{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:46:32Z","timestamp":1787503592754,"version":"build-2736575974"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS047101"],"award-info":[{"award-number":["NS047101"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG072053"],"award-info":[{"award-number":["AG072053"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG018440"],"award-info":[{"award-number":["AG018440"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.nbd.2025.106942","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T02:30:25Z","timestamp":1746757825000},"page":"106942","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Differential roles of human tau isoforms in the modulation of inflammation and development of neuropathology"],"prefix":"10.1016","volume":"211","author":[{"given":"Brian","family":"Spencer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Schueler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Rissman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2025.106942_bb0005","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s42003-024-05920-4","article-title":"Phosphorylation regulates tau\u2019s phase separation behavior and interactions with chromatin","volume":"7","author":"Abasi","year":"2024","journal-title":"Commun Biol."},{"key":"10.1016\/j.nbd.2025.106942_bb0010","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3389\/fnins.2020.00893","article-title":"Microglial activation and inflammation as a factor in the pathogenesis of progressive Supranuclear palsy (PSP)","volume":"14","author":"Alster","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2025.106942_bb0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41398-020-00954-8","article-title":"Neuroinflammation in dementia with Lewy bodies: a human post-mortem study","volume":"10","author":"Amin","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2025.106942_bb0020","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1046\/j.1471-4159.2003.01879.x","article-title":"Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms","volume":"86","author":"Andorfer","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.106942_bb0025","doi-asserted-by":"crossref","first-page":"10626","DOI":"10.1021\/bi00158a027","article-title":"Structure and novel exons of the human tau gene","volume":"31","author":"Andreadis","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.nbd.2025.106942_bb0030","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.3233\/JAD-170388","article-title":"Increased vulnerability of the Hippocampus in transgenic mice overexpressing APP and triple repeat tau","volume":"61","author":"Arner","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2025.106942_bb0035","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb2639","article-title":"Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer\u2019s disease","volume":"13","author":"Ayalon","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2025.106942_bb0040","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3389\/fncel.2018.00488","article-title":"Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response","volume":"12","author":"Bachiller","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.106942_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105172","article-title":"What are activated and reactive glia and what is their role in neurodegeneration?","volume":"148","author":"Bennett","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2025.106942_bb0050","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0197-4580(97)00056-0","article-title":"Frequency of stages of Alzheimer-related lesions in different age categories","volume":"18","author":"Braak","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2025.106942_bb0055","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.nbd.2015.03.003","article-title":"Glia and alpha-synuclein in neurodegeneration: a complex interaction","volume":"85","author":"Bruck","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2025.106942_bb0060","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1523\/JNEUROSCI.4989-14.2015","article-title":"Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer\u2019s disease mouse model","volume":"35","author":"Castillo-Carranza","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.106942_bb0065","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41582-023-00883-2","article-title":"Tau-targeting therapies for Alzheimer disease: current status and future directions","volume":"19","author":"Congdon","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2025.106942_bb0070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s40259-023-00633-2","article-title":"Anti-amyloid monoclonal antibodies for the treatment of Alzheimer\u2019s disease","volume":"38","author":"Cummings","year":"2024","journal-title":"BioDrugs"},{"key":"10.1016\/j.nbd.2025.106942_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-016-0227-5","article-title":"Tau passive immunization inhibits not only tau but also Abeta pathology","volume":"9","author":"Dai","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.nbd.2025.106942_bb0080","article-title":"Assessing burrowing, nest construction, and hoarding in mice","volume":"e2607","author":"Deacon","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.nbd.2025.106942_bb0085","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3233\/JAD-2005-8301","article-title":"Tau-induced neurodegeneration: a clue to its mechanism","volume":"8","author":"Del","year":"2005","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2025.106942_bb0090","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s12031-011-9589-0","article-title":"Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau)","volume":"45","author":"Dickson","year":"2011","journal-title":"J. