{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:45:09Z","timestamp":1789825509399,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202305AC160001"],"award-info":[{"award-number":["202305AC160001"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960203"],"award-info":[{"award-number":["81960203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Non-coding RNA Research"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ncrna.2025.05.006","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T19:38:40Z","timestamp":1747337920000},"page":"184-196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Tongue squamous cell carcinoma-derived exosomes miR-21-5p affect tumor progression via promoting M2 macrophage polarization"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-698X","authenticated-orcid":false,"given":"Zixian","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabei","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixian","family":"Gai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-5171","authenticated-orcid":false,"given":"Jiemei","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ncrna.2025.05.006_bib1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/cncr.23183","article-title":"Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma","volume":"112","author":"Rusthoven","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.ncrna.2025.05.006_bib2","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00784-024-05974-y","article-title":"Treatment strategy for cervical lymph node metastases from early-stage tongue and floor of the mouth squamous cell carcinoma using tumour budding and depth of invasion as predictors","volume":"28","author":"Ogawa","year":"2024","journal-title":"Clin. Oral Invest."},{"key":"10.1016\/j.ncrna.2025.05.006_bib3","doi-asserted-by":"crossref","first-page":"C1611","DOI":"10.1152\/ajpcell.00098.2022","article-title":"Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis","volume":"323","author":"Matsuo","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ncrna.2025.05.006_bib4","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/hed.27022","article-title":"Emerging histopathologic markers in early\u2010stage oral tongue cancer: a systematic review and meta\u2010analysis","volume":"44","author":"Elseragy","year":"2022","journal-title":"Head Neck"},{"key":"10.1016\/j.ncrna.2025.05.006_bib5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13045-024-01559-0","article-title":"Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy","volume":"17","author":"Toledo","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ncrna.2025.05.006_bib6","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.7150\/thno.50928","article-title":"Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes","volume":"11","author":"Han","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.ncrna.2025.05.006_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/iub.2543","article-title":"Autophagy drives plasticity and functional polarization of tumor\u2010associated macrophages","volume":"74","author":"Kuo","year":"2022","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ncrna.2025.05.006_bib8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ncb3090","article-title":"Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth","volume":"17","author":"Zhou","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ncrna.2025.05.006_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jare.2022.11.001","article-title":"Biomolecule-functionalized nanoformulations for prostate cancer theranostics","volume":"51","author":"Pranav","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ncrna.2025.05.006_bib10","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/bjs\/znac375","article-title":"Using a microRNA panel of circulating exosomes for diagnosis of pancreatic cancer: multicentre case\u2013control study","volume":"110","author":"Yang","year":"2023","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.ncrna.2025.05.006_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202304023","article-title":"Adipose\u2010derived mesenchymal stem cell\u2010derived exosomes biopotentiated extracellular matrix hydrogels accelerate diabetic wound healing and skin regeneration","volume":"10","author":"Song","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ncrna.2025.05.006_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202003505","article-title":"Shedding light on extracellular vesicle biogenesis and bioengineering","volume":"8","author":"Teng","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ncrna.2025.05.006_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41580-021-00425-y","article-title":"Plant and animal small RNA communications between cells and organisms","volume":"23","author":"Chen","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ncrna.2025.05.006_bib14","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1038\/s41467-021-24610-x","article-title":"Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ncrna.2025.05.006_bib15","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1158\/0008-5472.CAN-20-2990","article-title":"Macrophage-based approaches for cancer immunotherapy","volume":"81","author":"Anderson","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.ncrna.2025.05.006_bib16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00281-013-0367-7","article-title":"Tumor-associated macrophages: functional diversity, clinical significance, and open questions","volume":"35","author":"Biswas","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.ncrna.2025.05.006_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.478","article-title":"Tumor\u2010derived exosomal miR\u201019b\u20103p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway","volume":"11","author":"Chen","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.ncrna.2025.05.006_bib18","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13046-022-02499-8","article-title":"Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis","volume":"41","author":"Qiu","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ncrna.2025.05.006_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1032106","article-title":"Exosomal miR-452-5p induce M2 macrophage polarization to accelerate hepatocellular carcinoma progression by targeting TIMP3","volume":"2022","author":"Zongqiang","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.ncrna.2025.05.006_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111407","article-title":"Pancreatic cancer stem cell-derived exosomal miR-210 mediates macrophage M2 polarization and promotes gemcitabine resistance by targeting FGFRL1","volume":"127","author":"Guo","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ncrna.2025.05.006_bib21","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.cmet.2023.04.013","article-title":"Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment","volume":"35","author":"Wang","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.ncrna.2025.05.006_bib22","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1158\/2326-6066.CIR-23-0595","article-title":"ANXA3-Rich exosomes derived from tumor-associated macrophages regulate