{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:14:49Z","timestamp":1764260089990,"version":"build-2065373602"},"reference-count":108,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T00:00:00Z","timestamp":1557532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002993","name":"Consejer\u00eda de Educaci\u00f3n, Universidades y Sostenibilidad, Gobierno de Canarias","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002993","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nefrolog\u00eda"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.nefro.2019.02.011","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T17:10:27Z","timestamp":1559322627000},"page":"592-602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["La hipercalciuria idiop\u00e1tica revisada. \u00bfAnomal\u00eda metab\u00f3lica o enfermedad?"],"prefix":"10.1016","volume":"39","author":[{"given":"V\u00edctor M.","family":"Garc\u00eda Nieto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Luis Yanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Tejera Carre\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German","family":"Perez Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Moraleda Mesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nefro.2019.02.011_bib0545","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0022-5347(17)71257-8","article-title":"Calcium and phosphorus excretion in the urine of patients with renal or ureteral calculi","volume":"44","author":"Flocks","year":"1940","journal-title":"J Urol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0550","first-page":"1077","article-title":"Idiopathic hypercalciuria (A preliminary report)","volume":"46","author":"Albright","year":"1953","journal-title":"Proc R Soc Med."},{"key":"10.1016\/j.nefro.2019.02.011_bib0555","first-page":"568","article-title":"A propos de lithiase urinaire infantile","volume":"30","author":"Valverde","year":"1962","journal-title":"Acta Urol Belg."},{"key":"10.1016\/j.nefro.2019.02.011_bib0560","first-page":"767","article-title":"L\u2019hypercalciurie idiopathique avec nanisme et atteinte r\u00e9nale chez l\u2019enfant","volume":"38","author":"Royer","year":"1962","journal-title":"Ann Pediatr (Paris)."},{"key":"10.1016\/j.nefro.2019.02.011_bib0565","first-page":"209","article-title":"Results of the treatment of pre-urolithiasis state in children with recurrent urinary tract infections","volume":"8","author":"Kami\u0144ska","year":"2000","journal-title":"Pol Merkur Lekarski."},{"key":"10.1016\/j.nefro.2019.02.011_bib0570","first-page":"155","article-title":"The nephrologist and nephrolithiasis. Take it or leave it?","volume":"33","author":"Garc\u00eda-Nieto","year":"2013","journal-title":"Nefrologia."},{"key":"10.1016\/j.nefro.2019.02.011_bib0575","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S0022-3476(81)80389-7","article-title":"Hematuria preceding renal calculus formation in children with hypercalciuria","volume":"99","author":"Roy","year":"1981","journal-title":"J Pediatr."},{"key":"10.1016\/j.nefro.2019.02.011_bib0580","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0022-3476(81)80390-3","article-title":"The association of idiopathic hypercalciuria and asymptomatic gross hematuria in children","volume":"99","author":"Kalia","year":"1981","journal-title":"J Pediatr."},{"key":"10.1016\/j.nefro.2019.02.011_bib0585","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000396125","article-title":"Hypercalciuria in children","volume":"27","author":"Moore","year":"1981","journal-title":"Contr Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0590","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1651-2227.1987.tb10459.x","article-title":"Idiopathic hypercalciuria in children. Classification, clinical manifestations and outcome","volume":"76","author":"Cervera","year":"1987","journal-title":"Acta Paediatr Scand."},{"key":"10.1016\/j.nefro.2019.02.011_bib0595","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000189034","article-title":"Short-term experimental hypercalciuria does not produce hematuria in normal subjects","volume":"73","author":"Welch","year":"1996","journal-title":"Nephron."},{"key":"10.1016\/j.nefro.2019.02.011_bib0600","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1046\/j.1523-1755.1998.00065.x","article-title":"Association of thin basement membrane nephropathy with hypercalciuria, hyperuricosuria and nephrolithiasis","volume":"54","author":"Praga","year":"1998","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0605","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/BF00853603","article-title":"Management of children with unobstructed urinary tract infection","volume":"1","author":"Jodal","year":"1987","journal-title":"Pediatr Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0610","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/00365590410033434","article-title":"Childhood idiopathic hypercalciuria","volume":"38","author":"Escribano","year":"2004","journal-title":"Scand J Urol Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0615","first-page":"428","article-title":"Hipercalciuria idiop\u00e1tica en ni\u00f1os con infecci\u00f3n del tracto urinario","volume":"112","author":"Balestracci","year":"2014","journal-title":"Arch Argent Pediatr."},{"key":"10.1016\/j.nefro.2019.02.011_bib0620","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00467-007-0519-x","article-title":"Idiopathic hypercalciuria associated with urinary tract infection in children","volume":"22","author":"Stojanovi\u0107","year":"2007","journal-title":"Pediatr Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0625","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.anpedi.2017.04.013","article-title":"A family history of renal lithiasis in children diagnosed of urinary tract infection by Escherichia coli","volume":"88","author":"Sotoca Fern\u00e1ndez","year":"2018","journal-title":"An Pediatr (Barc)."},{"key":"10.1016\/j.nefro.2019.02.011_bib0630","first-page":"143","article-title":"Metabolic studies in patients with idiopathic hypercalciuria","volume":"29","author":"Edwards","year":"1965","journal-title":"Clin Sci."},{"key":"10.1016\/j.nefro.2019.02.011_bib0635","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1172\/JCI107774","article-title":"The hypercalciurias. Causes, parathyroid functions, and diagnostic criteria","volume":"54","author":"Pak","year":"1974","journal-title":"J Clin Invest."