{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:40:25Z","timestamp":1787240425483,"version":"build-2736575974"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","award":["AS-BRPT-112-14"],"award-info":[{"award-number":["AS-BRPT-112-14"]}],"id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","award":["AS-BRPT-110-11"],"award-info":[{"award-number":["AS-BRPT-110-11"]}],"id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","award":["AS-KPQ-111-KNT"],"award-info":[{"award-number":["AS-KPQ-111-KNT"]}],"id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.nbd.2026.107459","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:11:05Z","timestamp":1779721865000},"page":"107459","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["ROS-HIF1\u03b1-driven glycolytic reprogramming sustains ATP production in Huntington's disease"],"prefix":"10.1016","volume":"226","author":[{"given":"Ching-Wen","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Pang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W.","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Hua","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Jing","family":"Siew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijuang","family":"Chern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2026.107459_bb0005","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.dnarep.2008.09.004","article-title":"Mitochondrial DNA damage is a hallmark of chemically induced and the R6\/2 transgenic model of Huntington's disease","volume":"8","author":"Acevedo-Torres","year":"2009","journal-title":"DNA Repair"},{"key":"10.1016\/j.nbd.2026.107459_bb0010","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1038\/ncomms3917","article-title":"A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington\u2019s disease in mice","volume":"4","author":"Acu\u00f1a","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107459_bb0015","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.nbd.2026.107459_bb0020","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2011.112","article-title":"Neurodegenerative processes in Huntington's disease","volume":"2","author":"Bano","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2026.107459_bb0025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41419-021-03505-1","article-title":"The crosstalk between HIFs and mitochondrial dysfunctions in cancer development","volume":"12","author":"Bao","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2026.107459_bb0030","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1046\/j.1471-4159.2001.00689.x","article-title":"Increased oxidative damage to DNA in a transgenic mouse model of Huntington\u2019s disease","volume":"79","author":"Bogdanov","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2026.107459_bb0035","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molmed.2019.10.007","article-title":"Regulation of mitochondrial ATP production: Ca2+ signaling and quality control","volume":"26","author":"Boyman","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.nbd.2026.107459_bb0040","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0006-8993(93)91276-X","article-title":"The effects of pharmacologic doses of 2-deoxy-d-glucose on local cerebral blood flow in the awake, unrestrained rat","volume":"618","author":"Breier","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2026.107459_bb0045","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.410410514","article-title":"Oxidative damage and metabolic dysfunction in Huntington\u2019s disease: selective vulnerability of the basal ganglia","volume":"41","author":"Browne","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2026.107459_bb0050","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/j.neuron.2025.05.014","article-title":"Distinct molecular patterns in R6\/2 HD mouse brain: insights from spatiotemporal transcriptomics","volume":"113","author":"Burns","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107459_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106672","article-title":"Metabolic dysregulation in Huntington's disease: neuronal and glial perspectives","volume":"201","author":"Chang","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2026.107459_bb0060","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1093\/hmg\/dds178","article-title":"Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington\u2019s disease","volume":"21","author":"Chaturvedi","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2026.107459_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112480","article-title":"Altered Aconitase 2 activity in Huntington's disease peripheral blood cells and mouse model striatum","volume":"18","author":"Chen","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2026.107459_bb0070","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3109\/1354750X.2014.935955","article-title":"Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients","volume":"19","author":"Ciancarelli","year":"2014","journal-title":"Biomarkers"},{"key":"10.1016\/j.nbd.2026.107459_bb0075","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1\u03b1 by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2026.107459_bb0080","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw8546","article-title":"Astrocyte molecular signatures in Huntington's disease","volume":"11","author":"Diaz-Castro","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.nbd.2026.107459_bb0085","doi-asserted-by":"crossref","first-page":"29083","DOI":"10.1074\/jbc.270.49.29083","article-title":"Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences","volume":"270","author":"Ebert","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2026.107459_bb0090","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2026.107459_bb0095","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baz046","article-title":"PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data","volume":"2019","author":"Franz\u00e9n","year":"2019","journal-title":"Database"},{"key":"10.1016\/j.nbd.2026.107459_bb0100","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1046\/j.1471-4159.1994.63041392.x","article-title":"Glucose