{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:00:56Z","timestamp":1791838856629,"version":"4.3.4"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_212322"],"award-info":[{"award-number":["310030_212322"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["223414"],"award-info":[{"award-number":["223414"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.nbd.2025.106950","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T20:51:21Z","timestamp":1746737481000},"page":"106950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Non-linear microglial, inflammatory and oligodendrocyte dynamics across stages of Alzheimer's disease"],"prefix":"10.1016","volume":"211","author":[{"given":"Aur\u00e9lien M.","family":"Badina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Ceyz\u00e9riat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Amoss\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Tresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurene","family":"Abjean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Gu\u00e9nat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Vauthey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stergios","family":"Tsartsalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Millet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin B.","family":"Tournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2025.106950_bb0005","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000001142","article-title":"Baicalin promotes CNS remyelination via PPAR\u03b3 signal pathway","volume":"9","author":"Ai","year":"2022","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.nbd.2025.106950_bb0010","article-title":"The potential role of glial cells in driving the prion-like transcellular propagation of tau in tauopathies","volume":"14","author":"Amro","year":"2021","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.nbd.2025.106950_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24031869","article-title":"Molecular mechanisms of neuroinflammation in aging and Alzheimer\u2019s disease progression","volume":"24","author":"Andronie-Cioara","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2025.106950_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112328","article-title":"Decoding the role of the CCL2\/CCR2 axis in Alzheimer\u2019s disease and innovating therapeutic approaches: keeping all options open","volume":"135","author":"Arfaei","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.nbd.2025.106950_bb0025","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1002\/glia.23074","article-title":"Microglia contributes to plaque growth by cell death due to uptake of amyloid beta in the brain of Alzheimer\u2019s disease mouse model","volume":"64","author":"Baik","year":"2016","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.nbd.2025.106950_bb0030","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/brain\/awae293","article-title":"BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis","volume":"148","author":"Bergner","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2025.106950_bb0035","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/glia.22966","article-title":"Dark microglia: a new phenotype predominantly associated with pathological states","volume":"64","author":"Bisht","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2025.106950_bb0040","article-title":"EnhancedVolcano: publication-ready volcano plots with enhanced colouring and labeling","author":"Blighe","year":"2024","journal-title":"Bioconducter"},{"key":"10.1016\/j.nbd.2025.106950_bb0045","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-\u03b2 and tau the trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nbd.2025.106950_bb0050","first-page":"563","article-title":"Increase in neuronal local connectivity following cortical demyelination prevents cognitive impairment in multiple sclerosis","volume":"28","author":"Boffa","year":"2022","journal-title":"Mult. Scler. J."},{"key":"10.1016\/j.nbd.2025.106950_bb0055","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.jalz.2018.03.007","article-title":"Evidence of demyelination in mild cognitive impairment and dementia using a direct and specific magnetic resonance imaging measure of myelin content","volume":"14","author":"Bouhrara","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2025.106950_bb0060","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/s41593-020-0687-6","article-title":"Synergy between amyloid-beta and tau in Alzheimer\u2019s disease","volume":"23","author":"Busche","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2025.106950_bb0065","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s10875-021-01031-5","article-title":"Genomic spectrum and phenotypic heterogeneity of human IL-21 receptor deficiency","volume":"41","author":"Cagdas","year":"2021","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.nbd.2025.106950_bb0205","article-title":"Genome wide annotation for human","author":"Carlson","year":"2025","journal-title":"Bioconductor"},{"key":"10.1016\/j.nbd.2025.106950_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072759","article-title":"Demyelination in mild cognitive impairment suggests progression path to Alzheimer\u2019s disease","volume":"8","author":"Carmeli","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.nbd.2025.106950_bb0075","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1002\/alz.12821","article-title":"Microglial limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer\u2019s disease","volume":"19","author":"Castranio","year":"2022","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2025.106950_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106623","article-title":"Inhibition of the mitochondrial pyruvate carrier in astrocytes reduces amyloid and tau accumulation in the 3xTgAD mouse model of Alzheimer\u2019s disease","volume":"200","author":"Ceyz\u00e9riat","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2025.106950_bb0085","doi-asserted-by":"crossref","first-page":"510396","DOI":"10.1155\/2013\/510396","article-title":"Microglia play a major role in direct viral-induced demyelination","volume":"2013","author":"Chatterjee","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.nbd.2025.106950_bb0090","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41586-023-05788-0","article-title":"Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy","volume":"615","author":"Chen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2025.106950_bb0095","article-title":"Demyelination triggers divergent neuropathological consequences in APP and APP\/PSEN1 transgenic mouse models of Alzheimer\u2019s