{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:26:19Z","timestamp":1790799979931,"version":"4.1.0"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM134864"],"award-info":[{"award-number":["R35 GM134864"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM134864"],"award-info":[{"award-number":["R35 GM134864"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2210963"],"award-info":[{"award-number":["2210963"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.nbd.2026.107309","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T01:02:46Z","timestamp":1770253366000},"page":"107309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers"],"prefix":"10.1016","volume":"220","author":[{"given":"Brianna","family":"Hnath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Ekambaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay V.","family":"Dokholyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.nbd.2026.107309_bb0005","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10571-016-0366-z","article-title":"Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake","volume":"36","author":"Abels","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.nbd.2026.107309_bb0010","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41582-023-00878-z","article-title":"Neuropsychological Impairment in Amyotrophic Lateral Sclerosis\u2013Frontotemporal Spectrum Disorder","volume":"19","author":"Abrahams","year":"2023","journal-title":"Nat. Rev. Neurol."},{"issue":"13","key":"10.1016\/j.nbd.2026.107309_bb0015","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.3390\/cells12131763","article-title":"Recent advances in extracellular vesicles in amyotrophic lateral sclerosis and emergent perspectives","volume":"12","author":"Afonso","year":"2023","journal-title":"Cells"},{"issue":"19","key":"10.1016\/j.nbd.2026.107309_bb0020","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi9156","article-title":"Endocytosis Blocks the Vesicular Secretion of Exosome Marker Proteins","volume":"10","author":"Ai","year":"2024","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.nbd.2026.107309_bb0025","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.3390\/cells10112930","article-title":"Exosomes in ageing and motor neurone disease: biogenesis, uptake mechanisms, modifications in disease and uses in the development of biomarkers and therapeutics","volume":"10","author":"Anakor","year":"2021","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.nbd.2026.107309_bb0030","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3390\/cells11050845","article-title":"The neurotoxicity of vesicles secreted by ALS patient myotubes is specific to exosome-like and not larger subtypes","volume":"11","author":"Anakor","year":"2022","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.nbd.2026.107309_bb0035","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/S1535-9476(20)35048-9","article-title":"Session 5: functional proteomics I","volume":"3","author":"Anders","year":"2004","journal-title":"Mol. Cell. Proteomics"},{"issue":"2","key":"10.1016\/j.nbd.2026.107309_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149272","article-title":"Microparticle-induced activation of the vascular endothelium requires Caveolin-1\/caveolae","volume":"11","author":"Andrews","year":"2016","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.nbd.2026.107309_bb0045","doi-asserted-by":"crossref","first-page":"a007526","DOI":"10.1101\/cshperspect.a007526","article-title":"Protein folding and quality control in the ER","volume":"3","author":"Araki","year":"2011","journal-title":"Cold Spring Harbor perspectives in biology"},{"issue":"August","key":"10.1016\/j.nbd.2026.107309_bb0050","article-title":"Intercellular transmission of pathogenic proteins in ALS: exploring the pathogenic wave","volume":"184","author":"Arnold","year":"2023","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0055","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/jnc.12493","article-title":"Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis","volume":"129","author":"Atkin","year":"2014","journal-title":"J. Neurochem."},{"issue":"9","key":"10.1016\/j.nbd.2026.107309_bb0060","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1021\/acschembio.8b00729","article-title":"Investigation of anti-SOD1 antibodies yields new structural insight into SOD1 misfolding and surprising behavior of the antibodies themselves","volume":"13","author":"Atlasi","year":"2018","journal-title":"ACS Chem. Biol."},{"issue":"5","key":"10.1016\/j.nbd.2026.107309_bb0065","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00401-020-02203-0","article-title":"The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis","volume":"140","author":"Bampton","year":"2020","journal-title":"Acta Neuropathol."},{"issue":"September","key":"10.1016\/j.nbd.2026.107309_bb0070","article-title":"Mechanisms of SOD1 regulation by post-translational modifications","volume":"26","author":"Banks","year":"2019","journal-title":"Redox Biol."