{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:54:54Z","timestamp":1791082494167,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","award":["CX001261"],"award-info":[{"award-number":["CX001261"]}],"id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.nbd.2026.107605","type":"journal-article","created":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T06:03:30Z","timestamp":1789279410000},"page":"107605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Matrix metalloproteinase-9 is associated with CX3CL1 on tau and amyloid biomarker pathways in APOE4 carriers"],"prefix":"10.1016","volume":"229","author":[{"given":"Aimee K.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Van Hulle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Zylstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Cronin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Rivera-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemys\u0142aw R.","family":"Kac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey E.","family":"Gleason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Auger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2026.107605_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2020.116989","volume":"416","author":"Abe","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nbd.2026.107605_bb0010","doi-asserted-by":"crossref","DOI":"10.1161\/01.STR.0000127420.10990.76","article-title":"Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer disease","volume":"35","author":"Adair","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.nbd.2026.107605_bb0015","article-title":"Alzheimer's disease facts and figures","volume":"22","year":"2026","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107605_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111200","article-title":"APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-\u03baB activation","volume":"40","author":"Arnaud","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.nbd.2026.107605_bb0025","doi-asserted-by":"crossref","first-page":"7910","DOI":"10.1523\/JNEUROSCI.16-24-07910.1996","article-title":"Matrix Metalloproteinase-9 (MMP-9) is synthesized in neurons of the human Hippocampus and is capable of degrading the amyloid-\u03b2 peptide (1\u201340)","volume":"16","author":"Backstrom","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107605_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/alz.052662","article-title":"Longitudinal changes of multiple CSF phosphorylated tau sites in dominantly inherited Alzheimer disease","volume":"17","author":"Barthelemy","year":"2021","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107605_bb0035","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s43587-023-00380-7","article-title":"CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer\u2019s disease","volume":"3","author":"Barth\u00e9lemy","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.nbd.2026.107605_bb0040","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/385640a0","article-title":"A new class of membrane-bound chemokine with a CX3C motif","volume":"385","author":"Bazan","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2026.107605_bb0045","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature11087","article-title":"Apolipoprotein E controls cerebrovascular integrity via cyclophilin a","volume":"485","author":"Bell","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2026.107605_bb0050","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1038\/s41591-023-02380-x","article-title":"Astrocyte reactivity influences amyloid-\u03b2 effects on tau pathology in preclinical Alzheimer\u2019s disease","volume":"29","author":"Bellaver","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.nbd.2026.107605_bb0055","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s12974-018-1310-6","article-title":"Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy","volume":"15","author":"Bemiller","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2026.107605_bb0060","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00702-022-02461-0","article-title":"Don\u2019t forget about tau: the effects of ApoE4 genotype on Alzheimer\u2019s disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment\u2014data from the dementia competence network","volume":"129","author":"Benson","year":"2022","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nbd.2026.107605_bb0065","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-\u03b2 and tau: the trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nbd.2026.107605_bb0070","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13024-017-0200-1","article-title":"Absence of CX3CR1 impairs the internalization of tau by microglia","volume":"12","author":"Bol\u00f3s","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2026.107605_bb0075","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1002\/alz.13784","article-title":"The six brain-specific TAU isoforms and their role in Alzheimer\u2019s disease and related neurodegenerative dementia syndromes","volume":"20","author":"Buchholz","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107605_bb0080","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/j.bbamcr.2011.08.009","article-title":"Cross talk between smooth muscle cells and monocytes\/activated monocytes via CX3CL1\/CX3CR1 axis augments expression of pro-atherogenic molecules","volume":"1813","author":"Butoi","year":"2011","journal-title":"Biochimica et Biophysica Acta (BBA) \u2013 Mol. Cell Res."