{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:39:16Z","timestamp":1761845956850,"version":"3.41.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG61356","R01AG079133","R01AG015819","P30AG10161","P30AG72975","R01AG17917"],"award-info":[{"award-number":["U01AG61356","R01AG079133","R01AG015819","P30AG10161","P30AG72975","R01AG17917"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.nbd.2025.106927","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T16:05:41Z","timestamp":1745856341000},"page":"106927","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The temporal onset of associations of cortical proteins with cognitive resilience vary during late life"],"prefix":"10.1016","volume":"211","author":[{"given":"Andrea R.","family":"Zammit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahram","family":"Oveisgharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladislav A.","family":"Petyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip L.","family":"De Jager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aron S.","family":"Buchman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.nbd.2025.106927_bb0005","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1093\/cercor\/bhy315","article-title":"The effect of onset age of visual deprivation on visual cortex surface area across-species","volume":"29","author":"Andelin","year":"2019","journal-title":"Cereb. Cortex"},{"issue":"1","key":"10.1016\/j.nbd.2025.106927_bb0010","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"2018","journal-title":"J. R. Stat. Soc. B. Methodol."},{"issue":"4","key":"10.1016\/j.nbd.2025.106927_bb0015","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000087446","article-title":"The rush memory and aging project: study design and baseline characteristics of the study cohort","volume":"25","author":"Bennett","year":"2005","journal-title":"Neuroepidemiology"},{"issue":"s1","key":"10.1016\/j.nbd.2025.106927_bb0020","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.3233\/JAD-179939","article-title":"Religious orders study and rush memory and aging project","volume":"64","author":"Bennett","year":"2018","journal-title":"J. Alzheimers Dis."},{"issue":"3","key":"10.1016\/j.nbd.2025.106927_bb0025","first-page":"804","article-title":"Varied effects of age-related neuropathologies on the trajectory of late life cognitive decline","volume":"140","author":"Boyle","year":"2017","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.nbd.2025.106927_bb0030","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1093\/brain\/awab092","article-title":"To what degree is late life cognitive decline driven by age-related neuropathologies?","volume":"144","author":"Boyle","year":"2021","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.nbd.2025.106927_bb0035","doi-asserted-by":"crossref","first-page":"e811","DOI":"10.1212\/WNL.0000000000006954","article-title":"Physical activity, common brain pathologies, and cognition in community-dwelling older adults","volume":"92","author":"Buchman","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2025.106927_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.630318","article-title":"Adenylate kinase 4 promotes inflammatory gene expression via Hif1\u03b1 and AMPK in macrophages","volume":"12","author":"Chin","year":"2021","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.nbd.2025.106927_bb0045","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1038\/tp.2012.38","article-title":"Cognitive reserve, presynaptic proteins and dementia in the elderly","volume":"2","author":"Honer","year":"2012","journal-title":"Transl. Psychiatry"},{"issue":"5","key":"10.1016\/j.nbd.2025.106927_bb0050","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1038\/tp.2012.38","article-title":"Cognitive reserve, presynaptic proteins and dementia in the elderly","volume":"2","author":"Honer","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2025.106927_bb0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neurobiolaging.2019.07.013","article-title":"Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline","volume":"84","author":"Kim","year":"2019","journal-title":"Neurobiol. Aging"},{"issue":"8","key":"10.1016\/j.nbd.2025.106927_bb0060","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1162\/0898929042304796","article-title":"Sensitive periods in the development of the brain and behavior","volume":"16","author":"Knudsen","year":"2004","journal-title":"J. Cogn. Neurosci."},{"issue":"4","key":"10.1016\/j.nbd.2025.106927_bb0065","article-title":"Therapeutic window, a critical developmental stage for stem cell therapies","volume":"5","author":"Li","year":"2010","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.nbd.2025.106927_bb0070","article-title":"Transcriptome signatures for cognitive resilience among individuals with pathologically confirmed Alzheimer disease","author":"Li","year":"2024","journal-title":"medRxiv"},{"issue":"20","key":"10.1016\/j.nbd.2025.106927_bb0075","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1016\/j.cell.2023.08.039","article-title":"Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer\u2019s disease pathology","volume":"186","author":"Mathys","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.106927_bb0080","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neubiorev.2014.12.001","article-title":"Sensitive and critical periods during neurotypical and aberrant neurodevelopment: a framework for neurodevelopmental disorders","volume":"50","author":"Meredith","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"S1","key":"10.1016\/j.nbd.2025.106927_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/alz.093123","article-title":"Brain and blood transcriptome-wide association studies identify three novel genes associated with cognitive