transporter isoform expression in Huntington\u2019s disease brain","volume":"63","author":"Gamberino","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2026.107459_bb0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2020.12.067","article-title":"Expression of glucose transporters in human neurodegenerative diseases","volume":"540","author":"G\u0142uchowska","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2026.107459_bb0110","article-title":"Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke","volume":"5","author":"Guan","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.nbd.2026.107459_bb0115","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13059-019-1874-1","article-title":"Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression","volume":"20","author":"Hafemeister","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.nbd.2026.107459_bb0120","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.89376.3","article-title":"Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment","volume":"12","author":"Hagihara","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2026.107459_bb0125","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2026.107459_bb0130","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1002\/2211-5463.13285","article-title":"Multiplatform metabolomic analysis of the R6\/2 mouse model of Huntington's disease","volume":"11","author":"Hashimoto","year":"2021","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.nbd.2026.107459_bb0135","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/01.wnl.0000194318.74946.b6","article-title":"Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2\u2019dG","volume":"66","author":"Hersch","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2026.107459_bb0140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ymben.2003.10.002","article-title":"Accumulation of 2-deoxy-d-glucose-6-phosphate as a measure of glucose uptake in the isolated perfused heart: a 31P NMR study","volume":"6","author":"Hopkins","year":"2004","journal-title":"Metab. Eng."},{"key":"10.1016\/j.nbd.2026.107459_bb0145","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.nbd.2026.107459_bb0150","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41467-022-28803-w","article-title":"Fully-automated and ultra-fast cell-type identification using specific marker combinations from single-cell transcriptomic data","volume":"13","author":"Ianevski","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107459_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2019.00103","article-title":"Mitochondrial dysfunction in Huntington\u2019s disease; interplay between HSF1, p53 and PGC-1\u03b1 transcription factors","volume":"13","author":"Intihar","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2026.107459_bb0160","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1101\/gad.12.2.149","article-title":"Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha","volume":"12","author":"Iyer","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.nbd.2026.107459_bb0165","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1212\/WNL.43.12.2689","article-title":"Evidence for irnnairment of energy metabofism in vivo in Huntington\u2019s disease using localized 1H NMR spectroscopy","volume":"43","author":"Jenkins","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2026.107459_bb0170","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1038\/s41593-019-0486-0","article-title":"Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration","volume":"22","author":"Joshi","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2026.107459_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117827","article-title":"The role of mitochondrial dysfunction in Huntington\u2019s disease: implications for therapeutic targeting","volume":"183","author":"Joshi","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.nbd.2026.107459_bb0180","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.bbadis.2014.06.012","article-title":"AMPK-alpha1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington\u2019s disease","volume":"1842","author":"Ju","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2026.107459_bb0185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/JP280572","article-title":"Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology","volume":"599","author":"Kierans","year":"2021","journal-title":"J. Physiol."},{"key":"10.1016\/j.nbd.2026.107459_bb0190","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","article-title":"HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia","volume":"3","author":"Kim","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.nbd.2026.107459_bb0195","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1093\/hmg\/ddq306","article-title":"Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease","volume":"19","author":"Kim","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2026.107459_bb0200","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1111\/j.1471-4159.1989.tb08560.x","article-title":"Simultaneous in Vivb monitoring of cerebral deoxyglucose and deoxyglucos-6-phosphate by l3C{lH} nuclear magnetic resonance spectroscopy","volume":"53","author":"Kotyk","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2026.107459_bb0205","first-page":"217","article-title":"Oxidative stress and Huntington\u2019s disease: the good, the bad, and the ugly","volume":"5","author":"Kumar","year":"2016","journal-title":"Journal of Huntington\u2019s Dis."