{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:53:03Z","timestamp":1777884783839,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ60489"],"award-info":[{"award-number":["2025JJ60489"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ6638"],"award-info":[{"award-number":["2024JJ6638"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ3050"],"award-info":[{"award-number":["2024JJ3050"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["2023QYJC010"],"award-info":[{"award-number":["2023QYJC010"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA0805200"],"award-info":[{"award-number":["2021YFA0805200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401496"],"award-info":[{"award-number":["82401496"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571433"],"award-info":[{"award-number":["82571433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571632"],"award-info":[{"award-number":["82571632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301628"],"award-info":[{"award-number":["82301628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171254"],"award-info":[{"award-number":["82171254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371272"],"award-info":[{"award-number":["82371272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZB20230870"],"award-info":[{"award-number":["GZB20230870"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M753690"],"award-info":[{"award-number":["2024M753690"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2022RC1027"],"award-info":[{"award-number":["2022RC1027"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["R2023047"],"award-info":[{"award-number":["R2023047"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.nbd.2025.107243","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T22:55:58Z","timestamp":1766703358000},"page":"107243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tri-modal assessment reveals early visual pathway degeneration in patients with MSA-C"],"prefix":"10.1016","volume":"218","author":[{"given":"Chunrong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiyan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daji","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riwei","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linliu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huirong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beisha","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.nbd.2025.107243_bb0005","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1007\/s00415-016-8230-0","article-title":"Retinal thinning correlates with clinical severity in multiple system atrophy","volume":"263","author":"Ahn","year":"2016","journal-title":"J. Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2025.107243_bb0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10633-022-09887-7","article-title":"Evaluation of the visual system with visual evoked potential and optical coherence tomography in patients with idiopathic Parkinson\u2019s disease and with multiple system atrophy","volume":"145","author":"Batum","year":"2022","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.nbd.2025.107243_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101119","article-title":"Circadian clock organization in the retina: from clock components to rod and cone pathways and visual function","volume":"94","author":"Bhoi","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"issue":"12","key":"10.1016\/j.nbd.2025.107243_bb0020","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S1474-4422(22)00173-9","article-title":"Imaging of the optic nerve: technological advances and future prospects","volume":"21","author":"Biousse","year":"2022","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2025.107243_bb0025","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.neuroimage.2004.06.018","article-title":"A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume","volume":"23","author":"Buckner","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbd.2025.107243_bb0030","doi-asserted-by":"crossref","DOI":"10.1007\/s00702-025-02918-y","article-title":"Optical coherence tomography reveals retinal structural abnormalities in \u03b1-synucleinopathies: insights from the Padua-CESNE cohort","author":"Campagnolo","year":"2025","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"11","key":"10.1016\/j.nbd.2025.107243_bb0035","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.tins.2023.08.009","article-title":"Internal models of self-motion: neural computations by the vestibular cerebellum","volume":"46","author":"Cullen","year":"2023","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2025.107243_bb0040","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41593-020-00754-9","article-title":"Diversity and dynamism in the cerebellum","volume":"24","author":"De Zeeuw","year":"2021","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.nbd.2025.107243_bb0045","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/mds.23523","article-title":"Retinal nerve fiber layer loss in multiple system atrophy","volume":"26","author":"Fischer","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107243_bb0050","article-title":"\u03b1-Synuclein pathology in post-mortem retina and optic nerve is specific for \u03b1-synucleinopathies","volume":"9(1):124","author":"Hart de Ruyter","year":"2023","journal-title":"NPJ. Parkinsons. Dis."},{"issue":"1","key":"10.1016\/j.nbd.2025.107243_bb0055","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00401-024-02769-z","article-title":"Neuropathological hallmarks in the post-mortem retina of neurodegenerative diseases","volume":"148","author":"Hart de Ruyter","year":"2024","journal-title":"Acta Neuropathol."},{"issue":"12","key":"10.1016\/j.nbd.2025.107243_bb0060","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S1474-4422(24)00396-X","article-title":"Multiple system atrophy: advances in pathophysiology, diagnosis, and treatment","volume":"23","author":"Krismer","year":"2024","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2025.107243_bb0065","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/ana.25972","article-title":"Parafoveal change and dopamine loss in the retina with Parkinson\u2019s disease","volume":"89","author":"Lee","year":"2021","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.nbd.2025.107243_bb0070","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41582-022-00618-9","article-title":"Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease","volume":"18","author":"Lee","year":"2022","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2025.107243_bb0075","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s00415-021-10703-6","article-title":"Retina thickness in atypical parkinsonism: a systematic review and meta-analysis","volume":"269","author":"Ma","year":"2022","journal-title":"J. Neurol."