{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:09:22Z","timestamp":1790482162397,"version":"4.1.0"},"reference-count":200,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["LCYSSQ20220823091405012"],"award-info":[{"award-number":["LCYSSQ20220823091405012"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752130"],"award-info":[{"award-number":["2024M752130"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M773565"],"award-info":[{"award-number":["2025M773565"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009330","name":"Medical Science and Technology Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["A2023283"],"award-info":[{"award-number":["A2023283"]}],"id":[{"id":"10.13039\/501100009330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304464"],"award-info":[{"award-number":["82304464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["JCYJ20240813093859010"],"award-info":[{"award-number":["JCYJ20240813093859010"]}],"id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.nbd.2025.107122","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:05:28Z","timestamp":1758773128000},"page":"107122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["\u03b17 nicotinic acetylcholine receptor and depression: Mechanistic insights and therapeutic prospects"],"prefix":"10.1016","volume":"216","author":[{"given":"Canmao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianrong","family":"Xun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2025.107122_bb0005","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/jps.10256","article-title":"Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells","volume":"91","author":"Abbruscato","year":"2002","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.nbd.2025.107122_bb0010","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00213-014-3745-5","article-title":"Behavioral effects of nicotinic antagonist mecamylamine in a rat model of depression: prefrontal cortex level of BDNF protein and monoaminergic neurotransmitters","volume":"232","author":"Aboul-Fotouh","year":"2015","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nbd.2025.107122_bb0015","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.pnpbp.2018.05.018","article-title":"Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice","volume":"86","author":"Alzarea","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107122_bb0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbr.2019.03.019","article-title":"Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice","volume":"366","author":"Alzarea","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0025","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2174\/0118715273311527240916050749","article-title":"The Alpha-7 nicotinic receptor positive allosteric modulator PNU120596 attenuates lipopolysaccharide-induced depressive-like behaviors and cognitive impairment by regulating the PPAR-alpha signaling pathway in mice","volume":"24","author":"Alzarea","year":"2025","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.nbd.2025.107122_bb0030","first-page":"12","article-title":"The effect of an alpha-7 nicotinic allosteric modulator PNU120596 and NMDA receptor antagonist Memantine on depressive-like behavior induced by LPS in mice: the involvement of brain microglia","author":"Alzarea","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.nbd.2025.107122_bb0035","first-page":"14","article-title":"The alpha-7 nicotinic receptor positive allosteric modulator alleviates lipopolysaccharide induced depressive-like behavior by regulating microglial function, trophic factor, and chloride transporters in mice","author":"Alzarea","year":"2024","journal-title":"Brain Sci."},{"key":"10.1016\/j.nbd.2025.107122_bb0040","doi-asserted-by":"crossref","first-page":"1466166","DOI":"10.3389\/fnins.2025.1466166","article-title":"Abnormal response to chronic social defeat stress and fear extinction in a mouse model of Lynx2-based cholinergic dysregulation","volume":"19","author":"Anderson","year":"2025","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0045","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/FBP.0b013e32832c713e","article-title":"Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex","volume":"20","author":"Andreasen","year":"2009","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0050","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1177\/0269881108091587","article-title":"Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in the mouse forced swim and mouse tail suspension tests","volume":"23","author":"Andreasen","year":"2009","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0055","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1177\/0269881110364271","article-title":"Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test","volume":"25","author":"Andreasen","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0060","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.pbb.2011.11.004","article-title":"Combined alpha7 nicotinic acetylcholine receptor agonism and partial serotonin transporter inhibition produce antidepressant-like effects in the mouse forced swim and tail suspension tests: a comparison of SSR180711 and PNU-282987","volume":"100","author":"Andreasen","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nbd.2025.107122_bb0065","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuropharm.2013.04.060","article-title":"A combined alpha7 nicotinic acetylcholine receptor agonist and monoamine reuptake inhibitor, NS9775, represents a novel profile with potential benefits in emotional and cognitive disturbances","volume":"73","author":"Andreasen","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2025.107122_bb0070","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/13543784.2020.1764938","article-title":"Selective alpha7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia - a review","volume":"29","author":"Antonio-Tolentino","year":"2020","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.nbd.2025.107122_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175810","article-title":"Targeting alpha7-nAChR by galantamine mitigates reserpine-induced fibromyalgia-like symptoms in rats: involvement of cAMP\/PKA, PI3K\/AKT, and M1\/M2 microglia polarization","volume":"952","author":"Atta","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0080","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1080\/01616412.2021.1949684","article-title":"(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by alpha7 nicotinic acetylcholine receptor potentiation","volume":"43","author":"Bagdas","year":"2021","journal-title":"Neurol. Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0085","first-page":"133","article-title":"Association of the Nicotinic Receptor alpha7 subunit gene (CHRNA7) with schizophrenia and visual backward masking","volume":"4","author":"Bakanidze","year":"2013","journal-title":"Front. Psych."