{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:21:29Z","timestamp":1784892089495,"version":"3.55.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T00:00:00Z","timestamp":1747526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2406900"],"award-info":[{"award-number":["2022YFC2406900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.nbd.2025.106967","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T19:48:32Z","timestamp":1747684112000},"page":"106967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Transcriptomic and glucose metabolism of connectome dynamics variability in temporal lobe epilepsy revealed by simultaneous PET-fMRI"],"prefix":"10.1016","volume":"212","author":[{"given":"Jie","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bixiao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2025.106967_bb0005","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/978-1-62703-059-5_23","article-title":"Partial least squares methods: partial least squares correlation and partial least square regression","volume":"930","author":"Abdi","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.nbd.2025.106967_bb0010","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/cercor\/bhs352","article-title":"Tracking whole-brain connectivity dynamics in the resting state","volume":"24","author":"Allen","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2025.106967_bb0015","doi-asserted-by":"crossref","first-page":"25138","DOI":"10.1073\/pnas.2008004117","article-title":"Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder","volume":"117","author":"Anderson","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2025.106967_bb0020","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3389\/fphys.2019.01583","article-title":"Vascular integrity and signaling determining brain development, network excitability, and Epileptogenesis","volume":"10","author":"Baruah","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.nbd.2025.106967_bb0025","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/ana.24691","article-title":"The spectrum of structural and functional imaging abnormalities in temporal lobe epilepsy","volume":"80","author":"Bernhardt","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2025.106967_bb0030","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41583-019-0212-7","article-title":"The brain\u2019s default network: updated anatomy, physiology and evolving insights","volume":"20","author":"Buckner","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2025.106967_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104847","article-title":"The alteration of cortical microstructure similarity in drug-resistant epilepsy correlated with mTOR pathway genes","volume":"97","author":"Cao","year":"2023","journal-title":"eBioMedicine"},{"issue":"4","key":"10.1016\/j.nbd.2025.106967_bb0040","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2025.106967_bb0045","first-page":"459","article-title":"Neurology collaborators, 2019. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the global burden of disease study 2016","volume":"18","author":"GBD","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2025.106967_bb0050","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1136\/jnnp-2019-320748","article-title":"Thalamic arousal network disturbances in temporal lobe epilepsy and improvement after surgery","volume":"90","author":"Gonz\u00e1lez","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nbd.2025.106967_bb0055","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/s41588-023-01485-w","article-title":"meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture","volume":"55","author":"GWAS","year":"2023","journal-title":"Nat Genet"},{"key":"10.1016\/j.nbd.2025.106967_bb0060","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature11405","article-title":"An anatomically comprehensive atlas of the adult human brain transcriptome","volume":"489","author":"Hawrylycz","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2025.106967_bb0065","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/cns.14039","article-title":"Altered neurovascular coupling in children with idiopathic generalized epilepsy","volume":"29","author":"Hu","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.nbd.2025.106967_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2024.103628","article-title":"Systematically altered connectome gradient in benign childhood epilepsy with centrotemporal spikes: potential effect on cognitive function","volume":"43","author":"Hu","year":"2024","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.nbd.2025.106967_bb0075","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1038\/s41467-018-07524-z","article-title":"Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies","volume":"9","author":"International League Against Epilepsy Consortium on Complex Epilepsies","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.106967_bb0080","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/jon.12671","article-title":"Clinical FDG-PET findings in patients with temporal lobe epilepsy: concordance with EEG and MRI","volume":"30","author":"Jaisani","year":"2020","journal-title":"J. Neuroimaging"},{"issue":"Suppl. 3","key":"10.1016\/j.nbd.2025.106967_bb0085","first-page":"S13","article-title":"An update on the seizures beget seizures theory","volume":"64","author":"Jiruska","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2025.106967_bb0090","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.nicl.2016.02.013","article-title":"Computational analysis in epilepsy neuroimaging: a survey of features and methods","volume":"11","author":"Kini","year":"2016","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.nbd.2025.106967_bb0095","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1177\/0883073818796373","article-title":"Evolution of brain glucose metabolic abnormalities in children with epilepsy and SCN1A gene variants","volume":"33","author":"Kumar","year":"2018","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.nbd.2025.106967_bb0100","doi-asserted-by":"crossref","first-page":"eabc6457","DOI":"10.1126\/sciadv.abc6457","article-title":"Network-based atrophy modeling in the common epilepsies: a worldwide ENIGMA study","volume":"6","author":"Larivi\u00e8re","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.nbd.2025.106967_bb0105","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/epi.16540","article-title":"Functional connectome contractions in temporal lobe epilepsy: microstructural underpinnings and predictors of surgical outcome","volume":"61","author":"Larivi\u00e8re","year":"2020","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2025.106967_bb0110","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1038\/s41467-022-31730-5","article-title":"Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression","volume":"13","author":"Larivi\u00e8re","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.106967_bb0115","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1038\/s41467-021-21943-5","article-title":"Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.106967_bb0120","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1111\/epi.17325","article-title":"Interictal dynamic network transitions in mesial temporal lobe epilepsy","volume":"63","author":"Li","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2025.106967_bb0125","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1002\/jnr.24915","article-title":"Altered static and dynamic functional network connectivity in temporal lobe epilepsy with different disease duration and their relationships with attention","volume":"99","author":"Liang","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2025.106967_bb0130","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neuroimage.2017.02.066","article-title":"Individual differences and time-varying features of modular brain architecture","volume":"152","author":"Liao","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2025.106967_bb0135","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0301-0082(03)00005-4","article-title":"To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways","volume":"69","author":"Liou","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2025.106967_bb0145","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.seizure.2021.02.011","article-title":"Longitudinal changes in gray and white matter microstructure during epileptogenesis in pilocarpine-induced epileptic rats","volume":"90","author":"Luna-Munguia","year":"2021","journal-title":"Seizure"},{"key":"10.1016\/j.nbd.2025.106967_bb0150","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.72129","article-title":"Standardizing workflows in imaging transcriptomics with the abagen toolbox","volume":"10","author":"Markello","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2025.106967_bb0155","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1086\/687857","article-title":"Network and multilayer network approaches to understanding human brain dynamics","volume":"83","author":"Muldoon","year":"2016","journal-title":"Philos. of Sci."