{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T21:44:03Z","timestamp":1774734243308,"version":"3.50.1"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Foundation for Medical Research","doi-asserted-by":"publisher","award":["DPA20140629798"],"award-info":[{"award-number":["DPA20140629798"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-16-37\\u20130003CE"],"award-info":[{"award-number":["ANR-16-37\\u20130003CE"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-16-16\\u20130018CE"],"award-info":[{"award-number":["ANR-16-16\\u20130018CE"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019125","name":"Sorbonne University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001595","name":"Dystonia Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022554","name":"Paris Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.nbd.2025.107071","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T23:09:50Z","timestamp":1756768190000},"page":"107071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Characterization of mice with cell type-specific Gnal loss of function provides insights on GNAL-linked dystonia"],"prefix":"10.1016","volume":"215","author":[{"given":"Sophie","family":"Longueville","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiyi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Naon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Valjent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assunta","family":"Pelosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Roze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise-Laure","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Antoine","family":"Girault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Herv\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2025.107071_bb0005","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.79135","article-title":"Functional abnormalities in the cerebello-thalamic pathways in a mouse model of DYT25 dystonia","volume":"11","author":"Aissa","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2025.107071_bb0010","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/mds.30220","article-title":"Definition and classification of dystonia","volume":"40","author":"Albanese","year":"2025","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107071_bb0015","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pediatrneurol.2016.02.018","article-title":"Clinical course of six children with GNAO1 mutations causing a severe and distinctive movement disorder","volume":"59","author":"Ananth","year":"2016","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.nbd.2025.107071_bb0020","doi-asserted-by":"crossref","first-page":"eabg5970","DOI":"10.1126\/sciadv.abg5970","article-title":"Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine\u2019s rewarding effects but preserves natural reward processing","volume":"7","author":"Andrianarivelo","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.nbd.2025.107071_bb0025","doi-asserted-by":"crossref","first-page":"14845","DOI":"10.1073\/pnas.1009874107","article-title":"Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors","volume":"107","author":"Bateup","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2025.107071_bb0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0896-6273(00)80435-3","article-title":"Mice deficient in G(olf) are anosmic","volume":"20","author":"Belluscio","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.107071_bb0035","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1523\/JNEUROSCI.1039-08.2008","article-title":"Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol","volume":"28","author":"Bertran-Gonzalez","year":"2008","journal-title":"J. Neurosci."},{"issue":"Pt 4","key":"10.1016\/j.nbd.2025.107071_bb0040","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/brain\/117.4.859","article-title":"The behavioural and motor consequences of focal lesions of the basal ganglia in man","volume":"117","author":"Bhatia","year":"1994","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2025.107071_bb0045","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1038\/s41593-024-01694-4","article-title":"Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs","volume":"27","author":"Bonnavion","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0050","doi-asserted-by":"crossref","first-page":"9065","DOI":"10.1523\/JNEUROSCI.1211-21.2021","article-title":"Selective manipulation of G-protein gamma(7) subunit in mice provides new insights into striatal control of motor behavior","volume":"41","author":"Brunori","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0055","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/mp.2014.73","article-title":"D1R\/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses","volume":"19","author":"Cahill","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107071_bb0065","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/mds.26598","article-title":"Phenotypic insights into ADCY5-associated disease","volume":"31","author":"Chang","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107071_bb0060","series-title":"Conditional knockout of striatal Gnal produces dystonia-like motor phenotypes","author":"Chambers","year":"2024"},{"key":"10.1016\/j.nbd.2025.107071_bb0070","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/ana.24119","article-title":"Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia","volume":"75","author":"Chen","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2025.107071_bb0075","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1021\/acschemneuro.5b00020","article-title":"Identification of G protein-biased agonists that fail to recruit beta-arrestin or promote internalization of the D1 dopamine receptor","volume":"6","author":"Conroy","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0080","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1046\/j.1471-4159.2001.00201.x","article-title":"Galpha(olf) is necessary for coupling D1 and A2a receptors to adenylyl cyclase in the striatum","volume":"76","author":"Corvol","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.107071_bb0085","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/sj.npp.1301230","article-title":"Quantitative changes in G alpha olf protein levels, but not D1 receptor, alter specifically acute responses to psychostimulants","volume":"32","author":"Corvol","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2025.107071_bb0090","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1097\/00001756-199707280-00021","article-title":"Effects of repeated amphetamine treatment on the locomotor activity of the dopamine D1A-deficient mouse","volume":"8","author":"Crawford","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2025.107071_bb0095","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11846","article-title":"Concurrent activation of striatal direct and indirect pathways during action initiation","volume":"494","author":"Cui","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2025.107071_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12995","article-title":"Regulation of GluA1 phosphorylation by d-amphetamine and methylphenidate in the cerebellum","volume":"26","author":"Cutando","year":"2021","journal-title":"Addict. Biol."