{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:11:19Z","timestamp":1788315079144,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32 NS121727-01"],"award-info":[{"award-number":["T32 NS121727-01"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001414"],"award-info":[{"award-number":["UL1 TR001414"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001873"],"award-info":[{"award-number":["UL1 TR001873"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002373"],"award-info":[{"award-number":["UL1 TR002373"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002345"],"award-info":[{"award-number":["UL1 TR002345"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001857"],"award-info":[{"award-number":["UL1 TR001857"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U24 AG21886"],"award-info":[{"award-number":["U24 AG21886"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG062421"],"award-info":[{"award-number":["P30 AG062421"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG062715"],"award-info":[{"award-number":["P30 AG062715"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG051406"],"award-info":[{"award-number":["U01 AG051406"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P50 AG005681"],"award-info":[{"award-number":["P50 AG005681"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P50 AG008702"],"award-info":[{"award-number":["P50 AG008702"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG079519"],"award-info":[{"award-number":["RF1AG079519"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P50 AG005133"],"award-info":[{"award-number":["P50 AG005133"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19 AG068054"],"award-info":[{"award-number":["U19 AG068054"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P50 AG16537"],"award-info":[{"award-number":["P50 AG16537"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG051412"],"award-info":[{"award-number":["U01 AG051412"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG066519"],"award-info":[{"award-number":["P30 AG066519"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["5P30AG072946"],"award-info":[{"award-number":["5P30AG072946"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disabilities Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.nbd.2025.107114","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:52:25Z","timestamp":1758588745000},"page":"107114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Regional differences in astrocytic Aquaporin-4 protein levels and distribution in aging and Alzheimer's disease in down syndrome"],"prefix":"10.1016","volume":"216","author":[{"given":"Cherie A.","family":"Stringer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley K.S.","family":"Miyasato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Camey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krina A.","family":"Ghadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phong T.","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse R.","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sierra T.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine A.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna M.","family":"Gawronski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Phelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A.","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan P.","family":"Harp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Mapstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K.","family":"Kofler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos D.","family":"Ikonomovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2025.107114_bb0005","author":"Alzheimer'\u2019s Disease International"},{"key":"10.1016\/j.nbd.2025.107114_bb0010","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.nbd.2025.107114_bb0015","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s11689-022-09435-z","article-title":"Conducting clinical trials in persons with down syndrome: summary from the NIH INCLUDE down syndrome clinical trials readiness working group","volume":"14","author":"Baumer","year":"2022","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.nbd.2025.107114_bb0020","author":"Cell Classification"},{"issue":"1","key":"10.1016\/j.nbd.2025.107114_bb0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s40259-023-00633-2","article-title":"Anti-amyloid monoclonal antibodies for the treatment of Alzheimer\u2019s disease","volume":"38","author":"Cummings","year":"2024","journal-title":"BioDrugs"},{"key":"10.1016\/j.nbd.2025.107114_bb0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev-neuro-091922-031205","article-title":"Astrocyte Endfeet in brain function and pathology: open questions","volume":"46","author":"D\u00edaz-Castro","year":"2023","journal-title":"Annu. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2025.107114_bb0035","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3233\/JAD-160836","article-title":"Down syndrome, partial trisomy 21, and absence of Alzheimer\u2019s disease: the role of APP","volume":"56","author":"Doran","year":"2017","journal-title":"J Alzheimer\u2019s Dis"},{"key":"10.1016\/j.nbd.2025.107114_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/S0074-7750(10)39004-5","article-title":"Health conditions associated with aging and end of life of adults with down syndrome. Int rev res","volume":"39(C):107-126","author":"Esbensen","year":"2010","journal-title":"Ment. Retard."},{"key":"10.1016\/j.nbd.2025.107114_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.635880","article-title":"(Dys)regulation of synaptic activity and neurotransmitter release by \u03b2-amyloid: a look beyond Alzheimer\u2019s disease pathogenesis","volume":"14","author":"Fagiani","year":"2021","journal-title":"Front. Mol. Neurosci."},{"issue":"11","key":"10.1016\/j.nbd.2025.107114_bb0050","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S1474-4422(21)00245-3","article-title":"Alzheimer\u2019s disease associated with down syndrome: a genetic form of dementia","volume":"20","author":"Fortea","year":"2021","journal-title":"Lancet Neurol."