},{"key":"10.1016\/j.nbd.2026.107605_bb0085","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.3390\/ijms21249739","article-title":"The roles of matrix metalloproteinases and their inhibitors in human diseases","volume":"21","author":"Cabral-Pacheco","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2026.107605_bb0090","doi-asserted-by":"crossref","DOI":"10.1002\/alz70859_106943","article-title":"Impact of icosapent ethyl on CSF NULISA vascular, metabolic, and AD biomarkers in cognitively unimpaired veterans at risk for dementia","volume":"21","author":"Carlsson","year":"2025","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107605_bb0095","series-title":"Handbook of Clinical Neurology","first-page":"85","article-title":"Cerebrospinal fluid in the dementias","year":"2018"},{"key":"10.1016\/j.nbd.2026.107605_bb0100","article-title":"CX3CL1\/CX3CR1 in Alzheimer's disease: a target for neuroprotection","volume":"2016","author":"Chen","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.nbd.2026.107605_bb0105","article-title":"Advances in the multifunctional roles of CX3CL1 in the central nervous system","volume":"18","author":"Chen","year":"2026","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nbd.2026.107605_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14502","article-title":"Clinical utility of plasma p-tau217 in identifying abnormal brain amyloid burden in an Asian cohort with high prevalence of concomitant cerebrovascular disease","volume":"21","author":"Chong","year":"2025","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107605_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/alz.082746","article-title":"Optimal combination of CSF phosphorylated-tau forms to predict Alzheimer's disease pathological burden as measured by PET","volume":"19","author":"Collij","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107605_bb0125","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.nbd.2026.107605_bb0130","series-title":"Progress in molecular biology and translational science","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.02.005","article-title":"Biochemical and biological attributes of matrix metalloproteinases","author":"Cui","year":"2017"},{"key":"10.1016\/j.nbd.2026.107605_bb0135","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The cellular phase of Alzheimer's disease","volume":"164","author":"De Strooper","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2026.107605_bb0140","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/418932a","article-title":"Cognitive change and the APOE \u025b4 allele","volume":"418","author":"Deary","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.nbd.2026.107605_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1249320","article-title":"Age-dependent changes on fractalkine forms and their contribution to neurodegenerative diseases","volume":"16","author":"Eugen\u00edn","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nbd.2026.107605_bb0150","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.exger.2009.09.005","article-title":"Blood-based biomarkers of microvascular pathology in Alzheimer's disease","volume":"45","author":"Ewers","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.nbd.2026.107605_bb0155","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1001\/archneur.64.3.noc60123","article-title":"Cerebrospinal fluid tau\/\u03b2-Amyloid42 ratio as a prediction of cognitive decline in nondemented older adults","volume":"64","author":"Fagan","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nbd.2026.107605_bb0160","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1084\/jem.20182238","article-title":"The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology","volume":"216","author":"Fan","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2026.107605_bb0165","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.3390\/ijms24032909","article-title":"Endothelial dysfunction in neurodegenerative diseases","volume":"24","author":"Fang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2026.107605_bb0170","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1038\/s41467-023-42834-x","article-title":"NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing","volume":"14","author":"Feng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107605_bb0175","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.nbd.2014.06.021","article-title":"Neuroprotective role of MMP-9 overexpression in the brain of Alzheimer's 5xFAD mice","volume":"70","author":"Fragkouli","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2026.107605_bb0180","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000005415","article-title":"Dissociable influences of APOE \u03b54 and polygenic risk of AD dementia on amyloid and cognition","volume":"90","author":"Ge","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2026.107605_bb0185","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2026.107605_bb0190","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology","volume":"83","author":"Grundke-Iqbal","year":"1986","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nbd.2026.107605_bb0195","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbi.2021.11.021","article-title":"ICAM-1 protects neurons against amyloid-\u03b2 and improves cognitive behaviors in 5xFAD mice by inhibiting NF-\u03baB","volume":"100","author":"Guha","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2026.107605_bb0200","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/s41593-019-0419-y","article-title":"Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling","volume":"22","author":"Gunner","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nbd.2026.107605_bb0205","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The amyloid-\u03b2 pathway in Alzheimer's disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nbd.2026.107605_bb0210","series-title":"Methodology in the Social Sciences","article-title":"Introduction to mediation, moderation, and conditional process analysis: A regression-based approach","author":"Hayes","year":"2022"},{"key":"10.1016\/j.nbd.2026.107605_bb0215","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3233\/JAD-200146","article-title":"Analysis of the relationship between Metalloprotease-9 and tau protein in Alzheimer's disease","volume":"76","author":"Hernandes-Alejandro","year":"2020","journal-title":"J. Alzheimer's Dis"},{"key":"10.1016\/j.nbd.2026.107605_bb0220","doi-asserted-by":"crossref","first-page":"15078","DOI":"10.1074\/jbc.M114.610931","article-title":"Sequential amyloid-\u03b2 degradation by the matrix metalloproteases MMP-2 and MMP-9","volume":"290","author":"Hernandez-Guillamon","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.nbd.2026.107605_bb0225","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/jnci\/93.3.178","article-title":"Development of matrix metalloproteinase inhibitors in Cancer therapy","volume":"93","author":"Hidalgo","year":"2001","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"10.1016\/j.nbd.2026.107605_bb0230","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1182\/blood-2002-12-3775","article-title":"The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion","volume":"102","author":"Hundhausen","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.nbd.2026.107605_bb0235","doi-asserted-by":"crossref","first-page":"8026","DOI":"10.3390\/ijms24098026","article-title":"The