{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:12:29Z","timestamp":1792066349367,"version":"4.4.0"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD036071"],"award-info":[{"award-number":["HD036071"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disabilities Research Center","doi-asserted-by":"publisher","award":["P50 HD103526"],"award-info":[{"award-number":["P50 HD103526"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010553","name":"University of California Davis MIND Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS110100"],"award-info":[{"award-number":["NS110100"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.nbd.2026.107292","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:10:01Z","timestamp":1770077401000},"page":"107292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The apolipoprotein gene: a modulating role on brain volume and cognitive function in carriers of the fragile X premutation"],"prefix":"10.1016","volume":"220","author":[{"given":"Poonnada","family":"Jiraanont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blythe","family":"Durbin-Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Hyun","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hessl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi J.","family":"Hagerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Tassone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.nbd.2026.107292_bb0005","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1073\/pnas.0812697106","article-title":"Apolipoprotein E \u03b54 is associated with disease-specific effects on brain atrophy in Alzheimer\u2019s disease and frontotemporal dementia","volume":"106","author":"Agosta","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nbd.2026.107292_bb0010","series-title":"Analysis of Ordinal Categorical Data","author":"Agresti","year":"2010"},{"issue":"18","key":"10.1016\/j.nbd.2026.107292_bb0015","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1212\/WNL.0b013e318271f7ff","article-title":"FXTAS: new insights and the need for revised diagnostic criteria","volume":"79","author":"Apartis","year":"2012","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.63.1.63","article-title":"Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia","volume":"63","author":"Bartzokis","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.nbd.2026.107292_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.nbd.2026.107292_bb2000","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-025-00843-y","article-title":"Apolipoprotein E in Alzheimer\u2019s disease: molecular insights and therapeutic opportunities","volume":"20","author":"Belaidi","year":"2025","journal-title":"Mol. Neurodegeneration"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0030","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B. Methodol."},{"issue":"8","key":"10.1016\/j.nbd.2026.107292_bb0035","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1001\/archneur.64.8.1193","article-title":"Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E \u03b52\/\u03b52 genotype","volume":"64","author":"Berlau","year":"2007","journal-title":"Arch. Neurol."},{"issue":"9","key":"10.1016\/j.nbd.2026.107292_bb0040","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1212\/01.wnl.0000343853.00346.a4","article-title":"APOE \u03b52 is associated with intact cognition but increased Alzheimer pathology in the oldest old","volume":"72","author":"Berlau","year":"2009","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.nbd.2026.107292_bb0045","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrn2494","article-title":"Thirty years of Alzheimer\u2019s disease genetics: the implications of systematic meta-analyses","volume":"9","author":"Bertram","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2026.107292_bb0050","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1136\/jnnp-2016-313937","article-title":"Selective subcortical contributions to gait impairments in males with the FMR1 premutation","volume":"88","author":"Birch","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.nbd.2026.107292_bb0055","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1212\/01.WNL.0000149643.91367.8A","article-title":"APOE genotype and cognitive decline in a middle-aged cohort","volume":"64","author":"Blair","year":"2005","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.nbd.2026.107292_bb0060","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1172\/JCI112130","article-title":"Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system","volume":"76","author":"Boyles","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2026.107292_bb0065","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.nicl.2017.12.016","article-title":"Age-related functional brain changes in FMR1 premutation carriers","volume":"17","author":"Brown","year":"2018","journal-title":"NeuroImage Clin."},{"issue":"2","key":"10.1016\/j.nbd.2026.107292_bb0070","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.neuroimage.2004.06.018","article-title":"A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume","volume":"23","author":"Buckner","year":"2004","journal-title":"Neuroimage"},{"issue":"12","key":"10.1016\/j.nbd.2026.107292_bb0075","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.3390\/ijms21124391","article-title":"Fragile X-associated tremor\/ataxia syndrome (FXTAS): pathophysiology and clinical implications","volume":"21","author":"Cabal-Herrera","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.nbd.2026.107292_bb0080","article-title":"Hippocampal volumes in UK Biobank are associated with APOE only in older adults","volume":"16","author":"Chaloemtoem","year":"2024","journal-title":"Alzheimers Dement. (Amst.)"