},{"key":"10.1016\/j.nbd.2025.106967_bb0160","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2201151119","article-title":"Seizure-induced strengthening of a recurrent excitatory circuit in the dentate gyrus is proconvulsant","volume":"119","author":"Nasrallah","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2025.106967_bb0165","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s40478-022-01453-1","article-title":"High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy","volume":"10","author":"Pai","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2025.106967_bb0170","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuroimage.2018.06.020","article-title":"On the relationship between instantaneous phase synchrony and correlation-based sliding windows for time-resolved fMRI connectivity analysis","volume":"181","author":"Pedersen","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2025.106967_bb0175","doi-asserted-by":"crossref","first-page":"13376","DOI":"10.1073\/pnas.1814785115","article-title":"Multilayer network switching rate predicts brain performance","volume":"115","author":"Pedersen","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2025.106967_bb0180","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.biopsych.2019.12.005","article-title":"Schizotypy-related magnetization of cortex in healthy adolescence is Colocated with expression of schizophrenia-related genes","volume":"88","author":"Romero-Garcia","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.106967_bb0185","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2016.230","article-title":"A comprehensive map of molecular drug targets","volume":"16","author":"Santos","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.nbd.2025.106967_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1255","article-title":"Assessment of dynamic functional connectivity in resting-state fmri using the sliding window technique","volume":"9","author":"Savva","year":"2019","journal-title":"Brain and Behavior"},{"key":"10.1016\/j.nbd.2025.106967_bb0195","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1093\/cercor\/bhx179","article-title":"Local-global Parcellation of the human cerebral cortex from intrinsic functional connectivity MRI","volume":"28","author":"Schaefer","year":"2018","journal-title":"Cereb. Cortex"},{"issue":"4","key":"10.1016\/j.nbd.2025.106967_bb0200","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2025.106967_bb0205","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1038\/s41467-020-17051-5","article-title":"Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders","volume":"11","author":"Seidlitz","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.106967_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2023.119933","article-title":"The interacting brain: dynamic functional connectivity among canonical brain networks dissociates cooperative from competitive social interactions","volume":"269","author":"Shaw","year":"2023","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2025.106967_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102349","article-title":"Alterations in the metabolic networks of temporal lobe epilepsy patients: a graph theoretical analysis using FDG-PET","volume":"27","author":"Shim","year":"2020","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.nbd.2025.106967_bb0220","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/cercor\/bhx249","article-title":"Adolescent tuning of association cortex in human structural brain networks","volume":"28","author":"V\u00e1\u0161a","year":"2018","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2025.106967_bb0225","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/acn3.51168","article-title":"Altered coupling between resting-state glucose metabolism and functional activity in epilepsy","volume":"7","author":"Wang","year":"2020","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.nbd.2025.106967_bb0230","article-title":"The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1","volume":"11","author":"Wang","year":"2023","journal-title":"Genes Dis"},{"key":"10.1016\/j.nbd.2025.106967_bb0235","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S1474-4422(19)30079-1","article-title":"Small vessel disease: mechanisms and clinical implications","volume":"18","author":"Wardlaw","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2025.106967_bb0240","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Cambridge (Mass.))"},{"key":"10.1016\/j.nbd.2025.106967_bb0245","article-title":"BrainNet viewer: a network visualization tool for human brain connectomics","volume":"8","author":"Xia","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.nbd.2025.106967_bb0250","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00259-023-06433-8","article-title":"Differences in whole-brain metabolism are associated with the expression of genes related to neurovascular unit integrity and synaptic plasticity in temporal lobe epilepsy","volume":"51","author":"Xiao","year":"2023","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.nbd.2025.106967_bb0255","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/epi.16759","article-title":"Temporal variability profiling of the default mode across epilepsy subtypes","volume":"62","author":"Yang","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2025.106967_bb0260","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2025.106967_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0287037","article-title":"BayesGmed: an R-package for Bayesian causal mediation analysis","volume":"18","author":"Yimer","year":"2023","journal-title":"PloS One"},{"key":"10.1016\/j.nbd.2025.106967_bb0270","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10548-023-00966-9","article-title":"Differences in the default mode network of temporal lobe epilepsy patients detected by Hilbert-Huang transform based dynamic functional connectivity","volume":"36","author":"Yuan","year":"2023","journal-title":"Brain Topogr."},{"key":"10.1016\/j.nbd.2025.106967_bb0275","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125001834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125001834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:12:32Z","timestamp":1762348352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125001834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":54,"alternative-id":["S0969996125001834"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106967","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomic and glucose metabolism of connectome dynamics variability in temporal lobe epilepsy revealed by simultaneous PET-fMRI","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.106967","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106967"}}