},{"issue":"24","key":"10.1016\/j.nbd.2026.107309_bb0075","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.3390\/cells12242819","article-title":"Age-related alternative splicing: driver or passenger in the aging process?","volume":"12","author":"Baralle","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0080","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-016-0111-6","article-title":"Stathmin 1\/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons","volume":"11","author":"Bellouze","year":"2016","journal-title":"Mol. Neurodegener."},{"issue":"3","key":"10.1016\/j.nbd.2026.107309_bb0085","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000213341","article-title":"What are the functions of caveolins and their role in neurologic disorders?","volume":"104","author":"Benarroch","year":"2025","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.nbd.2026.107309_bb0090","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0968-0004(94)90205-4","article-title":"Calnexin: a membrane-bound chaperone of the endoplasmic reticulum","volume":"19","author":"Bergeron","year":"1994","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jnc.13033","article-title":"The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer\u2019s disease","volume":"133","author":"Blair","year":"2015","journal-title":"J. Neurochem."},{"issue":"January","key":"10.1016\/j.nbd.2026.107309_bb0100","article-title":"Mutant VAPB: culprit or innocent bystander of amyotrophic lateral sclerosis?","volume":"4","author":"Borgese","year":"2021","journal-title":"Contact"},{"issue":"6","key":"10.1016\/j.nbd.2026.107309_bb0105","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1111\/j.1471-4159.2007.04453.x","article-title":"The synaptic vesicle proteome","volume":"101","author":"Burr\u00e9","year":"2007","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.nbd.2026.107309_bb0110","first-page":"C459","article-title":"Caveolins and Cavins in the trafficking, maturation, and degradation of caveolae: implications for cell physiology","volume":"312","author":"Busija","year":"2017","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0115","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1038\/s41598-018-25137-w","article-title":"Nucleolar-Nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription","volume":"8","author":"B\u00fctepage","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0120","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1703244","article-title":"Inhibiting extracellular vesicles formation and release: a review of EV inhibitors","volume":"9","author":"Catalano","year":"2020","journal-title":"J. Extracell. Vesicles"},{"issue":"4","key":"10.1016\/j.nbd.2026.107309_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001832","article-title":"Endocytic crosstalk: Cavins, caveolins, and caveolae regulate Clathrin-independent endocytosis","volume":"12","author":"Chaudhary","year":"2014","journal-title":"PLoS Biol."},{"issue":"February","key":"10.1016\/j.nbd.2026.107309_bb0130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.sbi.2020.12.002","article-title":"SOD1 oligomers in amyotrophic lateral sclerosis","volume":"66","author":"Choi","year":"2021","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"18","key":"10.1016\/j.nbd.2026.107309_bb0135","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1002\/1878-0261.13285","article-title":"DNA repair as a shared Hallmark in Cancer and ageing","volume":"16","author":"Clarke","year":"2022","journal-title":"Mol. Oncol."},{"issue":"9","key":"10.1016\/j.nbd.2026.107309_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108456","article-title":"Rare variant burden analysis within enhancers identifies CAV1 as an ALS risk gene","volume":"33","author":"Cooper-Knock","year":"2020","journal-title":"Cell Rep."},{"issue":"14","key":"10.1016\/j.nbd.2026.107309_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12144","article-title":"A brief history of nearly EV-erything \u2013 the rise and rise of extracellular vesicles","volume":"10","author":"Couch","year":"2021","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0150","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13000-024-01473-6","article-title":"Cerebrospinal fluid and blood exosomes as biomarkers for amyotrophic lateral sclerosis; a systematic review","volume":"19","author":"Darabi","year":"2024","journal-title":"Diagn. Pathol."},{"issue":"9","key":"10.1016\/j.nbd.2026.107309_bb0155","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.3390\/v13091881","article-title":"How viruses use the VCP\/P97 ATPase molecular machine","volume":"13","author":"Das","year":"2021","journal-title":"Viruses"},{"issue":"January","key":"10.1016\/j.nbd.2026.107309_bb0160","article-title":"Trends in the diagnostic delay and pathway for amyotrophic lateral sclerosis patients across different countries","volume":"13","author":"De Campos","year":"2023","journal-title":"Front. Neurol."