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A."},{"key":"10.1016\/j.nbd.2025.106956_bb0600","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.679413","article-title":"IL-17 inhibits oligodendrocyte progenitor cell proliferation and differentiation by increasing K(+) channel Kv1.3","volume":"15","author":"Liu","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.106956_bb0605","article-title":"The neuroprotective effect of short chain fatty acids against Sepsis-associated encephalopathy in mice","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2025.106956_bb0610","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/intimm\/10.6.775","article-title":"Specific suppression of T helper alloreactivity by allo-MHC class I-restricted CD8+CD28- T cells","volume":"10","author":"Liu","year":"1998","journal-title":"Int. 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Disord."},{"key":"10.1016\/j.nbd.2025.106956_bb1040","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.chom.2022.05.005","article-title":"Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death","volume":"30","author":"Teng","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.nbd.2025.106956_bb1045","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.chom.2017.03.002","article-title":"Age-associated microbial Dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction","volume":"21","author":"Thevaranjan","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.nbd.2025.106956_bb1050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13073-022-01148-1","article-title":"The gut microbiota in multiple sclerosis varies with disease activity","volume":"15","author":"Thirion","year":"2023","journal-title":"Genome Med."},{"key":"10.1016\/j.nbd.2025.106956_bb1055","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/S0140-6736(18)30481-1","article-title":"Multiple sclerosis","volume":"391","author":"Thompson","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2025.106956_bb1060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113246","article-title":"A validated UHPLC-MS method for tryptophan metabolites: application in the diagnosis of multiple sclerosis","volume":"185","author":"Tomosi","year":"2020","journal-title":"J. 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