{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:20:41Z","timestamp":1778577641841,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JPJS00420240019"],"award-info":[{"award-number":["JPJS00420240019"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.nbd.2025.107151","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:02:05Z","timestamp":1761116525000},"page":"107151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Elevated TFEB expression with limited activation in peripheral blood mononuclear cells reflects altered lysosomal enzyme dynamics in Parkinson's disease"],"prefix":"10.1016","volume":"217","author":[{"given":"Yasuaki","family":"Mizutani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Nawashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souta","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Ohdake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayuri","family":"Shima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Mutoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohisa","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2025.107151_bb0005","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1056\/NEJMoa033277","article-title":"Mutations in the glucocerebrosidase gene and Parkinson\u2019s disease in Ashkenazi Jews","volume":"351","author":"Aharon-Peretz","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nbd.2025.107151_bb0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jocn.2019.07.069","article-title":"Deterioration of postural deformity in Parkinson\u2019s disease patients with punding and hobbyism","volume":"69","author":"Aoki","year":"2019","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.nbd.2025.107151_bb0015","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/mds.28496","article-title":"Profiling the biochemical signature of GBA-related Parkinson\u2019s disease in peripheral blood mononuclear cells","volume":"36","author":"Avenali","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107151_bb0020","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/jnc.14564","article-title":"Lysosome biogenesis in health and disease","volume":"148","author":"Bajaj","year":"2019","journal-title":"J. Neurochem"},{"key":"10.1016\/j.nbd.2025.107151_bb0025","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2025.107151_bb0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuroscience.2014.01.001","article-title":"Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer\u2019s disease-linked presenilin 1 A246E mutation can be reversed with cAMP","volume":"263","author":"Coffey","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2025.107151_bb0035","doi-asserted-by":"crossref","first-page":"E1817","DOI":"10.1073\/pnas.1305623110","article-title":"TFEB-mediated autophagy rescues midbrain dopamine neurons from \u03b1-synuclein toxicity","volume":"110","author":"Decressac","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2025.107151_bb0040","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000336909","article-title":"A validation study of the Japanese version of the Addenbrooke\u2019s cognitive examination-revised","volume":"2","author":"Dos Santos Kawata","year":"2012","journal-title":"Dement. Geriatr. Cogn. Dis. Extra"},{"key":"10.1016\/j.nbd.2025.107151_bb0045","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","article-title":"The FAB: a frontal assessment battery at bedside","volume":"55","author":"Dubois","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2025.107151_bb0050","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results: MDS-UPDRS: Clinimetric Assessment","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107151_bb0055","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1111\/febs.14731","article-title":"The structure of mammalian \u03b2-mannosidase provides insight into \u03b2-mannosidosis and nystagmus","volume":"286","author":"Gytz","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.nbd.2025.107151_bb0060","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00401-021-02268-5","article-title":"Periphery and brain, innate and adaptive immunity in Parkinson\u2019s disease","volume":"141","author":"Harms","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2025.107151_bb0065","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.jmb.2020.01.037","article-title":"Autophagy in Parkinson\u2019s disease","volume":"432","author":"Hou","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.nbd.2025.107151_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0247443","article-title":"Associations between probable REM sleep behavior disorder, olfactory disturbance, and clinical symptoms in Parkinson\u2019s disease: a multicenter cross-sectional study","volume":"16","author":"Iijima","year":"2021","journal-title":"PloS One"},{"key":"10.1016\/j.nbd.2025.107151_bb0075","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/mds.29410","article-title":"Levodopa dose equivalency in Parkinson\u2019s disease: updated systematic review and proposals","volume":"38","author":"Jost","year":"2023","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107151_bb0080","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.parkreldis.2014.02.011","article-title":"Daytime sleep in Parkinson\u2019s disease measured by episodes of immobility","volume":"20","author":"Kotschet","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2025.107151_bb0085","doi-asserted-by":"crossref","first-page":"1014950","DOI":"10.1155\/2022\/1014950","article-title":"Prevalence of Fabry disease among patients with Parkinson\u2019s disease","volume":"2022","author":"Lackova","year":"2022","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.nbd.2025.107151_bb0090","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.3390\/ijms20184349","article-title":"Inhibition of mitochondrial complex I impairs release of \u03b1-galactosidase by jurkat cells","volume":"20","author":"Lambert","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2025.107151_bb0095","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2741\/4807","article-title":"Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells","volume":"25","author":"Li","year":"2020","journal-title":"Front. Biosci."