},{"issue":"Suppl. 2","key":"10.1016\/j.nbd.2025.107071_bb0105","first-page":"S53","article-title":"Pharmacology of drugs used as stimulants","volume":"61","author":"Docherty","year":"2021","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107071_bb0110","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/1044-7431(91)90040-U","article-title":"G(olf) in the basal ganglia","volume":"2","author":"Drinnan","year":"1991","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0115","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nn.2286","article-title":"D2R striatopallidal neurons inhibit both locomotor and drug reward processes","volume":"12","author":"Durieux","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0120","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/emboj.2011.400","article-title":"Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions","volume":"31","author":"Durieux","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2025.107071_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106403","article-title":"Loss-of-function of GNAL dystonia gene impairs striatal dopamine receptors-mediated adenylyl cyclase\/ cyclic AMP signaling pathway","volume":"191","author":"El Atiallah","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2025.107071_bb0130","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/sj.bjp.0703170","article-title":"The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptors","volume":"129","author":"El Yacoubi","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107071_bb0135","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1002\/mds.28686","article-title":"The emerging role of Phosphodiesterases in movement disorders","volume":"36","author":"Erro","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107071_bb0140","doi-asserted-by":"crossref","first-page":"20196","DOI":"10.1074\/jbc.M213140200","article-title":"Regulation of dopamine D1 receptor trafficking and desensitization by oligomerization with glutamate N-methyl-D-aspartate receptors","volume":"278","author":"Fiorentini","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2025.107071_bb0145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0031-6997(24)01396-6","article-title":"Actions of caffeine in the brain with special reference to factors that contribute to its widespread use","volume":"51","author":"Fredholm","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.nbd.2025.107071_bb0150","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/ng.2496","article-title":"Mutations in GNAL cause primary torsion dystonia","volume":"45","author":"Fuchs","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2025.107071_bb0155","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-neuro-061010-113641","article-title":"Modulation of striatal projection systems by dopamine","volume":"34","author":"Gerfen","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0160","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.1523\/JNEUROSCI.2707-07.2007","article-title":"Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs","volume":"27","author":"Gong","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0165","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.tins.2013.09.003","article-title":"New genetic insights highlight \u2018old\u2019 ideas on motor dysfunction in dystonia","volume":"36","author":"Goodchild","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0170","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fnana.2011.00048","article-title":"Identification of a specific assembly of the g protein golf as a critical and regulated module of dopamine and adenosine-activated cAMP pathways in the striatum","volume":"5","author":"Herve","year":"2011","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.nbd.2025.107071_bb0175","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1523\/JNEUROSCI.13-05-02237.1993","article-title":"G(olf) and Gs in rat basal ganglia: possible involvement of G(olf) in the coupling of dopamine D1 receptor with adenylyl cyclase","volume":"13","author":"Herve","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0180","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1523\/JNEUROSCI.21-12-04390.2001","article-title":"Galpha(olf) levels are regulated by receptor usage and control dopamine and adenosine action in the striatum","volume":"21","author":"Herve","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0185","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.neuron.2010.05.011","article-title":"Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior","volume":"66","author":"Hikida","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.107071_bb0190","doi-asserted-by":"crossref","first-page":"8102","DOI":"10.1523\/JNEUROSCI.0473-17.2017","article-title":"ERK\/MAPK Signaling is required for pathway-specific striatal motor functions","volume":"37","author":"Hutton","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0195","doi-asserted-by":"crossref","first-page":"16936","DOI":"10.1074\/jbc.C300075200","article-title":"Motor dysfunction in type 5 adenylyl cyclase-null mice","volume":"278","author":"Iwamoto","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2025.107071_bb0200","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-5793(04)00333-3","article-title":"Disruption of type 5 adenylyl cyclase negates the developmental increase in Galphaolf expression in the striatum","volume":"564","author":"Iwamoto","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nbd.2025.107071_bb0205","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1046\/j.1471-4159.2003.01698.x","article-title":"SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain","volume":"85","author":"Jin","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.107071_bb0210","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1126\/science.2499043","article-title":"Golf: an olfactory neuron specific-G protein involved in odorant signal transduction","volume":"244","author":"Jones","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.nbd.2025.107071_bb0215","article-title":"The Signaling and pharmacology of the dopamine D1 receptor","volume":"15","author":"Jones-Tabah","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0220","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1111\/j.1460-9568.2005.04353.x","article-title":"Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine-induced locomotor activity, reward and CREB phosphorylation","volume":"22","author":"Karasinska","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0225","doi-asserted-by":"crossref","first-page":"14139","DOI":"10.1073\/pnas.1918736117","article-title":"Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor","volume":"117","author":"Kaya","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2025.107071_bb0230","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/mds.28861","article-title":"A homozygous missense variant in PPP1R1B\/DARPP-32 is associated with generalized complex dystonia","volume":"37","author":"Khan","year":"2022","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107071_bb0235","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/mdc3.14059","article-title":"Sex differences in dystonia","volume":"11","author":"Kilic-Berkmen","year":"2024","journal-title":"Mov Disord Clin Pract."