},{"issue":"19","key":"10.1016\/j.nbd.2025.107114_bb0055","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.1073\/pnas.86.19.7611","article-title":"Brain interleukin 1 and S-100 immunoreactivity are elevated in down syndrome and Alzheimer disease","volume":"86","author":"Griffin","year":"1989","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"20","key":"10.1016\/j.nbd.2025.107114_bb0060","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1212\/WNL.0000000000004643","article-title":"In vivo staging of regional amyloid deposition","volume":"89","author":"Grothe","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2025.107114_bb0065","article-title":"A Paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4(147):147ra111-147ra111","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"issue":"49","key":"10.1016\/j.nbd.2025.107114_bb0070","doi-asserted-by":"crossref","first-page":"16180","DOI":"10.1523\/JNEUROSCI.3020-14.2014","article-title":"Impairment of Glymphatic pathway function promotes tau pathology after traumatic brain injury","volume":"34","author":"Iliff","year":"2014","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.nbd.2025.107114_bb0075","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The Glymphatic system \u2013 a beginner\u2019s guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.nbd.2025.107114_bb0080","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s12276-023-01148-0","article-title":"Pathological phenotypes of astrocytes in Alzheimer\u2019s disease","volume":"56","author":"Kim","year":"2024","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.nbd.2025.107114_bb0085","doi-asserted-by":"crossref","first-page":"12334","DOI":"10.1038\/s41598-024-61962-y","article-title":"Cerebrovascular disease emerges with age and Alzheimer\u2019s disease in adults with down syndrome","volume":"14","author":"Lao","year":"2024","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.nbd.2025.107114_bb0090","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive astrocytes: production, function, and therapeutic potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.nbd.2025.107114_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106749","article-title":"Astrocytic proteins involved in regulation of the extracellular environment are increased in the Alzheimer\u2019s disease middle temporal gyrus","volume":"204","author":"Liu","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2025.107114_bb0100","article-title":"Alzheimer disease in down syndrome: overview, pathophysiology\/risk factors","author":"Medscape","year":"2024","journal-title":"Epidemiology"},{"key":"10.1016\/j.nbd.2025.107114_bb0105","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.40070","article-title":"Aquaporin-4-dependent glymphatic solute transport in the rodent brain","volume":"7","author":"Mestre","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2025.107114_bb0110","series-title":"Down syndrome population will see a clinical trial of new Alzheimer\u2019s drug - LuMind IDSC foundation","volume":"11","author":"O\u2019Neill","year":"2024"},{"key":"10.1016\/j.nbd.2025.107114_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106100","article-title":"The effect of aquaporin-4 mis-localization on a\u03b2 deposition in mice","volume":"181","author":"Pedersen","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2025.107114_bb0120","author":"Pixel Classification"},{"key":"10.1016\/j.nbd.2025.107114_bb0125","author":"Pixel classification"},{"issue":"3","key":"10.1016\/j.nbd.2025.107114_bb0130","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/ana.410430316","article-title":"Molecular mapping of Alzheimer-type dementia in down\u2019s syndrome","volume":"43","author":"Prasher","year":"1998","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2025.107114_bb0135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s42466-021-00102-7","article-title":"Glymphatic system, AQP4, and their implications in Alzheimer\u2019s disease","volume":"3","author":"Silva","year":"2021","journal-title":"Neurological Research and Practice."},{"issue":"1","key":"10.1016\/j.nbd.2025.107114_bb0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13195-022-00999-5","article-title":"Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid \u03b2 plaque formation in mice","volume":"14","author":"Simon","year":"2022","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"10.1016\/j.nbd.2025.107114_bb0145","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s40478-019-0728-0","article-title":"Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer\u2019s disease by remodeling peri-plaque astrocyte structure","volume":"7","author":"Smith","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.nbd.2025.107114_bb0150","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2025.107114_bb0155","first-page":"703","article-title":"Alzheimer\u2019s disease in down syndrome: an overlooked population for prevention trials","volume":"4","author":"Strydom","year":"2018","journal-title":"Alzheimer\u2019s & Dementia: Translational Research & Clinical Interventions."},{"issue":"12","key":"10.1016\/j.nbd.2025.107114_bb0160","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of a\u03b2-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2025.107114_bb0165","author":"U.S. Food and Drug Administration"},{"key":"10.1016\/j.nbd.2025.107114_bb0170","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-030-77375-5_2","article-title":"Astrocytes: the housekeepers and guardians of the CNS","volume":"26","author":"Verkhratsky","year":"2021","journal-title":"Adv Neurobiol."},{"issue":"8","key":"10.1016\/j.nbd.2025.107114_bb0175","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.25573","article-title":"Longitudinal clinical and cognitive changes along the Alzheimer disease continuum in down syndrome","volume":"5","author":"Videla","year":"2022","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.nbd.2025.107114_bb0180","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1186\/1742-2094-10-84","article-title":"Down\u2019s syndrome, neuroinflammation, and Alzheimer neuropathogenesis","volume":"10","author":"Wilcock","year":"2013","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.nbd.2025.107114_bb0185","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.neuroscience.2009.01.023","article-title":"Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer\u2019s disease","volume":"159","author":"Wilcock","year":"2009","journal-title":"Neuroscience"},{"issue":"9","key":"10.1016\/j.nbd.2025.107114_bb0190","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrn3983","article-title":"A genetic cause of Alzheimer disease: mechanistic insights from down syndrome","volume":"16","author":"Wiseman","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2025.107114_bb0195","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1001\/jamaneurol.2016.4370","article-title":"Association of Perivascular Localization of Aquaporin-4 with cognition and Alzheimer disease in aging brains","volume":"74","author":"Zeppenfeld","year":"2017","journal-title":"JAMA Neurol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125003316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125003316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:05:33Z","timestamp":1780373133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125003316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":39,"alternative-id":["S0969996125003316"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107114","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regional differences in astrocytic Aquaporin-4 protein levels and distribution in aging and Alzheimer's disease in down syndrome","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107114","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107114"}}