{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:37:38Z","timestamp":1768473458401,"version":"3.49.0"},"reference-count":127,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH129749"],"award-info":[{"award-number":["R01MH129749"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.nbd.2025.107191","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T11:14:23Z","timestamp":1763637263000},"page":"107191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Shank3 establishes AMPA receptor subunit composition at cerebellar mossy fiber-granule cell synapses and is associated with altered regional microglial morphology"],"prefix":"10.1016","volume":"217","author":[{"given":"Rajaram","family":"Kshetri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raheem F.H.","family":"Al Aameri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben D.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2025.107191_bb0005","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.64833","article-title":"Deleting mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice","volume":"10","author":"Achilly","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.nbd.2025.107191_bb0010","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.pnpbp.2017.08.002","article-title":"Upregulation of IL-9 and JAK-STAT signaling pathway in children with autism","volume":"79","author":"Ahmad","year":"2017","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107191_bb0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/bs.pmbts.2019.06.012","article-title":"Microglia as possible therapeutic targets for autism spectrum disorders","volume":"167","author":"Andoh","year":"2019","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0020","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.conb.2011.12.006","article-title":"Regulation of AMPA receptor trafficking and synaptic plasticity","volume":"22","author":"Anggono","year":"2012","journal-title":"Curr. Opin. Neurobiol."},{"issue":"5","key":"10.1016\/j.nbd.2025.107191_bb0025","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/brain\/121.5.889","article-title":"A clinicopathological study of autism","volume":"121","author":"Bailey","year":"1998","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.nbd.2025.107191_bb0030","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/nn.4319","article-title":"SHANK3 controls maturation of social reward circuits in the VTA","volume":"19","author":"Bariselli","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"2\u20133","key":"10.1016\/j.nbd.2025.107191_bb0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijdevneu.2004.09.006","article-title":"Neuroanatomic observations of the brain in autism: a review and future directions","volume":"23","author":"Bauman","year":"2005","journal-title":"Int. J. Develop. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0040","series-title":"International Review of Neurobiology","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-418700-9.00001-0","article-title":"Autism spectrum disorder and the cerebellum","volume":"vol. 113","author":"Becker","year":"2013"},{"key":"10.1016\/j.nbd.2025.107191_bb0045","doi-asserted-by":"crossref","DOI":"10.1002\/aur.1925","article-title":"Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder","volume":"11","author":"Berg","year":"2018","journal-title":"Autism Res."},{"key":"10.1016\/j.nbd.2025.107191_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2018.00337","article-title":"Sex hormones regulate SHANK expression","volume":"11","author":"Berkel","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2040-2392-4-17","article-title":"SHANK3 haploinsufficiency: a \u201ccommon\u201d but underdiagnosed highly penetrant monogenic cause of autism spectrum disorders","volume":"4","author":"Betancur","year":"2013","journal-title":"Mol. Autism."},{"key":"10.1016\/j.nbd.2025.107191_bb0060","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41398-018-0142-6","article-title":"Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors","volume":"8","author":"Bey","year":"2018","journal-title":"Transl. Psychiatry"},{"issue":"11","key":"10.1016\/j.nbd.2025.107191_bb0065","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/s00018-019-03068-7","article-title":"AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking","volume":"76","author":"Bissen","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0070","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.mcn.2004.01.009","article-title":"Differential expression and dendritic transcript localization of Shank family members: identification of a dendritic targeting element in the 3\u2032 untranslated region of Shank1 mRNA","volume":"26","author":"B\u00f6ckers","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0075","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2040-2392-1-15","article-title":"Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication","volume":"1","author":"Bozdagi","year":"2010","journal-title":"Mol. Autism."