},{"key":"10.1016\/j.nbd.2026.107292_bb0085","series-title":"R Package Version 2019.4-25","article-title":"Ordinal - regression models for ordinal data","author":"Christensen","year":"2019"},{"key":"10.1016\/j.nbd.2026.107292_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2318-8-14","article-title":"The association of APOE genotype and cognitive decline in interaction with risk factors in a 65\u201369 year old community sample","volume":"8","author":"Christensen","year":"2008","journal-title":"BMC Geriatr."},{"issue":"5123","key":"10.1016\/j.nbd.2026.107292_bb0095","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.nbd.2026.107292_bb0100","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng0694-180","article-title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease","volume":"7","author":"Corder","year":"1994","journal-title":"Nat. Genet."},{"issue":"16","key":"10.1016\/j.nbd.2026.107292_bb0105","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1093\/hmg\/ddu139","article-title":"Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age","volume":"23","author":"Deelen","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.nbd.2026.107292_bb0110","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0022-2275(20)31622-9","article-title":"Biochemical analysis of cell-derived apoE3 particles active in stimulating neurite outgrowth","volume":"42","author":"DeMattos","year":"2001","journal-title":"J. Lipid Res."},{"issue":"48","key":"10.1016\/j.nbd.2026.107292_bb0115","doi-asserted-by":"crossref","first-page":"15317","DOI":"10.1523\/JNEUROSCI.4026-09.2009","article-title":"ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo","volume":"29","author":"Dumanis","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107292_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2024.123056","article-title":"Enlarged perivascular spaces and their association with motor, cognition, MRI markers and cerebrovascular risk factors in male fragile X premutation carriers","volume":"461","author":"Elias-Mas","year":"2024","journal-title":"J. Neurol. Sci"},{"issue":"16","key":"10.1016\/j.nbd.2026.107292_bb0125","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer disease meta analysis consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"issue":"17\u201318","key":"10.1016\/j.nbd.2026.107292_bb0130","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.cca.2011.04.035","article-title":"Association of apoliprotein E polymorphisms and metabolic syndrome in subjects with extreme obesity","volume":"412","author":"Ferreira","year":"2011","journal-title":"Clin. Chim. Acta"},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0135","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1373\/clinchem.2009.136101","article-title":"A novel FMR1 PCR method for the routine detection of low abundance expanded alleles and full mutations in fragile X syndrome","volume":"56","author":"Filipovic-Sadic","year":"2010","journal-title":"Clin. Chem."},{"issue":"8","key":"10.1016\/j.nbd.2026.107292_bb0140","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1212\/WNL.53.8.1825","article-title":"APOE-\u03b54 is associated with less frontal and more medial temporal lobe atrophy in AD","volume":"53","author":"Geroldi","year":"1999","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0145","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2466\/pms.1992.74.3.883","article-title":"Reliabilities, norms and factor structure of the behavioral dyscontrol scale","volume":"74","author":"Grigsby","year":"1992","journal-title":"Percept. Mot. Skills"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-013-1138-1","article-title":"Fragile X-associated tremor\/ataxia syndrome (FXTAS): pathology and mechanisms","volume":"126","author":"Hagerman","year":"2013","journal-title":"Acta Neuropathol."},{"issue":"8","key":"10.1016\/j.nbd.2026.107292_bb0155","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S1474-4422(13)70125-X","article-title":"Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor\/ataxia syndrome","volume":"12","author":"Hagerman","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2026.107292_bb0160","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/nyas.12693","article-title":"Fragile X-associated tremor\/ataxia syndrome","volume":"1338","author":"Hagerman","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"7","key":"10.1016\/j.nbd.2026.107292_bb0165","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nrneurol.2016.82","article-title":"Fragile X-associated tremor\/ataxia syndrome\u2014features, mechanisms and management. Review","volume":"12","author":"Hagerman","year":"2016","journal-title":"Nat. Rev. Neurol"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0170","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1212\/WNL.57.1.127","article-title":"Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X","volume":"57","author":"Hagerman","year":"2001","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0175","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1866-1955-6-31","article-title":"Emerging topics in FXTAS","volume":"6","author":"Hall","year":"2014","journal-title":"J. Neurodev. Disord."