},{"issue":"6","key":"10.1016\/j.nbd.2026.107309_bb0165","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3390\/v13061117","article-title":"Role of vesicle-associated membrane protein-associated proteins (VAP) a and VAPB in nuclear egress of the Alphaherpesvirus pseudorabies virus","volume":"13","author":"Dorsch","year":"2021","journal-title":"Viruses"},{"issue":"13","key":"10.1016\/j.nbd.2026.107309_bb0170","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1093\/hmg\/ddu068","article-title":"C9ORF72, implicated in Amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking","volume":"23","author":"Farg","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"10.1016\/j.nbd.2026.107309_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011552","article-title":"Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients","volume":"5","author":"Forsberg","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0180","first-page":"C242","article-title":"Role of Caveolin-1 in the regulation of lipoprotein metabolism","volume":"295","author":"Frank","year":"2008","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"5","key":"10.1016\/j.nbd.2026.107309_bb0185","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neuron.2020.03.005","article-title":"The loss of TBK1 kinase activity in motor neurons or in all cell types differentially impacts ALS disease progression in SOD1 mice","volume":"106","author":"Gerbino","year":"2020","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0190","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neulet.2007.09.024","article-title":"Evidence for Secretion of Cu,Zn Superoxide Dismutase via Exosomes from a Cell Model of Amyotrophic Lateral Sclerosis","volume":"428","author":"Gomes","year":"2007","journal-title":"Neurosci. Lett."},{"issue":"5","key":"10.1016\/j.nbd.2026.107309_bb0195","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S1474-4422(21)00465-8","article-title":"Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis","volume":"21","author":"Goutman","year":"2022","journal-title":"Lancet Neurol."},{"issue":"39","key":"10.1016\/j.nbd.2026.107309_bb0200","doi-asserted-by":"crossref","first-page":"16398","DOI":"10.1073\/pnas.1102645108","article-title":"Intermolecular transmission of superoxide dismutase 1 misfolding in living cells","volume":"108","author":"Grad","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"9","key":"10.1016\/j.nbd.2026.107309_bb0205","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1073\/pnas.1312245111","article-title":"Intercellular propagated misfolding of wild-type cu\/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms","volume":"111","author":"Grad","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5166","key":"10.1016\/j.nbd.2026.107309_bb0210","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor Neuron Degeneration in Mice That Express a Human Cu,Zn Superoxide Dismutase Mutation","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.nbd.2026.107309_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009805","article-title":"Loss of ALS2\/Alsin exacerbates motor dysfunction in a SOD1H46R-expressing mouse ALS model by disturbing Endolysosomal trafficking","volume":"5","author":"Hadano","year":"2010","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.nbd.2026.107309_bb0220","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1093\/hmg\/ddw180","article-title":"Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice","volume":"25","author":"Hadano","year":"2016","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0225","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/bab.2112","article-title":"Role of neddylation in neurological development and diseases","volume":"69","author":"He","year":"2022","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.nbd.2026.107309_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpj.2022.04.037","article-title":"Toxic SOD1 Trimers Are Off-Pathway in the Formation of Amyloid-like Fibrils in ALS","author":"Hnath","year":"2022","journal-title":"Biophys. J."},{"issue":"7","key":"10.1016\/j.nbd.2026.107309_bb0235","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4686","article-title":"Big versus small: the impact of aggregate size in disease","volume":"32","author":"Hnath","year":"2023","journal-title":"Protein Sci."},{"issue":"10","key":"10.1016\/j.nbd.2026.107309_bb0240","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1093\/emboj\/17.10.2855","article-title":"Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes","volume":"17","author":"Jansa","year":"1998","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.nbd.2026.107309_bb0245","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1074\/mcp.M111.016550","article-title":"An interaction map of endoplasmic reticulum chaperones and Foldases","volume":"11","author":"Jansen","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"issue":"3","key":"10.1016\/j.nbd.2026.107309_bb0250","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1007\/s12035-018-1218-2","article-title":"Pathological modification of TDP-43 in amyotrophic lateral sclerosis with SOD1 mutations","volume":"56","author":"Jeon","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.nbd.2026.107309_bb0255","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1042\/BSR20120006","article-title":"Regulation of intracellular membrane trafficking and cell dynamics by Syntaxin-6","volume":"32","author":"Jung","year":"2012","journal-title":"Biosci. Rep."