{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:00:04Z","timestamp":1789034404799,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011713","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","award":["20\\u20130238"],"award-info":[{"award-number":["20\\u20130238"]}],"id":[{"id":"10.13039\/100011713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","award":["OoR2022\/100004"],"award-info":[{"award-number":["OoR2022\/100004"]}],"id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1615\/19"],"award-info":[{"award-number":["1615\/19"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["New Biotechnology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.nbt.2026.05.002","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:59:14Z","timestamp":1777942754000},"page":"9-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Multi-specific targeting of CD44 and the catalytic and hemopexin domains of MMP9 as a therapeutic strategy for osteoclast inhibition"],"prefix":"10.1016","volume":"94","author":[{"given":"Dan","family":"Pasternak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shani","family":"Ohayon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Levaot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7056-2418","authenticated-orcid":false,"given":"Niv","family":"Papo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbt.2026.05.002_bib1","first-page":"1","article-title":"Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function","author":"Li","year":"2023","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.nbt.2026.05.002_bib2","article-title":"Osteoimmunology: the crosstalk between T cells, B cells, and osteoclasts in rheumatoid arthritis","author":"Yang","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nbt.2026.05.002_bib3","first-page":"4695","article-title":"Paget \u2019 s disease of bone: an osteoimmunological disorder","author":"Press","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.nbt.2026.05.002_bib4","doi-asserted-by":"crossref","DOI":"10.1172\/JCI24281","article-title":"Paget disease of bone","volume":"115","author":"Roodman","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nbt.2026.05.002_bib5","first-page":"1","article-title":"Osteoclast signal transduction during bone metastasis formation","volume":"8","author":"M\u00f3csai","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.nbt.2026.05.002_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1067\/mgn.2001.113534","article-title":"Osteoporosis overview","volume":"22","author":"Peterson","year":"2001","journal-title":"Geriatr Nurs (Minne)"},{"key":"10.1016\/j.nbt.2026.05.002_bib7","article-title":"The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta \u2011 analysis","author":"Salari","year":"2021","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.nbt.2026.05.002_bib8","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.nbt.2026.05.002_bib9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.maturitas.2010.01.002","article-title":"Molecular biology of bone remodeling: Implications for new therapeutic targets for osteoporosis","volume":"65","author":"Gallagher","year":"2010","journal-title":"Maturitas"},{"key":"10.1016\/j.nbt.2026.05.002_bib10","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/bcp.13867","article-title":"Pharmacology of bisphosphonates","volume":"85","author":"Cremers","year":"2019","journal-title":"Br J Clin Pharm"},{"key":"10.1016\/j.nbt.2026.05.002_bib11","first-page":"475","article-title":"R. & A Gr\u00f6tz, K. Adverse effects of bisphosphonates: current issues. J Support Oncol 5:475-482","volume":"5","author":"Diel","year":"2007","journal-title":"J Support Oncol"},{"key":"10.1016\/j.nbt.2026.05.002_bib12","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0025-6196(11)60752-0","article-title":"Adverse effects of bisphosphonates: Implications for osteoporosis management","volume":"84","author":"Kennel","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.nbt.2026.05.002_bib13","first-page":"1504","article-title":"Bone Resorption by Osteoclasts","volume":"289","author":"Teitelbaum","year":"2000"},{"key":"10.1016\/j.nbt.2026.05.002_bib14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1359\/jbmr.081112","article-title":"Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine\/human) RANKL","volume":"24","author":"Kostenuik","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.nbt.2026.05.002_bib15","doi-asserted-by":"crossref","first-page":"272","DOI":"10.4103\/2278-330X.119895","article-title":"Denosumab: A comprehensive review","volume":"02","author":"Narayanan","year":"2013","journal-title":"South Asian J Cancer"},{"key":"10.1016\/j.nbt.2026.05.002_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115157","article-title":"Denosumab failure associated with escape from suppression of bone resorption","volume":"131","author":"Jones","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.nbt.2026.05.002_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-023-39076-8","article-title":"Developing