{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:48:56Z","timestamp":1782978536718,"version":"3.54.5"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017794","name":"Alzheimer's Disease Research Center, Wake Forest School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007306","name":"Arizona Department of Health Services","doi-asserted-by":"publisher","award":["211002"],"award-info":[{"award-number":["211002"]}],"id":[{"id":"10.13039\/100007306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG006576"],"award-info":[{"award-number":["U01 AG006576"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG025711"],"award-info":[{"award-number":["R01 AG025711"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG003949"],"award-info":[{"award-number":["R01 AG003949"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P50 AG016574"],"award-info":[{"award-number":["P50 AG016574"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG017216"],"award-info":[{"award-number":["R01 AG017216"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG046139"],"award-info":[{"award-number":["U01 AG046139"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG032990"],"award-info":[{"award-number":["R01 AG032990"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG006786"],"award-info":[{"award-number":["U01 AG006786"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG018023"],"award-info":[{"award-number":["R01 AG018023"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG19610"],"award-info":[{"award-number":["P30 AG19610"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008335","name":"Arizona Biomedical Research Commission","doi-asserted-by":"publisher","award":["1001"],"award-info":[{"award-number":["1001"]}],"id":[{"id":"10.13039\/100008335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008335","name":"Arizona Biomedical Research Commission","doi-asserted-by":"publisher","award":["0011"],"award-info":[{"award-number":["0011"]}],"id":[{"id":"10.13039\/100008335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008335","name":"Arizona Biomedical Research Commission","doi-asserted-by":"publisher","award":["05-901"],"award-info":[{"award-number":["05-901"]}],"id":[{"id":"10.13039\/100008335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008335","name":"Arizona Biomedical Research Commission","doi-asserted-by":"publisher","award":["4001"],"award-info":[{"award-number":["4001"]}],"id":[{"id":"10.13039\/100008335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008539","name":"CurePSP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U24 NS072026"],"award-info":[{"award-number":["U24 NS072026"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS080820"],"award-info":[{"award-number":["R01 NS080820"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006484","name":"AbbVie Deutschland GmbH & Co KG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.nbd.2025.107060","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T06:49:57Z","timestamp":1755240597000},"page":"107060","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A role for the autophagy receptor NBR1 in the degradation of tau aggregates"],"prefix":"10.1016","volume":"214","author":[{"given":"Marie","family":"Neu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwan","family":"Parfentev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory K.","family":"Potts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"St\u00f6berl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Korffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Striebinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Geist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Papageorgiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Tarhonskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"McKitterick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"van Bergeijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Untucht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon D.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela J.","family":"Heimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gasparini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar E.","family":"Ehrnhoefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2025.107060_bb0005","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2016.89","article-title":"Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases","volume":"3","author":"Allen","year":"2016","journal-title":"Sci Data"},{"key":"10.1016\/j.nbd.2025.107060_bb0010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s004010100423","article-title":"Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease","volume":"103","author":"Augustinack","year":"2002","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2025.107060_bb0015","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1016\/j.cell.2024.03.015","article-title":"Human iPSC 4R tauopathy model uncovers modifiers of tau propagation","volume":"187","author":"Bravo","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.107060_bb0020","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1038\/s41598-017-03519-w","article-title":"Enhanced derivation of human pluripotent stem cell-derived cortical glutamatergic neurons by a small molecule","volume":"7","author":"Cao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2025.107060_bb0025","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nbt.1529","article-title":"Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling","volume":"27","author":"Chambers","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.nbd.2025.107060_bb0030","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/ncb1901","article-title":"Transmission and spreading of tauopathy in transgenic mouse brain","volume":"11","author":"Clavaguera","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.nbd.2025.107060_bb0035","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1093\/brain\/awv127","article-title":"First effects of rising amyloid-\u03b2 in transgenic mouse brain: synaptic transmission and gene expression","volume":"138","author":"Cummings","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2025.107060_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-019-0518-8","article-title":"Tau and atrophy: domain-specific relationships with cognition","volume":"11","author":"Digma","year":"2019","journal-title":"Alzheimer's Res