{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:30:52Z","timestamp":1787585452576,"version":"build-2736575974"},"reference-count":124,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2020Z73J5A"],"award-info":[{"award-number":["2020Z73J5A"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015822","name":"Fondazione Roma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG-22-92296"],"award-info":[{"award-number":["AARG-22-92296"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG-21-851219"],"award-info":[{"award-number":["AARG-21-851219"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.nbd.2026.107527","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:49:01Z","timestamp":1783601341000},"page":"107527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Midbrain dopamine loss drives parvalbumin interneuron vulnerability through tissue plasminogen activator-linked perineuronal-net breakdown and hippocampal disinhibition"],"prefix":"10.1016","volume":"227","author":[{"given":"Emma","family":"Cauzzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Ficch\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"De Paolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Saba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Montanari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Loffredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"La Barbera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Krashia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Nobili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"D'Amelio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2026.107527_bb0005","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/biomedicines9010047","article-title":"Quinpirole-mediated regulation of dopamine D2 receptors inhibits glial cell-induced neuroinflammation in cortex and striatum after brain injury","volume":"9","author":"Alam","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.nbd.2026.107527_bb0010","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3233\/JAD-181190","article-title":"Parvalbumin-positive neuron loss and amyloid-\u03b2 deposits in the frontal cortex of Alzheimer\u2019s disease-related mice","volume":"72","author":"Ali","year":"2019","journal-title":"J. Alzheimer\u2019s Dis"},{"key":"10.1016\/j.nbd.2026.107527_bb0015","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1528-1167.2006.00554.x","article-title":"Incidence and predictors of seizures in patients with Alzheimer\u2019s disease","volume":"47","author":"Amatniek","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2026.107527_bb0020","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/S0140-6736(17)32399-1","article-title":"Why do so many clinical trials of therapies for Alzheimer\u2019s disease fail?","volume":"390","author":"Anderson","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2026.107527_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040906","article-title":"Dopamine D4 receptor activation increases hippocampal gamma oscillations by enhancing synchronization of fast-spiking interneurons","volume":"7","author":"Andersson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2026.107527_bb0030","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0006-8993(87)90974-7","article-title":"Loss of parvalbumin-immunoreactive neurones from cortex in Alzheimer-type dementia","volume":"418","author":"Arai","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2026.107527_bb0035","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.neuron.2009.04.027","article-title":"Instantaneous modulation of gamma oscillation frequency by balancing excitation with inhibition","volume":"62","author":"Atallah","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107527_bb0040","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00401-005-1060-2","article-title":"Loss of perineuronal net N-acetylgalactosamine in Alzheimer\u2019s disease","volume":"110","author":"Baig","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2026.107527_bb0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn2044","article-title":"Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks","volume":"8","author":"Bartos","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-1789.2010.01117.x","article-title":"Partial loss of parvalbumin-containing hippocampal interneurons in dementia with Lewy bodies","volume":"31","author":"Bernstein","year":"2011","journal-title":"Neuropathology"},{"key":"10.1016\/j.nbd.2026.107527_bb0055","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1007\/s00259-023-06132-4","article-title":"Sex differences in dementia with Lewy bodies: an imaging study of neurotransmission pathways","volume":"50","author":"Boccalini","year":"2023","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.nbd.2026.107527_bb0060","doi-asserted-by":"crossref","first-page":"8643","DOI":"10.1523\/JNEUROSCI.20-22-08643.2000","article-title":"Neuroprotective role of dopamine against hippocampal cell death","volume":"20","author":"Bozzi","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0065","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0306-4522(97)00068-7","article-title":"Parvalbumin-immunoreactive neurons in the hippocampal formation of Alzheimer\u2019s diseased brain","volume":"80","author":"Brady","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2026.107527_bb0070","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1111\/epi.17004","article-title":"Anticonvulsant dopamine type 2 receptor agonist activates inhibitory parvalbumin interneurons","volume":"62","author":"Brodovskaya","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.nbd.2026.107527_bb0075","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.neuron.2007.12.026","article-title":"Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse","volume":"57","author":"Bucurenciu","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107527_bb0080","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-neuro-062111-150444","article-title":"Mechanisms of gamma oscillations","volume":"35","author":"Buzs\u00e1ki","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0085","doi-asserted-by":"crossref","first-page":"9130","DOI":"10.1073\/pnas.1300454110","article-title":"Perineuronal nets protect fast-spiking interneurons