},{"key":"10.1016\/j.nbd.2025.107122_bb0090","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/j.1471-4159.2007.05085.x","article-title":"Depolarization-induced differentiation of PC12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway","volume":"104","author":"Banno","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.107122_bb0095","doi-asserted-by":"crossref","first-page":"633","DOI":"10.5604\/01.3001.0010.3844","article-title":"The alpha7-nACh nicotinic receptor and its role in memory and selected diseases of the central nervous system","volume":"71","author":"Baranowska","year":"2017","journal-title":"Postepy Hig. Med. Dosw. (Online)"},{"key":"10.1016\/j.nbd.2025.107122_bb0100","doi-asserted-by":"crossref","first-page":"6971","DOI":"10.1073\/pnas.90.15.6971","article-title":"Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor","volume":"90","author":"Bertrand","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2025.107122_bb0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/1533317514539540","article-title":"Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer\u2019s disease","volume":"30","author":"Braga","year":"2015","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"10.1016\/j.nbd.2025.107122_bb0110","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1111\/jcmm.12304","article-title":"Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischaemia","volume":"18","author":"Brea","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.nbd.2025.107122_bb0115","doi-asserted-by":"crossref","first-page":"1196786","DOI":"10.3389\/fnins.2023.1196786","article-title":"Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the alpha7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats","volume":"17","author":"Brems","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0120","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0091-3057(96)00354-1","article-title":"Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo","volume":"57","author":"Briggs","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nbd.2025.107122_bb0125","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.cell.2024.01.032","article-title":"Structural mechanisms of alpha7 nicotinic receptor allosteric modulation and activation","volume":"187","author":"Burke","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.107122_bb0130","doi-asserted-by":"crossref","first-page":"10376","DOI":"10.1021\/acs.jmedchem.9b01467","article-title":"Synthesis, pharmacological characterization, and structure-activity relationships of noncanonical selective agonists for alpha7 nAChRs","volume":"62","author":"Camacho-Hernandez","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.nbd.2025.107122_bb0135","article-title":"Activation of alpha7 nicotinic acetylcholine receptor by its selective agonist improved learning and memory of amyloid precursor protein\/Presenilin 1 (APP\/PS1) mice via the Nrf2\/HO-1 pathway","volume":"28","author":"Cao","year":"2022","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.nbd.2025.107122_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135118","article-title":"PNU282987 alleviates Abeta-induced anxiety and depressive-like behaviors through upregulation of alpha7nAChR by ERK-serotonin receptors pathway","volume":"731","author":"Chang","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2025.107122_bb0145","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1111\/cns.14207","article-title":"Anti-neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression-like behaviors via hypothalamic alpha7nAchR\/JAK2\/STAT3\/NF-kappaB pathway in rats exposed to chronic unpredictable mild stress","volume":"29","author":"Chen","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.nbd.2025.107122_bb0150","first-page":"933","article-title":"Effect of transcutaneous auricular vagus nerve stimulation on the splenic alpha7nAchR\/JAK2\/STAT3 signaling pathway in LPS-induced depressive-like behavior rats","volume":"48","author":"Chen","year":"2023","journal-title":"Zhen Ci Yan Jiu"},{"key":"10.1016\/j.nbd.2025.107122_bb0155","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1523\/JNEUROSCI.2973-13.2014","article-title":"Presynaptic alpha7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation","volume":"34","author":"Cheng","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0160","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bcp.2015.07.015","article-title":"The effect of alpha7 nicotinic receptor activation on glutamatergic transmission in the hippocampus","volume":"97","author":"Cheng","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0165","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.neuropharm.2015.04.016","article-title":"Activation of alpha7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons","volume":"95","author":"Cheng","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2025.107122_bb0170","first-page":"1","article-title":"The antidepressants and sexual dysfunction: a pharmacovigilance-pharmacodynamic study of the FDA adverse event reporting system","author":"Cheng","year":"2024","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.nbd.2025.107122_bb0175","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1007\/s00018-021-03853-3","article-title":"Tyrosine phosphorylation differentially fine-tunes ionotropic and metabotropic responses of human alpha7 nicotinic acetylcholine receptor","volume":"78","author":"Chrestia","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2025.107122_bb0180","doi-asserted-by":"crossref","first-page":"11171","DOI":"10.1021\/acs.jmedchem.6b01506","article-title":"Design and synthesis of a new series of 4-Heteroarylamino-1\u2032-azaspirooxazole-5,3\u2032-bicyclo[2.2.2]octanes as alpha7 nicotinic receptor agonists. 1. Development of pharmacophore and early structure-activity relationship","volume":"59","author":"Cook","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.nbd.2025.107122_bb0185","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3389\/fimmu.2017.00618","article-title":"Neuroimmune interactions in schizophrenia: focus on Vagus nerve stimulation and activation of the alpha-7 nicotinic acetylcholine receptor","volume":"8","author":"Corsi-Zuelli","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2025.107122_bb0190","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1189\/jlb.4RU0814-381R","article-title":"CHRFAM7A, a human-specific and partially duplicated alpha7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury","volume":"97","author":"Costantini","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.nbd.2025.107122_bb0195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.euroneuro.2021.04.020","article-title":"The effects of JNJ-39393406 a positive allosteric nicotine modulator on mood and cognition in patients with unipolar depression: a double-blind, add-on, placebo-controlled trial","volume":"51","author":"Davidson","year":"2021","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0200","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1074\/jbc.M110.180067","article-title":"Function of partially duplicated human alpha77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response","volume":"286","author":"de Lucas-Cerrillo","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2025.107122_bb0205","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1073\/pnas.85.14.5274","article-title":"Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats","volume":"85","author":"Di Chiara","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2025.107122_bb0210","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuron.2013.06.006","article-title":"Nicotine decreases ethanol-induced dopamine signaling and increases self-administration via stress hormones","volume":"79","author":"Doyon","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.107122_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26040998","article-title":"Different classes of antidepressants inhibit the rat alpha7 nicotinic acetylcholine receptor by interacting within the ion channel: a functional and structural study","volume":"26","author":"Duarte","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.nbd.2025.107122_bb0220","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bcp.2015.07.032","article-title":"Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection","volume":"97","author":"Egea","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0225","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1002\/ptr.7766","article-title":"Aqueous