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2025.106942_bib297","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/nbdi.1999.0279","article-title":"Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes","volume":"7","author":"Duff","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2025.106942_bb0095","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1093\/brain\/awad024","article-title":"Tilavonemab in early Alzheimer's disease: results from a phase 2, randomized, double-blind study","volume":"146","author":"Florian","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2025.106942_bb0100","first-page":"983","article-title":"Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain","volume":"152","author":"Funato","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2025.106942_bb0105","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuroscience.2016.05.004","article-title":"Impaired burrowing is the most prominent behavioral deficit of aging htau mice","volume":"329","author":"Geiszler","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2025.106942_bb0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.semcdb.2003.12.015","article-title":"Tau protein and neurodegeneration","volume":"15","author":"Goedert","year":"2004","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.nbd.2025.106942_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0251611","article-title":"Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression","volume":"16","author":"Grundman","year":"2021","journal-title":"PloS One"},{"key":"10.1016\/j.nbd.2025.106942_bb0120","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.3389\/fphar.2019.01008","article-title":"Neuroinflammation as a common feature of neurodegenerative disorders","volume":"10","author":"Guzman-Martinez","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.nbd.2025.106942_bb0125","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/jamaneurol.2019.1424","article-title":"Association of Amyloid and tau with Cognition in preclinical Alzheimer disease: a longitudinal study","volume":"76","author":"Hanseeuw","year":"2019","journal-title":"JAMA Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2025.106942_bib298","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41467-019-13787-x","article-title":"Transmission of tauopathy strains is independent of their isoform composition","volume":"11","author":"He","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.106942_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fnagi.2020.00011","article-title":"Differences between human and murine tau at the N-terminal end","volume":"12","author":"Hernandez","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2025.106942_bb0135","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0896-6273(02)00789-4","article-title":"Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration","volume":"35","author":"Higuchi","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.106942_bb0140","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuron.2010.11.030","article-title":"Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration","volume":"68","author":"Hoover","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.106942_bb0145","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1001\/jama.2019.7437","article-title":"Associations of amyloid, tau, and neurodegeneration biomarker profiles with rates of memory decline among individuals without dementia","volume":"321","author":"Jack","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.nbd.2025.106942_bb0150","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0877-24.2024","article-title":"Targeting endogenous tau in seeded Tauopathy models inhibits tau spread","volume":"44","author":"Jang","year":"2024","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.106942_bb0155","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s13195-024-01620-7","article-title":"Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer's disease, positive for plasma p-tau217","volume":"16","author":"Kovacech","year":"2024","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.nbd.2025.106942_bb0160","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.trci.2016.06.004","article-title":"NPT088 reduces both amyloid-beta and tau pathologies in transgenic mice","volume":"2","author":"Levenson","year":"2016","journal-title":"Alzheimers Dement (N Y)."},{"key":"10.1016\/j.nbd.2025.106942_bb0165","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/78078","article-title":"Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein","volume":"25","author":"Lewis","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2025.106942_bb0170","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mcn.2017.04.009","article-title":"Extensive uptake of alpha-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage","volume":"82","author":"Lindstrom","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.106942_bb0175","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-3223(02)01348-3","article-title":"Depression in Alzheimer\u2019s disease: overview and treatment","volume":"52","author":"Lyketsos","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.106942_bb0180","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.arr.2012.06.003","article-title":"Tau protein kinases: involvement in Alzheimer\u2019s disease","volume":"12","author":"Martin","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.nbd.2025.106942_bb0185","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/mco2.1","article-title":"Plasma pTau181 as a biomarker for Alzheimer's disease","volume":"1","author":"Meng","year":"2020","journal-title":"MedComm"},{"key":"10.1016\/j.nbd.2025.106942_bb0190","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/nan.12084","article-title":"Phosphorylation of tau protein at sites Ser(396-404) is one of the earliest events in Alzheimer\u2019s disease and down syndrome","volume":"40","author":"Mondragon-Rodriguez","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.nbd.2025.106942_bb0195","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/s41591-023-02326-3","article-title":"Tau-targeting antisense oligonucleotide MAPT(Rx) in mild Alzheimer\u2019s disease: a phase 1b, randomized, placebo-controlled trial","volume":"29","author":"Mummery","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2025.106942_bb0200","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0006-8993(03)02361-8","article-title":"Astrocytes accumulate a beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains","volume":"971","author":"Nagele","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2025.106942_bb0205","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.molmed.2015.03.003","article-title":"Tau immunotherapy for Alzheimer\u2019s disease","volume":"21","author":"Pedersen","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.nbd.2025.106942_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019567","article-title":"Olfactory and visuospatial learning and memory performance in two strains of Alzheimer\u2019s disease model mice--a longitudinal study","volume":"6","author":"Phillips","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.nbd.2025.106942_bb0215","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1523\/JNEUROSCI.1065-09.2009","article-title":"Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology","volume":"29","author":"Polydoro","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.106942_bb0220","doi-asserted-by":"crossref","first-page":"10637","DOI":"10.1523\/JNEUROSCI.3279-05.2005","article-title":"Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)","volume":"25","author":"Ramsden","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.106942_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121570","article-title":"A novel triple repeat mutant tau transgenic model that mimics aspects of pick\u2019s disease and fronto-temporal tauopathies","volume":"10","author":"Rockenstein","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.nbd.2025.106942_bib296","doi-asserted-by":"crossref","first-page":"1149761","DOI":"10.3389\/fnins.2023.1149761","article-title":"Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy","volume":"17","author":"Sahara","year":"2023","journal-title":"Front Neurosci."},{"key":"10.1016\/j.nbd.2025.106942_bb0230","doi-asserted-by":"crossref","first-page":"12754","DOI":"10.1074\/jbc.RA119.009487","article-title":"Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation","volume":"294","author":"Saito","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2025.106942_bb0235","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1074\/jbc.M111.277061","article-title":"Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease","volume":"287","author":"Saman","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2025.106942_bb0240","doi-asserted-by":"crossref","first-page":"20522","DOI":"10.1074\/jbc.M111.323279","article-title":"Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of tau protein in aggresomes","volume":"287","author":"Santa-Maria","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2025.106942_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19040998","article-title":"The neurotoxic role of extracellular tau protein","volume":"19","author":"Sebastian-Serrano","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2025.106942_bb0250","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/alz.12452","article-title":"Current directions in tau research: highlights from tau 2020","volume":"18","author":"Sexton","year":"2022","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2025.106942_bb0255","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jalz.2016.04.003","article-title":"CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease","volume":"12","author":"Shi","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2025.106942_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/biom6010006","article-title":"Tau protein hyperphosphorylation and aggregation in Alzheimer\u2019s disease and other Tauopathies, and possible neuroprotective strategies","volume":"6","author":"Simic","year":"2016","journal-title":"Biomolecules"},{"key":"10.1016\/j.nbd.2025.106942_bb0265","doi-asserted-by":"crossref","first-page":"7971","DOI":"10.1523\/JNEUROSCI.0775-16.2016","article-title":"Reducing endogenous alpha-Synuclein mitigates the degeneration of selective neuronal populations in an Alzheimer\u2019s disease transgenic mouse model","volume":"36","author":"Spencer","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.106942_bb0270","series-title":"Alzheimer disease","first-page":"179","article-title":"Structural basis of the cognitive alterations in Alzheimer disease","author":"Terry","year":"1994"},{"key":"10.1016\/j.nbd.2025.106942_bb0275","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1038\/s41598-021-83910-w","article-title":"Pathologically phosphorylated tau at S396\/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged wild-type mice","volume":"11","author":"Torres","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2025.106942_bb0280","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s13311-015-0397-z","article-title":"Immunotherapeutic approaches targeting amyloid-beta, alpha-Synuclein, and tau for the treatment of neurodegenerative disorders","volume":"13","author":"Valera","year":"2016","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nbd.2025.106942_bb0285","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dadm.2016.04.001","article-title":"Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile","volume":"3","author":"Winston","year":"2016","journal-title":"Alzheimers Dement (Amst)."},{"key":"10.1016\/j.nbd.2025.106942_bb0290","doi-asserted-by":"crossref","first-page":"E8187","DOI":"10.1073\/pnas.1616344113","article-title":"Tau prions from Alzheimer\u2019s disease and chronic traumatic encephalopathy patients propagate in cultured cells","volume":"113","author":"Woerman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2025.106942_bb0295","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125001585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125001585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T11:01:24Z","timestamp":1748343684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125001585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":62,"alternative-id":["S0969996125001585"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106942","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential roles of human tau isoforms in the modulation of inflammation and development of neuropathology","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106942","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106942"}}