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0080","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0896-6273(92)90120-3","article-title":"Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit","volume":"8","author":"Burnashev","year":"1992","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.nbd.2025.107191_bb0085","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nn.3974","article-title":"Synaptic diversity enables temporal coding of coincident multisensory inputs in single neurons","volume":"18","author":"Chabrol","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"21","key":"10.1016\/j.nbd.2025.107191_bb0090","doi-asserted-by":"crossref","first-page":"12132","DOI":"10.1073\/pnas.96.21.12132","article-title":"Impaired cerebellar synapse maturation in waggler, a mutant mouse with a disrupted neuronal calcium channel \u03b3 subunit","volume":"96","author":"Chen","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2025.107191_bb0095","doi-asserted-by":"crossref","first-page":"1258615","DOI":"10.3389\/fnmol.2023.1258615","article-title":"Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome","volume":"16","author":"Chojnacka","year":"2023","journal-title":"Front. Mol. Neurosci."},{"issue":"12","key":"10.1016\/j.nbd.2025.107191_bb0100","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1111\/ejn.16043","article-title":"Shank3 deficits in the anteromedial bed nucleus of the stria terminalis trigger an anxiety phenotype in mice","volume":"57","author":"Contestabile","year":"2023","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0105","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.66765","article-title":"Enhanced functional detection of synaptic calcium-permeable AMPA receptors using intracellular NASPM","volume":"12","author":"Coombs","year":"2023","journal-title":"eLife"},{"issue":"5","key":"10.1016\/j.nbd.2025.107191_bb0110","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0196-16.2016","article-title":"Immature neurons and radial glia, but not astrocytes or microglia, are altered in adult Cntnap2 and Shank3 mice, models of Autism","volume":"3","author":"Cope","year":"2016","journal-title":"eNeuro"},{"issue":"10","key":"10.1016\/j.nbd.2025.107191_bb0115","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1113\/JP279029","article-title":"Ca2+-permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease","volume":"599","author":"Cull-Candy","year":"2021","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.nbd.2025.107191_bb0120","doi-asserted-by":"crossref","first-page":"624","DOI":"10.2174\/1871527321666220510141735","article-title":"The role of Ca2+ permeable AMPA receptors in neurodegeneration, neurotoxicity, and Neuroinflammation","volume":"22","author":"da Silva","year":"2023","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0125","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/s41598-017-01747-8","article-title":"Characterizing microglia activation: a spatial statistics approach to maximize information extraction","volume":"7","author":"Davis","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.nbd.2025.107191_bb0135","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuron.2018.10.018","article-title":"The AMPA receptor code of synaptic plasticity","volume":"100","author":"Diering","year":"2018","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0140","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1134\/S1990747820030046","article-title":"Participation of Ca2+-permeable AMPA receptors in synaptic plasticity","volume":"14","author":"Dolgacheva","year":"2020","journal-title":"Biochem. (Mosc.) Suppl. A: Membr. Cell Biol."},{"issue":"6622","key":"10.1016\/j.nbd.2025.107191_bb0145","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/386279a0","article-title":"GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors","volume":"386","author":"Dong","year":"1997","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.nbd.2025.107191_bb0150","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1523\/JNEUROSCI.19-16-06930.1999","article-title":"Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2","volume":"19","author":"Dong","year":"1999","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0155","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0046-18.2018","article-title":"Behavioral phenotyping of an improved mouse model of Phelan\u2013McDermid syndrome with a complete deletion of the Shank3 gene","volume":"5","author":"Drapeau","year":"2018","journal-title":"eNeuro"},{"issue":"24","key":"10.1016\/j.nbd.2025.107191_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417297","article-title":"Microglia modulate neurodevelopment in autism Spectrum disorder and schizophrenia","volume":"24","author":"Fan","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0165","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s12311-012-0355-9","article-title":"Consensus paper: pathological role of the cerebellum in autism","volume":"11","author":"Fatemi","year":"2012","journal-title":"Cerebellum"},{"issue":"MAY","key":"10.1016\/j.nbd.2025.107191_bb0170","first-page":"2","article-title":"RuBi-glutamate: two-photon and visible-light photoactivation of neurons and dendritic spines","volume":"3","author":"Fino","year":"2009","journal-title":"Front. Neural Circ."