a dual VEGF\/PDL1 inhibitor based on high-affinity scFv heterodimers as an anti-cancer therapeutic strategy","volume":"13","author":"Tzuri","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.nbt.2026.05.002_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2002979","article-title":"A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and \u03b1 v \u03b2 3 integrin for osteoporosis therapy","volume":"16","author":"Zur","year":"2018","journal-title":"PLoS Biol"},{"key":"10.1016\/j.nbt.2026.05.002_bib19","first-page":"203","article-title":"Matrix Metalloproteinases in Bone Resorption, Remodeling, and Repair","volume":"148","author":"Paiva","year":"2017"},{"key":"10.1016\/j.nbt.2026.05.002_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/cells9051076","article-title":"Structure and Function of Human Matrix Metalloproteinases","volume":"9","author":"Laronha","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.nbt.2026.05.002_bib21","article-title":"Biochemical and Biological Attributes of Matrix Metalloproteinases","volume":"147","author":"Cui","year":"2017"},{"key":"10.1016\/j.nbt.2026.05.002_bib22","article-title":"CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity","volume":"5","author":"Li","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.nbt.2026.05.002_bib23","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/jcp.21137","article-title":"Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function","volume":"213","author":"Samanna","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.nbt.2026.05.002_bib24","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1083\/jcb.200202120","article-title":"Hyaluronan-CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9","volume":"158","author":"Spessotto","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nbt.2026.05.002_bib25","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1042\/BCJ20200628","article-title":"Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy","volume":"478","author":"Yosef","year":"2021","journal-title":"Biochem J"},{"key":"10.1016\/j.nbt.2026.05.002_bib26","doi-asserted-by":"crossref","unstructured":"Gozlan, D.S., Meiri, R., Shapira, G., Coban, M. & Radisky, E.S. Modifying inhibitor specificity for homologous enzymes by machine learning. (2025) doi:10.1111\/febs.70249.","DOI":"10.1111\/FEBS.70249\/v2\/response1"},{"key":"10.1016\/j.nbt.2026.05.002_bib27","unstructured":"Schmidt, U., Weigert, M., Broaddus, C. & Myers, G. Cell Detection with Star-convex Polygons."},{"issue":"3","key":"10.1016\/j.nbt.2026.05.002_bib28","first-page":"403","article-title":"Structural basis for ligand recognition by RGD (Arg-Gly-Asp)-dependent integrins","volume":"32","author":"Takagi","year":"2004","journal-title":"Society"},{"key":"10.1016\/j.nbt.2026.05.002_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-14-609","article-title":"MMP-9 expression varies according to molecular subtypes of breast cancer","volume":"14","author":"Yousef","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.nbt.2026.05.002_bib30","first-page":"35944","article-title":"Role of Matrix Metalloproteinase-9 Dimers in Cell Migration","volume":"285","author":"Dufour","year":"2010","journal-title":"J"},{"key":"10.1016\/j.nbt.2026.05.002_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-024-01835-5","article-title":"ROS\/MMP-9 mediated CS degradation in BMSC inhibits citric acid metabolism participating in the dual regulation of bone remodelling","volume":"10","author":"Da","year":"2024","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.nbt.2026.05.002_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.11005\/jbm.2023.30.2.127","article-title":"Origin of osteoclasts: osteoclast precursor cells","volume":"30","author":"Tsai","year":"2023","journal-title":"J Bone Metab"},{"key":"10.1016\/j.nbt.2026.05.002_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-024-57526-9","article-title":"Real-time analysis of osteoclast resorption and fusion dynamics in response to bone resorption inhibitors","volume":"14","author":"Panwar","year":"2024","journal-title":"Sci Rep"}],"container-title":["New Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871678426000567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1871678426000567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:04:22Z","timestamp":1784185462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1871678426000567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"alternative-id":["S1871678426000567"],"URL":"https:\/\/doi.org\/10.1016\/j.nbt.2026.05.002","relation":{},"ISSN":["1871-6784"],"issn-type":[{"value":"1871-6784","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-specific targeting of CD44 and the catalytic and hemopexin domains of MMP9 as a therapeutic strategy for osteoclast inhibition","name":"articletitle","label":"Article Title"},{"value":"New Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbt.2026.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}