extract of Ceratonia siliqua L. leaves elicits antioxidant, anti-inflammatory, and AChE inhibiting effects in amyloid-beta42-induced cognitive deficit mice: role of alpha7-nAChR in modulating Jak2\/PI3K\/Akt\/GSK-3beta\/beta-catenin cascade","volume":"37","author":"El Sayed","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0230","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1021\/jm070256g","article-title":"Allosteric modulators of the alpha7 nicotinic acetylcholine receptor","volume":"51","author":"Faghih","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.nbd.2025.107122_bb0235","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1523\/JNEUROSCI.5378-07.2008","article-title":"Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7 nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons","volume":"28","author":"Fernandes","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.comppsych.2024.152488","article-title":"Non-invasive vagus nerve stimulation conditions increased invigoration and wanting in depression","volume":"132","author":"Ferstl","year":"2024","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107122_bb0245","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.1523\/JNEUROSCI.0932-17.2017","article-title":"Preferential disruption of prefrontal GABAergic function by Nanomolar concentrations of the alpha7nACh negative modulator Kynurenic acid","volume":"37","author":"Flores-Barrera","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0250","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1523\/JNEUROSCI.18-04-01187.1998","article-title":"Acetylcholine activates an alpha-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells","volume":"18","author":"Frazier","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0255","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1176\/appi.ajp.2008.07071135","article-title":"Initial phase 2 trial of a nicotinic agonist in schizophrenia","volume":"165","author":"Freedman","year":"2008","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107122_bb0260","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1046\/j.1471-4159.1999.0721117.x","article-title":"Antidepressants noncompetitively inhibit nicotinic acetylcholine receptor function","volume":"72","author":"Fryer","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.107122_bb0265","first-page":"3643","article-title":"Human neuronal threonine-for-leucine-248 alpha 7 mutant nicotinic acetylcholine receptors are highly Ca2+ permeable","volume":"97","author":"Fucile","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2025.107122_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.577912","article-title":"Cholinergic modulation of glial function during aging and chronic Neuroinflammation","volume":"14","author":"Gamage","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0275","doi-asserted-by":"crossref","first-page":"772","DOI":"10.7326\/0003-4819-155-11-201112060-00009","article-title":"Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis","volume":"155","author":"Gartlehner","year":"2011","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.nbd.2025.107122_bb0280","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2013.08.008","article-title":"Dopamine D(2) and acetylcholine alpha7 nicotinic receptors have subcellular distributions favoring mediation of convergent signaling in the mouse ventral tegmental area","volume":"252","author":"Garzon","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2025.107122_bb0285","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jad.2018.07.017","article-title":"CHRNA7 copy number gains are enriched in adolescents with major depressive and anxiety disorders","volume":"239","author":"Gillentine","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.nbd.2025.107122_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911245","article-title":"The microbiota-gut-brain Axis in psychiatric disorders","volume":"23","author":"Goralczyk-Binkowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2025.107122_bb0295","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/383713a0","article-title":"Hippocampal synaptic transmission enhanced by low concentrations of nicotine","volume":"383","author":"Gray","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2025.107122_bb0300","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbi.2020.11.024","article-title":"Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder","volume":"92","author":"Green","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2025.107122_bb0305","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuron.2011.04.026","article-title":"Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity","volume":"71","author":"Gu","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.107122_bb0310","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1046\/j.1471-4159.2000.0751997.x","article-title":"Involvement of alpha7 nicotinic acetylcholine receptors in activation of tyrosine hydroxylase and dopamine beta-hydroxylase gene expression in PC12 cells","volume":"75","author":"Gueorguiev","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.107122_bb0315","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/jnc.13049","article-title":"Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing ca(2+) release from the endoplasmic reticulum","volume":"133","author":"Guerra-Alvarez","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.107122_bb0320","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-025-05001-5","article-title":"Exploring the connection between BDNF\/TrkB and AC\/cAMP\/PKA\/CREB signaling pathways: potential for neuroprotection and therapeutic targets for neurological disorders","author":"Gupta","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2025.107122_bb0325","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1038\/npp.2016.101","article-title":"The alpha7 nicotinic agonist ABT-126 in the treatment of cognitive impairment associated with schizophrenia in nonsmokers: results from a randomized controlled phase 2b study","volume":"41","author":"Haig","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2025.107122_bb0330","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.611764","article-title":"Hypoxia augments cerebral inflammation in a dextran sulfate sodium-induced colitis mouse model","volume":"14","author":"Han","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0335","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.arcmed.2004.11.010","article-title":"Effects of long-term administration of nicotine and fluoxetine on sleep in depressed patients","volume":"35","author":"Haro","year":"2004","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0340","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbrc.2018.04.077","article-title":"Alpha7 nicotinic acetylcholine receptor activation protects against myocardial reperfusion injury through modulation of autophagy","volume":"500","author":"Hou","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2025.107122_bb0345","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1159\/000521010","article-title":"Expression of the alpha7 nAChR subunit duplicate form (CHRFAM7A) was down-regulated in patients with intracranial infection and reduced inflammation in in vitro model by p38 MAPK","volume":"29","author":"Hu","year":"2022","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.nbd.2025.107122_bb0350","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3109\/00207454.2012.657377","article-title":"Neuroprotection by nicotine against colchicine-induced apoptosis is mediated by PI3-kinase\u2014Akt