},{"issue":"9","key":"10.1016\/j.nbd.2026.107309_bb0260","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1073\/pnas.0511266103","article-title":"Common dynamical signatures of familial amyotrophic lateral sclerosis-associated structurally diverse cu, Zn superoxide dismutase mutants","volume":"103","author":"Khare","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"42","key":"10.1016\/j.nbd.2026.107309_bb0265","doi-asserted-by":"crossref","first-page":"15094","DOI":"10.1073\/pnas.0406650101","article-title":"The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis","volume":"101","author":"Khare","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.nbd.2026.107309_bb0270","doi-asserted-by":"crossref","first-page":"R471","DOI":"10.1016\/j.cub.2018.02.010","article-title":"Rab GTPases and membrane trafficking in neurodegeneration","volume":"28","author":"Kiral","year":"2018","journal-title":"Curr. Biol."},{"issue":"8","key":"10.1016\/j.nbd.2026.107309_bb0275","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nrm1433","article-title":"\u03b1-Catenin: at the junction of intercellular adhesion and actin dynamics","volume":"5","author":"Kobielak","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.nbd.2026.107309_bb0280","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948014","article-title":"The ubiquitin-conjugating enzyme UBE2QL1 coordinates Lysophagy in response to Endolysosomal damage","volume":"20","author":"Koerver","year":"2019","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0285","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12035-011-8182-4","article-title":"Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies","volume":"44","author":"Koren","year":"2011","journal-title":"Mol. Neurobiol."},{"issue":"S1","key":"10.1016\/j.nbd.2026.107309_bb0290","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1134\/S0006297922140103","article-title":"Integrated stress response in neuronal pathology and in health","volume":"87","author":"Korneeva","year":"2022","journal-title":"Biochem. Mosc."},{"issue":"June","key":"10.1016\/j.nbd.2026.107309_bb0295","article-title":"VAP proteins \u2013 from organelle tethers to pathogenic host interactors and their role in neuronal disease","volume":"10","author":"Kors","year":"2022","journal-title":"Front. Cell Development. Biol."},{"issue":"13","key":"10.1016\/j.nbd.2026.107309_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111001","article-title":"Loss of Stathmin-2, a Hallmark of TDP-43-associated ALS, causes motor neuropathy","volume":"39","author":"Krus","year":"2022","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0305","first-page":"1259","article-title":"Dual function of HPF1 in the modulation of PARP1 and PARP2 activities","volume":"4","author":"Kurgina","year":"2021","journal-title":"Communicat. Biol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0310","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1756-6606-2-23","article-title":"Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2\/Alsin","volume":"2","author":"Lai","year":"2009","journal-title":"Mol. Brain"},{"issue":"3","key":"10.1016\/j.nbd.2026.107309_bb0315","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201904113","article-title":"ALIX- and ESCRT-III\u2013dependent sorting of Tetraspanins to exosomes","volume":"219","author":"Larios","year":"2020","journal-title":"J. Cell Biol."},{"issue":"8","key":"10.1016\/j.nbd.2026.107309_bb0320","doi-asserted-by":"crossref","first-page":"jcs243097","DOI":"10.1242\/jcs.243097","article-title":"CLASPs at a glance","volume":"133","author":"Lawrence","year":"2020","journal-title":"J. Cell Sci."},{"issue":"46","key":"10.1016\/j.nbd.2026.107309_bb0325","doi-asserted-by":"crossref","first-page":"40151","DOI":"10.1074\/jbc.M111.279711","article-title":"Alsin and SOD1G93A proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity","volume":"286","author":"Li","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0330","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12964-023-01103-6","article-title":"A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication","volume":"21","author":"Liu","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"8","key":"10.1016\/j.nbd.2026.107309_bb0335","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1111\/febs.15716","article-title":"The role of PARP1 in neurodegenerative diseases and aging","volume":"289","author":"Mao","year":"2022","journal-title":"FEBS J."