},{"issue":"7","key":"10.1016\/j.nbd.2025.107191_bb0175","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s11064-011-0398-1","article-title":"Systematizing and cloning of genes involved in the cerebellar cortex circuit development","volume":"36","author":"Furuichi","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.nbd.2025.107191_bb0180","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3389\/fncel.2020.592710","article-title":"Neural mechanisms underlying repetitive behaviors in rodent models of autism Spectrum disorders","volume":"14","author":"Gandhi","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"44","key":"10.1016\/j.nbd.2025.107191_bb0185","doi-asserted-by":"crossref","first-page":"14805","DOI":"10.1523\/JNEUROSCI.1161-10.2010","article-title":"Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet Brain-2","volume":"30","author":"Giza","year":"2010","journal-title":"J. Neurosci."},{"issue":"JUL","key":"10.1016\/j.nbd.2025.107191_bb0190","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnsyn.2019.00020","article-title":"Approaches and limitations in the investigation of synaptic transmission and plasticity","volume":"11","author":"Glasgow","year":"2019","journal-title":"Front. Synapt. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0195","first-page":"82","article-title":"Calcium permeable-AMPA receptors and excitotoxicity in neurological disorders","volume":"15","author":"Guo","year":"2021","journal-title":"Front. Neural Circ."},{"issue":"8","key":"10.1016\/j.nbd.2025.107191_bb0200","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s41593-019-0445-9","article-title":"Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice","volume":"22","author":"Guo","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0205","article-title":"Restoring thalamocortical circuit dysfunction by correcting HCN channelopathy in Shank3 mutant mice","volume":"101534","author":"Guo","year":"2024","journal-title":"Cell Reports Med."},{"issue":"48","key":"10.1016\/j.nbd.2025.107191_bb0210","doi-asserted-by":"crossref","first-page":"12129","DOI":"10.1523\/JNEUROSCI.1849-16.2016","article-title":"Cerebellar shank2 regulates excitatory synapse density, motor coordination, and specific repetitive and anxiety-like behaviors","volume":"36","author":"Ha","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0215","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3389\/fnmol.2018.00405","article-title":"Shank and zinc mediate an AMPA receptor subunit switch in developing neurons","volume":"11","author":"Ha","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0220","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1046\/j.1471-4159.1995.65031077.x","article-title":"Properties of AMPA receptors expressed in rat cerebellar granule cell cultures: Ca2+ influx studies","volume":"65","author":"Hack","year":"1995","journal-title":"J. Neurochem."},{"issue":"NOV","key":"10.1016\/j.nbd.2025.107191_bb0225","first-page":"420","article-title":"Autism spectrum disorders and neuropathology of the cerebellum","volume":"9","author":"Hampson","year":"2015","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2025.107191_bb0230","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrn.2016.37","article-title":"Synaptic AMPA receptor composition in development, plasticity and disease","volume":"17","author":"Henley","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"issue":"5007","key":"10.1016\/j.nbd.2025.107191_bb0235","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1126\/science.1709304","article-title":"Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition","volume":"252","author":"Hollmann","year":"1991","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.nbd.2025.107191_bb0240","article-title":"Microglia: Synaptic modulator in autism spectrum disorder","volume":"13","author":"Hu","year":"2022","journal-title":"Front. Psychol."},{"key":"10.1016\/j.nbd.2025.107191_bb0245","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2022.12.001","article-title":"Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)","volume":"108","author":"Hughes","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.nbd.2025.107191_bb0255","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12264-017-0112-7","article-title":"Cellular and circuitry bases of autism: lessons learned from the Temporospatial manipulation of autism genes in the brain","volume":"33","author":"Hulbert","year":"2017","journal-title":"Neurosci. Bull."},{"issue":"2","key":"10.1016\/j.nbd.2025.107191_bb0260","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1113\/JP276698","article-title":"Modulation of information processing by AMPA receptor auxiliary subunits","volume":"599","author":"Jacobi","year":"2021","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0265","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/aur.1529","article-title":"Altered striatal synaptic function and abnormal behaviour in Shank3 Exon4\u20139 deletion mouse model of autism","volume":"9","author":"Jaramillo","year":"2016","journal-title":"Autism Res."