disease","volume":"33","author":"Cheng","year":"2023","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nbd.2025.106950_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.847097","article-title":"Age and Alzheimer\u2019s disease-related oligodendrocyte changes in hippocampal subregions","volume":"16","author":"DeFlitch","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.106950_bb0105","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.4049\/jimmunol.180.11.7376","article-title":"Production of CCL2 by central nervous system cells regulates development of murine experimental autoimmune encephalomyelitis through the recruitment of TNF- and iNOS-expressing macrophages and myeloid dendritic cells","volume":"180","author":"Dogan","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2025.106950_bb0110","doi-asserted-by":"crossref","first-page":"908","DOI":"10.4103\/1673-5374.232486","article-title":"Association between Alzheimer\u2019s disease pathogenesis and early demyelination and oligodendrocyte dysfunction","volume":"13","author":"Dong","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.nbd.2025.106950_bb0115","doi-asserted-by":"crossref","DOI":"10.1186\/s12987-022-00365-5","article-title":"Microglia-derived CCL2 has a prime role in neocortex neuroinflammation","volume":"19","author":"Errede","year":"2022","journal-title":"Fluids and Barriers of the Cns"},{"key":"10.1016\/j.nbd.2025.106950_bb0120","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-020-00688-1","article-title":"Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer\u2019s disease mouse model with suppression of glymphatic clearance","volume":"12","author":"Feng","year":"2020","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.nbd.2025.106950_bb0125","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1016\/j.neuron.2022.09.023","article-title":"CNS remyelination and inflammation: from basic mechanisms to therapeutic opportunities","volume":"110","author":"Franklin","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.106950_bb0130","article-title":"The major risk factors for Alzheimer\u2019s disease: age, sex, and genes modulate the microglia response to a\u03b2 plaques","volume":"27","author":"Frigerio","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2025.106950_bb0135","article-title":"GSVA: gene set variation analysis for microarray and RNA-Seq data. Bmc","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2025.106950_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2017.00227","article-title":"Microglia responses in acute and chronic neurological diseases: what microglia-specific transcriptomic studies taught (and did not teach) us","volume":"9","author":"Hirbec","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2025.106950_bb0145","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.90964.3","article-title":"Myelin dystrophy impairs signal transmission and working memory in a multiscale model of the aging prefrontal cortex","volume":"12","author":"Ibanez","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2025.106950_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(98)00040-0","article-title":"Microglia-specific localisation of a novel calcium binding protein, Iba1","volume":"57","author":"Ito","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.nbd.2025.106950_bb0155","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s12035-015-9113-6","article-title":"Absence of CCL2 and CCL3 ameliorates central nervous system grey matter but not white matter demyelination in the presence of an intact blood-brain barrier","volume":"53","author":"Janssen","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2025.106950_bb0160","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-022-02486-y","article-title":"Microglial amyloid beta clearance is driven by PIEZO1 channels","volume":"19","author":"J\u00e4ntti","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"1276\u20131290","key":"10.1016\/j.nbd.2025.106950_bb0165","article-title":"A unique microglia type associated with restricting development of Alzheimer\u2019s disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.106950_bb0170","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1128\/JVI.79.11.7113-7120.2005","article-title":"Viral expression of CCL2 is sufficient to induce demyelination in RAG1 mice infected with a neurotropic coronavirus","volume":"79","author":"Kim","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.nbd.2025.106950_bb0175","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41582-023-00801-6","article-title":"Inflammation in multiple sclerosis: consequences for remyelination and disease progression","volume":"19","author":"Klotz","year":"2023","journal-title":"Nat. Rev. Neurol."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2025.106950_bb0180","first-page":"E131","article-title":"The Geneva brain collection","volume":"1225","author":"Kovari","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"873\u2013884","key":"10.1016\/j.nbd.2025.106950_bb0185","article-title":"Dysregulation of the secretory pathway connects Alzheimer\u2019s disease genetics to aggregate formation","volume":"12","author":"Kuo","year":"2021","journal-title":"Cell Syst."},{"key":"10.1016\/j.nbd.2025.106950_bb0190","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025813118","article-title":"Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation","volume":"118","author":"Larochelle","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2025.106950_bb0195","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1172\/JCI75933","article-title":"IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis","volume":"125","author":"Lee","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2025.106950_bb0200","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11064-024-04325-3","article-title":"The role of oligodendrocyte lineage cells in the pathogenesis of Alzheimer\u2019s disease","volume":"50","author":"Liu","year":"2025","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2025.106950_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2023.12.001","article-title":"An exhausted-like microglial population accumulates in aged and genotype Alzheimer's brains","volume":"57","author":"Millet","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2025.106950_bb0215","doi-asserted-by":"crossref","DOI":"10.1186\/s12979-022-00302-y","article-title":"Composition of the infiltrating immune cells in the brain of healthy individuals: effect of aging","volume":"19","author":"Nevalainen","year":"2022","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.nbd.2025.106950_bb0220","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-021-01180-z","article-title":"Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer\u2019s disease","volume":"9","author":"Park","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2025.106950_bb0225","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2016.00491","article-title":"Gray and white matter demyelination and remyelination detected with multimodal quantitative MRI analysis at 11.7T in a chronic mouse model of multiple sclerosis","volume":"10","author":"Petiet","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2025.106950_bb0230","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1469-7580.2005.00454.x","article-title":"NG2-expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system","volume":"207","author":"Polito","year":"2005","journal-title":"J. Anat."