},{"key":"10.1016\/j.nbd.2026.107459_bb0210","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neuron.2020.06.021","article-title":"Cell type-specific transcriptomics reveals that mutant Huntingtin leads to mitochondrial RNA release and neuronal innate immune activation","volume":"107","author":"Lee","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107459_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101109","article-title":"HIF-1\u03b1 protects against oxidative stress by directly targeting mitochondria","volume":"25","author":"Li","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.nbd.2026.107459_bb0220","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/s41419-022-05389-1","article-title":"PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism","volume":"13","author":"Liao","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2026.107459_bb0225","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41419-024-06523-x","article-title":"CHCHD2 up-regulation in Huntington disease mediates a compensatory protective response against oxidative stress","volume":"15","author":"Liu","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2026.107459_bb0230","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1563-23.2024","article-title":"Imbalance in glucose metabolism regulates the transition of microglia from homeostasis to disease-associated microglia stage 1","volume":"44","author":"Liu","year":"2024","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107459_bb0235","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41392-025-02141-x","article-title":"Energy metabolism in health and diseases","volume":"10","author":"Liu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.nbd.2026.107459_bb0240","first-page":"2813","article-title":"Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress","volume":"25","author":"Lou","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2026.107459_bb0245","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1152\/jn.00333.2021","article-title":"Developmental shift to mitochondrial respiration for energetic support of sustained transmission during maturation at the calyx of held","volume":"126","author":"Lujan","year":"2021","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2026.107459_bb0250","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2026.107459_bb0255","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2026.107459_bb0260","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s43587-021-00054-2","article-title":"Hypoxia compromises the mitochondrial metabolism of Alzheimer's disease microglia via HIF1","volume":"1","author":"March-Diaz","year":"2021","journal-title":"Nature Aging."},{"key":"10.1016\/j.nbd.2026.107459_bb0265","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/0008-5472.CAN-03-3294","article-title":"2-deoxy-d-glucose increases the efficacy of Adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo","volume":"64","author":"Maschek","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.nbd.2026.107459_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049838","article-title":"Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington\u2019s disease: zQ175","volume":"7","author":"Menalled","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.nbd.2026.107459_bb0275","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1172\/JCI45691","article-title":"Energy deficit in Huntington disease: why it matters","volume":"121","author":"Mochel","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.nbd.2026.107459_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cophys.2018.11.007","article-title":"Epigenetic regulation of the hypoxic response","volume":"7","author":"Nam","year":"2019","journal-title":"Curr. Opin. Physio."},{"key":"10.1016\/j.nbd.2026.107459_bb0285","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20145304","article-title":"Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases","volume":"10","author":"Narayanan","year":"2014","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.nbd.2026.107459_bb0290","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31154-6","article-title":"Instant clue: a software suite for interactive data visualization and analysis","volume":"8","author":"Nolte","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2026.107459_bb0295","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cmet.2006.01.012","article-title":"HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption","volume":"3","author":"Papandreou","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.nbd.2026.107459_bb0300","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(99)00578-9","article-title":"Oxidative damage to mitochondrial DNA in Huntington\u2019s disease parietal cortex","volume":"272","author":"Polidori","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2026.107459_bb0305","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.metabol.2016.05.018","article-title":"Role of metabolism in neurodegenerative disorders","volume":"65","author":"Procaccini","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.nbd.2026.107459_bb0310","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1093\/hmg\/ddad125","article-title":"Arginine methylation of RNA-binding proteins is impaired in Huntington's disease","volume":"32","author":"Ratovitski","year":"2023","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2026.107459_bb0315","doi-asserted-by":"crossref","DOI":"10.1038\/srep42093","article-title":"Fast and quantitative T1\u03c1-weighted dynamic glucose enhanced MRI","volume":"7","author":"Schuenke","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2026.107459_bb0320","doi-asserted-by":"crossref","first-page":"23757","DOI":"10.1016\/S0021-9258(17)31580-6","article-title":"Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1","volume":"269","author":"Semenza","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2026.107459_bb0325","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1718","article-title":"Expression of hypoxia-inducible factor 1\u03b1, glucose transporter 1, and hexokinase 2 in primary central nervous system lymphoma and the correlation with the biological behaviors","volume":"10","author":"Shen","year":"2020","journal-title":"Brain Behav."