Ther"},{"key":"10.1016\/j.nbd.2025.107060_bb0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.nbd.2025.107060_bib273","doi-asserted-by":"crossref","first-page":"8449","DOI":"10.1126\/sciadv.adm8449","article-title":"Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion","volume":"10","author":"Ferrari","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.nbd.2025.107060_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.00068","article-title":"A connected network of interacting proteins is involved in human-tau toxicity in Drosophila","volume":"14","author":"Feuillette","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2025.107060_bb0055","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s40478-024-01825-9","article-title":"Correction: tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain","volume":"12","author":"Frey","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2025.107060_bb0060","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nature07287","article-title":"An intrinsic mechanism of corticogenesis from embryonic stem cells","volume":"455","author":"Gaspard","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2025.107060_bb0065","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","article-title":"Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease","volume":"60","author":"Giannakopoulos","year":"2003","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.nbd.2025.107060_bib272","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.jalz.2016.09.001","article-title":"The ordered assembly of tau is the gain-of-toxic function that causes human tauopathies","volume":"12","author":"Goedert","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.nbd.2025.107060_bb0070","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","article-title":"Microtubule-associated protein tau. A component of Alzheimer paired helical filaments","volume":"261","author":"Grundke-Iqbal","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2025.107060_bb0075","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.neuron.2011.05.006","article-title":"Deriving excitatory neurons of the neocortex from pluripotent stem cells","volume":"70","author":"Hansen","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.107060_bb0080","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1006\/mcne.2001.1000","article-title":"Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors","volume":"18","author":"Hartmann","year":"2001","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.107060_bb0085","doi-asserted-by":"crossref","first-page":"19855","DOI":"10.1074\/jbc.R114.549295","article-title":"Prion-like properties of tau protein: the importance of extracellular tau as a therapeutic target*","volume":"289","author":"Holmes","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2025.107060_bb0090","doi-asserted-by":"crossref","first-page":"E4376","DOI":"10.1073\/pnas.1411649111","article-title":"Proteopathic tau seeding predicts tauopathy in vivo","volume":"111","author":"Holmes","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nbd.2025.107060_bb0095","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1523\/JNEUROSCI.2642-12.2013","article-title":"Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like Tauopathy","volume":"33","author":"Iba","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107060_bb0100","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1038\/ncomms4496","article-title":"Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52","volume":"5","author":"Jo","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.107060_bb0105","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s41586-022-05575-3","article-title":"An atlas of substrate specificities for the human serine\/threonine kinome","volume":"613","author":"Johnson","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2025.107060_bb0110","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.molcel.2009.01.020","article-title":"A role for NBR1 in Autophagosomal degradation of Ubiquitinated substrates","volume":"33","author":"Kirkin","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.nbd.2025.107060_bb0115","doi-asserted-by":"crossref","first-page":"24374","DOI":"10.1016\/S0021-9258(20)80536-5","article-title":"Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease","volume":"268","author":"K\u00f6pke","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2025.107060_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2011.00017","article-title":"GSK3 and Alzheimer's disease: facts and fiction","volume":"4","author":"Kremer","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2025.107060_bb0125","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.neurobiolaging.2011.11.009","article-title":"Autophagic degradation of tau in primary neurons and its enhancement by trehalose","volume":"33","author":"Kr\u00fcger","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2025.107060_bb0130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pneurobio.2013.03.001","article-title":"Tau degradation: the ubiquitin\u2013proteasome system versus the autophagy-lysosome system","volume":"105","author":"Lee","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2025.107060_bb0135","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41593-020-00764-7","article-title":"Molecular characterization of selectively vulnerable neurons in Alzheimer's disease","volume":"24","author":"Leng","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2025.107060_bb0140","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1038\/s41467-023-39314-7","article-title":"Fully co-factor-free ClearTau platform produces seeding-competent tau fibrils for reconstructing pathological tau aggregates","volume":"14","author":"Limorenko","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.107060_bb0145","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-1326-3-8","article-title":"Tau exon 10 alternative splicing and tauopathies","volume":"3","author":"Liu","year":"2008","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2025.107060_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.1022821","article-title":"The emerging role of autophagy and mitophagy in tauopathies: from pathogenesis to translational implications in Alzheimer's disease","volume":"14","author":"Liu","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2025.107060_bb0155","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3233\/JAD-2005-8104","article-title":"Regional conformational change involving phosphorylation of tau protein at the Thr231, precedes the structural change detected by Alz-50 antibody in Alzheimer's