},{"key":"10.1016\/j.nbd.2025.107071_bb0240","doi-asserted-by":"crossref","first-page":"11465","DOI":"10.1073\/pnas.0402028101","article-title":"Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice","volume":"101","author":"Kobayashi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2025.107071_bb0245","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nn.3100","article-title":"Distinct roles for direct and indirect pathway striatal neurons in reinforcement","volume":"15","author":"Kravitz","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0250","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/jamaneurol.2013.4677","article-title":"Mutations in GNAL: a novel cause of craniocervical dystonia","volume":"71","author":"Kumar","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nbd.2025.107071_bb0255","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.brainresrev.2011.02.005","article-title":"Brain regions and genes affecting limb-clasping responses","volume":"67","author":"Lalonde","year":"2011","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.nbd.2025.107071_bb0260","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/41771","article-title":"Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor","volume":"388","author":"Ledent","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2025.107071_bb0265","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0092-8674(02)00962-5","article-title":"Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor","volume":"111","author":"Lee","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.107071_bb0270","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/jpet.114.214411","article-title":"Dopamine D1 receptor signaling: does GalphaQ-phospholipase C actually play a role?","volume":"351","author":"Lee","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2025.107071_bb0275","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1471-4159.2001.00422.x","article-title":"The olfactory G protein G(alphaolf) possesses a lower GDP-affinity and deactivates more rapidly than G(salphashort): consequences for receptor-coupling and adenylyl cyclase activation","volume":"78","author":"Liu","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.107071_bb0280","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1188472","article-title":"Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward","volume":"330","author":"Lobo","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.nbd.2025.107071_bb0285","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1021\/acs.jmedchem.9b00351","article-title":"Defining structure-functional selectivity relationships (SFSR) for a class of non-catechol dopamine D(1) receptor agonists","volume":"62","author":"Martini","year":"2019","journal-title":"J. Med. Chem."},{"issue":"557\u2013568","key":"10.1016\/j.nbd.2025.107071_bb0290","article-title":"Molecular deconvolution platform to establish disease mechanisms by surveying GPCR Signaling","volume":"24","author":"Masuho","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2025.107071_bb0295","doi-asserted-by":"crossref","first-page":"18125","DOI":"10.1523\/JNEUROSCI.2382-13.2013","article-title":"D1 dopamine receptor coupling to PLCbeta regulates forward locomotion in mice","volume":"33","author":"Medvedev","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0300","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1093\/brain\/awaa217","article-title":"Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders","volume":"143","author":"Mencacci","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2025.107071_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149105","article-title":"Neuron specific quantitation of Galpha(olf) expression and signaling in murine brain tissue","volume":"1842","author":"Millett","year":"2024","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2025.107071_bb0310","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1001\/archneur.60.10.1365","article-title":"The basal ganglia and involuntary movements: impaired inhibition of competing motor patterns","volume":"60","author":"Mink","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2025.107071_bb0315","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/mds.27219","article-title":"A familial case of PDE10A-associated childhood-onset chorea with bilateral striatal lesions","volume":"33","author":"Miyatake","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107071_bb0320","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/s41380-022-01439-4","article-title":"Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects","volume":"27","author":"Montalban","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107071_bb0325","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fnint.2014.00056","article-title":"Distinct motor impairments of dopamine D1 and D2 receptor knockout mice revealed by three types of motor behavior","volume":"8","author":"Nakamura","year":"2014","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0330","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev-neuro-071013-013916","article-title":"Reassessing models of basal ganglia function and dysfunction","volume":"37","author":"Nelson","year":"2014","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0335","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.nbd.2011.01.026","article-title":"The functional neuroanatomy of dystonia","volume":"42","author":"Neychev","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2025.107071_bb0340","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1002\/mds.27523","article-title":"PDE10A and ADCY5 mutations linked to molecular and microstructural basal ganglia pathology","volume":"33","author":"Niccolini","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107071_bb0345","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejphar.2004.01.004","article-title":"SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography","volume":"486","author":"O\u2019Sullivan","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107071_bb0350","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1124\/mol.105.011809","article-title":"cAMP and extracellular signal-regulated kinase signaling in response to d-amphetamine and methylphenidate in the prefrontal cortex in vivo: role of beta 1-adrenoceptors","volume":"68","author":"Pascoli","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107071_bb0355","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.biopsych.2010.08.031","article-title":"Cyclic adenosine monophosphate-independent tyrosine phosphorylation of NR2B mediates cocaine-induced extracellular signal-regulated kinase