},{"key":"10.1016\/j.nbd.2026.107459_bb0330","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.nbd.2026.107459_bb0335","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s00018-005-5084-5","article-title":"Synaptic dysfunction in Huntington's disease: a new perspective","volume":"62","author":"Smith","year":"2005","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.nbd.2026.107459_bb0340","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/1531-8249(199901)45:1<25::AID-ART6>3.0.CO;2-E","article-title":"Biochemical abnormalities and excitotoxicity in Huntington\u2019s disease brain","volume":"45","author":"Tabrizi","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2026.107459_bb0345","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/1531-8249(200001)47:1<80::AID-ANA13>3.0.CO;2-K","article-title":"Mitochondrial dysfunction and free radical damage in the Huntington R6\/2 transgenic mouse","volume":"47","author":"Tabrizi","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2026.107459_bb0350","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.nbd.2011.02.008","article-title":"Gene expression profiling of R6\/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease","volume":"42","author":"Tang","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2026.107459_bb0355","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41581-022-00587-8","article-title":"The effect of HIF on metabolism and immunity","volume":"18","author":"Taylor","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.nbd.2026.107459_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104849","article-title":"GLUT-1 changes in paediatric Huntington disease brain cortex and fibroblasts: an observational case-control study","volume":"97","author":"Tramutola","year":"2023","journal-title":"eBioMedicine"},{"key":"10.1016\/j.nbd.2026.107459_bb0365","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.1021\/jm200605a","article-title":"Important role of oxidative stress biomarkers in Huntington's disease","volume":"54","author":"T\u00fanez","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.nbd.2026.107459_bb0370","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/hmg\/dds516","article-title":"Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease","volume":"22","author":"Valencia","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2026.107459_bb0375","first-page":"96","article-title":"Acute toxicity and cardio-respiratory effects of 2-deoxy-D-glucose: a promising radio sensitiser","volume":"19","author":"Vijayaraghavan","year":"2006","journal-title":"Biomedical and Environmental Sciences"},{"key":"10.1016\/j.nbd.2026.107459_bb0380","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2026.107459_bb0385","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1158\/1535-7163.233.3.3","article-title":"Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1\u03b1","volume":"3","author":"Welsh","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.nbd.2026.107459_bb0390","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuron.2020.01.004","article-title":"Genome-wide in vivo CNS screening identifies genes that modify CNS neuronal survival and mHTT toxicity","volume":"106","author":"Wertz","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107459_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2023.149246","article-title":"Altered anterograde axonal transport of mitochondria in cultured striatal neurons of a knock-in mouse model of Huntington's disease","volume":"691","author":"Wu","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2026.107459_bb0400","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/s41419-021-04352-w","article-title":"PRMT3 promotes tumorigenesis by methylating and stabilizing HIF1\u03b1 in colorectal cancer","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2026.107459_bb0405","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41420-025-02453-5","article-title":"PKM2-mediated metabolic reprogramming of microglia in neuroinflammation","volume":"11","author":"Zhang","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.nbd.2026.107459_bb0410","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2018.00329","article-title":"A mitochondria-associated oxidative stress perspective on Huntington's disease","volume":"11","author":"Zheng","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2026.107459_bb0415","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s10020-023-00759-7","article-title":"PRMT3 methylates HIF-1\u03b1 to enhance the vascular calcification induced by chronic kidney disease","volume":"30","author":"Zhou","year":"2024","journal-title":"Mol. Med."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126002044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126002044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:52:44Z","timestamp":1785275564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996126002044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":83,"alternative-id":["S0969996126002044"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107459","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROS-HIF1\u03b1-driven glycolytic reprogramming sustains ATP production in Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107459","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107459"}}