disease","volume":"8","author":"Luna-Mu\u00f1oz","year":"2005","journal-title":"J Alzheimer's Dis"},{"key":"10.1016\/j.nbd.2025.107060_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103658","article-title":"Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model","volume":"25","author":"Manos","year":"2022","journal-title":"IScience"},{"key":"10.1016\/j.nbd.2025.107060_bb0165","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.molcel.2011.07.039","article-title":"Serine 403 phosphorylation of p62\/SQSTM1 regulates selective Autophagic clearance of Ubiquitinated proteins","volume":"44","author":"Matsumoto","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.nbd.2025.107060_bb0170","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41419-025-07611-2","article-title":"A variant of the autophagic receptor NDP52 counteracts phospho-TAU accumulation and emerges as a protective factor for Alzheimer's disease","volume":"16","author":"Mattioni","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2025.107060_bb0175","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer's disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2025.107060_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1051494","article-title":"Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling","volume":"10","author":"Minaya","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.nbd.2025.107060_bb0185","doi-asserted-by":"crossref","first-page":"9738","DOI":"10.1523\/JNEUROSCI.6007-09.2010","article-title":"The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function","volume":"30","author":"Moreau","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107060_bb0190","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/archneur.58.3.397","article-title":"Mild cognitive impairment represents early-stage Alzheimer disease","volume":"58","author":"Morris","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2025.107060_bb0195","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.4161\/auto.28479","article-title":"Phosphorylation of NBR1 by GSK3 modulates protein aggregation","volume":"10","author":"Nicot","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.nbd.2025.107060_bb0200","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202208092","article-title":"NBR1: the archetypal selective autophagy receptor","volume":"221","author":"Rasmussen","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.nbd.2025.107060_bb0205","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.redox.2016.11.004","article-title":"Inhibition of autophagy with Bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons","volume":"11","author":"Redmann","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.nbd.2025.107060_bb0210","series-title":"NBR1 Directly Promotes the Formation of p62 \u2013 Ubiquitin Condensates Via its PB1 and UBA Domains","author":"Savova","year":"2020"},{"key":"10.1016\/j.nbd.2025.107060_bb0215","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbamcr.2013.03.019","article-title":"Substrate recognition in selective autophagy and the ubiquitin\u2013proteasome system","volume":"1843","author":"Schreiber","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2025.107060_bb0220","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.nbd.2025.107060_bb0225","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer's disease is a synaptic failure","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.nbd.2025.107060_bb0230","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1038\/s41467-020-16984-1","article-title":"Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons","volume":"11","author":"Silva","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.107060_bb0235","doi-asserted-by":"crossref","first-page":"eabl8809","DOI":"10.1126\/sciadv.abl8809","article-title":"Alzheimer's disease: ablating single master site abolishes tau hyperphosphorylation","volume":"8","author":"Stefanoska","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.nbd.2025.107060_bb0240","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.stemcr.2018.06.022","article-title":"Genetically engineered iPSC-derived FTDP-17 MAPT neurons display mutation-specific neurodegenerative and neurodevelopmental phenotypes","volume":"11","author":"Verheyen","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.nbd.2025.107060_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107908","article-title":"Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models","volume":"32","author":"Wan","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2025.107060_bb0250","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.conb.2021.03.003","article-title":"A current view on tau protein phosphorylation in Alzheimer's disease","volume":"69","author":"Wegmann","year":"2021","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.nbd.2025.107060_bb0255","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s40478-025-02000-4","article-title":"hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation","volume":"13","author":"Weidling","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nbd.2025.107060_bb0260","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.cell.2020.10.029","article-title":"Tau PTM profiles identify patient heterogeneity and stages of Alzheimer's disease","volume":"183","author":"Wesseling","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.107060_bb0265","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/15548627.2018.1532258","article-title":"The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau)","volume":"15","author":"Xu","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.nbd.2025.107060_bb0270","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.apsb.2022.01.008","article-title":"Impairment of the autophagy\u2013lysosomal pathway in Alzheimer's diseases: pathogenic mechanisms and therapeutic potential","volume":"12","author":"Zhang","year":"2022","journal-title":"Acta Pharm. Sin. B"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125002761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125002761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:57:03Z","timestamp":1778576223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125002761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":56,"alternative-id":["S0969996125002761"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107060","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A role for the autophagy receptor NBR1 in the degradation of tau aggregates","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107060"}}