{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:36:06Z","timestamp":1790354166837,"version":"4.1.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.nbd.2025.106798","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T18:19:41Z","timestamp":1736360381000},"page":"106798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Elevation of ganglioside degradation pathway drives GM2 and GM3 within amyloid plaques in a transgenic mouse model of Alzheimer's disease"],"prefix":"10.1016","volume":"205","author":[{"given":"Wenxuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Ollen-Bittle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn N.","family":"Whitehead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2025.106798_bb0005","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.ijbiomac.2020.08.165","article-title":"\u03b2-Amyloid (1\u201342) peptide adsorbs but does not insert into ganglioside-containing phospholipid membranes in the liquid-disordered state: modelling and experimental studies","volume":"164","author":"Ahyayauch","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.nbd.2025.106798_bb0010","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.3390\/ijms25126401","article-title":"Understanding A\u03b2 peptide binding to lipid membranes: a biophysical perspective","volume":"Vol. 25","author":"Ahyayauch","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2025.106798_bb0015","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1001\/archneur.65.11.1509","article-title":"Frequent amyloid deposition without significant cognitive impairment among the elderly","volume":"65","author":"Aizenstein","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2025.106798_bb0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(07)63001-5","article-title":"The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)","volume":"163","author":"Amaral","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nbd.2025.106798_bb0025","doi-asserted-by":"crossref","first-page":"9411","DOI":"10.1002\/anie.201603178","article-title":"GM1 ganglioside inhibits \u03b2-amyloid oligomerization induced by sphingomyelin","volume":"55","author":"Amaro","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.nbd.2025.106798_bb0030","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.neurobiolaging.2006.08.002","article-title":"Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer\u2019s disease","volume":"28","author":"Barrier","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2025.106798_bb0035","series-title":"The American journal of human genetics","first-page":"118","article-title":"Alteration of ganglioside biosynthesis responsible for complex hereditary spastic paraplegia. cell.com","volume":"93","author":"Boukhris","year":"2013"},{"key":"10.1016\/j.nbd.2025.106798_bb0040","article-title":"Probing amyloid-\u03b2 pathology in transgenic Alzheimer\u2019s disease (tgArcSwe) mice using MALDI imaging mass spectrometry","volume":"469\u2013478","author":"Carlred","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.106798_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130364","article-title":"Increased expression of simple ganglioside species GM2 and GM3 detected by MALDI imaging mass spectrometry in a combined rat model of A\u03b2 toxicity and stroke","volume":"10","author":"Caughlin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2025.106798_bb0050","doi-asserted-by":"crossref","DOI":"10.3791\/55254","article-title":"Sublimation of DAN matrix for the detection and visualization of gangliosides in rat brain tissue for MALDI imaging mass spectrometry","author":"Caughlin","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.nbd.2025.106798_bb0055","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16389-z","article-title":"Age-dependent and regional heterogeneity in the long-chain base of A-series gangliosides observed in the rat brain using MALDI imaging","volume":"7","author":"Caughlin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2025.106798_bb0060","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.bbagen.2018.03.011","article-title":"Membrane-lipid homeostasis in a prodromal rat model of Alzheimer\u2019s disease: characteristic profiles in ganglioside distributions during aging detected using MALDI imaging mass spectrometry","volume":"1862","author":"Caughlin","year":"2018","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.nbd.2025.106798_bb0065","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1007\/s12035-018-1317-0","article-title":"Chloroquine restores ganglioside homeostasis and improves pathological and behavioral outcomes post-stroke in the rat","volume":"56","author":"Caughlin","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2025.106798_bb0070","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.bpj.2017.03.009","article-title":"Impact of GM1 on membrane-mediated aggregation\/oligomerization of \u03b2-amyloid: unifying view","volume":"113","author":"Cebecauer","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.nbd.2025.106798_bb0075","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.bpj.2017.03.009","article-title":"Impact of GM1 on membrane-mediated aggregation\/oligomerization of \u03b2-amyloid: unifying view","volume":"113","author":"Cebecauer","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.nbd.2025.106798_bb0080","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1074\/jbc.M111.274142","article-title":"Comparative Lipidomic analysis of mouse and human brain with Alzheimer disease","volume":"287","author":"Chan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2025.106798_bb0085","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/jnc.14146","article-title":"Role of the GM1 