{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:36:04Z","timestamp":1790742964970,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"EU Framework Programme for Research and Innovation Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["101072895"],"award-info":[{"award-number":["101072895"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015068","name":"Universidade de Santiago de Compostela","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.nbd.2026.107509","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:41:23Z","timestamp":1782492083000},"page":"107509","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Aging ADNP syndrome mice exhibit mutation\/sex-dependent disruption of motor behavior and circadian rhythmicity"],"prefix":"10.1016","volume":"227","author":[{"given":"Artur","family":"Galushkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliezer","family":"Giladi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Illana","family":"Gozes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.nbd.2026.107509_bb0005","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/mp.2015.208","article-title":"Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory","volume":"21","author":"Amram","year":"2016","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.nbd.2026.107509_bb0010","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.3390\/ijms24043754","article-title":"Alzheimer\u2019s disease: an updated overview of its genetics","volume":"24","author":"Andrade-Guerrero","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.nbd.2026.107509_bb0015","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/ana.25702","article-title":"Sleep deprivation affects tau phosphorylation in human cerebrospinal fluid","volume":"87","author":"Barth\u00e9lemy","year":"2020","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0020","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13148-019-0658-5","article-title":"Gene domain-specific DNA methylation episignatures highlight distinct molecular entities of ADNP syndrome","volume":"11","author":"Bend","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.nbd.2026.107509_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1430989","article-title":"The impacts of sex and the 5xFAD model of Alzheimer\u2019s disease on the sleep and spatial learning responses to feeding time","volume":"15","author":"Campbell","year":"2024","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0030","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s40478-023-01529-6","article-title":"Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer\u2019s disease","volume":"11","author":"Carrero","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"issue":"8","key":"10.1016\/j.nbd.2026.107509_bb0035","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1038\/s41380-023-02129-5","article-title":"Adnp-mutant mice with cognitive inflexibility, CaMKII\u03b1 hyperactivity, and synaptic plasticity deficits","volume":"28","author":"Cho","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2026.107509_bb0040","article-title":"The link between circadian disruption and Alzheimer\u2019s disease and related dementias: insights from peripheral inflammation","volume":"46","author":"Cordi","year":"2025","journal-title":"Curr. Opin. Physio."},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0045","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1742-4682-11-16","article-title":"Cosinor-based rhythmometry","volume":"11","author":"Cornelissen","year":"2014","journal-title":"Theor. Biol. Med. Model."},{"issue":"3","key":"10.1016\/j.nbd.2026.107509_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2025.e00570","article-title":"Maximizing the benefit and managing the risk of anti-amyloid monoclonal antibody therapy for Alzheimer\u2019s disease: strategies and research directions","volume":"22","author":"Cummings","year":"2025","journal-title":"Neurotherapeutics"},{"issue":"8","key":"10.1016\/j.nbd.2026.107509_bb0055","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.neurobiolaging.2014.02.011","article-title":"Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer\u2019s disease with plaques and tangles","volume":"35","author":"Di Meco","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.nbd.2026.107509_bb0060","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3233\/JAD-220643","article-title":"Somatic mutations and Alzheimer\u2019s disease","volume":"90","author":"Downey","year":"2022","journal-title":"J. Alzheimer\u2019s Dis"},{"key":"10.1016\/j.nbd.2026.107509_bb0065","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuroscience.2021.11.042","article-title":"Chronic fragmentation of the daily sleep-wake rhythm increases amyloid-beta levels and neuroinflammation in the 3xTg-AD mouse model of Alzheimer\u2019s disease","volume":"481","author":"Duncan","year":"2022","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.nbd.2026.107509_bb0070","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/(SICI)1098-1063(1999)9:5<534::AID-HIPO7>3.0.CO;2-R","article-title":"Locomotor activity causes a rapid up-regulation of vasoactive intestinal peptide in the rat hippocampus","volume":"9","author":"Eilam","year":"1999","journal-title":"Hippocampus"},{"issue":"8","key":"10.1016\/j.nbd.2026.107509_bb0075","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1002\/alz.12963","article-title":"Alzheimer\u2019s