},{"issue":"November","key":"10.1016\/j.nbd.2026.107309_bb0340","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fnmol.2019.00262","article-title":"Prion-like propagation of protein misfolding and aggregation in amyotrophic lateral sclerosis","volume":"12","author":"McAlary","year":"2019","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0345","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/life13010121","article-title":"Extracellular vesicles in amyotrophic lateral sclerosis","volume":"13","author":"McCluskey","year":"2022","journal-title":"Life"},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0350","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1038\/s41467-019-11111-1","article-title":"Identification of intracellular Cavin target proteins reveals Cavin-PP1alpha interactions regulate apoptosis","volume":"10","author":"McMahon","year":"2019","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.nbd.2026.107309_bb0355","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/jnc.15181","article-title":"Disorders of synaptic vesicle fusion machinery","volume":"157","author":"Melland","year":"2021","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.nbd.2026.107309_bb0360","doi-asserted-by":"crossref","first-page":"115","DOI":"10.15698\/cst2018.05.136","article-title":"Endolysosomal dysfunction and exosome secretion: implications for neurodegenerative disorders","volume":"2","author":"Miranda","year":"2018","journal-title":"Cell Stress"},{"issue":"2","key":"10.1016\/j.nbd.2026.107309_bb0365","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1007\/s11033-022-07904-1","article-title":"Multifaceted roles of MAGOH proteins","volume":"50","author":"Mitra","year":"2023","journal-title":"Mol. Biol. Rep."},{"issue":"September","key":"10.1016\/j.nbd.2026.107309_bb0370","article-title":"SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron","volume":"158","author":"Mitsui","year":"2022","journal-title":"Neurochem. Int."},{"issue":"3","key":"10.1016\/j.nbd.2026.107309_bb0375","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrm3284","article-title":"Septins: the fourth component of the cytoskeleton","volume":"13","author":"Mostowy","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.nbd.2026.107309_bb0380","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1073\/pnas.1017275108","article-title":"Prion-like propagation of mutant superoxide Dismutase-1 misfolding in neuronal cells","volume":"108","author":"M\u00fcnch","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.nbd.2026.107309_bb0385","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1021\/acs.chemrev.0c01122","article-title":"Amyloid oligomers: a joint experimental\/computational perspective on Alzheimer\u2019s disease, Parkinson\u2019s disease, type II diabetes, and amyotrophic lateral sclerosis","volume":"121","author":"Nguyen","year":"2021","journal-title":"Chem. Rev."},{"issue":"6","key":"10.1016\/j.nbd.2026.107309_bb0390","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/10409238.2018.1553926","article-title":"Rab-dependent cellular trafficking and amyotrophic lateral sclerosis","volume":"53","author":"Parakh","year":"2018","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0395","doi-asserted-by":"crossref","first-page":"14223","DOI":"10.1038\/s41598-018-31773-z","article-title":"Misfolded SOD1 pathology in sporadic amyotrophic lateral sclerosis","volume":"8","author":"Par\u00e9","year":"2018","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.nbd.2026.107309_bb0400","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3390\/genes15111381","article-title":"Dynamic expression of genes encoding ubiquitin conjugating enzymes (E2s) during neuronal differentiation and maturation: implications for neurodevelopmental disorders and neurodegenerative diseases","volume":"15","author":"Paubel","year":"2024","journal-title":"Genes"},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0405","doi-asserted-by":"crossref","DOI":"10.1038\/srep22155","article-title":"TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion","volume":"6","author":"Pokrishevsky","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.nbd.2026.107309_bb0410","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1073\/pnas.1516725113","article-title":"Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis","volume":"113","author":"Proctor","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"7","key":"10.1016\/j.nbd.2026.107309_bb0415","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1007225","article-title":"\u03b2-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS Etiology","volume":"15","author":"Proctor","year":"2019","journal-title":"PLoS Comput. Biol."},{"issue":"11","key":"10.1016\/j.nbd.2026.107309_bb0420","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1080\/15548627.2023.2235196","article-title":"LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles","volume":"19","author":"Qiao","year":"2023","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0425","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/ng0596-43","article-title":"Motor neurons in cu\/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury","volume":"13","author":"Reaume","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nbd.2026.107309_bb0430","series-title":"Progress in Molecular Biology and Translational Science","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-385883-2.00002-3","article-title":"The complex molecular biology of amyotrophic lateral sclerosis (ALS)","volume":"vol. 107","author":"Redler","year":"2012"},{"issue":"32","key":"10.1016\/j.nbd.2026.107309_bb0435","doi-asserted-by":"crossref","first-page":"7057","DOI":"10.1021\/bi200614y","article-title":"Glutathionylation at Cys-111 induces