},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0180","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/brain\/awq368","article-title":"A voxel-based morphometry study of grey matter loss in fragile X-associated tremor\/ataxia syndrome","volume":"134","author":"Hashimoto","year":"2011","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.nbd.2026.107292_bb0185","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/mds.23646","article-title":"Diffusion tensor imaging in male premutation carriers of the fragile X mental retardation gene","volume":"26","author":"Hashimoto","year":"2011","journal-title":"Mov. Disord."},{"issue":"8","key":"10.1016\/j.nbd.2026.107292_bb0190","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1523\/JNEUROSCI.5471-06.2007","article-title":"Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1","volume":"27","author":"Hayashi","year":"2007","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0195","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41398-024-02848-5","article-title":"A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank","volume":"14","author":"Heise","year":"2024","journal-title":"Transl. Psychiatry"},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0200","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0304-3940(96)12348-X","article-title":"Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study","volume":"204","author":"Helkala","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2026.107292_bb0205","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ana.27267","article-title":"Longitudinal analysis of Neuroradiological biomarkers for fragile X-associated tremor\/Ataxia syndrome and implications for clinical trials","volume":"98","author":"Hessl","year":"2025","journal-title":"Ann. Neurol"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0210","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1471-4159.2004.03007.x","article-title":"Multiple pathways of apolipoprotein E signaling in primary neurons","volume":"93","author":"Hoe","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2026.107292_bb0215","first-page":"1","article-title":"The R package geepack for generalized estimating equations","volume":"15","author":"H\u00f8jsgaard","year":"2006","journal-title":"J. Stat. Softw."},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0220","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006312","article-title":"Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease","volume":"2","author":"Holtzman","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.nbd.2026.107292_bb0225","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2014.08.025","article-title":"Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer\u2019s diseases","volume":"72 Pt A","author":"Huang","year":"2014","journal-title":"Neurobiol. Dis."},{"issue":"37","key":"10.1016\/j.nbd.2026.107292_bb0230","doi-asserted-by":"crossref","first-page":"7408","DOI":"10.1523\/JNEUROSCI.2994-18.2019","article-title":"Differential signaling mediated by ApoE2, ApoE3, and ApoE4 in human neurons parallels Alzheimer\u2019s disease risk","volume":"39","author":"Huang","year":"2019","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0235","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-14183-0","article-title":"Both cis and trans-acting genetic factors drive somatic instability in female carriers of the FMR1 premutation","volume":"12","author":"Hwang","year":"2022","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.nbd.2026.107292_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027415","article-title":"The association of APOE genotype with cognitive function in persons aged 35 years or older","volume":"6","author":"Izaks","year":"2011","journal-title":"PloS One"},{"issue":"8","key":"10.1016\/j.nbd.2026.107292_bb0245","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41582-024-00988-2","article-title":"Multifaceted roles of APOE in Alzheimer disease","volume":"20","author":"Jackson","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.nbd.2026.107292_bb0250","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1086\/374321","article-title":"Fragile X premutation tremor\/ataxia syndrome: molecular, clinical, and neuroimaging correlates","volume":"72","author":"Jacquemont","year":"2003","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.nbd.2026.107292_bb0255","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1352\/0895-8017(2004)109<154:AIIWTF>2.0.CO;2","article-title":"Aging in individuals with the FMR1 mutation","volume":"109","author":"Jacquemont","year":"2004","journal-title":"Am. J. Ment. Retard."