disease phenotypes show different sleep architecture","volume":"19","author":"Falg\u00e0s","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107509_bb0080","series-title":"The Mouse in Biomedical Research","first-page":"637","article-title":"Mouse models in aging research","author":"Flurkey","year":"2007"},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neulet.2004.09.077","article-title":"Sexual dimorphism of activity-dependent neuroprotective protein in the mouse arcuate nucleus","volume":"373","author":"Furman","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2026.107509_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.crbiot.2024.100254","article-title":"From circadian sleep disruption to neuroprotection: the potential of VIP\/PACAP in Alzheimer\u2019s disease treatment","volume":"8","author":"Galushkin","year":"2024","journal-title":"Curr. Res. Biotechnol."},{"key":"10.1016\/j.nbd.2026.107509_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2025.115573","article-title":"Intranasal NAP (davunetide): neuroprotection and circadian rhythmicity","volume":"220","author":"Galushkin","year":"2025","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"19","key":"10.1016\/j.nbd.2026.107509_bb0100","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.3390\/cells11192994","article-title":"Distinct impairments characterizing different ADNP mutants reveal aberrant cytoplasmic-nuclear crosstalk","volume":"11","author":"Ganaiem","year":"2022","journal-title":"Cells"},{"issue":"18","key":"10.1016\/j.nbd.2026.107509_bb0105","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.3390\/cells12182251","article-title":"NAP (davunetide): the neuroprotective ADNP drug candidate penetrates cell nuclei explaining pleiotropic mechanisms","volume":"12","author":"Ganaiem","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0110","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/cm.21776","article-title":"Tau, ADNP, and sex","volume":"81","author":"Gozes","year":"2024","journal-title":"Cytoskeleton"},{"issue":"4","key":"10.1016\/j.nbd.2026.107509_bb0115","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02740606","article-title":"VIP: molecular biology and neurobiological function","volume":"3","author":"Gozes","year":"1989","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2026.107509_bb0120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fnmol.2018.00151","article-title":"ADNP, a microtubule interacting protein, provides neuroprotection through end binding proteins and tau: an amplifier effect","volume":"11","author":"Gozes","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0125","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41398-023-02618-9","article-title":"Unexpected gender differences in progressive supranuclear palsy reveal efficacy for davunetide in women","volume":"13","author":"Gozes","year":"2023","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0130","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41398-020-00904-4","article-title":"Tauopathy in the young autistic brain: novel biomarker and therapeutic target","volume":"10","author":"Grigg","year":"2020","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0135","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/s41598-017-00743-2","article-title":"The fractal organization of ultradian rhythms in avian behavior","volume":"7","author":"Guzm\u00e1n","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.nbd.2026.107509_bb0140","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.1172\/JCI98199","article-title":"Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome","volume":"128","author":"Hacohen-Kleiman","year":"2018","journal-title":"J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.nbd.2026.107509_bb0145","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s12031-020-01700-x","article-title":"Sex-and region-dependent expression of the autism-linked ADNP correlates with social- and speech-related genes in the canary brain","volume":"70","author":"Hacohen-Kleiman","year":"2020","journal-title":"J. Mol. Neurosci. MN"},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0150","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s10194-018-0844-4","article-title":"PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache","volume":"19","author":"Holland","year":"2018","journal-title":"J. Headache Pain"},{"issue":"2","key":"10.1016\/j.nbd.2026.107509_bb0155","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1172\/JCI90328","article-title":"The aging clock: circadian rhythms and later life","volume":"127","author":"Hood","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.nbd.2026.107509_bb0160","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/mp.2016.255","article-title":"ADNP\/NAP dramatically increase microtubule end-binding protein-tau interaction: a novel avenue for protection against tauopathy","volume":"22","author":"Ivashko-Pachima","year":"2017","journal-title":"Mol. Psychiatry"},{"issue":"5","key":"10.1016\/j.nbd.2026.107509_bb0165","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/s41380-019-0563-5","article-title":"Discovery of autism\/intellectual disability somatic mutations in Alzheimer\u2019s brains: mutated ADNP cytoskeletal impairments and repair as a case