ganglioside oligosaccharide portion in the TrkA-dependent neurite sprouting in neuroblastoma cells","volume":"143","author":"Chiricozzi","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.106798_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21030868","article-title":"GM1 ganglioside is a key factor in maintaining the mammalian neuronal functions avoiding neurodegeneration","volume":"21","author":"Chiricozzi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2025.106798_bb0095","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.nbd.2007.05.003","article-title":"Glycolipid and ganglioside metabolism imbalances in Huntington\u2019s disease","volume":"27","author":"Desplats","year":"2007","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.nbd.2025.106798_bb0100","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nrn3012","article-title":"Linking lipids to Alzheimer\u2019s disease: cholesterol and beyond","volume":"12","author":"Di Paolo","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2025.106798_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-26310-y","article-title":"A metabolome atlas of the aging mouse brain","volume":"12","author":"Ding","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.106798_bb0110","doi-asserted-by":"crossref","first-page":"8100","DOI":"10.1073\/pnas.1508767112","article-title":"Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis","volume":"112","author":"Dodge","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2025.106798_bb0115","doi-asserted-by":"crossref","DOI":"10.1007\/s00216-016-0076-x","article-title":"Multimodal detection of GM2 and GM3 lipid species in the brain of mucopolysaccharidosis type II mouse by serial imaging mass spectrometry and immunohistochemistry","author":"Dufresne","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.nbd.2025.106798_bb0120","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-021-01216-4","article-title":"Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer\u2019s disease","volume":"9","author":"Emre","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2025.106798_bb0125","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.bbalip.2010.05.004","article-title":"Lipids in Alzheimer\u2019s disease: a century-old story","volume":"1801","author":"Foley","year":"2010","journal-title":"Biochimica et Biophysica Acta (BBA) \u2013 Mol. Cell Biol. Lip."},{"key":"10.1016\/j.nbd.2025.106798_bb0130","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-021-02374-x","article-title":"Anti-inflammatory role of GM1 and other gangliosides on microglia","volume":"19","author":"Galleguillos","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2025.106798_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009764","article-title":"Synaptic plasticity in the Hippocampus of a APP\/PS1 mouse model of Alzheimer\u2019s disease is impaired in old but not young mice","volume":"5","author":"Gengler","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2025.106798_bb0140","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.neuron.2012.09.036","article-title":"Hippocampal pyramidal neurons comprise two distinct cell types that are countermodulated by metabotropic receptors","volume":"76","author":"Graves","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.106798_bb0145","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s12031-007-0060-1","article-title":"Brain uptake and utilization of fatty acids, lipids and lipoproteins: application to neurological disorders","volume":"33","author":"Hamilton","year":"2007","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2025.106798_bb0150","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/brain\/awt270","article-title":"Mutations in B4GALNT1 (GM2 synthase) underlie a new disorder of ganglioside biosynthesis","volume":"136","author":"Harlalka","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2025.106798_bb0155","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1016\/j.febslet.2015.09.033","article-title":"Alzheimer\u2019s disease is associated with disordered localization of ganglioside GM1 molecular species in the human dentate gyrus","volume":"589","author":"Hirano-Sakamaki","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2025.106798_bb0160","article-title":"Lipid rafts: linking Alzheimer\u2019s amyloid-\u03b2 production, aggregation, and toxicity at neuronal membranes","volume":"2011","author":"Hooper","year":"2010","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2025.106798_bb0165","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1212\/WNL.51.3.728","article-title":"The incidence of dementia: a meta-analysis","volume":"51","author":"Jorm","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2025.106798_bb0170","doi-asserted-by":"crossref","unstructured":"Kakio, A., Nishimoto, S. ichi, Yanagisawa, K., Kozutsumi, Y., Matsuzaki, K., 2002. Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid. Biochemistry 41, 7385\u20137390. doi:https:\/\/doi.org\/10.1021\/BI0255874.","DOI":"10.1021\/bi0255874"},{"key":"10.1016\/j.nbd.2025.106798_bb0175","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1021\/acschemneuro.7b00314","article-title":"Novel Trimodal MALDI imaging mass spectrometry (IMS3) at 10 \u03bcm reveals spatial lipid and peptide correlates implicated in A\u03b2 plaque pathology in Alzheimer\u2019s disease","volume":"8","author":"Kaya","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.nbd.2025.106798_bb0180","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1021\/acschemneuro.6b00391","article-title":"Delineating amyloid plaque associated neuronal sphingolipids in transgenic Alzheimer\u2019s disease mice (tgArcSwe) using MALDI imaging mass spectrometry","volume":"8","author":"Kaya","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.nbd.2025.106798_bb0185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1021\/acschemneuro.9b00532","article-title":"Spatial Lipidomics reveals region and long Chain Base specific accumulations of Monosialogangliosides in amyloid plaques in familial Alzheimer\u2019s disease mice (5xFAD) brain","volume":"11","author":"Kaya","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.nbd.2025.106798_bb0190","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.nbd.2025.106798_bb0195","first-page":"1","article-title":"Ganglioside biochemistry. ISRN","volume":"2012","author":"Kolter","year":"2012","journal-title":"Biochem"},{"key":"10.1016\/j.nbd.2025.106798_bb0200","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0197-0186(92)90058-Y","article-title":"Cortical distribution of gangliosides in Alzheimer\u2019s disease","volume":"20","author":"Kracun","year":"1992","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.nbd.2025.106798_bb0205","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.neuint.2011.06.007","article-title":"Amyloid-\u03b2 induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action","volume":"59","author":"Kreutz","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.nbd.2025.106798_bb0210","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.neuron.2018.02.002","article-title":"Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer\u2019s disease models","volume":"97","author":"Lee","year":"2018","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.nbd.2025.106798_bb0215","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2025.106798_bb0220","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2 C T method","volume":"25","author":"Livak","year":"2001","journal-title":"METHODS"},{"key":"10.1016\/j.nbd.2025.106798_bb0225","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1523\/JNEUROSCI.6348-09.2010","article-title":"Impaired ganglioside metabolism in Huntington\u2019s disease and neuroprotective role of GM1","volume":"30","author":"Maglione","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.106798_bb0230","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0925-4439(99)00074-5","article-title":"Biochemical consequences of mutations causing the GM2 gangliosidoses","volume":"1455","author":"Mahuran","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.nbd.2025.106798_bb0235","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41428-018-0041-y","article-title":"Responsibility of lipid compositions for the amyloid \u00df assembly induced by ganglioside nanoclusters in mouse synaptosomal membranes","volume":"50","author":"Matsubara","year":"2018","journal-title":"Polym. J."},{"key":"10.1016\/j.nbd.2025.106798_bb0240","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1021\/ar500127z","article-title":"How do membranes initiate alzheimers disease? Formation of toxic amyloid fibrils by the amyloid \u03b2-protein on ganglioside clusters","volume":"47","author":"Matsuzaki","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.nbd.2025.106798_bb0245","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.bbapap.2018.09.010","article-title":"GM1 locates to mature amyloid structures implicating a prominent role for glycolipid-protein interactions in Alzheimer pathology","volume":"1867","author":"Michno","year":"2019","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"10.1016\/j.nbd.2025.106798_bb0250","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.4c00006","article-title":"Spatial Neurolipidomics at the single amyloid-\u03b2 plaque level in postmortem human Alzheimer\u2019s disease brain","author":"Michno","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.nbd.2025.106798_bb0255","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1471-4159.2004.02849.x","article-title":"Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains","volume":"92","author":"Molander-Melin","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.106798_bb0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/NEN.0b013e3181919a48","article-title":"Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship","volume":"68","author":"Nelson","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2025.106798_bb0265","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease Neuropathologic changes with cognitive status: a review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2025.106798_bb0270","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-neuro-061010-113613","article-title":"Amyloid precursor protein processing and Alzheimer\u2019s disease","volume":"34","author":"O\u2019Brien","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2025.106798_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121356","article-title":"Imbalance in fatty-acid-chain length of gangliosides triggers Alzheimer amyloid deposition in the Precuneus","volume":"10","author":"Oikawa","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2025.106798_bb0280","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-024-02759-1","article-title":"Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer\u2019s disease","volume":"147","author":"Ollen-Bittle","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2025.106798_bb0285","series-title":"Paxinos and Franklin\u2019s the Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2019"},{"key":"10.1016\/j.nbd.2025.106798_bb0290","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1134\/S0006297909030018","article-title":"Ganglioside GM3 and its biological functions","volume":"74","author":"Prokazova","year":"2009","journal-title":"Biochem. Mosc."