cytokine CX3CL1 and ADAMs\/MMPs in concerted cross-talk influencing neurodegenerative diseases","volume":"24","author":"Iemmolo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2026.107605_bb0240","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(00)80438-9","article-title":"Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion","volume":"91","author":"Imai","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.nbd.2026.107605_bb0245","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.3390\/ijms26115352","article-title":"Pathophysiological roles of the CX3CL1-CX3CR1 Axis in renal disease, cardiovascular disease, and Cancer","volume":"26","author":"Iwahashi","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nbd.2026.107605_bb0250","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nbd.2026.107605_bb0255","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107605_bb0260","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/acn3.274","article-title":"CSF a\u03b242\/a\u03b240 and a\u03b242\/a\u03b238 ratios: better diagnostic markers of Alzheimer disease","volume":"3","author":"Janelidze","year":"2016","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.nbd.2026.107605_bb0265","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000006082","article-title":"CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease","volume":"91","author":"Janelidze","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2026.107605_bb0270","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1038\/s41467-020-15436-0","article-title":"Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease","volume":"11","author":"Janelidze","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107605_bb0275","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad057","article-title":"Plasma phosphorylated tau 217 in preclinical Alzheimer's disease","volume":"5","author":"Jonaitis","year":"2023","journal-title":"Brain Commun."},{"key":"10.1016\/j.nbd.2026.107605_bb0280","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1515\/revneuro-2018-0008","article-title":"Role of p38\/MAPKs in Alzheimer's disease: implications for amyloid beta toxicity targeted therapy","volume":"30","author":"Kheiri","year":"2018","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.nbd.2026.107605_bb0285","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3390\/cells9051076","article-title":"Structure and function of human matrix metalloproteinases","volume":"9","author":"Laronha","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.nbd.2026.107605_bb0290","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-024-00755-3","article-title":"Clarifying the association of CSF a\u03b2, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease","volume":"19","author":"Lehmann","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2026.107605_bb0295","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3233\/JAD-160722","article-title":"Cerebrospinal fluid A\u03b242\/40 corresponds better than A\u03b242 to amyloid PET in Alzheimer's disease","volume":"55","author":"Lewczuk","year":"2016","journal-title":"J. Alzheimer's Dis"},{"key":"10.1016\/j.nbd.2026.107605_bb0300","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1080\/21691401.2026.2644164","article-title":"MMP9 as a shared immune-related gene in Alzheimer's and Huntington's diseases: a cross-tissue transcriptomic analysis","volume":"54","author":"Li","year":"2026","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.nbd.2026.107605_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2025.149954","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases as the biomarkers of Alzheimer's disease: a meta-analysis","author":"Mak","year":"2025","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2026.107605_bb0310","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nbd.2026.107605_bb0315","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jalz.2014.06.015","article-title":"APOE \u03b54: the most prevalent yet understudied risk factor for Alzheimer's disease","volume":"10","author":"Michaelson","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107605_bb0320","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.lfs.2018.07.036","article-title":"Exploring the potential of marine microbes in clinical management of Alzheimer's disease: a road map for bioprospecting and identifying promising isolates","volume":"208","author":"Muralidharan","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.nbd.2026.107605_bb0325","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1038\/s41467-025-60099-4","article-title":"The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease","volume":"16","author":"Murphy","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nbd.2026.107605_bb0330","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nbd.2006.11.011","article-title":"Soluble adhesion molecules and angiotensin-converting enzyme in dementia","volume":"26","author":"Nielsen","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nbd.2026.107605_bb0335","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.expneurol.2012.07.018","article-title":"Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation","volume":"237","author":"N\u00fcbling","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2026.107605_bb0340","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1742-2094-8-9","article-title":"CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease","volume":"8","author":"Pabon","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.nbd.2026.107605_bb0345","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.3390\/cells9102277","article-title":"The impact of the CX3CL1\/CX3CR1 Axis in neurological disorders","volume":"9","author":"Pawelec","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.nbd.2026.107605_bb0350","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0140-6736(93)91705-Q","article-title":"Apolipoprotein E polymorphism and Alzheimer's disease","volume":"342","author":"Poirier","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.nbd.2026.107605_bb0355","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbi.2017.01.020","article-title":"Markers of neuroinflammation associated with Alzheimer's disease pathology in older adults","volume":"62","author":"Popp","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2026.107605_bb0360","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s12035-024-04315-0","article-title":"The link between matrix metalloproteinases and Alzheimer's disease pathophysiology","volume":"62","author":"Radosinska","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nbd.2026.107605_bb0365","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/alz.12362","article-title":"Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060)","volume":"17","author":"Rajan","year":"2021","journal-title":"Alzheimers Dement. J. Alzheimers Assoc."