},{"issue":"50","key":"10.1016\/j.nbd.2026.107292_bb0260","doi-asserted-by":"crossref","first-page":"18227","DOI":"10.1523\/JNEUROSCI.3266-12.2012","article-title":"Apolipoprotein E, not fibrillar \u03b2-amyloid, reduces cerebral glucose metabolism in normal aging","volume":"32","author":"Jagust","year":"2012","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.nbd.2026.107292_bb0265","doi-asserted-by":"crossref","first-page":"445","DOI":"10.31887\/DCNS.2013.15.4\/hjahn","article-title":"Memory loss in Alzheimer\u2019s disease","volume":"15","author":"Jahn","year":"2013","journal-title":"Dialogues Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2026.107292_bb0270","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10048-010-0270-5","article-title":"New clinical findings in the fragile X-associated tremor ataxia syndrome (FXTAS)","volume":"12","author":"Juncos","year":"2011","journal-title":"Neurogenetics"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0275","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41598-018-36450-9","article-title":"The effect of apolipoprotein E polymorphism on serum metabolome\u2013a population-based 10-year follow-up study","volume":"9","author":"Karjalainen","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0280","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuron.2009.06.026","article-title":"The role of apolipoprotein E in Alzheimer\u2019s disease","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.nbd.2026.107292_bb0285","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.neurobiolaging.2014.03.006","article-title":"18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons","volume":"35","author":"Knopman","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"6","key":"10.1016\/j.nbd.2026.107292_bb0290","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/hmg\/ddy410","article-title":"Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor\/ataxia syndrome","volume":"28","author":"Kong","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2026.107292_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest package: tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J. Stat. Softw."},{"issue":"8","key":"10.1016\/j.nbd.2026.107292_bb0300","doi-asserted-by":"crossref","first-page":"830","DOI":"10.2310\/JIM.0b013e3181af59c4","article-title":"Fragile X-associated tremor\/ataxia syndrome: clinical phenotype, diagnosis, and treatment","volume":"57","author":"Leehey","year":"2009","journal-title":"J. Invest. Med."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0305","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0306-4522(95)00014-A","article-title":"Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes","volume":"67","author":"Lehtovirta","year":"1995","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0310","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13024-020-00413-4","article-title":"APOE2: protective mechanism and therapeutic implications for Alzheimer\u2019s disease","volume":"15","author":"Li","year":"2020","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0315","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","article-title":"Longitudinal data analysis using generalized linear models","volume":"73","author":"Liang","year":"1986","journal-title":"Biometrika"},{"issue":"4","key":"10.1016\/j.nbd.2026.107292_bb0320","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3233\/JAD-170072","article-title":"Effect of APOE genotype on amyloid deposition, brain volume, and memory in cognitively normal older individuals","volume":"58","author":"Lim","year":"2017","journal-title":"J. Alzheimer\u2019s Dis"},{"issue":"2","key":"10.1016\/j.nbd.2026.107292_bb0325","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0330","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/humu.22177","article-title":"Somatic expansion in mouse and human carriers of fragile X premutation alleles","volume":"34","author":"Lokanga","year":"2013","journal-title":"Hum. Mutat."},{"issue":"5","key":"10.1016\/j.nbd.2026.107292_bb0335","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1007\/s11682-019-00069-9","article-title":"Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity","volume":"14","author":"Lyall","year":"2020","journal-title":"Brain Imaging Behav."},{"issue":"Suppl","key":"10.1016\/j.nbd.2026.107292_bb0340","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1194\/jlr.R800069-JLR200","article-title":"Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer\u2019s disease to AIDS","volume":"50 Suppl","author":"Mahley","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.nbd.2026.107292_bb0345","doi-asserted-by":"crossref","DOI":"10.3389\/fninf.2022.862805","article-title":"vol2Brain: a new online pipeline for whole brain MRI analysis","volume":"16","author":"Manj\u00f3n","year":"2022","journal-title":"Front. Neuroinform."},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0350","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"issue":"12","key":"10.1016\/j.nbd.2026.107292_bb0355","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001242","article-title":"Continuous and periodic expansion of CAG repeats in Huntington\u2019s disease R6\/1 mice","volume":"6","author":"M\u00f8llersen","year":"2010","journal-title":"PLoS Genet."},{"issue":"12","key":"10.1016\/j.nbd.2026.107292_bb0360","doi-asserted-by":"crossref","DOI":"10.3390\/genes15121509","article-title":"Is the relationship between cardiovascular disease and Alzheimer\u2019s disease genetic? A scoping review","volume":"15","author":"Moore","year":"2024","journal-title":"Genes (Basel)"},{"issue":"5160","key":"10.1016\/j.nbd.2026.107292_bb0365","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.8171342","article-title":"Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro","volume":"264","author":"Nathan","year":"1994","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.nbd.2026.107292_bb0370","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1001\/jamaneurol.2017.2188","article-title":"Apolipoprotein E genotype and sex risk factors for Alzheimer disease: a meta-analysis","volume":"74","author":"Neu","year":"2017","journal-title":"JAMA Neurol."