against oxidative stress","volume":"110","author":"Cabungcal","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2026.107527_bb0090","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1523\/JNEUROSCI.0425-20.2020","article-title":"Inhibitory parvalbumin basket cell activity is selectively reduced during hippocampal sharp wave ripples in a mouse model of familial Alzheimer\u2019s disease","volume":"40","author":"Caccavano","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0095","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1177\/0271678X16654497","article-title":"Metabolic connectomics targeting brain pathology in dementia with Lewy bodies","volume":"37","author":"Caminiti","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nbd.2026.107527_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2023.105288","article-title":"Dopaminergic connectivity reconfiguration in the dementia with Lewy bodies continuum","volume":"108","author":"Caminiti","year":"2023","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nbd.2026.107527_bb0105","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.neuron.2012.12.020","article-title":"Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits","volume":"77","author":"Campanac","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107527_bb0110","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.1523\/JNEUROSCI.0291-20.2020","article-title":"Perineuronal nets regulate the inhibitory perisomatic input onto parvalbumin interneurons and \u03b3 activity in the prefrontal cortex","volume":"40","author":"Carceller","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0115","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.neuroscience.2013.07.053","article-title":"Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus","volume":"250","author":"Castorina","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2026.107527_bb0120","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neurobiolaging.2018.08.024","article-title":"Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer\u2019s disease can be rescued by enriched environment","volume":"72","author":"Cattaud","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2026.107527_bb0125","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s12017-013-8241-2","article-title":"Calcineurin inhibition rescues early synaptic plasticity deficits in a mouse model of Alzheimer\u2019s disease","volume":"15","author":"Cavallucci","year":"2013","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.nbd.2026.107527_bb0130","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.neuron.2017.11.033","article-title":"Distinct inhibitory circuits orchestrate cortical beta and gamma band oscillations","volume":"96","author":"Chen","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107527_bb0135","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.dib.2015.06.008","article-title":"Cell type specificity of tissue plasminogen activator in the mouse barrel cortex","volume":"4","author":"Chu","year":"2015","journal-title":"Data Brief"},{"key":"10.1016\/j.nbd.2026.107527_bb0140","article-title":"Degradation of perineuronal nets in the ventral hippocampus of adult rats recreates an adolescent-like phenotype of stress susceptibility","volume":"4","author":"Colodete","year":"2024","journal-title":"Biol. Psychiatry Glob. Open Sci."},{"key":"10.1016\/j.nbd.2026.107527_bb0145","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.nbd.2018.05.006","article-title":"Dopamine loss alters the hippocampus-nucleus accumbens synaptic transmission in the Tg2576 mouse model of Alzheimer\u2019s disease","volume":"116","author":"Cordella","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2026.107527_bb0150","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0081-20.2020","article-title":"Dopamine D2-like receptors modulate intrinsic properties and synaptic transmission of parvalbumin interneurons in the mouse primary motor cortex","volume":"7","author":"Cousineau","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.nbd.2026.107527_bb0155","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.neurol.2017.03.028","article-title":"Do we know how to diagnose epilepsy early in Alzheimer\u2019s disease?","volume":"173","author":"Cretin","year":"2017","journal-title":"Rev. Neurol. (Paris)"},{"key":"10.1016\/j.nbd.2026.107527_bb0160","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/alzrt269","article-title":"Alzheimer\u2019s disease drug-development pipeline: few candidates, frequent failures","volume":"6","author":"Cummings","year":"2014","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"10.1016\/j.nbd.2026.107527_bb0165","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3233\/JAD-171018","article-title":"Volume and connectivity of the ventral tegmental area are linked to neurocognitive signatures of Alzheimer\u2019s disease in humans","volume":"63","author":"De Marco","year":"2018","journal-title":"JAD"},{"key":"10.1016\/j.nbd.2026.107527_bb0170","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40035-024-00423-y","article-title":"Transcranial alternating current stimulation (tACS) at gamma frequency: an up-and-coming tool to modify the progression of Alzheimer\u2019s disease","volume":"13","author":"De Paolis","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.nbd.2026.107527_bb0175","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13195-025-01736-4","article-title":"Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer\u2019s disease-like deficits in Tg2576 mice","volume":"17","author":"De Paolis","year":"2025","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"10.1016\/j.nbd.2026.107527_bb0180","article-title":"Resilience to Alzheimer\u2019s disease associates with alterations in perineuronal nets","author":"de Vries","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107527_bb0185","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuron.2017.06.028","article-title":"Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican","volume":"95","author":"Favuzzi","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107527_bb0190","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1038\/s41380-022-01634-3","article-title":"The extracellular matrix and perineuronal nets in