activation","volume":"69","author":"Pascoli","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107071_bb0360","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2024.1394659","article-title":"Post-transcriptional regulation and subcellular localization of G-protein gamma7 subunit: implications for striatal function and behavioral responses to cocaine","volume":"18","author":"Pelletier","year":"2024","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.nbd.2025.107071_bb0365","doi-asserted-by":"crossref","first-page":"6253","DOI":"10.1523\/JNEUROSCI.1529-16.2017","article-title":"Heterozygous Gnal mice are a novel animal model with which to study dystonia pathophysiology","volume":"37","author":"Pelosi","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101678","article-title":"Dystonia and dopamine: from phenomenology to pathophysiology","volume":"182","author":"Ribot","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2025.107071_bb0375","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pneurobio.2014.07.002","article-title":"Genetic animal models of dystonia: common features and diversities","volume":"121","author":"Richter","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2025.107071_bb0380","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0006-8993(94)90007-8","article-title":"Developmental changes in Gs and G(olf) proteins and adenylyl cyclases in mouse brain membranes","volume":"643","author":"Rius","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2025.107071_bb0385","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/mds.27286","article-title":"A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea","volume":"33","author":"Salpietro","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107071_bb0390","doi-asserted-by":"crossref","first-page":"29787","DOI":"10.1074\/jbc.M110.142620","article-title":"Adenosine a(2A) receptor Signaling and G(olf) assembly show a specific requirement for the gamma(7) subtype in the striatum","volume":"285","author":"Schwindinger","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2025.107071_bb0395","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1523\/JNEUROSCI.5255-07.2008","article-title":"A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs","volume":"28","author":"Shen","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0400","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/sj.npp.1300852","article-title":"Receptor crosstalk: characterization of mice deficient in dopamine D1 and adenosine A2A receptors","volume":"31","author":"Short","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2025.107071_bb0405","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0022-3565(25)13248-5","article-title":"Stimulation of a dopamine D1 receptor enhances inositol phosphates formation in rat brain","volume":"253","author":"Undie","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2025.107071_bb0410","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1046\/j.1471-4159.1994.62052045.x","article-title":"Evidence for a distinct D1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain","volume":"62","author":"Undie","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.107071_bb0415","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/npp.2010.186","article-title":"A dopamine D1 receptor-dependent beta-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice","volume":"36","author":"Urs","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2025.107071_bb0420","series-title":"Multiple functions of Cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice","author":"Varani","year":"2024"},{"key":"10.1016\/j.nbd.2025.107071_bb0425","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1093\/hmg\/ddt102","article-title":"Role of g\u03b1(olf) in familial and sporadic adult-onset primary dystonia","volume":"22","author":"Vemula","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2025.107071_bb0430","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mcn.2010.09.011","article-title":"A behavioral genetics approach to understanding D1 receptor involvement in phasic dopamine signaling","volume":"46","author":"Wall","year":"2011","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0435","doi-asserted-by":"crossref","first-page":"13548","DOI":"10.1523\/JNEUROSCI.3554-06.2006","article-title":"Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice","volume":"26","author":"Xiao","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107071_bb0440","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.10451","article-title":"Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling","volume":"4","author":"Xie","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2025.107071_bb0445","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/0092-8674(94)90026-4","article-title":"Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice","volume":"79","author":"Xu","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.107071_bb0450","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0092-8674(94)90557-6","article-title":"Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses","volume":"79","author":"Xu","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.107071_bb0455","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0006-8993(99)02258-1","article-title":"Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor","volume":"852","author":"Xu","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2025.107071_bb0460","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41467-017-02606-w","article-title":"Gs- versus golf-dependent functional selectivity mediated by the dopamine D(1) receptor","volume":"9","author":"Yano","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.107071_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104634","article-title":"Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia","volume":"134","author":"Yu-Taeger","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2025.107071_bb0470","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0092-8674(95)90145-0","article-title":"Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic","volume":"83","author":"Zhou","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.107071_bb0475","doi-asserted-by":"crossref","first-page":"RC91","DOI":"10.1523\/JNEUROSCI.20-16-j0001.2000","article-title":"G(olf)alpha mediates dopamine D1 receptor signaling","volume":"20","author":"Zhuang","year":"2000","journal-title":"J. Neurosci."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125002876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125002876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T10:22:13Z","timestamp":1772878933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125002876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":95,"alternative-id":["S0969996125002876"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107071","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.07.02.662743","asserted-by":"object"}]},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of mice with cell type-specific Gnal loss of function provides insights on GNAL-linked dystonia","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107071"}}