},{"issue":"6","key":"10.1016\/j.nbd.2026.107292_bb0375","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1007\/s12311-015-0659-7","article-title":"Characterization and early detection of balance deficits in fragile X premutation carriers with and without fragile X-associated tremor\/ataxia syndrome (FXTAS)","volume":"14","author":"O\u2019Keefe","year":"2015","journal-title":"Cerebellum"},{"key":"10.1016\/j.nbd.2026.107292_bb0380","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.gaitpost.2018.09.005","article-title":"Cognitive function impacts gait, functional mobility and falls in fragile X-associated tremor\/ataxia syndrome","volume":"66","author":"O\u2019Keefe","year":"2018","journal-title":"Gait Posture"},{"issue":"693","key":"10.1016\/j.nbd.2026.107292_bb0385","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ade6285","article-title":"Sleep deprivation exacerbates microglial reactivity and A\u03b2 deposition in a TREM2-dependent manner in mice","volume":"15","author":"Parhizkar","year":"2023","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0390","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.neuroimage.2010.12.081","article-title":"APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer\u2019s disease","volume":"55","author":"Pievani","year":"2011","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0395","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0005-2760(87)90295-5","article-title":"Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins","volume":"917","author":"Pitas","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2026.107292_bb0400","series-title":"R: A Language and Environment for Statistical Computing","year":"2023"},{"key":"10.1016\/j.nbd.2026.107292_bb0405","series-title":"R: A Language and Environment for Statistical Computing","year":"2025"},{"issue":"4","key":"10.1016\/j.nbd.2026.107292_bb0410","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/jgs.15727","article-title":"Apolipoprotein E genotypes, age, race, and cognitive decline in a population sample","volume":"67","author":"Rajan","year":"2019","journal-title":"J. Am. Geriatr. Soc."},{"issue":"5","key":"10.1016\/j.nbd.2026.107292_bb0415","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3174\/ajnr.A4169","article-title":"Memory part 2: the role of the medial temporal lobe","volume":"36","author":"Raslau","year":"2015","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0420","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13024-022-00574-4","article-title":"ApoE in Alzheimer\u2019s disease: pathophysiology and therapeutic strategies","volume":"17","author":"Raulin","year":"2022","journal-title":"Mol. Neurodegener."},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0425","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1037\/neu0000501","article-title":"Effects of APOE on cognitive aging in community-dwelling older adults","volume":"33","author":"Reas","year":"2019","journal-title":"Neuropsychology"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0430","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13195-023-01380-w","article-title":"Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status","volume":"16","author":"Reas","year":"2024","journal-title":"Alzheimer\u2019s Res. Ther."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0435","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41467-019-14279-8","article-title":"Exceptionally low likelihood of Alzheimer\u2019s dementia in APOE2 homozygotes from a 5,000-person neuropathological study","volume":"11","author":"Reiman","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107292_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101849","article-title":"Automated segmentation of changes in FLAIR-hyperintense white matter lesions in multiple sclerosis on serial magnetic resonance imaging","volume":"23","author":"Schmidt","year":"2019","journal-title":"NeuroImage Clin."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0445","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029848","article-title":"Genetic signatures of exceptional longevity in humans","volume":"7","author":"Sebastiani","year":"2012","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.nbd.2026.107292_bb0450","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/ajmg.b.30732","article-title":"Dementia in fragile X-associated tremor\/ataxia syndrome (FXTAS): comparison with Alzheimer\u2019s disease","volume":"147b","author":"Seritan","year":"2008","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"5","key":"10.1016\/j.nbd.2026.107292_bb0455","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/ana.24628","article-title":"APOE2 eases cognitive decline during aging: clinical and preclinical evaluations","volume":"79","author":"Shinohara","year":"2016","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0460","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/13854046.2015.1007169","article-title":"Factor structure and construct validity of the behavioral dyscontrol scale-II","volume":"29","author":"Shura","year":"2015","journal-title":"Clin. Neuropsychol."},{"issue":"8","key":"10.1016\/j.nbd.2026.107292_bb0465","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/gim.2013.12","article-title":"High apolipoprotein E4 allele frequency in FXTAS patients","volume":"15","author":"Silva","year":"2013","journal-title":"Genet. