{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:33:56Z","timestamp":1791232436816,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009281","name":"Thierry Latran Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013013","name":"Target ALS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004727","name":"VIB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007372","name":"Belgian Association against Neuromuscular Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007372","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010890","name":"Central People&apos;s Government of the People&apos;s Republic of China Scholarship Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"FWO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.nbd.2025.106815","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T11:24:02Z","timestamp":1738063442000},"page":"106815","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Sporadic ALS hiPSC-derived motor neurons show axonal defects linked to altered axon guidance pathways"],"prefix":"10.1016","volume":"206","author":[{"given":"Lisha","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina Stoklund","family":"Dittlau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adria","family":"Sicart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekin'\u2019s","family":"Janky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Van Damme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludo","family":"Van Den Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2025.106815_bb0005","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrneurol.2013.203","article-title":"The epidemiology of ALS: a conspiracy of genes, environment and time","volume":"9","author":"Al-Chalabi","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2025.106815_bb0010","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1136\/jnnp.2010.207464","article-title":"An estimate of amyotrophic lateral sclerosis heritability using twin data","volume":"81","author":"Al-Chalabi","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2025.106815_bb0015","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/S1474-4422(14)70219-4","article-title":"Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study","volume":"13","author":"Al-Chalabi","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2025.106815_bb0020","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1038\/s41467-021-27221-8","article-title":"Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins","volume":"12","author":"Altman","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.106815_bb0025","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrneurol.2011.150","article-title":"Clinical genetics of amyotrophic lateral sclerosis: what do we really know?","volume":"7","author":"Andersen","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2025.106815_bb0030","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.3390\/ijms21228680","article-title":"Increased C-X-C motif chemokine ligand 12 levels in cerebrospinal fluid as a candidate biomarker in sporadic amyotrophic lateral sclerosis","volume":"21","author":"Andr\u00e9s-Benito","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2025.106815_bb0035","doi-asserted-by":"crossref","first-page":"E736","DOI":"10.1073\/pnas.1222809110","article-title":"ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43","volume":"110","author":"Arnold","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2025.106815_bb0040","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41593-021-01006-0","article-title":"Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines","volume":"25","author":"Baxi","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2025.106815_bb0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s40478-023-01648-0","article-title":"A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons","volume":"11","author":"Beckers","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2025.106815_bb0050","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/21678421.2020.1779298","article-title":"Focus on the heterogeneity of amyotrophic lateral sclerosis","volume":"21","author":"Bendotti","year":"2020","journal-title":"Amyotroph. Later. Scleros. Frontotemp. Degenerat."},{"key":"10.1016\/j.nbd.2025.106815_bb0055","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Methodol."},{"key":"10.1016\/j.nbd.2025.106815_bb0060","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/s41592-019-0582-9","article-title":"Ilastik: interactive machine learning for (bio)image analysis","volume":"16","author":"Berg","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nbd.2025.106815_bb0065","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-022-04436-3","article-title":"TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A","volume":"603","author":"Brown","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2025.106815_bb0070","series-title":"Molecular and Cellular Neuroscience, RNA and Splicing Regulation in Neurodegeneration","first-page":"355","article-title":"A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells","volume":"56","author":"Burkhardt","year":"2013"},{"key":"10.1016\/j.nbd.2025.106815_bb0075","doi-asserted-by":"crossref","first-page":"e635","DOI":"10.1212\/WNL.0000000000005996","article-title":"The multistep hypothesis of ALS revisited: the role of genetic mutations","volume":"91","author":"Chi\u00f2","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2025.106815_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104877","article-title":"EphA4 targeting agents protect motor neurons from cell death induced by amyotrophic lateral sclerosis -astrocytes","volume":"25","author":"Dennys","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.nbd.2025.106815_bb0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2025.106815_bb0090","author":"FASTX-Toolkit"},{"key":"10.1016\/j.nbd.2025.106815_bb0095","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106177","article-title":"HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations","volume":"40","author":"Fazal","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2025.106815_bb0100","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/s41591-018-0140-5","article-title":"Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent","volume":"24","author":"Fujimori","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2025.106815_bb0105","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg3013","article-title":"C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility","volume":"7","author":"Fumagalli","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.nbd.2025.106815_bb0110","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1038\/s41598-023-28381-x","article-title":"In silico analysis of TUBA4A