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0270","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuron.2013.03.016","article-title":"Modeling autism by SHANK gene mutations in mice","volume":"78","author":"Jiang","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.107191_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106340","article-title":"Shank postsynaptic scaffolding proteins in autism spectrum disorder: mouse models and their dysfunctions in behaviors, synapses, and molecules","volume":"182","author":"Jung","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107921","article-title":"AMPA receptor auxiliary subunit GSG1L suppresses short-term facilitation in Corticothalamic synapses and determines seizure susceptibility","volume":"32","author":"Kamalova","year":"2020","journal-title":"Cell Rep."},{"issue":"35","key":"10.1016\/j.nbd.2025.107191_bb0285","doi-asserted-by":"crossref","first-page":"9019","DOI":"10.1523\/JNEUROSCI.0042-16.2016","article-title":"Pharmacologically counteracting a phenotypic difference in cerebellar GABAA receptor response to alcohol prevents excessive alcohol consumption in a high alcohol-consuming rodent genotype","volume":"36","author":"Kaplan","year":"2016","journal-title":"J. Neurosci."},{"issue":"11","key":"10.1016\/j.nbd.2025.107191_bb0290","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nrn2234","article-title":"Synaptic plasticity and addiction","volume":"8","author":"Kauer","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108932","article-title":"The autism-associated protein CHD8 is required for cerebellar development and motor function","volume":"35","author":"Kawamura","year":"2021","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0300","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12993-016-0087-y","article-title":"Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorder","volume":"12","author":"Kim","year":"2016","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.nbd.2025.107191_bb0305","series-title":"Development of a High-Throughput Pipeline to Characterize Microglia Morphological States at a Single-Cell Resolution","first-page":"1","volume":"11","author":"Kim","year":"2023"},{"key":"10.1016\/j.nbd.2025.107191_bb0310","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06085","article-title":"Cerebellar associative sensory learning defects in five mouse autism models","volume":"4","author":"Kloth","year":"2015","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0315","doi-asserted-by":"crossref","DOI":"10.1186\/s13229-019-0291-3","article-title":"Neuropsychiatric decompensation in adolescents and adults with Phelan-McDermid syndrome: a systematic review of the literature","volume":"10","author":"Kolevzon","year":"2019","journal-title":"Mol. Autism"},{"key":"10.1016\/j.nbd.2025.107191_bb0320","doi-asserted-by":"crossref","first-page":"18448","DOI":"10.1523\/JNEUROSCI.3017-13.2013","article-title":"Loss of predominant Shank3 isoforms results in Hippocampus-dependent impairments in behavior and synaptic transmission","volume":"33","author":"Kouser","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2015.06.005","article-title":"Microglia in the pathogenesis of autism spectrum disorders","volume":"100","author":"Koyama","year":"2015","journal-title":"Neurosci. Res."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13229-024-00628-y","article-title":"Behavioral decline in Shank3\u0394ex4\u201322 mice during early adulthood parallels cerebellar granule cell glutamatergic synaptic changes","volume":"15","author":"Kshetri","year":"2024","journal-title":"Mol. Autism."},{"key":"10.1016\/j.nbd.2025.107191_bb0335","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00094","article-title":"Shank3-mutant mice lacking exon 9 show altered excitation\/inhibition balance, enhanced rearing, and spatial memory deficit","volume":"9","author":"Lee","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"7124","key":"10.1016\/j.nbd.2025.107191_bb0340","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2006","journal-title":"Nature"},{"issue":"6785","key":"10.1016\/j.nbd.2025.107191_bb0345","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/35013064","article-title":"Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype","volume":"405","author":"Liu","year":"2000","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.nbd.2025.107191_bb0350","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nn1468","article-title":"Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses","volume":"8","author":"Liu","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"Pt 1","key":"10.1016\/j.nbd.2025.107191_bb0355","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1113\/jphysiol.2011.213926","article-title":"Ca2+ permeable AMPA receptors switch allegiances: mechanisms and consequences","volume":"590","author":"Liu","year":"2012","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0360","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.tins.2007.01.006","article-title":"Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death","volume":"30","author":"Liu","year":"2007","journal-title":"Trends Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2025.107191_bb0365","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (GTEx) project","volume":"45","author":"Lonsdale","year":"2013","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-019-0138-4","article-title":"Autism spectrum