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.nbd.2026.107292_bb0470","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0475","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2119\/molmed.2016.00122","article-title":"Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor\/ataxia syndrome: use of antioxidants in precision medicine","volume":"22","author":"Song","year":"2016","journal-title":"Mol. Med."},{"key":"10.1016\/j.nbd.2026.107292_bb0480","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.neuro.27.070203.144130","article-title":"The medial temporal lobe","volume":"27","author":"Squire","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.nbd.2026.107292_bb0485","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1016\/j.neurobiolaging.2015.06.024","article-title":"Total MRI load of cerebral small vessel disease and cognitive ability in older people","volume":"36","author":"Staals","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0490","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/(SICI)1096-8628(19990528)84:3<250::AID-AJMG17>3.0.CO;2-4","article-title":"FMRP expression as a potential prognostic indicator in fragile X syndrome","volume":"84","author":"Tassone","year":"1999","journal-title":"Am. J. Med. Genet."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0495","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1086\/302720","article-title":"Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome","volume":"66","author":"Tassone","year":"2000","journal-title":"Am. J. Hum. Genet."},{"issue":"7","key":"10.1016\/j.nbd.2026.107292_bb0500","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/jmg.38.7.453","article-title":"A majority of fragile X males with methylated, full mutation alleles have significant levels of FMR1 messenger RNA","volume":"38","author":"Tassone","year":"2001","journal-title":"J. Med. Genet."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0505","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2353\/jmoldx.2008.070073","article-title":"A rapid polymerase chain reaction-based screening method for identification of all expanded alleles of the fragile X (FMR1) gene in newborn and high-risk populations","volume":"10","author":"Tassone","year":"2008","journal-title":"J. Mol. Diagn."},{"issue":"18","key":"10.1016\/j.nbd.2026.107292_bb0510","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.3390\/cells12182330","article-title":"Insight and recommendations for fragile X-premutation-associated conditions from the fifth international conference on FMR1 premutation","volume":"12","author":"Tassone","year":"2023","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0515","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1037\/h0061266","article-title":"The Purdue Pegboard: norms and studies of reliability and validity","volume":"32","author":"Tiffin","year":"1948","journal-title":"J. Appl. Psychol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0520","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa219","article-title":"The human hippocampus and its subfield volumes across age, sex and APOE e4 status","volume":"3","author":"Veldsman","year":"2021","journal-title":"Brain Commun."},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0525","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/ana.21953","article-title":"Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease","volume":"67","author":"Vemuri","year":"2010","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0530","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tins.2019.11.002","article-title":"Neocortex-cerebellum circuits for cognitive processing","volume":"43","author":"Wagner","year":"2020","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2026.107292_bb0535","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.nbd.2004.10.013","article-title":"Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology","volume":"18","author":"Wang","year":"2005","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.nbd.2026.107292_bb0540","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2011.01.006","article-title":"A learning-based wrapper method to correct systematic errors in automatic image segmentation: consistently improved performance in hippocampus, cortex and brain segmentation","volume":"55","author":"Wang","year":"2011","journal-title":"Neuroimage"},{"issue":"8","key":"10.1016\/j.nbd.2026.107292_bb0545","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2013.2934","article-title":"Fragile X\u2013associated tremor\/ataxia syndrome: influence of the fmr1 gene on motor fiber tracts in males with normal and premutation alleles","volume":"70","author":"Wang","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nbd.2026.107292_bb0550","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2017.03.018","article-title":"Abnormal trajectories in cerebellum and brainstem volumes in carriers of the fragile X premutation","volume":"55","author":"Wang","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2026.107292_bb0555","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neurobiolaging.2019.09.009","article-title":"Interaction between ventricular expansion and structural changes in the corpus callosum and putamen in males with FMR1 normal and premutation alleles","volume":"86","author":"Wang","year":"2020","journal-title":"Neurobiol. Aging"},{"issue":"17","key":"10.1016\/j.nbd.2026.107292_bb0560","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179171","article-title":"Brain atrophy and white