mutations in amyotrophic lateral sclerosis to define mechanisms of microtubule disintegration","volume":"13","author":"Ganne","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2025.106815_bb0115","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1038\/s41467-022-31098-6","article-title":"NUP62 localizes to ALS\/FTLD pathological assemblies and contributes to TDP-43 insolubility","volume":"13","author":"Gleixner","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.106815_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/biot.201700652","article-title":"\u201cCyt\/Nuc,\u201d a customizable and documenting ImageJ macro for evaluation of protein distributions between cytosol and nucleus","volume":"13","author":"Grune","year":"2018","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.nbd.2025.106815_bb0125","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s41467-017-00911-y","article-title":"HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients","volume":"8","author":"Guo","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.106815_bb0130","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcab166","article-title":"TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain","volume":"3","author":"Harley","year":"2021","journal-title":"Brain Commun."},{"key":"10.1016\/j.nbd.2025.106815_bb0135","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2025.106815_bb0140","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/ana.20379","article-title":"Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis","volume":"57","author":"Jiang","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2025.106815_bb0145","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0092-8674(00)81336-7","article-title":"Deleted in colorectal cancer (DCC) encodes a netrin receptor","volume":"87","author":"Keino-Masu","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.106815_bb0150","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0140-6736(10)61156-7","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Kiernan","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2025.106815_bb0155","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.84382","article-title":"Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2","volume":"12","author":"Kim","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2025.106815_bb0160","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.stem.2014.03.004","article-title":"Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1","volume":"14","author":"Kiskinis","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.nbd.2025.106815_bb0165","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41593-018-0300-4","article-title":"ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair","volume":"22","author":"Klim","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2025.106815_bb0170","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/jnen\/nlw003","article-title":"The axon guidance protein Semaphorin 3A is increased in the motor cortex of patients with amyotrophic lateral sclerosis","volume":"75","author":"K\u00f6rner","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2025.106815_bb0175","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1111\/ejn.14326","article-title":"Expression of the axon-guidance protein receptor Neuropilin 1 is increased in the spinal cord and decreased in muscle of a mouse model of amyotrophic lateral sclerosis","volume":"49","author":"K\u00f6rner","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2025.106815_bb0180","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nbd.2025.106815_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001449","article-title":"Beyond Parkinson disease: amyotrophic lateral sclerosis and the axon guidance pathway","volume":"3","author":"Lesnick","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2025.106815_bb0190","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2025.106815_bb0195","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1038\/s41467-023-41033-y","article-title":"Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.106815_bb0200","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2025.106815_bb0205","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2025.106815_bb0210","article-title":"Identification of novel regulatory genes in development of the avian reproductive tracts","volume":"9","author":"Lim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2025.106815_bb0215","doi-asserted-by":"crossref","DOI":"10.1172\/JCI58675","article-title":"Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice","volume":"121","author":"Ma","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2025.106815_bb0220","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-022-04424-7","article-title":"TDP-43 represses cryptic exon inclusion in the FTD\u2013ALS gene UNC13A","volume":"603","author":"Ma","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2025.106815_bb0225","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. Journal"},{"key":"10.1016\/j.nbd.2025.106815_bb0230","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/ene.14393","article-title":"Amyotrophic lateral sclerosis: a clinical review","volume":"27","author":"Masrori","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nbd.2025.106815_bb0235","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41573-022-00612-2","article-title":"Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation","volume":"22","author":"Mead","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.nbd.2025.106815_bb0240","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.3389\/fnins.2019.01310","article-title":"ALS genetics, mechanisms, and therapeutics: where are we now?","volume":"13","author":"Mejzini","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2025.106815_bb0245","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41593-018-0293-z","article-title":"Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration","volume":"22","author":"Melamed","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2025.106815_bb0250","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1056\/NEJMoa2204705","article-title":"Trial of antisense oligonucleotide Tofersen for SOD1 ALS","volume":"387","author":"Miller","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2025.106815_bb0255","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3390\/jpm10040262","article-title":"Genomic portrait of a sporadic amyotrophic lateral sclerosis case in a large spinocerebellar Ataxia type 1 family","volume":"10","author":"Morello","year":"2020","journal-title":"J. Personaliz. Med."