{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:29:23Z","timestamp":1793363363450,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024020","name":"Universit\u00e9 de Mons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024020","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.nbd.2026.107435","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:05:58Z","timestamp":1778565958000},"page":"107435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Decoding Parkinson\u2019s progression: A multi-modal SuStaIn ensemble approach validated on real-world PPMI data"],"prefix":"10.1016","volume":"225","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2342-495X","authenticated-orcid":false,"given":"Moad","family":"Hani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u00efd","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Benjelloun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2026.107435_b1","doi-asserted-by":"crossref","DOI":"10.1016\/j.softx.2021.100811","article-title":"pySuStaIn: A python implementation of the subtype and stage inference algorithm","volume":"16","author":"Aksman","year":"2021","journal-title":"SoftwareX"},{"issue":"8","key":"10.1016\/j.nbd.2026.107435_b2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/mds.20897","article-title":"Changes in motor subtype and risk for incident dementia in parkinson\u2019s disease","volume":"21","author":"Alves","year":"2006","journal-title":"Mov Disord"},{"key":"10.1016\/j.nbd.2026.107435_b3","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101954","article-title":"Multi-study validation of data-driven disease progression models to characterize evolution of biomarkers in alzheimer\u2019s disease","volume":"24","author":"Archetti","year":"2019","journal-title":"Neuroimage Clin"},{"issue":"2","key":"10.1016\/j.nbd.2026.107435_b4","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.bbr.2009.12.048","article-title":"The cholinergic system and parkinson disease","volume":"221","author":"Bohnen","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.nbd.2026.107435_b5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.nbd.2026.107435_b6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1474-4422(06)70373-8","article-title":"Non-motor symptoms of parkinson\u2019s disease: diagnosis and management","volume":"5","author":"Chaudhuri","year":"2006","journal-title":"Lancet Neurol"},{"issue":"3","key":"10.1016\/j.nbd.2026.107435_b7","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.nbd.2026.107435_b8","article-title":"Subtype and stage inference with timescales","volume":"74","author":"Dong","year":"2021","journal-title":"Med Image Anal"},{"issue":"s1","key":"10.1016\/j.nbd.2026.107435_b9","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.3233\/JPD-181474","article-title":"The emerging evidence of the parkinson pandemic","volume":"8","author":"Dorsey","year":"2018","journal-title":"J Parkinsons Dis"},{"issue":"10","key":"10.1016\/j.nbd.2026.107435_b10","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/mds.21475","article-title":"Levodopa-induced dyskinesias","volume":"22","author":"Fabbrini","year":"2007","journal-title":"Mov Disord"},{"key":"10.1016\/j.nbd.2026.107435_b11","series-title":"Subtypes of parkinson\u2019s disease: what do they tell us about disease progression?","first-page":"34","author":"Fereshtehnejad","year":"2017"},{"issue":"8","key":"10.1016\/j.nbd.2026.107435_b12","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/jamaneurol.2015.0703","article-title":"New clinical subtypes of parkinson disease and their longitudinal progression","volume":"72","author":"Fereshtehnejad","year":"2015","journal-title":"JAMA Neurol"},{"issue":"7","key":"10.1016\/j.nbd.2026.107435_b13","first-page":"2158","article-title":"Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy","volume":"143","author":"Firth","year":"2020","journal-title":"Brain"},{"issue":"15","key":"10.1016\/j.nbd.2026.107435_b14","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement disorder society-sponsored revision of the unified parkinson\u2019s disease rating scale (MDS-UPDRS)","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov Disord"},{"issue":"1","key":"10.1016\/j.nbd.2026.107435_b15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/mdc3.12553","article-title":"Progression of MDS-UPDRS scores over five years in de novo parkinson disease from the parkinson\u2019s progression markers initiative cohort","volume":"5","author":"Holden","year":"2018","journal-title":"Mov Disord Clin Pr."