},{"key":"10.1016\/j.nbd.2025.107151_bb0100","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1038\/s41467-018-04849-7","article-title":"A TFEB nuclear export signal integrates amino acid supply and glucose availability","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2025.107151_bb0105","doi-asserted-by":"crossref","first-page":"4693703","DOI":"10.1155\/2016\/4693703","article-title":"The C-ETS2-TFEB axis promotes neuron survival under oxidative stress by regulating lysosome activity","volume":"2016","author":"Ma","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.nbd.2025.107151_bb0110","series-title":"Springer Texts in Statistics","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/978-1-4612-3794-5_5","article-title":"Identification of outliers","author":"Madansky","year":"1988"},{"key":"10.1016\/j.nbd.2025.107151_bb0115","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bbrc.2013.09.060","article-title":"TFEB activation promotes the recruitment of lysosomal glycohydrolases \u03b2-hexosaminidase and \u03b2-galactosidase to the plasma membrane","volume":"440","author":"Magini","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2025.107151_bb0120","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4161\/auto.19653","article-title":"MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB","volume":"8","author":"Martina","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.nbd.2025.107151_bb0125","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/ageing\/28.1.35","article-title":"Use of the GDS-15 geriatric depression scale as a screening instrument for depressive symptomatology in patients with Parkinson\u2019s disease and their carers in the community","volume":"28","author":"Meara","year":"1999","journal-title":"Age Ageing"},{"key":"10.1016\/j.nbd.2025.107151_bb0130","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.devcel.2011.07.016","article-title":"Transcriptional activation of lysosomal exocytosis promotes cellular clearance","volume":"21","author":"Medina","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.nbd.2025.107151_bb0135","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ncb3114","article-title":"Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB","volume":"17","author":"Medina","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.nbd.2025.107151_bb0140","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/gps.1610","article-title":"The Addenbrooke\u2019s cognitive examination revised (ACE-R): a brief cognitive test battery for dementia screening","volume":"21","author":"Mioshi","year":"2006","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107151_bb0145","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1002\/acn3.51856","article-title":"Enzymatic properties and clinical associations of serum alpha-galactosidase a in Parkinson\u2019s disease","volume":"10","author":"Mizutani","year":"2023","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.nbd.2025.107151_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081806","article-title":"A comparison of lysosomal enzymes expression levels in peripheral blood of mild- and severe-Alzheimer\u2019s disease and MCI patients: implications for regenerative medicine approaches","volume":"18","author":"Morena","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2025.107151_bb0155","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1242\/jcs.146365","article-title":"TFEB at a glance","volume":"129","author":"Napolitano","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.nbd.2025.107151_bb0160","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment: Moca: a brief screening tool for MCI","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.nbd.2025.107151_bb0165","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1474-4422(19)30024-9","article-title":"CSF and blood biomarkers for Parkinson\u2019s disease","volume":"18","author":"Parnetti","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2025.107151_bb0170","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease: MDS-PD clinical diagnostic criteria","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107151_bb0175","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nn.4475","article-title":"The role of peripheral immune cells in the CNS in steady state and disease","volume":"20","author":"Prinz","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2025.107151_bb0180","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1080\/15548627.2018.1535292","article-title":"Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration","volume":"15","author":"Rusmini","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.nbd.2025.107151_bb0185","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.nbd.2025.107151_bb0190","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ncb2718","article-title":"TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop","volume":"15","author":"Settembre","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.nbd.2025.107151_bb0195","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neurobiolaging.2013.08.003","article-title":"miR128 up-regulation correlates with impaired amyloid \u03b2(1-42) degradation in monocytes from patients with sporadic Alzheimer\u2019s disease","volume":"35","author":"Tiribuzi","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2025.107151_bb0200","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.ymthe.2018.02.022","article-title":"Overexpression of TFEB drives a pleiotropic neurotrophic effect and prevents Parkinson\u2019s disease-related neurodegeneration","volume":"26","author":"Torra","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.nbd.2025.107151_bb0205","first-page":"288","article-title":"Plasma mutant \u03b1-galactosidase a protein and globotriaosylsphingosine level in Fabry disease","volume":"1","author":"Tsukimura","year":"2014","journal-title":"Mol. Genet. Metab. Rep."},{"key":"10.1016\/j.nbd.2025.107151_bb0210","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/mds.20153","article-title":"Assessment of autonomic dysfunction in Parkinson\u2019s disease: the SCOPA-AUT","volume":"19","author":"Visser","year":"2004","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107151_bb0215","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3390\/cells8111317","article-title":"Autophagic- and lysosomal-related biomarkers for Parkinson\u2019s disease: lights and shadows","volume":"8","author":"Xicoy","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.nbd.2025.107151_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.582825","article-title":"Role of peripheral immune cells-mediated inflammation on the process of neurodegenerative diseases","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.nbd.2025.107151_bb0225","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1002\/mds.28815","article-title":"Evaluation of strategies for measuring lysosomal glucocerebrosidase activity","volume":"36","author":"Ysselstein","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107151_bb0230","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1080\/15548627.2018.1490850","article-title":"Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply","volume":"14","author":"Zhang","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.nbd.2025.107151_bb0235","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-020-2322-6","article-title":"Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson\u2019s disease models","volume":"11","author":"Zhuang","year":"2020","journal-title":"Cell Death Dis."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125003687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125003687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:57:19Z","timestamp":1778576239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125003687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":47,"alternative-id":["S0969996125003687"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107151","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated TFEB expression with limited activation in peripheral blood mononuclear cells reflects altered lysosomal enzyme dynamics in Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107151"}}