},{"key":"10.1016\/j.nbd.2025.106815_bb0260","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1093\/bioinformatics\/btp450","article-title":"ShortRead: a bioconductor package for input, quality assessment and exploration of high-throughput sequence data","volume":"25","author":"Morgan","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2025.106815_bb0265","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41467-017-02299-1","article-title":"Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation","volume":"9","author":"Naumann","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.106815_bb0270","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/21678421.2022.2078665","article-title":"HLA and amyotrophic lateral sclerosis: a systematic review and meta-analysis","volume":"24","author":"Nona","year":"2023","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1016\/j.nbd.2025.106815_bb0275","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13041-017-0287-x","article-title":"TBK1: a new player in ALS linking autophagy and neuroinflammation","volume":"10","author":"Oakes","year":"2017","journal-title":"Mol. Brain"},{"key":"10.1016\/j.nbd.2025.106815_bb0280","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/1471-2105-12-480","article-title":"GC-content normalization for RNA-Seq data","volume":"12","author":"Risso","year":"2011","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.nbd.2025.106815_bb0285","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1093\/bioinformatics\/btm453","article-title":"Moderated statistical tests for assessing differences in tag abundance","volume":"23","author":"Robinson","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2025.106815_bb0290","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.celrep.2017.01.041","article-title":"Islet coordinately regulates motor axon guidance and dendrite targeting through the frazzled\/DCC receptor","volume":"18","author":"Santiago","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2025.106815_bb0295","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.pneurobio.2009.05.004","article-title":"Axon guidance proteins: novel therapeutic targets for ALS?","volume":"88","author":"Schmidt","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2025.106815_bb0300","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.127736","article-title":"Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons","volume":"4","author":"Shi","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.nbd.2025.106815_bb0305","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/brain\/awz419","article-title":"Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis","volume":"143","author":"Smethurst","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2025.106815_bb0310","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.stemcr.2021.03.029","article-title":"Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition","volume":"16","author":"Stoklund Dittlau","year":"2021","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.nbd.2025.106815_bb0315","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-022-00591-3","article-title":"FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms","volume":"18","author":"Stoklund Dittlau","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2025.106815_bb0320","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13024-020-00397-1","article-title":"The role of TDP-43 mislocalization in amyotrophic lateral sclerosis","volume":"15","author":"Suk","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2025.106815_bb0325","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s13287-018-1048-1","article-title":"Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells","volume":"9","author":"Sun","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.nbd.2025.106815_bb0330","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ymeth.2016.09.016","article-title":"TrackMate: an open and extensible platform for single-particle tracking","volume":"115","author":"Tinevez","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.nbd.2025.106815_bb0335","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.3390\/ijms21103647","article-title":"Genetics and sex in the pathogenesis of amyotrophic lateral sclerosis (ALS): is there a link?","volume":"21","author":"Trojsi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2025.106815_bb0340","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41583-021-00431-1","article-title":"Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation","volume":"22","author":"Tziortzouda","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2025.106815_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmed.2023.12.003","article-title":"The sense of antisense therapies in ALS","author":"Van Daele","year":"2024","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.nbd.2025.106815_bb0350","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/nm.2901","article-title":"EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans","volume":"18","author":"Van Hoecke","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2025.106815_bb0355","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.molmed.2016.07.005","article-title":"Common molecular pathways in amyotrophic lateral sclerosis and frontotemporal dementia","volume":"22","author":"Weishaupt","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.nbd.2025.106815_bb0360","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.106815_bb0365","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.neuron.2023.01.010","article-title":"Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects","volume":"111","author":"Workman","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.106815_bb0370","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1242\/dev.098145","article-title":"Cxcl12\/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons","volume":"140","author":"Yang","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.nbd.2025.106815_bb0375","doi-asserted-by":"crossref","first-page":"11393","DOI":"10.1038\/s41598-018-29845-1","article-title":"Decreased signalling of EphA4 improves functional performance and motor neuron survival in the SOD1G93A ALS mouse model","volume":"8","author":"Zhao","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125000312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125000312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T16:14:47Z","timestamp":1740500087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125000312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":75,"alternative-id":["S0969996125000312"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106815","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sporadic ALS hiPSC-derived motor neurons show axonal defects linked to altered axon guidance pathways","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106815","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106815"}}