},{"issue":"21","key":"10.1016\/j.nbd.2026.107435_b16","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1212\/WNL.0b013e3181c34b47","article-title":"Validity of the MoCA and MMSE in the detection of MCI and dementia in parkinson disease","volume":"73","author":"Hoops","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2026.107435_b17","first-page":"3241","article-title":"Comparing machine learning algorithms for predicting progression in parkinson\u2019s disease","volume":"14","author":"I","year":"2024","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.nbd.2026.107435_b18","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1212\/WNL.40.10.1529","article-title":"Variable expression of parkinson\u2019s disease: a base-line analysis of the DATATOP cohort","volume":"40","author":"Jankovic","year":"1990","journal-title":"Neurology"},{"issue":"19","key":"10.1016\/j.nbd.2026.107435_b19","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1212\/WNL.0b013e3181fc29c9","article-title":"The MoCA: well-suited screen for cognitive impairment in parkinson disease","volume":"75","author":"JC","year":"2010","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nbd.2026.107435_b20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"issue":"2","key":"10.1016\/j.nbd.2026.107435_b21","first-page":"269","article-title":"Parkinson\u2019s disease subtypes in the oxford parkinson disease centre (OPDC) discovery cohort","volume":"8","author":"Lawton","year":"2018","journal-title":"J Park. Dis"},{"issue":"9","key":"10.1016\/j.nbd.2026.107435_b22","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/mds.25070","article-title":"Changes on brief cognitive instruments over time in parkinson\u2019s disease","volume":"27","author":"Lessig","year":"2012","journal-title":"Mov Disord"},{"issue":"1","key":"10.1016\/j.nbd.2026.107435_b23","first-page":"48","article-title":"Personalized risk prediction for clinical progression in early parkinson disease","volume":"81","author":"Lian","year":"2024","journal-title":"JAMA Neurol"},{"issue":"4","key":"10.1016\/j.nbd.2026.107435_b24","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.pneurobio.2011.09.005","article-title":"The parkinson progression marker initiative (PPMI)","volume":"95","author":"Marek","year":"2011","journal-title":"Prog Neurobiol"},{"issue":"2","key":"10.1016\/j.nbd.2026.107435_b25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat. Med."},{"issue":"6","key":"10.1016\/j.nbd.2026.107435_b26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrneurol.2012.80","article-title":"Olfactory dysfunction in parkinson disease","volume":"8","author":"RL","year":"2012","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.nbd.2026.107435_b27","series-title":"S-sustain: Scalable subtype and stage inference for high-dimensional omics data","author":"Tandon","year":"2024"},{"issue":"10","key":"10.1016\/j.nbd.2026.107435_b28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11910-017-0788-0","article-title":"Imaging the etiology of apathy, anxiety, and depression in parkinson\u2019s disease","volume":"17","author":"Thobois","year":"2017","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"11","key":"10.1016\/j.nbd.2026.107435_b29","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/mds.20153","article-title":"Assessment of autonomic dysfunction in parkinson\u2019s disease: the SCOPA-AUT","volume":"19","author":"Visser","year":"2004","journal-title":"Mov Disord"},{"issue":"5","key":"10.1016\/j.nbd.2026.107435_b30","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41591-021-01309-6","article-title":"Four distinct trajectories of tau deposition identified in alzheimer\u2019s disease","volume":"27","author":"Vogel","year":"2021","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.nbd.2026.107435_b31","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1038\/s41467-018-05892-0","article-title":"Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with subtype and stage inference","volume":"9","author":"Young","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.nbd.2026.107435_b32","first-page":"711","article-title":"Multiple orderings of events in disease progression","volume":"13939","author":"Young","year":"2023","journal-title":"Lect Notes Comput. Sci"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126001804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126001804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:59:08Z","timestamp":1790683148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996126001804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"alternative-id":["S0969996126001804"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107435","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decoding Parkinson\u2019s progression: A multi-modal SuStaIn ensemble approach validated on real-world PPMI data","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107435","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107435"}}