},{"issue":"2","key":"10.1016\/j.nbd.2025.107243_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/biom13020218","article-title":"Retinal structure abnormalities in Parkinson\u2019s disease and atypical parkinsonism","volume":"13","author":"Ma","year":"2023","journal-title":"Biomolecules"},{"issue":"14","key":"10.1016\/j.nbd.2025.107243_bb0085","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/mds.26360","article-title":"Progressive retinal structure abnormalities in multiple system atrophy","volume":"30","author":"Mendoza-Santiesteban","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2025.107243_bb0090","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fneur.2017.00206","article-title":"The retina in multiple system atrophy: systematic review and meta-analysis","volume":"8","author":"Mendoza-Santiesteban","year":"2017","journal-title":"Front. Neurol."},{"issue":"23","key":"10.1016\/j.nbd.2025.107243_bb0095","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1212\/WNL.0000000000004020","article-title":"Pathologic confirmation of retinal ganglion cell loss in multiple system atrophy","volume":"88","author":"Mendoza-Santiesteban","year":"2017","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nbd.2025.107243_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10633-016-9553-y","article-title":"ISCEV standard for clinical visual evoked potentials: (2016 update)","volume":"133","author":"Odom","year":"2016","journal-title":"Doc. Ophthalmol."},{"issue":"1","key":"10.1016\/j.nbd.2025.107243_bb0105","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41531-021-00236-0","article-title":"White matter and nigral alterations in multiple system atrophy-parkinsonian type","volume":"7","author":"Ogawa","year":"2021","journal-title":"NPJ. Parkinsons. Dis."},{"key":"10.1016\/j.nbd.2025.107243_bb0110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.preteyeres.2018.02.002","article-title":"Neuroprotective strategies for retinal disease","volume":"65","author":"Pardue","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"issue":"10","key":"10.1016\/j.nbd.2025.107243_bb0115","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1002\/mds.29195","article-title":"Diffusion magnetic resonance imaging microstructural abnormalities in multiple system atrophy: a comprehensive review","volume":"37","author":"Pasquini","year":"2022","journal-title":"Mov. Disord."},{"issue":"10","key":"10.1016\/j.nbd.2025.107243_bb0120","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S1474-4422(17)30278-8","article-title":"Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis","volume":"16","author":"Petzold","year":"2017","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2025.107243_bb0125","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3109\/01658107.2011.580898","article-title":"Retinal nerve fibre layer and macular thinning in spinocerebellar ataxia and cerebellar multisystem atrophy","volume":"35","author":"Pula","year":"2011","journal-title":"Neuroophthalmology"},{"issue":"10","key":"10.1016\/j.nbd.2025.107243_bb0130","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S1474-4422(25)00275-3","article-title":"The use of optical coherence tomography and visual evoked potentials in the 2024 McDonald diagnostic criteria for multiple sclerosis","volume":"24","author":"Saidha","year":"2025","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2025.107243_bb0135","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.neuroimage.2004.03.032","article-title":"A hybrid approach to the skull stripping problem in MRI","volume":"22","author":"S\u00e9gonne","year":"2004","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.nbd.2025.107243_bb0140","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/alz.12179","article-title":"Retinal imaging in Alzheimer\u2019s and neurodegenerative diseases","volume":"17","author":"Snyder","year":"2021","journal-title":"Alzheimers Dement."},{"issue":"16","key":"10.1016\/j.nbd.2025.107243_bb0145","doi-asserted-by":"crossref","first-page":"e1581","DOI":"10.1212\/WNL.0000000000207727","article-title":"Retinal optical coherence tomography features associated with incident and prevalent Parkinson disease","volume":"101","author":"Wagner","year":"2023","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.nbd.2025.107243_bb0150","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/mds.29005","article-title":"The movement disorder society criteria for the diagnosis of multiple system atrophy","volume":"37","author":"Wenning","year":"2022","journal-title":"Mov. Disord."},{"issue":"12","key":"10.1016\/j.nbd.2025.107243_bb0155","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1093\/brain\/awac317","article-title":"The use of optical coherence tomography in neurology: a review","volume":"145","author":"Xie","year":"2022","journal-title":"Brain"},{"issue":"31","key":"10.1016\/j.nbd.2025.107243_bb0160","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado0866","article-title":"Modulating amacrine cell-derived dopamine signaling promotes optic nerve regeneration and preserves visual function","volume":"10","author":"Zhang","year":"2024","journal-title":"Sci. Adv."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125004607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996125004607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:38:08Z","timestamp":1777603088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996125004607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":32,"alternative-id":["S0969996125004607"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107243","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tri-modal assessment reveals early visual pathway degeneration in patients with MSA-C","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2025.107243","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107243"}}