},{"key":"10.1016\/j.nbd.2026.107605_bb0370","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neurobiolaging.2020.06.018","article-title":"Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's disease","volume":"95","author":"Ringland","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2026.107605_bb0375","doi-asserted-by":"crossref","first-page":"17035","DOI":"10.1523\/JNEUROSCI.3987-10.2010","article-title":"APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF A\u03b242","volume":"30","author":"Sheline","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2026.107605_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107989","article-title":"CX3CL1\/CX3CR1 signaling targets for the treatment of neurodegenerative diseases","volume":"231","author":"Subbarayan","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.nbd.2026.107605_bb0385","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/jnc.13072","article-title":"APOE -modulated a\u03b2-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective","volume":"133","author":"Tai","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2026.107605_bb0390","doi-asserted-by":"crossref","DOI":"10.3390\/biom15040598","article-title":"Matrix metalloproteinases: pathophysiologic implications and potential therapeutic targets in cardiovascular disease","volume":"15","author":"Tanase","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.nbd.2026.107605_bb0395","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/alz.12204","article-title":"An examination of a novel multipanel of CSF biomarkers in the Alzheimer's disease clinical and pathological continuum","volume":"17","author":"Van Hulle","year":"2021","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107605_bb0400","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13024-024-00772-2","article-title":"Proteomic analysis of APOE\u03b54 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience","volume":"19","author":"Walker","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.nbd.2026.107605_bb0405","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/jamaneurol.2023.2169","article-title":"Associations of sex, race, and apolipoprotein E alleles with multiple domains of cognition among older adults","volume":"80","author":"Walters","year":"2023","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nbd.2026.107605_bb0410","article-title":"Diagnostic accuracy of plasma p-tau217\/A\u03b242 for Alzheimer's disease in clinical and community cohorts","volume":"21","author":"Wang","year":"2025","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nbd.2026.107605_bb0415","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.3233\/JAD-2012-129031","article-title":"Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration","volume":"33","author":"Wang","year":"2012","journal-title":"J. Alzheimer's Dis"},{"key":"10.1016\/j.nbd.2026.107605_bb0420","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nbd.2026.107605_bb0425","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbi.2021.12.008","article-title":"Associations of circulating C-reactive proteins, APOE \u03b54, and brain markers for Alzheimer's disease in healthy samples across the lifespan","volume":"100","author":"Wang","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.nbd.2026.107605_bb0430","doi-asserted-by":"crossref","first-page":"R69","DOI":"10.1186\/ar2441","article-title":"Altered fractalkine cleavage potentially promotes local inflammation in NOD salivary gland","volume":"10","author":"Wildenberg","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.nbd.2026.107605_bb0440","doi-asserted-by":"crossref","DOI":"10.1097\/IN9.0000000000000018","article-title":"The role of ApoE-mediated microglial lipid metabolism in brain aging and disease","volume":"5","author":"Yen","year":"2023","journal-title":"Immunometabolism"},{"key":"10.1016\/j.nbd.2026.107605_bb0445","series-title":"Matrix Metalloproteinases","first-page":"85","article-title":"72-kDa Gelatinase (Gelatinase a): Structure, Activation, Regulation, and Substrate Specificity","author":"Yu","year":"1998"},{"key":"10.1016\/j.nbd.2026.107605_bb0450","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.21037\/apm-20-1078","article-title":"MMP-9 regulates CX3CL1\/CX3CR1 in the early phase of neuropathic pain in chronic sciatic nerve constriction injury (CCI) rats","volume":"9","author":"Zhao","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.nbd.2026.107605_bb0455","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.20160844","article-title":"Soluble TREM2 induces inflammatory responses and enhances microglial survival","volume":"214","author":"Zhong","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.nbd.2026.107605_bb0460","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/(SICI)1098-1136(20000215)29:4<305::AID-GLIA2>3.0.CO;2-V","article-title":"Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation","volume":"29","author":"Zujovic","year":"2000","journal-title":"Glia"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126003505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996126003505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:44:32Z","timestamp":1791081872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996126003505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":90,"alternative-id":["S0969996126003505"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107605","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Matrix metalloproteinase-9 is associated with CX3CL1 on tau and amyloid biomarker pathways in APOE4 carriers","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbd.2026.107605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107605"}}