study","volume":"26","author":"Ivashko-Pachima","year":"2021","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.nbd.2026.107509_bb0170","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/0023677216653984","article-title":"Does age matter? The impact of rodent age on study outcomes","volume":"51","author":"Jackson","year":"2017","journal-title":"Lab. Anim"},{"key":"10.1016\/j.nbd.2026.107509_bb0175","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.semcdb.2021.04.026","article-title":"Sex differences in daily timekeeping and circadian clock circuits","volume":"126","author":"Joye","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.nbd.2026.107509_bb0180","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1001\/jamaneurol.2013.2334","article-title":"Sleep quality and preclinical Alzheimer disease","volume":"70","author":"Ju","year":"2013","journal-title":"JAMA Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0185","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biopsych.2021.09.018","article-title":"Novel ADNP syndrome mice reveal dramatic sex-specific peripheral gene expression with brain synaptic and tau pathologies","volume":"92","author":"Karmon","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2026.107509_bb0190","series-title":"De Novo Design of SIK3 Inhibitors Via Feedback-Driven Fine-Tuning of Seq2Seq-VAE","author":"Khan","year":"2025"},{"key":"10.1016\/j.nbd.2026.107509_bb0195","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ynstr.2016.09.001","article-title":"Interaction between circadian rhythms and stress","volume":"6","author":"Koch","year":"2017","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.nbd.2026.107509_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2025.115561","article-title":"Nanoparticles targeting the central circadian clock: potential applications for neurological disorders","volume":"220","author":"Le Meur","year":"2025","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.nbd.2026.107509_bb0205","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.physbeh.2009.07.007","article-title":"Accelerated re-entrainment to advanced light cycles in BALB\/cJ mice","volume":"98","author":"LeGates","year":"2009","journal-title":"Physiol. Behav."},{"issue":"0","key":"10.1016\/j.nbd.2026.107509_bb0210","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1740-3391-11-5","article-title":"Wavelet analysis of circadian and ultradian behavioral rhythms","volume":"11","author":"Leise","year":"2013","journal-title":"J. Circadian Rhythms"},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0215","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13024-025-00895-0","article-title":"Brain somatic mutations in Alzheimer\u2019s disease: linking genetic mosaicism to neurodegeneration","volume":"20","author":"Li","year":"2025","journal-title":"Mol. Neurodegener."},{"issue":"8","key":"10.1016\/j.nbd.2026.107509_bb0220","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.neuron.2024.01.024","article-title":"Mechanisms of sex differences in Alzheimer\u2019s disease","volume":"112","author":"Lopez-Lee","year":"2024","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.nbd.2026.107509_bb0225","doi-asserted-by":"crossref","first-page":"e501","DOI":"10.1038\/tp.2014.138","article-title":"Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer\u2019s pathologies","volume":"5","author":"Malishkevich","year":"2015","journal-title":"Transl. Psychiatry"},{"issue":"47","key":"10.1016\/j.nbd.2026.107509_bb0230","doi-asserted-by":"crossref","first-page":"34448","DOI":"10.1074\/jbc.M704756200","article-title":"Activity-dependent neuroprotective protein constitutes a novel element in the SWI\/SNF chromatin remodeling complex","volume":"282","author":"Mandel","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.nbd.2026.107509_bb0235","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.ydbio.2006.11.039","article-title":"Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis","volume":"303","author":"Mandel","year":"2007","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/jfmk11010037","article-title":"Moderate exercise stimulates PACAP-mediated neurogenesis in rat dentate gyrus and cerebellar cortex","volume":"11","author":"Maugeri","year":"2026","journal-title":"J. Funct. Morphol. Kinesiol."},{"issue":"6315","key":"10.1016\/j.nbd.2026.107509_bb0245","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.aah4968","article-title":"Mechanisms linking circadian clocks, sleep, and neurodegeneration","volume":"354","author":"Musiek","year":"2016","journal-title":"Science (New York, N.Y.)"},{"issue":"5","key":"10.1016\/j.nbd.2026.107509_bb0250","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/ana.26643","article-title":"Lecanamab ushers in a new era of anti-amyloid therapy for Alzheimer\u2019s disease","volume":"93","author":"Musiek","year":"2023","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0255","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41582-021-00577-7","article-title":"Circadian rhythms in neurodegenerative disorders","volume":"18","author":"Nassan","year":"2022","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.nbd.2026.107509_bb0260","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.neubiorev.2011.12.012","article-title":"The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward","volume":"36","author":"Novak","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0265","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0165-3806(03)00162-7","article-title":"Activity-dependent