{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:13:42Z","timestamp":1781180022403,"version":"3.54.1"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001673","name":"J\u00e9r\u00f4me Lejeune Foundation","doi-asserted-by":"publisher","award":["PNRR\\u2013 M4 C2 I1.1 -PRIN 2022CZTZ87- CUP F53D23006660006"],"award-info":[{"award-number":["PNRR\\u2013 M4 C2 I1.1 -PRIN 2022CZTZ87- CUP F53D23006660006"]}],"id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001673","name":"J\u00e9r\u00f4me Lejeune Foundation","doi-asserted-by":"publisher","award":["2209 - GRT-2023 A"],"award-info":[{"award-number":["2209 - GRT-2023 A"]}],"id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.nbd.2026.107304","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T07:59:49Z","timestamp":1770191989000},"page":"107304","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Hippocampal glial alterations are associated with Lamin B1 dysregulation and abnormal nuclear morphology in a rat model of fragile X syndrome"],"prefix":"10.1016","volume":"220","author":[{"given":"Alessandro","family":"Rava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Feo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bagnato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"D\u2019Oria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pezzullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Petrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Buzzelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Ascone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Di Trapano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Peruzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Trezza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.nbd.2026.107304_bb0005","doi-asserted-by":"crossref","first-page":"6566","DOI":"10.1007\/s12035-019-1541-2","article-title":"Cellular and molecular differences between area CA1 and the dentate gyrus of the Hippocampus","volume":"56","author":"Alkadhi","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"6411","key":"10.1016\/j.nbd.2026.107304_bb0010","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.aat0473","article-title":"Glia as architects of central nervous system formation and function","volume":"362","author":"Allen","year":"2018","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0015","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bbi.2010.08.003","article-title":"Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome","volume":"25","author":"Ashwood","year":"2011","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.nbd.2026.107304_bb0020","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.neuron.2019.02.041","article-title":"A synaptic perspective of fragile X syndrome and autism Spectrum disorders","volume":"101","author":"Bagni","year":"2019","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0025","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/glia.23508","article-title":"Microglia shape presynaptic properties at developing glutamatergic synapses","volume":"67","author":"Basilico","year":"2019","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.nbd.2026.107304_bb0030","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105819","article-title":"Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis","volume":"40","author":"Bedrosian","year":"2021","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.nbd.2026.107304_bb0035","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nrd.2017.221","article-title":"Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome","volume":"17","author":"Berry-Kravis","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.nbd.2026.107304_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114124","article-title":"Selective vulnerability of the ventral hippocampus-prelimbic cortex axis parvalbumin interneuron network underlies learning deficits of fragile X mice","volume":"43","author":"Bhandari","year":"2024","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.nbd.2026.107304_bb0045","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/jmg.2008.061796","article-title":"Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model","volume":"46","author":"Bilousova","year":"2009","journal-title":"J. Med. Genet."},{"issue":"9","key":"10.1016\/j.nbd.2026.107304_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci14090892","article-title":"A two-hit approach inducing flurothyl seizures in Fmr1 knockout mice impacts anxiety and repetitive Behaviors","volume":"14","author":"Blandin","year":"2024","journal-title":"Brain Sci."},{"key":"10.1016\/j.nbd.2026.107304_bb0055","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.neubiorev.2016.06.033","article-title":"Hippocampal dysfunction and cognitive impairment in fragile-X syndrome","volume":"68","author":"Bostrom","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6","key":"10.1016\/j.nbd.2026.107304_bb0060","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s004180050138","article-title":"A- and B-type lamins are differentially expressed in normal human tissues","volume":"107","author":"Broers","year":"1997","journal-title":"Histochem. Cell Biol."