dissociation of wild type and FALS mutant SOD1 dimers","volume":"50","author":"Redler","year":"2011","journal-title":"Biochemistry"},{"issue":"14","key":"10.1016\/j.nbd.2026.107309_bb0440","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1021\/bi500158w","article-title":"Non-native soluble oligomers of cu\/Zn superoxide dismutase (SOD1) contain a conformational epitope linked to cytotoxicity in amyotrophic lateral sclerosis (ALS)","volume":"53","author":"Redler","year":"2014","journal-title":"Biochemistry"},{"issue":"9","key":"10.1016\/j.nbd.2026.107309_bb0445","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/ncb2301","article-title":"Endolysosomal sorting of ubiquitylated Caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations","volume":"13","author":"Ritz","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.nbd.2026.107309_bb0450","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2013.00253","article-title":"An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis","volume":"7","author":"Rotunno","year":"2013","journal-title":"Front. Cell. Neurosci."},{"issue":"6","key":"10.1016\/j.nbd.2026.107309_bb0455","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/bies.20235","article-title":"Coronin proteins as multifunctional regulators of the cytoskeleton and membrane trafficking","volume":"27","author":"Rybakin","year":"2005","journal-title":"BioEssays"},{"issue":"6","key":"10.1016\/j.nbd.2026.107309_bb0460","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1096\/fj.201802652RR","article-title":"Neuron-targeted Caveolin-1 improves neuromuscular function and extends survival in SOD1G93A mice","volume":"33","author":"Sawada","year":"2019","journal-title":"FASEB J."},{"issue":"February","key":"10.1016\/j.nbd.2026.107309_bb0465","article-title":"The role of VCP mutations in the Spectrum of amyotrophic lateral sclerosis\u2014frontotemporal dementia","volume":"13","author":"Scarian","year":"2022","journal-title":"Front. Neurol."},{"issue":"10","key":"10.1016\/j.nbd.2026.107309_bb0470","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1074\/jbc.RA118.004825","article-title":"CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1","volume":"294","author":"Silverman","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.nbd.2026.107309_bb0475","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/1871520617666170918142114","article-title":"Genistein induces alterations of epigenetic modulatory signatures in human cervical Cancer cells","volume":"18","author":"Sundaram","year":"2018","journal-title":"Anti Cancer Agents Med. Chem."},{"issue":"5\u20136","key":"10.1016\/j.nbd.2026.107309_bb0480","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3109\/17482960802455416","article-title":"Exposure to chemicals and metals and risk of amyotrophic lateral sclerosis: a systematic review","volume":"10","author":"Sutedja","year":"2009","journal-title":"Amyotroph. Lateral Scler."},{"issue":"D1","key":"10.1016\/j.nbd.2026.107309_bb0485","doi-asserted-by":"crossref","first-page":"D730","DOI":"10.1093\/nar\/gkae1113","article-title":"The STRING database in 2025: protein networks with directionality of regulation","volume":"53","author":"Szklarczyk","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"36","key":"10.1016\/j.nbd.2026.107309_bb0490","doi-asserted-by":"crossref","first-page":"9801","DOI":"10.1523\/JNEUROSCI.2661-07.2007","article-title":"Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates","volume":"27","author":"Teuling","year":"2007","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0495","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and Update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0500","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and Update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"issue":"9","key":"10.1016\/j.nbd.2026.107309_bb0505","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.25382","article-title":"Microtubules, membranes, and movement: new roles for Stathmin-2 in axon integrity","volume":"102","author":"Thornburg-Suresh","year":"2024","journal-title":"J. Neurosci. Res."},{"issue":"10","key":"10.1016\/j.nbd.2026.107309_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113160","article-title":"Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis","volume":"42","author":"Tsioras","year":"2023","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0515","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nn1603","article-title":"Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis","volume":"9","author":"Urushitani","year":"2006","journal-title":"Nat. Neurosci."},{"issue":"June","key":"10.1016\/j.nbd.2026.107309_bb0520","article-title":"Role of SNAREs in unconventional secretion\u2014focus on the VAMP7-dependent secretion","volume":"10","author":"Vats","year":"2022","journal-title":"Front. Cell Development. Biol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0525","doi-asserted-by":"crossref","DOI":"10.1080\/2331205X.2019.1582400","article-title":"Genetic alterations of C9orf72, SOD1, TARDBP, FUS, and UBQLN2 genes in patients with amyotrophic lateral sclerosis","volume":"6","author":"Vildan","year":"2019","journal-title":"Cogent Med."