matter damage linked to peripheral bioenergetic deficits in the neurodegenerative disease FXTAS","volume":"22","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2026.107292_bb0565","article-title":"Clinical and molecular correlates of abnormal changes in the cerebellum and globus pallidus in fragile X Premutation","volume":"13-2022","author":"Wang","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nbd.2026.107292_bb0570","series-title":"Wechsler Adult Intelligence Scale","author":"Wechsler","year":"1997"},{"key":"10.1016\/j.nbd.2026.107292_bb0575","series-title":"Wechsler Adult Intelligence Scale-Fourth","author":"Wechsler","year":"2008"},{"key":"10.1016\/j.nbd.2026.107292_bb0580","series-title":"Wechsler Abbreviated Scale of Intelligence, Second Edition (WASI-II)","year":"2011"},{"issue":"18","key":"10.1016\/j.nbd.2026.107292_bb0585","doi-asserted-by":"crossref","first-page":"12029","DOI":"10.1016\/S0021-9258(18)99060-5","article-title":"Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma. Impact on receptor binding activity","volume":"266","author":"Weisgraber","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0590","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-98117-2","article-title":"Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults","volume":"11","author":"Weiss","year":"2021","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.nbd.2026.107292_bb0595","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25158103","article-title":"Apolipoproteine and KLOTHO gene variants do not affect the penetrance of fragile X-associated tremor\/ataxia syndrome","volume":"25","author":"Winarni","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"22","key":"10.1016\/j.nbd.2026.107292_bb0600","doi-asserted-by":"crossref","first-page":"10256","DOI":"10.1073\/pnas.1001412107","article-title":"Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer\u2019s disease","volume":"107","author":"Wolk","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"9","key":"10.1016\/j.nbd.2026.107292_bb0605","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41582-019-0228-7","article-title":"Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies","volume":"15","author":"Yamazaki","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"8","key":"10.1016\/j.nbd.2026.107292_bb0610","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tem.2023.05.002","article-title":"Apolipoprotein E in lipid metabolism and neurodegenerative disease","volume":"34","author":"Yang","year":"2023","journal-title":"Trends Endocrinol. Metab."},{"issue":"45","key":"10.1016\/j.nbd.2026.107292_bb0615","doi-asserted-by":"crossref","first-page":"8406","DOI":"10.1523\/JNEUROSCI.1535-22.2022","article-title":"Cerebellar contributions to the basal ganglia influence motor coordination, reward processing, and movement vigor","volume":"42","author":"Yoshida","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107292_bb0620","first-page":"3342","article-title":"ITK-SNAP: an interactive tool for semi-automatic segmentation of multi-modality biomedical images","author":"Yushkevich","year":"2016","journal-title":"IEEE"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0625","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67946-y","article-title":"FMR1 locus isoforms: potential biomarker candidates in fragile X-associated tremor\/ataxia syndrome (FXTAS)","volume":"10","author":"Zafarullah","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0630","article-title":"Novel loci and pathways significantly associated with longevity","volume":"6","author":"Zeng","year":"2016","journal-title":"Sci. Rep."},{"issue":"24","key":"10.1016\/j.nbd.2026.107292_bb0635","first-page":"7087","article-title":"Muts\u03b2 generates both expansions and contractions in a mouse model of the fragile X-associated disorders","volume":"24","author":"Zhao","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.nbd.2026.107292_bb0640","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.neuron.2020.02.034","article-title":"Alzheimer\u2019s risk factors age, APOE genotype, and sex drive distinct molecular pathways","volume":"106","author":"Zhao","year":"2020","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.nbd.2026.107292_bb0645","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13229-016-0105-9","article-title":"CGG-repeat dynamics and FMR1 gene silencing in fragile X syndrome stem cells and stem cell-derived neurons","volume":"7","author":"Zhou","year":"2016","journal-title":"Mol. Autism."}],"updated-by":[{"DOI":"10.1016\/j.nbd.2026.107448","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000}},{"DOI":"10.1016\/j.nbd.2026.107448","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000}}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126000367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126000367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T20:36:45Z","timestamp":1780864605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996126000367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":130,"alternative-id":["S0969996126000367"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107292","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The apolipoprotein gene: a modulating role on brain volume and cognitive function in carriers of the fragile X premutation","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107292","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107292"}}