pathways","volume":"122","author":"Huang","year":"2012","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0355","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12929-017-0355-7","article-title":"Drug candidates in clinical trials for Alzheimer\u2019s disease","volume":"24","author":"Hung","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.nbd.2025.107122_bb0360","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/s41380-023-02389-1","article-title":"Translational implications of CHRFAM7A, an elusive human-restricted fusion gene","volume":"29","author":"Ihnatovych","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107122_bb0365","author":"Institute of Health Metrics and Evaluation"},{"key":"10.1016\/j.nbd.2025.107122_bb0370","doi-asserted-by":"crossref","first-page":"22157","DOI":"10.1038\/s41598-020-79189-y","article-title":"The neuroprotective effects of activated alpha7 nicotinic acetylcholine receptor against mutant copper-zinc superoxide dismutase 1-mediated toxicity","volume":"10","author":"Ito","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2025.107122_bb0375","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuropharm.2017.03.005","article-title":"In vivo interactions between alpha7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-alpha: implication for nicotine dependence","volume":"118","author":"Jackson","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2025.107122_bb0380","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0140-6736(72)93021-8","article-title":"A cholinergic-adrenergic hypothesis of mania and depression","volume":"2","author":"Janowsky","year":"1972","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2025.107122_bb0385","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00006842-197405000-00008","article-title":"Acetylcholine and depression","volume":"36","author":"Janowsky","year":"1974","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.nbd.2025.107122_bb0390","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0896-6273(01)00332-4","article-title":"Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity","volume":"31","author":"Ji","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.107122_bb0395","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13041-021-00817-3","article-title":"Disrupting the alpha7nAChR-NR2A protein complex exerts antidepressant-like effects","volume":"14","author":"Jiang","year":"2021","journal-title":"Mol. Brain"},{"key":"10.1016\/j.nbd.2025.107122_bb0400","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/WNR.0b013e32832b7324","article-title":"Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell culture","volume":"20","author":"Johansson","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2025.107122_bb0405","doi-asserted-by":"crossref","first-page":"11244","DOI":"10.1523\/JNEUROSCI.3009-04.2004","article-title":"Precise localization of alpha7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental area","volume":"24","author":"Jones","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0410","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.3390\/ijerph18052470","article-title":"Impact of COVID-19 on mental health in adolescents: a systematic review","volume":"18","author":"Jones","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.nbd.2025.107122_bb0415","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1007\/s00018-016-2175-4","article-title":"Modulatory effects of alpha7 nAChRs on the immune system and its relevance for CNS disorders","volume":"73","author":"Kalkman","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.nbd.2025.107122_bb0420","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1007\/s00213-022-06250-1","article-title":"Rapid antidepressant-like effects of muscarinic receptor antagonists require BDNF-dependent signaling in the ventrolateral periaqueductal gray","volume":"239","author":"Kan","year":"2022","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nbd.2025.107122_bb0425","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/s41386-020-0628-9","article-title":"Double blind, two dose, randomized, placebo-controlled, cross-over clinical trial of the positive allosteric modulator at the alpha7 nicotinic cholinergic receptor AVL-3288 in schizophrenia patients","volume":"45","author":"Kantrowitz","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2025.107122_bb0430","doi-asserted-by":"crossref","first-page":"7903","DOI":"10.1523\/JNEUROSCI.22-18-07903.2002","article-title":"Nicotinic alpha 7 receptor clusters on hippocampal GABAergic neurons: regulation by synaptic activity and neurotrophins","volume":"22","author":"Kawai","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0435","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neulet.2018.11.022","article-title":"Activation of the alpha7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells","volume":"694","author":"Kimura","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2025.107122_bb0440","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/jnc.13660","article-title":"Alpha 7 nicotinic receptor coupling to heterotrimeric G proteins modulates RhoA activation, cytoskeletal motility, and structural growth","volume":"138","author":"King","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.107122_bb0445","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejphar.2011.09.167","article-title":"Differential effects of subtype-specific nicotinic acetylcholine receptor agonists on early and late hippocampal LTP","volume":"671","author":"Kroker","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0450","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1176\/appi.ajp.2015.14080978","article-title":"CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders","volume":"172","author":"Kunii","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107122_bb0455","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0165-0327(00)00292-5","article-title":"Association study of nicotinic-receptor variants and major depressive disorder","volume":"66","author":"Lai","year":"2001","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.nbd.2025.107122_bb0460","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/hipo.20271","article-title":"Presynaptic calcium stores contribute to nicotine-elicited potentiation of evoked synaptic transmission at CA3-CA1 connections in the neonatal rat hippocampus","volume":"17","author":"Le Magueresse","year":"2007","journal-title":"Hippocampus"},{"key":"10.1016\/j.nbd.2025.107122_bb0465","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ana.23815","article-title":"Adoptive regulatory T-cell therapy protects against cerebral ischemia","volume":"74","author":"Li","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2025.107122_bb0470","article-title":"Nicotine improves working memory via augmenting BDNF levels through alpha7 nAChR: evidence from clinical and pre-clinical studies","author":"Li","year":"2025","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0475","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0079-6468(07)00003-3","article-title":"Alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators","volume":"46","author":"Lightfoot","year":"2008","journal-title":"Prog. Med. Chem."