},{"issue":"19","key":"10.1016\/j.nbd.2026.107304_bb0065","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.1111\/bph.15211","article-title":"Hypersensitivity to amphetamine\u2019s psychomotor and reinforcing effects in serotonin transporter knockout rats: glutamate in the nucleus accumbens","volume":"177","author":"Caffino","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.nbd.2026.107304_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043920","article-title":"Maternal immune activation induced by prenatal lipopolysaccharide exposure leads to Long-lasting autistic-like social, cognitive and immune alterations in male Wistar rats","volume":"24","author":"Carbone","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2026.107304_bb0075","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.biomaterials.2015.07.017","article-title":"Cell shape dependent regulation of nuclear morphology","volume":"67","author":"Chen","year":"2015","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0080","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/glia.24091","article-title":"Increasing astrogenesis in the developing hippocampus induces autistic-like behavior in mice via enhancing inhibitory synaptic transmission","volume":"70","author":"Chen","year":"2022","journal-title":"Glia"},{"issue":"7","key":"10.1016\/j.nbd.2026.107304_bb0085","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/jdn.10217","article-title":"Cerebellum neuropathology and motor skill deficits in fragile X syndrome","volume":"82","author":"Chen","year":"2022","journal-title":"Int. J. Dev. Neurosci."},{"issue":"4","key":"10.1016\/j.nbd.2026.107304_bb0090","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.celrep.2017.12.092","article-title":"Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson\u2019s disease","volume":"22","author":"Chinta","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2026.107304_bb0095","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia function in the central nervous system during health and neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.nbd.2026.107304_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2024.105731","article-title":"Role of fragile X messenger ribonucleoprotein 1 in the pathophysiology of brain disorders: a glia perspective","volume":"162","author":"D\u2019Antoni","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"5","key":"10.1016\/j.nbd.2026.107304_bb0105","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.immuni.2025.04.009","article-title":"Microglia transcriptional states and their functional significance: context drives diversity","volume":"58","author":"Depp","year":"2025","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.nbd.2026.107304_bb0110","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.biocel.2012.01.023","article-title":"MMP9: a novel function in synaptic plasticity","volume":"44","author":"Dziembowska","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.nbd.2026.107304_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/genes16020149","article-title":"Systematic review: fragile X syndrome across the lifespan with a focus on genetics, neurodevelopmental, Behavioral and psychiatric associations","volume":"16","author":"Genovese","year":"2025","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.nbd.2026.107304_bb0120","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainres.2014.11.023","article-title":"Expression of fragile X mental retardation protein in neurons and glia of the developing and adult mouse brain","volume":"1596","author":"Gholizadeh","year":"2015","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13024-025-00810-7","article-title":"Mechanisms of astrocyte aging in reactivity and disease","volume":"20","author":"Gildea","year":"2025","journal-title":"Mol. Neurodegener."},{"issue":"5","key":"10.1016\/j.nbd.2026.107304_bb0130","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1093\/cercor\/bhz029","article-title":"Deletion of the KH1 domain of Fmr1 leads to transcriptional alterations and attentional deficits in rats","volume":"29","author":"Golden","year":"2019","journal-title":"Cereb. Cortex"},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0135","doi-asserted-by":"crossref","first-page":"18196","DOI":"10.1038\/s41598-022-23091-2","article-title":"Comparisons of quantitative approaches for assessing microglial morphology reveal inconsistencies, ecological fallacy, and a need for standardization","volume":"12","author":"Green","year":"2022","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.nbd.2026.107304_bb0140","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500775","article-title":"Structural-functional connectivity deficits of neocortical circuits in the Fmr1 (\u2212\/y) mouse model of autism","volume":"1","author":"Haberl","year":"2015","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.nbd.2026.107304_bb0145","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1172\/JCI66737","article-title":"Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model","volume":"123","author":"Heng","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"27","key":"10.1016\/j.nbd.2026.107304_bb0150","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1523\/JNEUROSCI.1069-16.2016","article-title":"Selective deletion of Astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to fragile X syndrome phenotypes in vivo","volume":"36","author":"Higashimori","year":"2016","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.nbd.2026.107304_bb0155","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.biopsych.2016.08.036","article-title":"Astrocytic Contributions to synaptic and learning abnormalities in a mouse model of fragile X syndrome","volume":"82","author":"Hodges","year":"2017","journal-title":"Biol. Psychiatry"},{"issue":"18","key":"10.1016\/j.nbd.2026.107304_bb0160","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1097\/WNR.0000000000000905","article-title":"Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-alpha expression","volume":"28","author":"Hodges","year":"2017","journal-title":"Neuroreport"},{"key":"10.1016\/j.nbd.2026.107304_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2019.112776","article-title":"Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of fragile X syndrome","volume":"215","author":"Hodges","year":"2020","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.nbd.2026.107304_bb0170","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3389\/fgene.2019.00249","article-title":"The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS","volume":"10","author":"Hoem","year":"2019","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0175","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13229-025-00648-2","article-title":"Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice","volume":"16","author":"Hooshmandi","year":"2025","journal-title":"Mol. Autism."