resilience","volume":"20","author":"Mews","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2025.106927_bb0090","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.neuro.24.1.167","article-title":"An integrative theory of prefrontal cortex function","volume":"24","author":"Miller","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2025.106927_bb0095","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41593-018-0154-9","article-title":"A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer\u2019s disease","volume":"21","author":"Mostafavi","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.nbd.2025.106927_bb0100","doi-asserted-by":"crossref","first-page":"e336","DOI":"10.1016\/S2666-7568(24)00033-3","article-title":"The time course of motor and cognitive decline in older adults and their associations with brain pathologies: a multicohort study","volume":"5","author":"Oveisgharan","year":"2024","journal-title":"Lancet Healthy Longevity."},{"issue":"5","key":"10.1016\/j.nbd.2025.106927_bb0105","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00401-021-02282-7","article-title":"Proteomic identification of select protein variants of the SNARE interactome associated with cognitive reserve in a large community sample","volume":"141","author":"Ramos-Miguel","year":"2021","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.nbd.2025.106927_bb0110","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40478-022-01352-5","article-title":"Insulin-like growth factor 5 associates with human A\u00df plaques and promotes cognitive impairment","volume":"10","author":"Rauskolb","year":"2022","journal-title":"Acta Neuropathol. Communicat."},{"issue":"24","key":"10.1016\/j.nbd.2025.106927_bb0115","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.nbd.2025.106927_bb0120","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3233\/JAD-2009-1227","article-title":"The neuropathology of older persons with and without dementia from community versus clinic cohorts","volume":"18","author":"Schneider","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2025.106927_bb0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-psych-010814-015104","article-title":"Critical periods in speech perception: new directions","volume":"66","author":"Werker","year":"2015","journal-title":"Annu. Rev. Psychol."},{"issue":"2","key":"10.1016\/j.nbd.2025.106927_bb0130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2990.2006.00689.x","article-title":"Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer\u2019s disease brains","volume":"32","author":"Wilhelmus","year":"2006","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"4","key":"10.1016\/j.nbd.2025.106927_bb0135","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1212\/WNL.0b013e31829c5e8a","article-title":"Life-span cognitive activity, neuropathologic burden, and cognitive aging","volume":"81","author":"Wilson","year":"2013","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.nbd.2025.106927_bb0140","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1212\/WNL.0000000000000715","article-title":"Clinical-pathologic study of depressive symptoms and cognitive decline in old age","volume":"83","author":"Wilson","year":"2014","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nbd.2025.106927_bb0145","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/s41467-019-09613-z","article-title":"Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age","volume":"10","author":"Wingo","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.nbd.2025.106927_bb0150","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/ana.25266","article-title":"Targeted brain proteomics uncover multiple pathways to Alzheimer\u2019s dementia","volume":"84","author":"Yu","year":"2018","journal-title":"Ann. Neurol."},{"issue":"11","key":"10.1016\/j.nbd.2025.106927_bb0155","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1001\/jamapsychiatry.2020.1807","article-title":"Cortical proteins associated with cognitive resilience in community-dwelling older persons","volume":"77","author":"Yu","year":"2020","journal-title":"JAMA Psychiat."},{"issue":"20","key":"10.1016\/j.nbd.2025.106927_bb0160","doi-asserted-by":"crossref","first-page":"e2264","DOI":"10.1212\/WNL.0000000000201120","article-title":"Association of AK4 protein from stem cell-derived neurons with cognitive reserve: an autopsy study","volume":"99","author":"Yu","year":"2022","journal-title":"Neurology"},{"issue":"13","key":"10.1016\/j.nbd.2025.106927_bb0165","doi-asserted-by":"crossref","first-page":"e1304","DOI":"10.1212\/WNL.0000000000200017","article-title":"Cortical Proteins and Individual Differences in Cognitive Resilience in Older Adults","volume":"98","author":"Zammit","year":"2022","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nbd.2025.106927_bb0170","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000207816","article-title":"Proteome-wide analyses identified cortical proteins associated with resilience for varied cognitive abilities","volume":"102","author":"Zammit","year":"2024","journal-title":"Neurology"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125001433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125001433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T15:01:03Z","timestamp":1748358063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125001433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":34,"alternative-id":["S0969996125001433"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106927","relation":{},"ISSN":["0969-9961"],"issn-type":[{"type":"print","value":"0969-9961"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The temporal onset of associations of cortical proteins with cognitive resilience vary during late life","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106927","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106927"}}