},{"key":"10.1016\/j.nbd.2025.106950_bb0235","doi-asserted-by":"crossref","first-page":"95","DOI":"10.14283\/jpad.2023.3","article-title":"Programmed death of microglia in Alzheimer\u2019s disease: autophagy, ferroptosis, and pyroptosis","volume":"10","author":"Qiu","year":"2023","journal-title":"J. Prev. Alzheimers Dis."},{"key":"10.1016\/j.nbd.2025.106950_bb0240","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13205-022-03123-4","article-title":"Hippocampus and its involvement in Alzheimer\u2019s disease: a review","volume":"12","author":"Rao","year":"2022","journal-title":"3 Biotech"},{"key":"10.1016\/j.nbd.2025.106950_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071717","article-title":"Microglia: agents of the CNS pro-inflammatory response","volume":"9","author":"Rodr\u00edguez-G\u00f3mez","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.nbd.2025.106950_bb0250","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/brain\/awae258","article-title":"Exploring the link between dystrophic microglia and the spread of Alzheimer\u2019s neuropathology","volume":"148","author":"Shahidehpour","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2025.106950_bb0255","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/brain\/awae258","article-title":"Exploring the link between dystrophic microglia and the spread of Alzheimer\u2019s neuropathology","volume":"148","author":"Shahidehpour","year":"2025","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2025.106950_bb0260","doi-asserted-by":"crossref","first-page":"1448-+","DOI":"10.1016\/j.immuni.2022.07.004","article-title":"Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration","volume":"55","author":"Silvin","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2025.106950_bb0265","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2016.00016","article-title":"Identification of vulnerable cell types in major brain disorders using single cell transcriptomes and expression weighted cell type enrichment","volume":"10","author":"Skene","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2025.106950_bb0270","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000156474","article-title":"Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress","volume":"15","author":"Sparkman","year":"2008","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.nbd.2025.106950_bb0275","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1750-3639.2001.tb00384.x","article-title":"Viral induced demyelination","volume":"11","author":"Stohlman","year":"2001","journal-title":"Brain Pathol."},{"key":"10.1016\/j.nbd.2025.106950_bb0280","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00401-009-0556-6","article-title":"Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer\u2019s disease","volume":"118","author":"Streit","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2025.106950_bb0285","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/glia.23782","article-title":"Dystrophic microglia in late-onset Alzheimer\u2019s disease","volume":"68","author":"Streit","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2025.106950_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2019.103414","article-title":"Role of GPCR signaling and calcium dysregulation in Alzheimer\u2019s disease","volume":"101","author":"Sushma","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.106950_bb0295","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neurobiolaging.2020.05.016","article-title":"Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer\u2019s disease","volume":"94","author":"Vanzulli","year":"2020","journal-title":"Neurobiol. Aging"},{"issue":"43","key":"10.1016\/j.nbd.2025.106950_bb0300","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.21105\/joss.01686","article-title":"Welcome to the tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J. Open Source Softw."},{"key":"10.1016\/j.nbd.2025.106950_bb0305","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-020-01907-0","article-title":"Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration","volume":"17","author":"Woollacott","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2025.106950_bb0310","doi-asserted-by":"crossref","DOI":"10.1186\/scrt124","article-title":"Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice","volume":"3","author":"Worlitzer","year":"2012","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.nbd.2025.106950_bb0315","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.nbd.2025.106950_bb0320","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/brain\/awy338","article-title":"Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease","volume":"142","author":"You","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2025.106950_bb0325","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10571-014-0101-6","article-title":"Microglial a\u03b2 receptors in Alzheimer\u2019s disease","volume":"35","author":"Yu","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2025.106950_bb0330","first-page":"4603","article-title":"Effects of the transcription factor Olig1 on the differentiation and remyelination of oligodendrocyte precursor cells after focal cerebral ischemia in rats","volume":"20","author":"Zhao","year":"2019","journal-title":"Mol. Med. Rep."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125001664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125001664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:01:49Z","timestamp":1778792509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125001664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":66,"alternative-id":["S0969996125001664"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106950","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.03.25.645240","asserted-by":"object"}]},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-linear microglial, inflammatory and oligodendrocyte dynamics across stages of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106950","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106950"}}