},{"key":"10.1016\/j.nbd.2026.107304_bb0180","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2022.12.001","article-title":"Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)","volume":"108","author":"Hughes","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(98)00040-0","article-title":"Microglia-specific localisation of a novel calcium binding protein, Iba1","volume":"57","author":"Ito","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"4","key":"10.1016\/j.nbd.2026.107304_bb0190","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/glia.23284","article-title":"Alterations in CA1 hippocampal synapses in a mouse model of fragile X syndrome","volume":"66","author":"Jawaid","year":"2018","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.nbd.2026.107304_bb0195","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/glia.23915","article-title":"Astroglial FMRP modulates synaptic signaling and behavior phenotypes in FXS mouse model","volume":"69","author":"Jin","year":"2021","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13229-022-00509-2","article-title":"Deletion of Fmr1 in parvalbumin-expressing neurons results in dysregulated translation and selective behavioral deficits associated with fragile X syndrome","volume":"13","author":"Kalinowska","year":"2022","journal-title":"Mol. Autism."},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0205","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0925-4927(97)00019-X","article-title":"Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome","volume":"75","author":"Kates","year":"1997","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.nbd.2026.107304_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2023.102257","article-title":"The impact of altered Lamin B1 levels on nuclear lamina structure and function in aging and human diseases","volume":"85","author":"Kim","year":"2023","journal-title":"Curr. Opin. Cell Biol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0215","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-71328-z","article-title":"Effectiveness of remote ischaemic conditioning is not affected by hyper-inflammation in a rat model of stroke","volume":"14","author":"Koncekova","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2026.107304_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1263310","article-title":"Lamin B1 as a key modulator of the developing and aging brain","volume":"17","author":"Koufi","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2026.107304_bb0225","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbi.2017.01.019","article-title":"Developmental microglial priming in postmortem autism spectrum disorder temporal cortex","volume":"62","author":"Lee","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0230","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13041-019-0478-8","article-title":"Altered cortical cytoarchitecture in the Fmr1 knockout mouse","volume":"12","author":"Lee","year":"2019","journal-title":"Mol. Brain"},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0235","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tcb.2017.08.004","article-title":"Nuclear Lamins: thin filaments with major functions","volume":"28","author":"de Leeuw","year":"2018","journal-title":"Trends Cell Biol."},{"issue":"9","key":"10.1016\/j.nbd.2026.107304_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/cells10092236","article-title":"Beyond activation: characterizing microglial functional phenotypes","volume":"10","author":"Lier","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.nbd.2026.107304_bb0245","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41420-020-0256-5","article-title":"The nuclear envelope: target and mediator of the apoptotic process","volume":"6","author":"Lindenboim","year":"2020","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.nbd.2026.107304_bb0250","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.nbd.2026.107304_bb0255","article-title":"Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder","volume":"15","author":"Long","year":"2024","journal-title":"Front. Psychol."},{"issue":"10","key":"10.1016\/j.nbd.2026.107304_bb0260","first-page":"3599","article-title":"Astrocytes and microglia in the coordination of CNS development and homeostasis","volume":"168","author":"Lopez-Ortiz","year":"2024","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0265","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1038\/s41598-017-05078-6","article-title":"Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis","volume":"7","author":"Mahajani","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2026.107304_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107176","article-title":"Cannabidiol and positive effects on object recognition memory in an in vivo model of fragile X syndrome: obligatory role of hippocampal GPR55 receptors","volume":"203","author":"Manduca","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0275","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13521","article-title":"Loss of Lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus","volume":"21","author":"Matias","year":"2022","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.nbd.2026.107304_bb0280","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.nbd.2026.107304_bb0285","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuropsychologia.2014.01.001","article-title":"Bigger is better and worse: on the intricate relationship between hippocampal size and memory","volume":"56","author":"Molnar","year":"2014","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.nbd.2026.107304_bb0290","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/bs.irn.2023.08.005","article-title":"Glial-mediated dysregulation of neurodevelopment in fragile X syndrome","volume":"173","author":"Napier","year":"2023","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.nbd.2026.107304_bb0295","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neures.2021.05.011","article-title":"Decreased Lamin B1 levels affect gene positioning and expression in postmitotic neurons","volume":"173","author":"Noguchi","year":"2021","journal-title":"Neurosci. Res."},{"issue":"15","key":"10.1016\/j.nbd.2026.107304_bb0300","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/glia.20573","article-title":"Developmental expression of FMRP in the astrocyte lineage: implications for fragile X syndrome","volume":"55","author":"Pacey","year":"2007","journal-title":"Glia"},{"issue":"10","key":"10.1016\/j.nbd.2026.107304_bb0305","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.400","article-title":"Persistent astrocyte activation in the fragile X mouse cerebellum","volume":"5","author":"Pacey","year":"2015","journal-title":"Brain Behav."},{"issue":"21","key":"10.1016\/j.nbd.2026.107304_bb0310","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: a field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"issue":"11","key":"10.1016\/j.nbd.2026.107304_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103293","article-title":"Altered inflammatory response in FMRP-deficient microglia","volume":"24","author":"Parrott","year":"2021","journal-title":"iScience"},{"issue":"7","key":"10.1016\/j.nbd.2026.107304_bib466","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS. Biol."},{"key":"10.1016\/j.nbd.2026.107304_bb0320","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.psyneuen.2014.07.002","article-title":"Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-ko mice","volume":"49","author":"Pietropaolo","year":"2014","journal-title":"Psychoneuroendocrinology"},{"issue":"10","key":"10.1016\/j.nbd.2026.107304_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102566","article-title":"Lamin B1 accumulation\u2019s effects on autosomal dominant leukodystrophy (ADLD): induction of reactivity in the astrocytes","volume":"10","author":"Ratti","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.nbd.2026.107304_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2024.111234","article-title":"Role of peroxisome proliferator-activated receptors alpha and gamma in mediating the beneficial effects of beta-caryophyllene in a rat model of fragile X syndrome","volume":"136","author":"Rava","year":"2025","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"34","key":"10.1016\/j.nbd.2026.107304_bb0335","doi-asserted-by":"crossref","first-page":"12002","DOI":"10.1523\/JNEUROSCI.1668-15.2015","article-title":"Defects of lipid synthesis are linked to the age-dependent demyelination caused by Lamin B1 overexpression","volume":"35","author":"Rolyan","year":"2015","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2026.107304_bb0340","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0264-17.2017","article-title":"Developmental emergence of phenotypes in the auditory brainstem nuclei of Fmr1 knockout mice","volume":"4","author":"Rotschafer","year":"2017","journal-title":"eNeuro"},{"issue":"11","key":"10.1016\/j.nbd.2026.107304_bb0345","doi-asserted-by":"crossref","first-page":"9306","DOI":"10.3390\/cimb45110582","article-title":"Hippocampal upregulation of complement component C3 in response to lipopolysaccharide stimuli in a model of fragile-X syndrome","volume":"45","author":"Santana-Coelho","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.nbd.2026.107304_bb0350","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46919","article-title":"FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory","volume":"8","author":"Sawicka","year":"2019","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.nbd.2026.107304_bb0355","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1080\/1028415X.2020.1819107","article-title":"Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats","volume":"25","author":"Schiavi","year":"2022","journal-title":"Nutr. Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2026.107304_bb0360","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/s41386-022-01454-7","article-title":"Anandamide and 2-arachidonoylglycerol differentially modulate autistic-like traits in a genetic model of autism based on FMR1 deletion in rats","volume":"48","author":"Schiavi","year":"2023","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.nbd.2026.107304_bb0365","doi-asserted-by":"crossref","DOI":"10.3390\/ph11020056","article-title":"Inflammation and neuro-immune dysregulations in autism Spectrum disorders","volume":"11","author":"Siniscalco","year":"2018","journal-title":"Pharmaceuticals (Basel)"},{"issue":"2","key":"10.1016\/j.nbd.2026.107304_bb0370","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00412-016-0614-5","article-title":"Nuclear morphologies: their diversity and functional relevance","volume":"126","author":"Skinner","year":"2017","journal-title":"Chromosoma"},{"key":"10.1016\/j.nbd.2026.107304_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2023.102313","article-title":"Lamins: the backbone of the