disorder","volume":"6","author":"Lord","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0375","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3390\/biomedicines12010210","article-title":"The impact of microglia on neurodevelopment and brain function in autism","volume":"12","author":"Luo","year":"2024","journal-title":"Biomedicines"},{"issue":"28","key":"10.1016\/j.nbd.2025.107191_bb0380","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0619-24.2024","article-title":"Trans-synaptic Association of Vesicular Zinc Transporter 3 and Shank3 supports synapse-specific dendritic spine structure and function in the mouse auditory cortex","volume":"44","author":"Manning","year":"2024","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0385","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbi.2019.04.037","article-title":"The influence of neuroinflammation in autism Spectrum disorder","volume":"79","author":"Matta","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.nbd.2025.107191_bb0390","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003128","article-title":"Co-expression profiling of autism genes in the mouse brain","volume":"9","author":"Menashe","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.nbd.2025.107191_bb0395","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-025-08736-2","article-title":"GluA2-containing AMPA receptors form a continuum of Ca2+-permeable channels","author":"Miguez-Cabello","year":"2025","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0400","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrn.2016.183","article-title":"SHANK proteins: roles at the synapse and in autism spectrum disorder","volume":"18","author":"Monteiro","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.nbd.2025.107191_bb0405","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.biopsych.2010.05.024","article-title":"Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism","volume":"68","author":"Morgan","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2025.107191_bb0410","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fnins.2015.00296","article-title":"The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders","volume":"9","author":"Mosconi","year":"2015","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0415","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13229-023-00557-2","article-title":"Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling","volume":"14","author":"Pagano","year":"2023","journal-title":"Mol. Autism."},{"issue":"6048","key":"10.1016\/j.nbd.2025.107191_bb0420","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"issue":"21","key":"10.1016\/j.nbd.2025.107191_bb0425","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: a field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"issue":"7344","key":"10.1016\/j.nbd.2025.107191_bb0430","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature09965","article-title":"Shank3 mutant mice display autistic-like behaviours and striatal dysfunction","volume":"472","author":"Pe\u00e7a","year":"2011","journal-title":"Nature"},{"issue":"FEB","key":"10.1016\/j.nbd.2025.107191_bb0435","article-title":"Astrocytes and microglia and their potential link with autism spectrum disorders","volume":"10","author":"Petrelli","year":"2016","journal-title":"Front. Cell. Neurosci."},{"issue":"12","key":"10.1016\/j.nbd.2025.107191_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109721","article-title":"Homologous organization of cerebellar pathways to sensory, motor, and associative forebrain","volume":"36","author":"Pisano","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2025.107191_bb0445","first-page":"1","article-title":"Exploring the role of AMPA receptor auxiliary proteins in synaptic functions and diseases","author":"Qneibi","year":"2024","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0450","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1152\/jn.00963.2016","article-title":"Recreational concentrations of alcohol enhance synaptic inhibition of cerebellar unipolar brush cells via pre- and postsynaptic mechanisms","volume":"118","author":"Richardson","year":"2017","journal-title":"J. Neurophysiol."},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0455","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1523\/JNEUROSCI.3277-12.2013","article-title":"Reduced GABAA receptor-mediated tonic inhibition in aged rat auditory thalamus","volume":"33","author":"Richardson","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0460","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00345","article-title":"The role of polyamine-dependent facilitation of calcium permeable ampars in short-term synaptic enhancement","volume":"12","author":"Rozov","year":"2018","journal-title":"Front. Cell. Neurosci."},{"issue":"6263","key":"10.1016\/j.nbd.2025.107191_bb0465","doi-asserted-by":"crossref","first-page":"aab3897","DOI":"10.1126\/science.aab3897","article-title":"Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders","volume":"350","author":"Sahin","year":"2015","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.nbd.2025.107191_bb0470","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/jnc.13232","article-title":"Shank synaptic scaffold proteins: keys to understanding the pathogenesis of autism and other synaptic disorders","volume":"135","author":"Sala","year":"2015","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.nbd.2025.107191_bb0475","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.neunet.2008.05.004","article-title":"Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum","volume":"21","author":"Sato","year":"2008","journal-title":"Neural Netw."