memory","volume":"27","author":"Fawcett","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2026.107527_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108392","article-title":"The complex molecular pharmacology of the dopamine D2 receptor: implications for pramipexole, ropinirole, and rotigotine","volume":"245","author":"Ferraiolo","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.nbd.2026.107527_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-025-03588-w","article-title":"Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer\u2019s disease","volume":"15","author":"Ficch\u00ec","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.nbd.2026.107527_bb0205","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/mds.26586","article-title":"Hippocampal \u03b1-synuclein and interneurons in Parkinson\u2019s disease: data from human and mouse models","volume":"31","author":"Flores-Cuadrado","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2026.107527_bb0210","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.neuron.2007.01.031","article-title":"Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior","volume":"53","author":"Fuchs","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107527_bb0215","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1523\/JNEUROSCI.23-05-01622.2003","article-title":"Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex","volume":"23","author":"Gao","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0220","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jalz.2015.12.003","article-title":"Why has therapy development for dementia failed in the last two decades?","volume":"12","author":"Gauthier","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107527_bb0225","doi-asserted-by":"crossref","DOI":"10.1177\/1759091420925356","article-title":"Loss of hippocampal calretinin and parvalbumin interneurons in the 5XFAD mouse model of Alzheimer\u2019s disease","volume":"12","author":"Giesers","year":"2020","journal-title":"ASN Neuro"},{"key":"10.1016\/j.nbd.2026.107527_bb0230","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1152\/jn.00335.2002","article-title":"Mechanisms of dopamine activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex","volume":"88","author":"Gorelova","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nbd.2026.107527_bib616","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.expneurol.2016.10.009","article-title":"Functional alterations of the dopaminergic and glutamatergic systems in spontaneous \u03b1-synuclein overexpressing rats","volume":"287","author":"Guatteo","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2026.107527_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101271","article-title":"Hyperexcitable parvalbumin interneurons render hippocampal circuitry vulnerable to amyloid beta","volume":"23","author":"Hijazi","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.nbd.2026.107527_bb0240","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1038\/s41380-023-02168-y","article-title":"Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer\u2019s disease","volume":"28","author":"Hijazi","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2026.107527_bb0245","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neuroscience.2012.05.034","article-title":"Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment","volume":"217","author":"Howell","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2026.107527_bb0250","doi-asserted-by":"crossref","DOI":"10.1126\/science.1255263","article-title":"Interneurons. Fast-spiking, parvalbumin+ GABAergic interneurons: from cellular design to microcircuit function","volume":"345","author":"Hu","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.nbd.2026.107527_bb0255","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3233\/JAD-190954","article-title":"In vivo MRI structural and PET metabolic connectivity study of dopamine pathways in Alzheimer\u2019s disease","volume":"75","author":"Iaccarino","year":"2020","journal-title":"J. Alzheimer\u2019s Dis"},{"key":"10.1016\/j.nbd.2026.107527_bb0260","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nn.4231","article-title":"PV plasticity sustained through D1\/5 dopamine signaling required for long-term memory consolidation","volume":"19","author":"Karunakaran","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0265","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.10372","article-title":"Effect of rotigotine vs placebo on cognitive functions among patients with mild to moderate Alzheimer disease: a randomized clinical trial","volume":"3","author":"Koch","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.nbd.2026.107527_bb0270","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neurobiolaging.2004.03.008","article-title":"Decreased EEG synchronization in Alzheimer\u2019s disease and mild cognitive impairment","volume":"26","author":"Koenig","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2026.107527_bb0275","article-title":"The VTA dopaminergic system as diagnostic and therapeutical target for Alzheimer\u2019s disease","volume":"13","author":"Krashia","year":"2022","journal-title":"Front. Psychol."},{"key":"10.1016\/j.nbd.2026.107527_bb0280","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/s41467-024-47028-7","article-title":"Native-state proteomics of parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer\u2019s pathology","volume":"15","author":"Kumar","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107527_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102031","article-title":"Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer\u2019s disease","volume":"202","author":"La Barbera","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2026.107527_bb0290","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13024-022-00580-6","article-title":"Upregulation of Ca2+\u2212binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer\u2019s disease in Tg2576 mice","volume":"17","author":"La Barbera","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2026.107527_bb0295","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.4103\/NRR.NRR-D-24-00322","article-title":"How dopamine tunes parvalbumin interneurons in the hippocampus: new experimental observations in Alzheimer\u2019s disease","volume":"20","author":"La