nucleocytoskeleton interface","volume":"86","author":"Sobo","year":"2024","journal-title":"Curr. Opin. Cell Biol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0380","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jgg.2024.10.005","article-title":"The interplay between histone modifications and nuclear lamina in genome regulation","volume":"52","author":"Sun","year":"2025","journal-title":"J. Genet. Genomics"},{"issue":"6149","key":"10.1016\/j.nbd.2026.107304_bb0385","doi-asserted-by":"crossref","DOI":"10.1126\/science.1240104","article-title":"Nuclear Lamin-a scales with tissue stiffness and enhances matrix-directed differentiation","volume":"341","author":"Swift","year":"2013","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0390","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12929-020-00673-8","article-title":"Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes","volume":"27","author":"Szpirer","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.nbd.2026.107304_bb0395","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ibror.2018.11.001","article-title":"Differential expression of nuclear Lamin subtypes in the neural cells of the adult rat cerebral cortex","volume":"5","author":"Takamori","year":"2018","journal-title":"IBRO Rep."},{"key":"10.1016\/j.nbd.2026.107304_bb0400","article-title":"Astrocytes in fragile X syndrome","volume":"17","author":"Talvio","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2026.107304_bb0405","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3389\/fnmol.2017.00269","article-title":"Loss of FMRP impaired hippocampal Long-term plasticity and spatial learning in rats","volume":"10","author":"Tian","year":"2017","journal-title":"Front. Mol. Neurosci."},{"issue":"21","key":"10.1016\/j.nbd.2026.107304_bb0410","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1093\/hmg\/ddv299","article-title":"Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS","volume":"24","author":"Till","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0415","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41380-018-0036-2","article-title":"The role of adult hippocampal neurogenesis in brain health and disease","volume":"24","author":"Toda","year":"2019","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.nbd.2026.107304_bb0420","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/glia.22287","article-title":"Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices","volume":"60","author":"Tremblay","year":"2012","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0425","doi-asserted-by":"crossref","DOI":"10.1063\/5.0082656","article-title":"Nuclear lamins: structure and function in mechanobiology","volume":"6","author":"Vahabikashi","year":"2022","journal-title":"APL Bioeng"},{"issue":"1","key":"10.1016\/j.nbd.2026.107304_bb0430","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12883-020-01715-2","article-title":"Reduced serum levels of pro-inflammatory chemokines in fragile X syndrome","volume":"20","author":"Van Dijck","year":"2020","journal-title":"BMC Neurol."},{"issue":"4","key":"10.1016\/j.nbd.2026.107304_bb0435","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1167\/iovs.66.4.45","article-title":"The influence of changes in microglia development on the plasticity of the developing visual cortex circuit in juvenile mice","volume":"66","author":"Wang","year":"2025","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.nbd.2026.107304_bb0440","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049485","article-title":"Mouse models of fragile X-related disorders","volume":"16","author":"Willemsen","year":"2023","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.nbd.2026.107304_bb0445","article-title":"Quantifying microglia morphology from photomicrographs of immunohistochemistry prepared tissue using ImageJ","volume":"136","author":"Young","year":"2018","journal-title":"J Vis Exp"},{"issue":"3","key":"10.1016\/j.nbd.2026.107304_bb0450","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/ene.14146","article-title":"The phenotypical implications of immune dysregulation in fragile X syndrome","volume":"27","author":"Yu","year":"2020","journal-title":"Eur. J. Neurol."},{"issue":"11","key":"10.1016\/j.nbd.2026.107304_bb0455","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.bbadis.2010.06.015","article-title":"Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of fragile X syndrome","volume":"1802","author":"Yuskaitis","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.nbd.2026.107304_bb0460","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1152\/jn.90558.2008","article-title":"Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models","volume":"101","author":"Zhang","year":"2009","journal-title":"J. Neurophysiol."},{"issue":"5","key":"10.1016\/j.nbd.2026.107304_bb0465","first-page":"433","article-title":"Differences in innate immune response between man and mouse","volume":"34","author":"Zschaler","year":"2014","journal-title":"Crit. Rev. Immunol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126000483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126000483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T22:01:54Z","timestamp":1778018514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996126000483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":94,"alternative-id":["S0969996126000483"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107304","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hippocampal glial alterations are associated with Lamin B1 dysregulation and abnormal nuclear morphology in a rat model of fragile X syndrome","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107304","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107304"}}