{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:14:53Z","timestamp":1787624093638,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82588301"],"award-info":[{"award-number":["82588301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371485"],"award-info":[{"award-number":["82371485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022817","name":"Lanzhou University Second Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["2nd-33"],"award-info":[{"award-number":["2nd-33"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-JQX0024"],"award-info":[{"award-number":["CSTB2024NSCQ-JQX0024"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.nbd.2026.107398","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T23:15:56Z","timestamp":1776294956000},"page":"107398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["\u03b11A-adrenergic receptor activation ameliorates fragmented spatial exploration by improving astrocyte-neuronal coupling in the medial entorhinal cortex of Alzheimer's disease mice"],"prefix":"10.1016","volume":"224","author":[{"given":"Fengjuan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2026.107398_bb0005","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75055","article-title":"Impaired astrocytic Ca(2+) signaling in awake-behaving Alzheimer\u2019s disease transgenic mice","volume":"11","author":"\u00c5bj\u00f8rsbr\u00e5ten","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2026.107398_bb0010","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S1474-4422(18)30490-3","article-title":"The role of astroglia in Alzheimer\u2019s disease: pathophysiology and clinical implications","volume":"18","author":"Arranz","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2026.107398_bb0015","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1523\/JNEUROSCI.5845-11.2012","article-title":"Bidirectional relationship between functional connectivity and amyloid-\u03b2 deposition in mouse brain","volume":"32","author":"Bero","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107398_bb0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41583-022-00641-1","article-title":"Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders","volume":"24","author":"Brandebura","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2026.107398_bb0025","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6422","article-title":"Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer\u2019s disease mouse model","volume":"5","author":"Delekate","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107398_bb0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ceca.2013.09.001","article-title":"\u03911-adrenergic receptors mediate coordinated ca2+ signaling of cortical astrocytes in awake, behaving mice","volume":"54","author":"Ding","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.nbd.2026.107398_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-47345-x","article-title":"Multicore fiber optic imaging reveals that astrocyte calcium activity in the mouse cerebral cortex is modulated by internal motivational state","volume":"15","author":"Gau","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107398_bb0040","article-title":"Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice","volume":"14","author":"Guo","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107398_bb0045","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nature03721","article-title":"Microstructure of a spatial map in the entorhinal cortex","volume":"436","author":"Hafting","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2026.107398_bb0050","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/35058528","article-title":"GLIA: listening and talking to the synapse","volume":"2","author":"Haydon","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2026.107398_bb0055","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/brain\/awz116","article-title":"Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation","volume":"142","author":"Howett","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.nbd.2026.107398_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116173","article-title":"Astrocytes in the medial entorhinal cortex are required for spatial exploration","volume":"44","author":"Huang","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2026.107398_bb0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0304-3940(89)90231-0","article-title":"Increased alpha 2- and beta 2-adrenergic receptors in cerebral microvessels in Alzheimer disease","volume":"106","author":"Kalaria","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2026.107398_bb0070","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1111\/j.1471-4159.1989.tb09242.x","article-title":"Adrenergic receptors in aging and Alzheimer\u2019s disease: increased beta 2-receptors in prefrontal cortex and hippocampus","volume":"53","author":"Kalaria","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2026.107398_bb0075","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-neuro-070918-050443","article-title":"The emerging nature of astrocyte diversity","volume":"42","author":"Khakh","year":"2019","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2026.107398_bb0080","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuron.2008.06.008","article-title":"Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks","volume":"59","author":"Kuchibhotla","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107398_bb0085","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.1169096","article-title":"Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice","volume":"323","author":"Kuchibhotla","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.nbd.2026.107398_bb0090","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s12264-021-00782-w","article-title":"Entrainment of astrocytic and neuronal ca(2+) population dynamics during information processing of working memory in mice","volume":"38","author":"Lin","year":"2022","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.nbd.2026.107398_bb0095","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/glia.24112","article-title":"Astrocyte-neuronal network interplay is disrupted in Alzheimer\u2019s disease mice","volume":"70","author":"Lines","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2026.107398_bb0100","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00401-020-02248-1","article-title":"The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer\u2019s disease","volume":"141","author":"Matchett","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2026.107398_bb0105","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021808","article-title":"Place cells, grid cells, and memory","volume":"7","author":"Moser","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.nbd.2026.107398_bb0110","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00401-019-02054-4","article-title":"The basis of cellular and regional vulnerability in Alzheimer's disease","volume":"138","author":"Mrdjen","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2026.107398_bb0115","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.neuron.2020.12.008","article-title":"Behaviorally consequential astrocytic regulation of neural circuits","volume":"109","author":"Nagai","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107398_bb0120","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1212\/WNL.0b013e3181e3966e","article-title":"Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline","volume":"74","author":"O\u2019Brien","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2026.107398_bb0125","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/glia.24178","article-title":"Astrocyte regulation of neural circuit activity and network states","volume":"70","author":"Oliveira","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.nbd.2026.107398_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1572956","article-title":"Early emergence of motivational and hedonic feeding deficits