},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0480","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.cell.2019.12.036","article-title":"Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism","volume":"180","author":"Satterstrom","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2025.107191_bb0485","series-title":"Microglia: Methods and Protocols","first-page":"13","article-title":"Morphology of microglia across contexts of health and disease","author":"Savage","year":"2019"},{"issue":"8","key":"10.1016\/j.nbd.2025.107191_bb0490","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1097\/00001756-199705260-00017","article-title":"Distribution of Ca2+-permeable AMPA receptors among cultured rat cerebellar granule cells","volume":"8","author":"Savidge","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/j.nbd.2025.107191_bb0495","series-title":"SHANK Mutations in Intellectual Disability and Autism Spectrum Disorder","author":"Schmeisser","year":"2016"},{"issue":"30","key":"10.1016\/j.nbd.2025.107191_bb0500","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.1523\/JNEUROSCI.0377-07.2007","article-title":"GABA affinity shapes IPSCs in thalamic nuclei","volume":"27","author":"Schofield","year":"2007","journal-title":"J. Neurosci."},{"issue":"11","key":"10.1016\/j.nbd.2025.107191_bb0505","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1242\/jcs.113.11.1851","article-title":"The Shank family of scaffold proteins","volume":"113","author":"Sheng","year":"2000","journal-title":"J. Cell Sci."},{"issue":"13","key":"10.1016\/j.nbd.2025.107191_bb0510","first-page":"2383","article-title":"Hyperexcitability and hyperplasticity disrupt cerebellar signal transfer in the IB2 KO mouse model of autism","volume":"39","author":"Soda","year":"2019","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0515","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1113\/jphysiol.2003.060285","article-title":"Increased neurotransmitter release during long-term potentiation at mossy fibre\u2013granule cell synapses in rat cerebellum","volume":"557","author":"Sola","year":"2004","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0520","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2040-2392-4-18","article-title":"Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency","volume":"4","author":"Soorya","year":"2013","journal-title":"Mol. Autism."},{"issue":"26","key":"10.1016\/j.nbd.2025.107191_bb0525","doi-asserted-by":"crossref","first-page":"9648","DOI":"10.1523\/JNEUROSCI.3125-14.2015","article-title":"Autism-associated insertion mutation (InsG) of Shank3 exon 21 causes impaired synaptic transmission and behavioral deficits","volume":"35","author":"Speed","year":"2015","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.nbd.2025.107191_bb0530","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1038\/s41593-017-0004-1","article-title":"Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice","volume":"20","author":"Stoodley","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0535","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.25755","article-title":"Plasticity of calcium-permeable ampa glutamate receptors in proopiomelanocortin neurons","volume":"6","author":"Suyama","year":"2017","journal-title":"eLife"},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0540","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/pr.109.002451","article-title":"Glutamate receptor ion channels: structure, regulation, and function","volume":"62","author":"Traynelis","year":"2010","journal-title":"Pharmacol. Rev."},{"issue":"5","key":"10.1016\/j.nbd.2025.107191_bb0545","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.siny.2016.04.009","article-title":"Autism and cerebellar dysfunction: evidence from animal models","volume":"21","author":"Tsai","year":"2016","journal-title":"Semin. Fetal Neonatal Med."},{"issue":"7413","key":"10.1016\/j.nbd.2025.107191_bb0550","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature11310","article-title":"Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice","volume":"488","author":"Tsai","year":"2012","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.nbd.2025.107191_bb0555","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.neuron.2018.07.027","article-title":"Mechanisms of channel block in calcium-permeable AMPA receptors","volume":"99","author":"Twomey","year":"2018","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0560","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism","volume":"57","author":"Vargas","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2025.107191_bb0565","first-page":"1","article-title":"Association of SHANK family with neuropsychiatric disorders: An update on genetic and animal model discoveries","author":"Wan","year":"2021","journal-title":"Cell. Mol. Neurobiol."