Barbera","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.nbd.2026.107527_bb0300","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-025-00893-2","article-title":"Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer\u2019s disease","author":"La Barbera","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2026.107527_bb0305","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nm.4330","article-title":"Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer\u2019s disease","volume":"23","author":"Lam","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2026.107527_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2013.07.025","article-title":"Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson\u2019s disease","volume":"1531","author":"Lanoue","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2026.107527_bb0315","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.nbd.2014.02.005","article-title":"tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury","volume":"66","author":"Lemarchant","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2026.107527_bb0320","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12915-022-01419-8","article-title":"Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure","volume":"20","author":"L\u00e9pine","year":"2022","journal-title":"BMC Biol."},{"key":"10.1016\/j.nbd.2026.107527_bb0325","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/cne.23701","article-title":"Cell-specific and developmental expression of lectican-cleaving proteases in mouse hippocampus and neocortex","volume":"523","author":"Levy","year":"2015","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2026.107527_bb0330","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/hipo.23503","article-title":"Elimination of perineuronal nets in CA1 disrupts GABA release and long-term contextual fear memory retention","volume":"33","author":"Liu","year":"2023","journal-title":"Hippocampus"},{"key":"10.1016\/j.nbd.2026.107527_bb0335","first-page":"327","article-title":"Phenotypic alterations in hippocampal NPY- and PV-expressing interneurons in a presymptomatic transgenic mouse model of Alzheimer\u2019s disease","volume":"8","author":"Mahar","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0340","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00406-022-01417-5","article-title":"Accelerated atrophy in dopaminergic targets and medial temporo-parietal regions precedes the onset of delusions in patients with Alzheimer\u2019s disease","volume":"273","author":"Manca","year":"2023","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0345","article-title":"Changes in neurotransmitter-related functional connectivity along the Alzheimer\u2019s disease continuum","volume":"7","author":"Manca","year":"2025","journal-title":"Brain Commun."},{"key":"10.1016\/j.nbd.2026.107527_bb0350","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tins.2007.05.003","article-title":"Role of GABAergic inhibition in hippocampal network oscillations","volume":"30","author":"Mann","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0355","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/hipo.22803","article-title":"Inhibition shapes the organization of hippocampal representations","volume":"28","author":"McKenzie","year":"2018","journal-title":"Hippocampus"},{"key":"10.1016\/j.nbd.2026.107527_bb0360","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.neuroscience.2010.05.022","article-title":"Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer\u2019s disease","volume":"169","author":"Morawski","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2026.107527_bb0365","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nn.2751","article-title":"Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory","volume":"14","author":"Murray","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0370","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61666","article-title":"Stimulus-induced gamma rhythms are weaker in human elderly with mild cognitive impairment and Alzheimer\u2019s disease","volume":"10","author":"Murty","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.nbd.2026.107527_bb0375","first-page":"1","article-title":"Early dopamine disruption in the entorhinal cortex of a knock-in model of Alzheimer\u2019s disease","author":"Nakagawa","year":"2026","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0380","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1523\/JNEUROSCI.0022-18.2018","article-title":"Control of excitation\/inhibition balance in a hippocampal circuit by calcium sensor protein regulation of presynaptic calcium channels","volume":"38","author":"Nanou","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0385","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14727","article-title":"Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer\u2019s disease","volume":"8","author":"Nobili","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107527_bb0390","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.1007\/s12035-018-0911-5","article-title":"Ambra1 shapes hippocampal inhibition\/excitation balance: role in neurodevelopmental disorders","volume":"55","author":"Nobili","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2026.107527_bb0395","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.neuroscience.2017.12.028","article-title":"Relationship between hippocampal subfields and category cued recall in AD and PDD: a multimodal MRI study","volume":"371","author":"Novellino","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2026.107527_bb0400","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrn.2016.141","article-title":"Network abnormalities and interneuron dysfunction in Alzheimer disease","volume":"17","author":"Palop","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0405","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer\u2019s disease","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.nbd.2026.107527_bb0410","doi-asserted-by":"crossref","first-page":"184","DOI":"10.5698\/1535-7511-12.5.184","article-title":"Seizures in Alzheimer disease: clinical and epidemiological data","volume":"12","author":"Pandis","year":"2012","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.nbd.2026.107527_bb0415","series-title":"Paxinos