},{"key":"10.1016\/j.nbd.2025.107122_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2022.116811","article-title":"Discovery of diarylheptanoids that activate alpha7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo","volume":"66","author":"Lin","year":"2022","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.nbd.2025.107122_bb0485","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1471-2202-13-155","article-title":"Functional alpha7beta2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid beta peptides","volume":"13","author":"Liu","year":"2012","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0490","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12974-020-01732-5","article-title":"Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression","volume":"17","author":"Liu","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2025.107122_bb0495","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12974-023-02768-z","article-title":"alpha7 nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect","volume":"20","author":"Liu","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2025.107122_bb0500","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jad.2024.03.005","article-title":"Transcutaneous auricular vagus nerve stimulation for post-stroke depression: a double-blind, randomized, placebo-controlled trial","volume":"354","author":"Liu","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.nbd.2025.107122_bb0505","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12964-025-02149-4","article-title":"An examination of the LPS-TLR4 immune response through the analysis of molecular structures and protein-protein interactions","volume":"23","author":"Luo","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.nbd.2025.107122_bb0510","doi-asserted-by":"crossref","DOI":"10.1111\/bcpt.70061","article-title":"Therapeutic targeting of the alpha7 nicotinic receptor: challenges and prospects for cognitive improvement in Alzheimer\u2019s and schizophrenia","volume":"137","author":"Magnussen","year":"2025","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.nbd.2025.107122_bb0515","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28031270","article-title":"Recent advances in the discovery of nicotinic acetylcholine receptor allosteric modulators","volume":"28","author":"Manetti","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.nbd.2025.107122_bb0520","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.euroneuro.2016.07.004","article-title":"Alpha7 nicotinic acetylcholine receptor agonists and PAMs as adjunctive treatment in schizophrenia. An experimental study","volume":"26","author":"Marcus","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0525","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2008.11.053","article-title":"Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaB","volume":"1256","author":"Marrero","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0530","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1124\/jpet.103.061655","article-title":"The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase","volume":"309","author":"Marrero","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2025.107122_bb0535","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.mcn.2006.08.011","article-title":"BDNF up-regulates alpha7 nicotinic acetylcholine receptor levels on subpopulations of hippocampal interneurons","volume":"33","author":"Massey","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0540","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00213-006-0516-y","article-title":"Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial","volume":"189","author":"McClernon","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nbd.2025.107122_bb0545","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/npp.2015.316","article-title":"Multiple nicotinic acetylcholine receptor subtypes in the mouse amygdala regulate affective behaviors and response to social stress","volume":"41","author":"Mineur","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2025.107122_bb0550","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1111\/bph.13769","article-title":"Hippocampal alpha7 nicotinic ACh receptors contribute to modulation of depression-like behaviour in C57BL\/6J mice","volume":"175","author":"Mineur","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0555","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26206139","article-title":"Neuroinflammation modulation via alpha7 nicotinic acetylcholine receptor and its chaperone, RIC-3","volume":"26","author":"Mizrachi","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.nbd.2025.107122_bb0560","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1124\/mol.114.093377","article-title":"The novel alpha7beta2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization","volume":"86","author":"Moretti","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0565","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1007\/s12035-020-02077-z","article-title":"Nicotine rescues depressive-like behaviors via alpha7-type nicotinic acetylcholine receptor activation in CaMKIV null mice","volume":"57","author":"Moriguchi","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2025.107122_bb0570","doi-asserted-by":"crossref","first-page":"183","DOI":"10.26502\/acbr.50170450","article-title":"Impact of antidepressants on weight gain: underlying mechanisms and mitigation strategies","volume":"9","author":"Mouawad","year":"2025","journal-title":"Arch. Clin. Biomed. Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104751","article-title":"Stimulation of toll-like receptor 4 downregulates the expression of alpha7 nicotinic acetylcholine receptors via histone deacetylase in rodent microglia","volume":"138","author":"Nakamura","year":"2020","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.nbd.2025.107122_bb0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110139","article-title":"Depression: biological markers and treatment","volume":"105","author":"Nedic Erjavec","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107122_bb0585","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.euroneuro.2019.09.009","article-title":"alpha7 nicotinic receptor full agonist reverse basolateral amygdala hyperactivity and attenuation of dopaminergic neuron activity in rats exposed to chronic mild stress","volume":"29","author":"Neves","year":"2019","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0590","doi-asserted-by":"crossref","first-page":"8059","DOI":"10.1073\/pnas.0701321104","article-title":"Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators","volume":"104","author":"Ng","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2025.107122_bb0595","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1096\/fj.14-251439","article-title":"Microtubule dynamics at the growth cone are mediated by alpha7 nicotinic receptor activation of a Galphaq and IP3 receptor pathway","volume":"28","author":"Nordman","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.nbd.2025.107122_bb0600","article-title":"BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents","volume":"246","author":"O\u2019Connor","year":"2024","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2025.107122_bb0605","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1471-4159.2007.04827.x","article-title":"bFGF promotes photoreceptor cell survival in vitro by PKA-mediated inactivation of glycogen synthase kinase 3beta and CREB-dependent Bcl-2 up-regulation","volume":"103","author":"O\u2019Driscoll","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.107122_bb0610","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00787-021-01856-w","article-title":"The impact of COVID-19 lockdown on child and adolescent mental health: systematic review","volume":"32","author":"Panchal","year":"2023","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107122_bb0615","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbi.2018.09.024","article-title":"Innate immunity in the postmortem brain of depressed and suicide subjects: role of toll-like receptors","volume":"75","author":"Pandey","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2025.107122_bb0620","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuropharm.2013.01.004","article-title":"Activation of the alpha7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT(1)a receptor antagonist","volume":"70","author":"Pandya","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nbd.2025.107122_bb0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2025.116387","article-title":"A phase 2, placebo-controlled study to evaluate the efficacy and safety of BNC210, an alpha-7 nicotinic receptor negative allosteric modulator, for acute, as-needed treatment of social anxiety disorder (SAD) - the PREVAIL study","volume":"346","author":"Papapetropoulos","year":"2025","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0630","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2400380","article-title":"BNC210, an alpha7 nicotinic receptor modulator, in post-traumatic stress disorder","volume":"4","author":"Papapetropoulos","year":"2025","journal-title":"NEJM Evid."