in the TgF344-AD rat model of Alzheimer\u2019s disease","volume":"17","author":"Ostlund","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2026.107398_bb0135","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.neuron.2014.04.038","article-title":"Norepinephrine controls astroglial responsiveness to local circuit activity","volume":"82","author":"Paukert","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107398_bb0140","doi-asserted-by":"crossref","first-page":"10412","DOI":"10.1038\/s41467-024-54777-y","article-title":"Altered expression of presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer\u2019s disease-relevant brain circuits","volume":"15","author":"Perdok","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107398_bb0145","doi-asserted-by":"crossref","DOI":"10.2196\/28222","article-title":"Using GPS tracking to investigate outdoor navigation patterns in patients with Alzheimer disease: cross-sectional study","volume":"5","author":"Puthusseryppady","year":"2022","journal-title":"JMIR Aging"},{"key":"10.1016\/j.nbd.2026.107398_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.603095","article-title":"Monitoring astrocytic Ca(2+) activity in freely behaving mice","volume":"14","author":"Qin","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2026.107398_bb0155","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1084\/jem.20171487","article-title":"P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer\u2019s disease model","volume":"215","author":"Reichenbach","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2026.107398_bb0160","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41593-023-01284-w","article-title":"Norepinephrine links astrocytic activity to regulation of cortical state","volume":"26","author":"Reitman","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2026.107398_bb0165","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41593-018-0325-8","article-title":"Astrocyte function from information processing to cognition and cognitive impairment","volume":"22","author":"Santello","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2026.107398_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111280","article-title":"Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease","volume":"40","author":"Shah","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2026.107398_bb0175","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.neuron.2023.03.034","article-title":"Mice identify subgoal locations through an action-driven mapping process","volume":"111","author":"Shamash","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107398_bb0180","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12017-009-8109-7","article-title":"Functional alterations in memory networks in early Alzheimer\u2019s disease","volume":"12","author":"Sperling","year":"2010","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.nbd.2026.107398_bb0185","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/108190","article-title":"Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer\u2019s disease","volume":"2010","author":"Stranahan","year":"2010","journal-title":"Neural Plast."},{"key":"10.1016\/j.nbd.2026.107398_bb0190","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuroscience.2007.01.031","article-title":"Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes","volume":"146","author":"Szot","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2026.107398_bb0195","doi-asserted-by":"crossref","first-page":"18974","DOI":"10.1073\/pnas.1209448109","article-title":"General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex","volume":"109","author":"Thrane","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2026.107398_bb0200","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuron.2013.12.025","article-title":"Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration","volume":"81","author":"Tononi","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107398_bb0205","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1152\/physrev.00042.2020","article-title":"Microcircuits for spatial coding in the medial entorhinal cortex","volume":"102","author":"Tukker","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.nbd.2026.107398_bb0210","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a035188","article-title":"Astroglial calcium signaling in aging and Alzheimer\u2019s disease","volume":"11","author":"Verkhratsky","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.nbd.2026.107398_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115322","article-title":"Osteocalcin modulates abeta42 aggregation to aid in amyloid reduction in mouse models of Alzheimer\u2019s disease","volume":"391","author":"Vijayan","year":"2025","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2026.107398_bb0220","doi-asserted-by":"crossref","DOI":"10.1117\/1.NPh.11.4.045010","article-title":"Mapping multi-regional functional connectivity of astrocyte-neuronal networks during behaviors","volume":"11","author":"Wang","year":"2024","journal-title":"Neurophotonics"},{"key":"10.1016\/j.nbd.2026.107398_bb0225","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/s41467-024-45656-7","article-title":"Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer\u2019s disease-associated pathology and cognition in mice","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107398_bb0230","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s13287-022-02959-0","article-title":"Engrafted glial progenitor cells yield long-term integration and sensory improvement in aged mice","volume":"13","author":"Yang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.nbd.2026.107398_bb0235","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/s41593-021-00949-8","article-title":"Fear learning induces \u03b17-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence","volume":"24","author":"Zhang","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2026.107398_bb0240","article-title":"Amyloid \u03b2-dependent neuronal silencing through synaptic decoupling","volume":"122","author":"Zhang","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2026.107398_bb0245","article-title":"ATP11B modulates microglial lipid metabolism and alleviates Alzheimer\u2019s disease pathology","volume":"6","author":"Zhang","year":"2025","journal-title":"MedComm (2020)"},{"key":"10.1016\/j.nbd.2026.107398_bb0250","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s12264-024-01264-5","article-title":"Neurotransmitter switching: a novel mechanism for fear generalization","volume":"40","author":"Zheng","year":"2024","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.nbd.2026.107398_bb0255","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbrc.2023.04.060","article-title":"Mice learn from the predator-attack experience to accelerate flight behavior via optimizing the strategy of environment exploration","volume":"665","author":"Zhong","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2026.107398_bb0260","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.brainresbull.2013.01.011","article-title":"Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice","volume":"94","author":"Zufferey","year":"2013","journal-title":"Brain Res. Bull."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126001439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126001439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:29:00Z","timestamp":1785151740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996126001439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":52,"alternative-id":["S0969996126001439"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107398","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b11A-adrenergic receptor activation ameliorates fragmented spatial exploration by improving astrocyte-neuronal coupling in the medial entorhinal cortex of Alzheimer's disease mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107398","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107398"}}