},{"issue":"15","key":"10.1016\/j.nbd.2025.107191_bb0570","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1093\/hmg\/ddr212","article-title":"Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3","volume":"20","author":"Wang","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.nbd.2025.107191_bb0575","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuron.2014.07.016","article-title":"The cerebellum, sensitive periods, and autism","volume":"83","author":"Wang","year":"2014","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0580","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/2040-2392-5-30","article-title":"Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice","volume":"5","author":"Wang","year":"2014","journal-title":"Mol. Autism."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0585","doi-asserted-by":"crossref","first-page":"11459","DOI":"10.1038\/ncomms11459","article-title":"Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism","volume":"7","author":"Wang","year":"2016","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.nbd.2025.107191_bb0590","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/ng.3931","article-title":"Classification of common human diseases derived from shared genetic and environmental determinants","volume":"49","author":"Wang","year":"2017","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.nbd.2025.107191_bb0595","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1172\/JCI87997","article-title":"Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism","volume":"127","author":"Wang","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2025.107191_bb0600","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fnmol.2013.00019","article-title":"Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses","volume":"6","author":"Won","year":"2013","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0605","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0896-6273(00)80689-3","article-title":"Clustering of AMPA receptors by the synaptic PDZ domain\u2013containing protein PICK1","volume":"22","author":"Xia","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2025.107191_bb0610","doi-asserted-by":"crossref","first-page":"1125428","DOI":"10.3389\/fnins.2023.1125428","article-title":"Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder","volume":"17","author":"Xiong","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0615","doi-asserted-by":"crossref","first-page":"1405510","DOI":"10.3389\/fnsyn.2024.1405510","article-title":"Roles of AMPA receptors in social behaviors","volume":"16","author":"Xu","year":"2024","journal-title":"Front. Synapt. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0620","doi-asserted-by":"crossref","first-page":"1405510","DOI":"10.3389\/fnsyn.2024.1405510","article-title":"Roles of AMPA receptors in social behaviors","volume":"16","author":"Xue","year":"2024","journal-title":"Front. Synapt. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0625","article-title":"Deciphering the role of Shank3 in dendritic morphology and synaptic function across postnatal developmental stages in the Shank3B KO mouse","author":"Yang","year":"2024","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.nbd.2025.107191_bb0630","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00341","article-title":"GABA neuronal deletion of Shank3 exons 14\u201316 in mice suppresses striatal excitatory synaptic input and induces social and locomotor abnormalities","volume":"12","author":"Yoo","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2025.107191_bb0635","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2019.00458","article-title":"Shank3 exons 14\u201316 deletion in glutamatergic neurons leads to social and repetitive behavioral deficits associated with increased cortical layer 2\/3 neuronal excitability","volume":"13","author":"Yoo","year":"2019","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.nbd.2025.107191_bb0640","article-title":"Neuropathological insights from SHANK3 mutant animal models","volume":"3","author":"Zhang","year":"2023","journal-title":"Age. Neurodegenerat. Dis."},{"issue":"1","key":"10.1016\/j.nbd.2025.107191_bb0645","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuron.2015.11.023","article-title":"Mice with Shank3 mutations associated with ASD and schizophrenia display both shared and distinct defects","volume":"89","author":"Zhou","year":"2016","journal-title":"Neuron"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125004085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125004085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:44:48Z","timestamp":1768394688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125004085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":127,"alternative-id":["S0969996125004085"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107191","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shank3 establishes AMPA receptor subunit composition at cerebellar mossy fiber-granule cell synapses and is associated with altered regional microglial morphology","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107191"}}