},{"key":"10.1016\/j.nbd.2025.107122_bb0635","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1124\/jpet.108.150151","article-title":"Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine","volume":"329","author":"Papke","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2025.107122_bb0640","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1089\/ars.2012.4671","article-title":"The microglial alpha7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2","volume":"19","author":"Parada","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.nbd.2025.107122_bb0645","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.4049\/jimmunol.159.11.5450","article-title":"Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription","volume":"159","author":"Parry","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2025.107122_bb0650","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1111\/ejn.15913","article-title":"alpha7 nicotinic acetylcholine receptor in memory processing","volume":"59","author":"Pastor","year":"2024","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0655","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.biopsych.2008.08.028","article-title":"Varenicline improves mood and cognition during smoking abstinence","volume":"65","author":"Patterson","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107122_bb0660","doi-asserted-by":"crossref","first-page":"1388998","DOI":"10.3389\/fimmu.2024.1388998","article-title":"Neuronal nicotinic acetylcholine receptor antibodies in autoimmune central nervous system disorders","volume":"15","author":"Pechlivanidou","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2025.107122_bb0665","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1523\/JNEUROSCI.19-14-05861.1999","article-title":"Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons","volume":"19","author":"Perkinton","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0670","doi-asserted-by":"crossref","first-page":"193","DOI":"10.30773\/pi.2019.0289","article-title":"Personalized psychiatry and depression: the role of sociodemographic and clinical variables","volume":"17","author":"Perna","year":"2020","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.nbd.2025.107122_bb0675","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.4088\/JCP.08m04441","article-title":"Varenicline augmentation in depressed smokers: an 8-week, open-label study","volume":"70","author":"Philip","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107122_bb0680","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/sj.npp.1301188","article-title":"SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia","volume":"32","author":"Pichat","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nbd.2025.107122_bb0685","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1152\/jn.01030.2012","article-title":"alpha7-containing nicotinic acetylcholine receptors on interneurons of the basolateral amygdala and their role in the regulation of the network excitability","volume":"110","author":"Pidoplichko","year":"2013","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2025.107122_bb0690","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064828","article-title":"Gating of long-term potentiation by nicotinic acetylcholine receptors at the cerebellum input stage","volume":"8","author":"Prestori","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.nbd.2025.107122_bb0695","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbi.2020.12.032","article-title":"A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes","volume":"94","author":"Pu","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2025.107122_bb0700","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/neu.10109","article-title":"Desensitization of neuronal nicotinic receptors","volume":"53","author":"Quick","year":"2002","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.nbd.2025.107122_bb0705","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00213-006-0568-z","article-title":"The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice","volume":"189","author":"Rabenstein","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nbd.2025.107122_bb0710","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1523\/JNEUROSCI.14-11-06935.1994","article-title":"Synaptic-type acetylcholine receptors raise intracellular calcium levels in neurons by two mechanisms","volume":"14","author":"Rathouz","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0715","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0165-1781(81)90012-3","article-title":"Physostigmine induction of depressive symptomatology in normal human subjects","volume":"4","author":"Risch","year":"1981","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0720","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/pcn.13286","article-title":"Inflamed brain: targeting immune changes and inflammation for treatment of depression","volume":"75","author":"Sakamoto","year":"2021","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0725","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043833","article-title":"Cognitive and emotional symptoms induced by chronic stress are regulated by EGR1 in a subpopulation of hippocampal pyramidal neurons","volume":"24","author":"Sancho-Balsells","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2025.107122_bb0730","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106759","article-title":"Potentiation and allosteric agonist activation of alpha7 nicotinic acetylcholine receptors: binding sites and hypotheses","volume":"191","author":"Sanders","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0735","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1528-1157.1998.tb01151.x","article-title":"Vagus nerve stimulation","volume":"39","author":"Schachter","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2025.107122_bb0740","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.toxlet.2017.11.025","article-title":"Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human alpha7-nicotinic acetylcholine receptor activity-an in vitro structure-activity analysis","volume":"293","author":"Scheffel","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.nbd.2025.107122_bb0745","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1523\/JNEUROSCI.13-02-00596.1993","article-title":"Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium","volume":"13","author":"Seguela","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0750","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.lpm.2019.10.019","article-title":"Vagus nerve stimulation and depression","volume":"48","author":"Senova","year":"2019","journal-title":"Presse Med."