ferroptosis and lymphatic metastasis of laryngeal squamous cell carcinoma","volume":"12","author":"Xu","year":"2024","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ncrna.2025.05.006_bib23","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.canlet.2022.01.005","article-title":"Tumor cell-derived exosomes deliver TIE2 protein to macrophages to promote angiogenesis in cervical cancer","volume":"529","author":"Du","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ncrna.2025.05.006_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118010","article-title":"Chishao - fuzi herbal pair restore the macrophage M1\/M2 balance in acute-on-chronic liver failure","volume":"328","author":"Tan","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ncrna.2025.05.006_bib25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s43556-024-00203-0","article-title":"Deleting fibroblast growth factor 2 in macrophages aggravates septic acute lung injury by increasing M1 polarization and inflammatory cytokine secretion","volume":"5","author":"Yi","year":"2024","journal-title":"Mol Biomed"},{"key":"10.1016\/j.ncrna.2025.05.006_bib26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.canlet.2019.12.013","article-title":"Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1\/STAT1 activation","volume":"472","author":"Shen","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ncrna.2025.05.006_bib27","doi-asserted-by":"crossref","first-page":"35832","DOI":"10.1021\/acsami.3c04692","article-title":"Defined surface physicochemical cues inhibit M1 polarization of human macrophages using colloidal self-assembled patterns","volume":"15","author":"Song","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ncrna.2025.05.006_bib28","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.freeradbiomed.2024.07.036","article-title":"The new pattern for dual NOTCH pathway involving nuclear transcription and mitochondrial regulation supports therapeutic mechanism of 4-butyl benzophenone derivatives against SIRS","volume":"223","author":"Song","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ncrna.2025.05.006_bib29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.actbio.2021.12.026","article-title":"Macrophage membrane-functionalized nanofibrous mats and their immunomodulatory effects on macrophage polarization","volume":"141","author":"Nakkala","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ncrna.2025.05.006_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2023.104223","article-title":"Somatostatin receptor2 (SSTR2) expression, prognostic implications, modifications and potential therapeutic strategies associates with head and neck squamous cell carcinomas","volume":"193","author":"Fan","year":"2024","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.ncrna.2025.05.006_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2022.103778","article-title":"Unraveling molecular mechanisms of head and neck cancer","volume":"178","author":"Antra","year":"2022","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.ncrna.2025.05.006_bib32","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1007\/s00198-015-3474-6","article-title":"IL-4 administration exerts preventive effects via suppression of underlying inflammation and TNF-\u03b1-induced apoptosis in steroid-induced osteonecrosis","volume":"27","author":"Wu","year":"2016","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.ncrna.2025.05.006_bib33","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.46094","article-title":"Liver metastases and immune checkpoint inhibitor efficacy in patients with refractory metastatic colorectal cancer: a secondary analysis of a randomized clinical trial","volume":"6","author":"Chen","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.ncrna.2025.05.006_bib34","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007807","article-title":"Non--invasive CT imaging biomarker to predict immunotherapy response in gastric cancer: a multicenter study","volume":"11","author":"Huang","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ncrna.2025.05.006_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2967\/jnumed.123.266158","article-title":"Examining the relationship and prognostic significance of cell-free DNA levels and the PSMA-positive tumor volume in men with prostate cancer: a retrospective\u2013prospective [68 Ga]Ga-PSMA-11 PET\/CT study","volume":"65","author":"Kluge","year":"2024","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ncrna.2025.05.006_bib36","article-title":"What are the risk factors of hospital length of stay in the novel coronavirus pneumonia (COVID-19) patients? A survival analysis in southwest China","volume":"17","author":"Wang","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.ncrna.2025.05.006_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2023.109873","article-title":"Tectoridin alleviates caerulein-induced severe acute pancreatitis by targeting ERK2 to promote macrophage M2 polarization","volume":"752","author":"Zhou","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ncrna.2025.05.006_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155153","article-title":"N6-methyladenosine modification of TSC1 mRNA contributes to macrophage polarization regulated by Coptisine in DSS-induced ulcerative colitis","volume":"122","author":"Zhao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ncrna.2025.05.006_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110781","article-title":"Carveol alleviates osteoarthritis progression by acting on synovial macrophage polarization transformation: an in vitro and in vivo study","volume":"387","author":"Chen","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ncrna.2025.05.006_bib40","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3389\/fimmu.2020.00934","article-title":"Corrigendum: coagulation factor X regulated by CASC2c recruited macrophages and induced M2 polarization in glioblastoma multiforme","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ncrna.2025.05.006_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.914956","article-title":"C1QTNF3 is upregulated during subcutaneous adipose tissue remodeling and stimulates macrophage chemotaxis and M1-like polarization","volume":"13","author":"Micallef","year":"2022","journal-title":"Front. Immunol."}],"container-title":["Non-coding RNA Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246805402500054X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246805402500054X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:52:12Z","timestamp":1762627932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S246805402500054X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":41,"alternative-id":["S246805402500054X"],"URL":"https:\/\/doi.org\/10.1016\/j.ncrna.2025.05.006","relation":{},"ISSN":["2468-0540"],"issn-type":[{"value":"2468-0540","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tongue squamous cell carcinoma-derived exosomes miR-21-5p affect tumor progression via promoting M2 macrophage polarization","name":"articletitle","label":"Article Title"},{"value":"Non-coding RNA Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ncrna.2025.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}