neuroprotective protein: a novel gene essential for brain formation","volume":"144","author":"Pinhasov","year":"2003","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.nbd.2026.107509_bb0270","series-title":"Circadian physiology","author":"Refinetti","year":"2016"},{"issue":"10284","key":"10.1016\/j.nbd.2026.107509_bb0275","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer\u2019s disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2026.107509_bb0280","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuroscience.2015.01.035","article-title":"Increased fragmentation of sleep\u2013wake cycles in the 5XFAD mouse model of Alzheimer\u2019s disease","volume":"290","author":"Sethi","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2026.107509_bb0285","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-024-02879-w","article-title":"ADNP is essential for sex-dependent hippocampal neurogenesis, through male unfolded protein response and female mitochondrial gene regulation","author":"Shapira","year":"2025","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0290","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/anbe.1998.0836","article-title":"Voluntary wheel running: a review and novel interpretation","volume":"56","author":"Sherwin","year":"1998","journal-title":"Anim. Behav."},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0295","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41398-019-0569-4","article-title":"The autism-mutated ADNP plays a key role in stress response","volume":"9","author":"Sragovich","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2026.107509_bb0300","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2019.00589","article-title":"VIP\/PACAP-based drug development: the ADNP\/NAP-derived mirror peptides SKIP and D-SKIP exhibit distinctive in vivo and in silico effects","volume":"13","author":"Sragovich","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.nbd.2026.107509_bb0305","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1038\/s41467-020-17197-2","article-title":"Suprachiasmatic VIP neurons are required for normal circadian rhythmicity and comprised of molecularly distinct subpopulations","volume":"11","author":"Todd","year":"2020","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.nbd.2026.107509_bb0310","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s12031-024-02234-2","article-title":"Sex-specific ADNP\/NAP (davunetide) regulation of cocaine-induced plasticity","volume":"74","author":"Toren","year":"2024","journal-title":"J. Mol. Neurosci. MN"},{"issue":"4","key":"10.1016\/j.nbd.2026.107509_bb0315","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.biopsych.2018.02.1173","article-title":"Clinical presentation of a complex neurodevelopmental disorder caused by mutations in ADNP","volume":"85","author":"Van Dijck","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nbd.2026.107509_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2022.112076","article-title":"Aging, circadian disruption and neurodegeneration: interesting interplay","volume":"172","author":"Verma","year":"2023","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.nbd.2026.107509_bb0325","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1124\/jpet.107.129551","article-title":"Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model","volume":"323","author":"Vulih-Shultzman","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nbd.2026.107509_bb0330","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1218193","article-title":"Altered circadian behavior and light sensing in mouse models of Alzheimer\u2019s disease","volume":"15","author":"Weigel","year":"2023","journal-title":"Front. Aging Neurosci."},{"issue":"12","key":"10.1016\/j.nbd.2026.107509_bb0335","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1212\/WNL.0000000000003732","article-title":"Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia","volume":"88","author":"Westwood","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2026.107509_bb0340","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neulet.2018.04.008","article-title":"Abnormal circadian locomotor rhythms and per gene expression in six-month-old triple transgenic mice model of Alzheimer\u2019s disease","volume":"676","author":"Wu","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2026.107509_bb0345","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1195001","article-title":"Preservation of \u223c12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock","volume":"14","author":"Zhu","year":"2023","journal-title":"Front. Physiol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126002548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126002548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:55:18Z","timestamp":1787583318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996126002548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":69,"alternative-id":["S0969996126002548"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107509","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aging ADNP syndrome mice exhibit mutation\/sex-dependent disruption of motor behavior and circadian rhythmicity","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107509","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107509"}}