and Franklin\u2019s the Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2019"},{"key":"10.1016\/j.nbd.2026.107527_bb0420","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1038\/s41380-025-02913-5","article-title":"Dopaminergic deficits along the spectrum of Alzheimer\u2019s disease","volume":"30","author":"Pilotto","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2026.107527_bb0425","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1126\/science.1072699","article-title":"Reactivation of ocular dominance plasticity in the adult visual cortex","volume":"298","author":"Pizzorusso","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.nbd.2026.107527_bb0430","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.919092","article-title":"Dopamine increases the intrinsic excitability of parvalbumin-expressing fast-spiking cells in the piriform cortex","volume":"16","author":"Potts","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0435","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/hipo.22408","article-title":"drd2-cre:ribotag mouse line unravels the possible diversity of dopamine d2 receptor-expressing cells of the dorsal mouse hippocampus","volume":"25","author":"Puighermanal","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.nbd.2026.107527_bb0440","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s00429-016-1314-x","article-title":"Anatomical and molecular characterization of dopamine D1 receptor-expressing neurons of the mouse CA1 dorsal hippocampus","volume":"222","author":"Puighermanal","year":"2017","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.nbd.2026.107527_bb0445","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/361453a0","article-title":"Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation","volume":"361","author":"Qian","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2026.107527_bb0450","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2025.1749815","article-title":"Alteration of hippocampal parvalbumin interneurons underlies memory impairment in rat model of Parkinson\u2019s disease","volume":"19","author":"Radovanovic","year":"2026","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0455","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41582-025-01123-5","article-title":"Amyloid-lowering immunotherapies for Alzheimer disease: current status and future directions","volume":"21","author":"Rafii","year":"2025","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nbd.2026.107527_bb0460","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.tins.2019.04.003","article-title":"Perineuronal nets: plasticity, protection, and therapeutic potential","volume":"42","author":"Reichelt","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0465","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085595","article-title":"Grey matter changes in cognitively impaired Parkinson\u2019s disease patients","volume":"9","author":"Rektorova","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nbd.2026.107527_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103895","article-title":"Altered inhibitory function in hippocampal CA2 contributes in social memory deficits in Alzheimer\u2019s mouse model","volume":"25","author":"Rey","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.nbd.2026.107527_bb0475","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1002\/acn3.50919","article-title":"Hippocampal epileptogenesis in autoimmune encephalitis","volume":"6","author":"Romoli","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.nbd.2026.107527_bb0480","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1038\/nn.4152","article-title":"Midbrain dopamine neurons bidirectionally regulate CA3-CA1 synaptic drive","volume":"18","author":"Rosen","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0485","doi-asserted-by":"crossref","first-page":"10102","DOI":"10.1523\/JNEUROSCI.1122-18.2018","article-title":"Aggrecan directs extracellular matrix-mediated neuronal plasticity","volume":"38","author":"Rowlands","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0490","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nn.3077","article-title":"Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition","volume":"15","author":"Royer","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0495","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13195-021-00925-1","article-title":"In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer\u2019s disease phases","volume":"13","author":"Sala","year":"2021","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"10.1016\/j.nbd.2026.107527_bb0500","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70213","article-title":"Association between the use of levodopa\/carbidopa, Alzheimer\u2019s disease biomarkers, and cognitive decline among participants in the national Alzheimer\u2019s coordinating center uniform data set","volume":"21","author":"S\u00e1rk\u00e1ny","year":"2025","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107527_bb0505","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neurobiolaging.2018.08.012","article-title":"In vivo mapping of brainstem nuclei functional connectivity disruption in Alzheimer\u2019s disease","volume":"72","author":"Serra","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2026.107527_bb0510","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3233\/JAD-210171","article-title":"Ventral tegmental area disconnection contributes two years early to correctly classify patients converted to Alzheimer\u2019s disease: implications for treatment","volume":"82","author":"Serra","year":"2021","journal-title":"J. Alzheimer\u2019s Dis"},{"key":"10.1016\/j.nbd.2026.107527_bb0515","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nature07991","article-title":"Parvalbumin neurons and gamma rhythms enhance cortical circuit performance","volume":"459","author":"Sohal","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2026.107527_bb0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113969","article-title":"Early derailment of firing properties in CA1 pyramidal cells of the ventral hippocampus in an Alzheimer\u2019s disease mouse model","volume":"350","author":"Spoleti","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2026.107527_bb0525","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/s41380-024-02408-9","article-title":"Dopamine