},{"key":"10.1016\/j.nbd.2026.107309_bb0530","series-title":"Unconventional Protein Secretion","article-title":"ER to Golgi-Dependent Protein Secretion: The Conventional Pathway","volume":"1459","author":"Viotti","year":"2016"},{"issue":"21","key":"10.1016\/j.nbd.2026.107309_bb0535","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01258-19","article-title":"The ICP0 protein of herpes simplex virus 1 (HSV-1) downregulates major autophagy adaptor proteins Sequestosome 1 and optineurin during the early stages of HSV-1 infection","volume":"93","author":"Waisner","year":"2019","journal-title":"J. Virol."},{"issue":"November","key":"10.1016\/j.nbd.2026.107309_bb0540","article-title":"Rab3 and Synaptotagmin proteins in the regulation of vesicle fusion and neurotransmitter release","volume":"309","author":"Wang","year":"2022","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.nbd.2026.107309_bb0545","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s00705-022-05484-w","article-title":"Role of the receptor for activated C kinase 1 during viral infection","volume":"167","author":"Wang","year":"2022","journal-title":"Arch. Virol."},{"issue":"20","key":"10.1016\/j.nbd.2026.107309_bb0550","doi-asserted-by":"crossref","first-page":"13940","DOI":"10.1074\/jbc.M809687200","article-title":"Modifications of superoxide dismutase (SOD1) in human erythrocytes","volume":"284","author":"Wilcox","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0555","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1038\/s41467-022-31873-5","article-title":"Shared mechanisms across the major psychiatric and neurodegenerative diseases","volume":"13","author":"Wingo","year":"2022","journal-title":"Nat. Commun."},{"issue":"14","key":"10.1016\/j.nbd.2026.107309_bb0560","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12182","article-title":"Updating MISEV: evolving the minimal requirements for studies of extracellular vesicles","volume":"10","author":"Witwer","year":"2021","journal-title":"J. Extracell. Vesicles"},{"issue":"26","key":"10.1016\/j.nbd.2026.107309_bb0565","doi-asserted-by":"crossref","first-page":"15230","DOI":"10.1073\/pnas.1917371117","article-title":"ALS\/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function","volume":"117","author":"Wu","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"April","key":"10.1016\/j.nbd.2026.107309_bb0570","article-title":"The role of RIM in neurotransmitter release: promotion of synaptic vesicle docking, priming, and fusion","volume":"17","author":"Wu","year":"2023","journal-title":"Front. Neurosci."},{"issue":"5","key":"10.1016\/j.nbd.2026.107309_bb0575","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3390\/v12050487","article-title":"Multifaceted functions of host cell caveolae\/Caveolin-1 in virus infections","volume":"12","author":"Xing","year":"2020","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0580","first-page":"56","article-title":"The roles of Exosomal immune checkpoint proteins in Tumors","volume":"8","author":"Xing","year":"2021","journal-title":"Mil. Med. Res."},{"issue":"2","key":"10.1016\/j.nbd.2026.107309_bb0585","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41419-017-0106-4","article-title":"Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111","volume":"9","author":"Xu","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.nbd.2026.107309_bb0590","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13024-015-0053-4","article-title":"SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation","volume":"10","author":"Zeineddine","year":"2015","journal-title":"Mol. Neurodegener."},{"issue":"5","key":"10.1016\/j.nbd.2026.107309_bb0595","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3892\/ijmm.2024.5372","article-title":"Interpreting the molecular mechanisms of RBBP4\/7 and their roles in human diseases (review)","volume":"53","author":"Zhan","year":"2024","journal-title":"Int. J. Mol. Med."},{"issue":"10","key":"10.1016\/j.nbd.2026.107309_bb0600","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1021\/pr200553c","article-title":"Proteome of skeletal muscle lipid droplet reveals association with mitochondria and apolipoprotein A-I","volume":"10","author":"Zhang","year":"2011","journal-title":"J. Proteome Res."},{"issue":"18","key":"10.1016\/j.nbd.2026.107309_bb0605","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1073\/pnas.1800187115","article-title":"Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis","volume":"115","author":"Zhu","year":"2018","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126000537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126000537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T21:56:47Z","timestamp":1778018207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996126000537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":121,"alternative-id":["S0969996126000537"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107309","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107309","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107309"}}