},{"key":"10.1016\/j.nbd.2025.106798_bb0295","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/sj.embor.7400784","article-title":"Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology","volume":"7","author":"Radde","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.nbd.2025.106798_bb0300","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0168-0102(03)00100-7","article-title":"Neonatal hypoxia-ischemia reduces ganglioside, phospholipid and cholesterol contents in the rat hippocampus","volume":"46","author":"Ramirez","year":"2003","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.nbd.2025.106798_bb0305","first-page":"663","article-title":"The GM1 and GM2 Gangliosidoses: natural history and Progress toward therapy","volume":"13","author":"Regier","year":"2016","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"10.1016\/j.nbd.2025.106798_bb0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199189","article-title":"Altered expression of genes involved in ganglioside biosynthesis in substantia nigra neurons in Parkinson\u2019s disease","volume":"13","author":"Schneider","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2025.106798_bb0315","article-title":"Alzheimer\u2019s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs","author":"Scoyni","year":"2023","journal-title":"Alzheimer\u2019s and Dementia."},{"key":"10.1016\/j.nbd.2025.106798_bb0320","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000213109","article-title":"Changes in the concentration and composition of human brain gangliosides with aging","volume":"29","author":"Segler Stahl","year":"1983","journal-title":"Gerontology"},{"key":"10.1016\/j.nbd.2025.106798_bb0325","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.nbd.2025.106798_bb0330","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ebiom.2016.03.035","article-title":"The role of amyloid-\u03b2 oligomers in toxicity, propagation, and immunotherapy","volume":"6","author":"Sengupta","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.nbd.2025.106798_bb0335","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.572965","article-title":"Gangliosides in the Brain: Physiology, Pathophysiology and Therapeutic Applications","author":"Sipione","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2025.106798_bb0340","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-1-4419-6741-1_12","article-title":"Gangliosides as regulators of cell membrane organization and functions","volume":"688","author":"Sonnino","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.nbd.2025.106798_bb0345","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1046\/j.1471-4159.1994.62031039.x","article-title":"Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II)","volume":"62","author":"Svennerholm","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.106798_bb0350","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ana.22248","article-title":"Longitudinal assessment of A\u03b2 and cognition in aging and Alzheimer disease","volume":"69","author":"Villemagne","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2025.106798_bb0355","article-title":"Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain","author":"Wang","year":"2020","journal-title":"Analyst"},{"key":"10.1016\/j.nbd.2025.106798_bb0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020808","article-title":"Imaging mass spectrometry detection of gangliosides species in the mouse brain following transient focal cerebral ischemia and long-term recovery","volume":"6","author":"Whitehead","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2025.106798_bb0365","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1002\/jnr.23090","article-title":"Deficiency of ganglioside GM1 correlates with Parkinson\u2019s disease in mice and humans","volume":"90","author":"Wu","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2025.106798_bb0370","doi-asserted-by":"crossref","DOI":"10.1038\/srep34505","article-title":"Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing","volume":"6","author":"Yamaguchi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2025.106798_bb0375","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.bbamem.2008.07.028","article-title":"Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis","volume":"1778","author":"Yamamoto","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2025.106798_bb0380","series-title":"Characterizing the Appearance and Growth of Amyloid Plaques in APP\/PS1 Mice","author":"Yan","year":"2009"},{"key":"10.1016\/j.nbd.2025.106798_bb0385","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10719-015-9579-5","article-title":"GM1 ganglioside and Alzheimer\u2019s disease","volume":"32","author":"Yanagisawa","year":"2015","journal-title":"Glycoconj. J."},{"issue":"10","key":"10.1016\/j.nbd.2025.106798_bb0390","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nm1095-1062","article-title":"GM1 ganglioside\u2013bound amyloid \u03b2\u2013protein (A\u03b2): a possible form of preamyloid in Alzheimer\u2019s disease","volume":"1","author":"Yanagisawa","year":"1995","journal-title":"Nat. Med."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125000142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125000142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T07:51:23Z","timestamp":1774338683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125000142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":78,"alternative-id":["S0969996125000142"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106798","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevation of ganglioside degradation pathway drives GM2 and GM3 within amyloid plaques in a transgenic mouse model of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106798","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106798"}}