},{"key":"10.1016\/j.nbd.2025.107122_bb0755","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0091-3057(01)00715-8","article-title":"Nicotinic\u2014serotonergic interactions in brain and behaviour","volume":"71","author":"Seth","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nbd.2025.107122_bb0760","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3389\/fimmu.2017.00553","article-title":"Autophagy plays an important role in anti-inflammatory mechanisms stimulated by Alpha7 nicotinic acetylcholine receptor","volume":"8","author":"Shao","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2025.107122_bb0765","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1523\/JNEUROSCI.5407-07.2008","article-title":"Action potential-independent and nicotinic receptor-mediated concerted release of multiple quanta at hippocampal CA3-mossy fiber synapses","volume":"28","author":"Sharma","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0770","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/aps.2009.64","article-title":"Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system","volume":"30","author":"Shen","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.nbd.2025.107122_bb0775","doi-asserted-by":"crossref","first-page":"L418","DOI":"10.1152\/ajplung.2001.281.2.L418","article-title":"Interactions between CBP, NF-kappaB, and CREB in the lungs after hemorrhage and endotoxemia","volume":"281","author":"Shenkar","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.nbd.2025.107122_bb0780","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3233\/JAD-150963","article-title":"Gx-50 inhibits neuroinflammation via alpha7 nAChR activation of the JAK2\/STAT3 and PI3K\/AKT pathways","volume":"50","author":"Shi","year":"2016","journal-title":"J Alzheimer\u2019s Dis"},{"key":"10.1016\/j.nbd.2025.107122_bb0785","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2020.101943","article-title":"The gut microbiota in anxiety and depression - a systematic review","volume":"83","author":"Simpson","year":"2021","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.nbd.2025.107122_bb0790","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1523\/JNEUROSCI.0027-07.2007","article-title":"Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse","volume":"27","author":"Solinas","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0795","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/s41398-023-02506-2","article-title":"Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase a in vivo","volume":"13","author":"Spies","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107122_bb0800","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.schres.2008.12.017","article-title":"Association of the 5\u2032-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia","volume":"109","author":"Stephens","year":"2009","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0805","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/jnr.20850","article-title":"Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C\/IP3 pathway and modulate the cell activation toward a neuroprotective role","volume":"83","author":"Suzuki","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0810","first-page":"20","article-title":"Inflammation regulation via an agonist and antagonists of alpha7 nicotinic acetylcholine receptors in RAW264.7 macrophages","author":"Tan","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.nbd.2025.107122_bb0815","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neulet.2014.03.067","article-title":"Antidepressant activity in mice elicited by 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor","volume":"569","author":"Targowska-Duda","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2025.107122_bb0820","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1177\/0269881118821100","article-title":"3-Furan-2-yl-N-p-tolyl-acrylamide, a highly selective positive allosteric modulator of alpha7 nicotinic receptors, produces anxiolytic-like activity in mice","volume":"33","author":"Targowska-Duda","year":"2019","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0825","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.euroneuro.2021.06.006","volume":"52","author":"Targowska-Duda","year":"2021","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0830","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106764","article-title":"Nicotinic acetylcholine receptors in neurological and psychiatric diseases","volume":"191","author":"Terry","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0835","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1399-5618.2011.00961.x","article-title":"Hippocampal alpha7 nicotinic acetylcholine receptor levels in patients with schizophrenia, bipolar disorder, or major depressive disorder","volume":"13","author":"Thomsen","year":"2011","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.nbd.2025.107122_bb0840","first-page":"37","article-title":"alpha7 nicotinic receptor agonists: potential therapeutic drugs for treatment of cognitive impairments in schizophrenia and Alzheimer\u2019s disease","volume":"4","author":"Toyohara","year":"2010","journal-title":"Open Med. Chem. J."},{"key":"10.1016\/j.nbd.2025.107122_bb0845","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/mds.26569","article-title":"A placebo-controlled trial of AQW051 in patients with moderate to severe levodopa-induced dyskinesia","volume":"31","author":"Trenkwalder","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107122_bb0850","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/ejn.14720","article-title":"Neuroinflammation and depression: a review","volume":"53","author":"Troubat","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0855","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032951","article-title":"Somatic integration of single ion channel responses of alpha7 nicotinic acetylcholine receptors enhanced by PNU-120596","volume":"7","author":"Uteshev","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.nbd.2025.107122_bb0860","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/1871524919666190320102834","article-title":"Aging affects nicotinic acetylcholine receptors in brain","volume":"19","author":"Utkin","year":"2019","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.nbd.2025.107122_bb0865","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-3940(99)00473-5","article-title":"Changes with aging and ischemia in nicotinic acetylcholine receptor subunit alpha7 mRNA expression in postmortem human frontal cortex and putamen","volume":"270","author":"Utsugisawa","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2025.107122_bb0870","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jad.2019.05.047","article-title":"The involvement of sleep in the relationship between the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and depression: a systematic review","volume":"256","author":"van Dalfsen","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.nbd.2025.107122_bb0875","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112190","article-title":"Peri-adolescent alcohol consumption increases sensitivity and dopaminergic response to nicotine during adulthood in female alcohol-preferring (P) rats: alterations to alpha7 nicotinic acetylcholine receptor expression","volume":"376","author":"Waeiss","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nbd.2025.107122_bb0880","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/schbul\/sbv072","article-title":"Phase 2 trial of an Alpha-7 nicotinic receptor agonist (TC-5619) in negative and cognitive symptoms of