkinson\u2019s disease","volume":"56","author":"O\u2019Keeffe","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2024.106702_bb0170","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.celrep.2015.01.060","article-title":"Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonism","volume":"10","author":"Osterberg Valerie","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2024.106702_bb0175","doi-asserted-by":"crossref","first-page":"19073","DOI":"10.1073\/pnas.1009803107","article-title":"Hierarchical order of coexisting pre- and postsynaptic forms of long-term potentiation at synapses in amygdala","volume":"107","author":"Shin","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nbd.2024.106702_bb0180","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1460-9568.2009.07056.x","article-title":"Asymmetries in long-term and short-term plasticity at thalamic and cortical inputs to the amygdala in vivo","volume":"31","author":"Sigur\u00f2sson","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106702_bb0185","doi-asserted-by":"crossref","unstructured":"Sorrentino ZA, Goodwin MS, Riffe CJ, Dhillon J-KS, Xia Y, Gorion K-M, Vijayaraghavan N, McFarland KN, Golbe LI, Yachnis AT, Giasson BI: Unique \u03b1-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression. Acta Neuropathologica Commun 2019, 7:142.","DOI":"10.1186\/s40478-019-0787-2"},{"key":"10.1016\/j.nbd.2024.106702_bb0190","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-Synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2024.106702_bb0195","article-title":"Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded \u03b1-synuclein inclusions","volume":"34","author":"Stoyka","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2024.106702_bb0200","doi-asserted-by":"crossref","first-page":"13586","DOI":"10.1523\/JNEUROSCI.5069-13.2014","article-title":"Mutant \u03b1-synuclein enhances firing frequencies in dopamine substantia Nigra neurons by oxidative impairment of A-type potassium channels","volume":"34","author":"Subramaniam","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2024.106702_bb0205","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11910-017-0788-0","article-title":"Imaging the etiology of apathy, anxiety, and depression in Parkinson\u2019s disease: implication for treatment","volume":"17","author":"Thobois","year":"2017","journal-title":"Curr Neurol Neurosci"},{"key":"10.1016\/j.nbd.2024.106702_bb0210","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1093\/brain\/awab242","article-title":"Dopamine-dependent early synaptic and motor dysfunctions induced by alpha-synuclein in the nigrostriatal circuit","volume":"144","author":"Tozzi","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2024.106702_bb0215","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuron.2011.08.033","article-title":"Exogenous \u03b1-Synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death","volume":"72","author":"Volpicelli-Daley Laura","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2024.106702_bb0220","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/nprot.2014.143","article-title":"Addition of exogenous \u03b1-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous \u03b1-synuclein to Lewy body and Lewy neurite\u2013like aggregates","volume":"9","author":"Volpicelli-Daley","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2024.106702_bb0225","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0166-2236(98)01362-9","article-title":"Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias","volume":"22","author":"West","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2024.106702_bb0230","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2021.768294","article-title":"Neural circuits for social interactions: from microcircuits to input-output circuits","volume":"15","author":"Xu","year":"2021","journal-title":"Front Neural Circuits"},{"key":"10.1016\/j.nbd.2024.106702_bb0235","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.neuroscience.2004.09.054","article-title":"The amygdala of patients with Parkinson\u2019s disease is silent in response to fearful facial expressions","volume":"131","author":"Yoshimura","year":"2005","journal-title":"Neuroscience"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124003024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996124003024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T10:27:39Z","timestamp":1733135259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996124003024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":47,"alternative-id":["S0969996124003024"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106702","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.05.20.594995","asserted-by":"object"}]},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b1-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2024.106702","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106702"}}