neuron degeneration in the ventral tegmental area causes hippocampal hyperexcitability in experimental Alzheimer\u2019s disease","volume":"29","author":"Spoleti","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2026.107527_bb0530","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0119-18.2018","article-title":"Characterization of tissue plasminogen activator expression and trafficking in the adult murine brain","volume":"5","author":"Stevenson","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.nbd.2026.107527_bb0535","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/mds.30148","article-title":"Selective effects of substantia nigra and locus coeruleus degeneration on cognition in Parkinson\u2019s disease","volume":"40","author":"Sun","year":"2025","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nbd.2026.107527_bb0540","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.25","article-title":"Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress","volume":"5","author":"Suttkus","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2026.107527_bb0545","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.neuroscience.2015.11.040","article-title":"The neuronal extracellular matrix restricts distribution and internalization of aggregated tau-protein","volume":"313","author":"Suttkus","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2026.107527_bb0550","first-page":"3234","article-title":"Development of a unilaterally-lesioned 6-OHDA mouse model of Parkinson\u2019s disease","author":"Thiele","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.nbd.2026.107527_bb0555","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1073\/pnas.1719897115","article-title":"Deletion of dopamine D2 receptors from parvalbumin interneurons in mouse causes schizophrenia-like phenotypes","volume":"115","author":"Tomasella","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2026.107527_bb0560","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/syn.20432","article-title":"D2 dopamine receptors recruit a GABA component for their attenuation of excitatory synaptic transmission in the adult rat prefrontal cortex","volume":"61","author":"Tseng","year":"2007","journal-title":"Synapse"},{"key":"10.1016\/j.nbd.2026.107527_bb0565","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/syn.20255","article-title":"Excitatory response of prefrontal cortical fast-spiking interneurons to ventral tegmental area stimulation in vivo","volume":"59","author":"Tseng","year":"2006","journal-title":"Synapse"},{"key":"10.1016\/j.nbd.2026.107527_bb0570","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2111069118","article-title":"Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories","volume":"118","author":"Tsetsenis","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2026.107527_bb0575","doi-asserted-by":"crossref","DOI":"10.1111\/ejn.70176","article-title":"Differential modulation of dopamine D2 receptor on somatostatin and parvalbumin interneurons in the CA1 area of the dorsal hippocampus","volume":"62","author":"Tuduri","year":"2025","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107527_bb0580","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41419-022-05543-9","article-title":"Modulations of the neuronal trafficking of tissue-type plasminogen activator (tPA) influences glutamate release","volume":"14","author":"Varangot","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nbd.2026.107527_bb0585","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71368-1","article-title":"Reduced monoaminergic nuclei MRI signal detectable in pre-symptomatic older adults with future memory decline","volume":"10","author":"Venneri","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nbd.2026.107527_bb0590","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","article-title":"Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model","volume":"149","author":"Verret","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2026.107527_bb0595","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1001\/jamaneurol.2013.136","article-title":"Seizures and epileptiform activity in the early stages of Alzheimer disease","volume":"70","author":"Vossel","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nbd.2026.107527_bb0600","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/15357597241280475","article-title":"Dopamine dilemma overexcites the hippocampus in Alzheimer\u2019s disease","volume":"24","author":"Wong","year":"2024","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.nbd.2026.107527_bb0605","doi-asserted-by":"crossref","first-page":"11607","DOI":"10.1073\/pnas.96.20.11607","article-title":"D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons","volume":"96","author":"Yan","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.nbd.2026.107527_bb0610","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neulet.2018.05.027","article-title":"Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer\u2019s disease mice","volume":"681","author":"Zallo","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2026.107527_bb0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109382","article-title":"Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated by perineuronal net might contribute to cognitive impairments in a mouse model of sepsis-associated encephalopathy","volume":"225","author":"Zhang","year":"2023","journal-title":"Neuropharmacology"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999612600272X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999612600272X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:51:48Z","timestamp":1787583108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096999612600272X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":124,"alternative-id":["S096999612600272X"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107527","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Midbrain dopamine loss drives parvalbumin interneuron vulnerability through tissue plasminogen activator-linked perineuronal-net breakdown and hippocampal disinhibition","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107527","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107527"}}