schizophrenia","volume":"42","author":"Walling","year":"2016","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.nbd.2025.107122_bb0885","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1111\/bph.13745","article-title":"Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors","volume":"175","author":"Wang","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.nbd.2025.107122_bb0890","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1124\/jpet.110.169961","article-title":"Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro","volume":"335","author":"Wang","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2025.107122_bb0895","doi-asserted-by":"crossref","first-page":"543","DOI":"10.18632\/aging.102640","article-title":"Activation of alpha7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.nbd.2025.107122_bb0900","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s12974-021-02341-6","article-title":"Mechanisms underlying antidepressant effect of transcutaneous auricular vagus nerve stimulation on CUMS model rats based on hippocampal alpha7nAchR\/NF-kappaB signal pathway","volume":"18","author":"Wang","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2025.107122_bb0905","doi-asserted-by":"crossref","first-page":"1167170","DOI":"10.3389\/fnagi.2023.1167170","article-title":"Involvement of baroreflex deficiency in the age-related loss of estrogen efficacy against cerebral ischemia","volume":"15","author":"Wang","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0910","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1007\/s12035-024-04438-4","article-title":"Transcutaneous auricular Vagus stimulation attenuates LPS-induced depression-like behavior by regulating central alpha7nAChR\/JAK2 signaling","volume":"62","author":"Wang","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2025.107122_bb0915","doi-asserted-by":"crossref","first-page":"27231","DOI":"10.1038\/srep27231","article-title":"CHRNA7 polymorphisms and dementia risk: interactions with apolipoprotein epsilon4 and cigarette smoking","volume":"6","author":"Weng","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2025.107122_bb0920","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/bja\/aen387","article-title":"Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane","volume":"102","author":"Westphalen","year":"2009","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.nbd.2025.107122_bb0925","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1124\/jpet.114.216804","article-title":"M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine","volume":"351","author":"Witkin","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2025.107122_bb0930","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1124\/jpet.104.070417","article-title":"Electrophysiological, pharmacological, and molecular evidence for alpha7-nicotinic acetylcholine receptors in rat midbrain dopamine neurons","volume":"311","author":"Wu","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2025.107122_bb0935","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuroscience.2023.08.026","article-title":"Vagus nerve stimulation relives irritable bowel syndrome and the associated depression via alpha7nAChR-mediated anti-inflammatory pathway","volume":"530","author":"Yan","year":"2023","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2025.107122_bb0940","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.apsb.2017.09.001","article-title":"The current agonists and positive allosteric modulators of alpha7 nAChR for CNS indications in clinical trials","volume":"7","author":"Yang","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.nbd.2025.107122_bb0945","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbrc.2022.01.034","article-title":"Atorvastatin ameliorates depressive behaviors via regulation of alpha7nAChR expression by PI3K\/Akt-BDNF pathway in mice","volume":"593","author":"Yang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2025.107122_bb0950","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2022.110652","article-title":"A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depression-like phenotypes in Chrna7 knock-out mice","volume":"120","author":"Yang","year":"2023","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107122_bb0955","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jad.2024.06.091","article-title":"Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis","volume":"362","author":"Yang","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.nbd.2025.107122_bb0960","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/STROKEAHA.124.048697","article-title":"Intermittent Theta burst stimulation over cerebellum facilitates neurological recovery in poststroke depression via the cAMP\/PKA\/CREB pathway","volume":"56","author":"Yang","year":"2025","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2025.107122_bb0965","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0361-9230(00)00237-9","article-title":"A comparison of the effects of nicotine on dopamine and non-dopamine neurons in the rat ventral tegmental area: an in vitro electrophysiological study","volume":"51","author":"Yin","year":"2000","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.nbd.2025.107122_bb0970","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1471-4159.2011.07466.x","article-title":"alpha7 nicotinic receptor activation reduces beta-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling","volume":"119","author":"Yu","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2025.107122_bb0975","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1002\/mds.26453","article-title":"alpha7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage","volume":"30","author":"Zhang","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107122_bb0980","doi-asserted-by":"crossref","first-page":"36705","DOI":"10.1038\/srep36705","article-title":"Depression-like phenotype by deletion of alpha7 nicotinic acetylcholine receptor: role of BDNF-TrkB in nucleus accumbens","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2025.107122_bb0985","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12974-017-1007-2","article-title":"Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress","volume":"14","author":"Zhao","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2025.107122_bb0990","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1021\/acschemneuro.9b00669","article-title":"Low-dose ketamine improves LPS-induced depression-like behavior in rats by activating cholinergic anti-inflammatory pathways","volume":"11","author":"Zhao","year":"2020","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.nbd.2025.107122_bb0995","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1523\/JNEUROSCI.0055-04.2004","article-title":"Brain-derived neurotrophic factor and trkB signaling in parasympathetic neurons: relevance to regulating alpha7-containing nicotinic receptors and synaptic function","volume":"24","author":"Zhou","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107122_bb1000","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1111\/bph.15412","article-title":"Anti-inflammatory effects of alpha7-nicotinic ACh receptors are exerted through interactions with adenylyl cyclase-6","volume":"178","author":"Zhu","year":"2021","journal-title":"Br. J. Pharmacol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125003390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125003390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:02:46Z","timestamp":1778792566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125003390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":200,"alternative-id":["S0969996125003390"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107122","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b17 nicotinic acetylcholine receptor and depression: Mechanistic insights and therapeutic prospects","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107122"}}