},{"key":"10.1016\/j.nefro.2019.02.011_bib0640","first-page":"S175","article-title":"Absence of secondary hyperparathyroidism in most patients with renal hypercalciuria","volume":"16","author":"Olmer","year":"1983","journal-title":"Kidney Int Suppl."},{"key":"10.1016\/j.nefro.2019.02.011_bib0645","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1542\/peds.97.2.216","article-title":"Renal and absorptive hypercalciuria: a metabolic disturbance with varying and interchanging modes of expression","volume":"97","author":"Aladjem","year":"1996","journal-title":"Pediatrics."},{"key":"10.1016\/j.nefro.2019.02.011_bib0650","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3109\/00365597609179678","article-title":"Bone mineral density in patients with urolithiasis. A preliminary report","volume":"10","author":"Alhava","year":"1976","journal-title":"Scand J Urol Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0655","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1210\/jcem-50-4-654","article-title":"Abnormal bone histology in idiopathic hypercalciuria","volume":"50","author":"Malluche","year":"1980","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib0660","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000414497","article-title":"About a primitive osseous origin of the so-called \u2018renal hypercalciuria\u2019","volume":"58","author":"Messa","year":"1987","journal-title":"Contrib Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0665","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1056\/NEJM198407123110201","article-title":"Evidence for disordered control of 1,25-dihydroxyvitamin D production in absorptive hypercalciuria","volume":"311","author":"Broadus","year":"1984","journal-title":"N Engl J Med."},{"key":"10.1016\/j.nefro.2019.02.011_bib0670","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1210\/jcem-61-3-490","article-title":"Elevated production rate of 1,25-dihydroxyvitamin D in patients with absorptive hypercalciuria","volume":"61","author":"Insogna","year":"1985","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib0675","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/ki.1976.33","article-title":"Bartter's syndrome with hyperplasia of renomedullary cells: successful treatment with indomethacin","volume":"9","author":"Verberckmoes","year":"1976","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0680","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0022-5347(17)52130-8","article-title":"The influence of renal prostaglandins on urinary calcium excretion in idiopathic urolithiasis","volume":"129","author":"Buck","year":"1983","journal-title":"J Urol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0685","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF02555148","article-title":"Evidence for a prostaglandin-mediated bone resorptive mechanism in subjects with fasting hypercalciuria","volume":"43","author":"Filipponi","year":"1988","journal-title":"Calcif Tissue Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0690","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1042\/cs0830075","article-title":"Increased urinary excretion of prostaglandin E2 in patients with idiopathic hypercalciuria is a primary phenomenon","volume":"83","author":"Henriquez-La Roche","year":"1992","journal-title":"Clin Sci (Lond)."},{"key":"10.1016\/j.nefro.2019.02.011_bib0695","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1210\/jcem-58-1-161","article-title":"A consideration of the hormonal basis and phosphate leak hypothesis of absorptive hypercalciuria","volume":"58","author":"Broadus","year":"1984","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib0700","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0022-3476(84)80606-X","article-title":"Hypophosphatemia and hypercalciuria in small premature infants fed human milk: evidence for inadequate dietary phosphorus","volume":"104","author":"Rowe","year":"1984","journal-title":"J Pediatr."},{"key":"10.1016\/j.nefro.2019.02.011_bib0705","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJM198503073121003","article-title":"Hereditary hypophosphatemic rickets with hypercalciuria","volume":"312","author":"Tieder","year":"1985","journal-title":"N Engl J Med."},{"key":"10.1016\/j.nefro.2019.02.011_bib0710","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000181718","article-title":"Continuing challenges to the understanding of the definition and pathophysiology of hypercalciuria","volume":"24","author":"Mart\u00ednez-Maldonado","year":"1979","journal-title":"Nephron."},{"key":"10.1016\/j.nefro.2019.02.011_bib0715","first-page":"823","article-title":"Family disposition to urinary concretions","volume":"2","author":"Clubbe","year":"1874","journal-title":"Lancet."},{"key":"10.1016\/j.nefro.2019.02.011_bib0720","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0022-5347(17)54715-1","article-title":"Familial absorptive hypercalciuria in a large kindred","volume":"126","author":"Pak","year":"1981","journal-title":"J Urol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0725","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1210\/jcem-55-2-369","article-title":"The role of dietary sodium on renal excretion and intestinal absorption of calcium and on vitamin D metabolism","volume":"55","author":"Breslau","year":"1982","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib0730","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ki.1982.168","article-title":"Importance of dietary sodium in the hypercalciuria syndrome","volume":"22","author":"Muldowney","year":"1982","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0735","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1210\/jcem-66-1-140","article-title":"Relationship of animal protein-rich diet to kidney stone formation and calcium metabolism","volume":"66","author":"Breslau","year":"1988","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib0740","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ki.1991.151","article-title":"Diet, vitamin D and vertebral mineral density in hypercalciuric calcium stone formers","volume":"39","author":"Bataille","year":"1991","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0745","first-page":"C121","article-title":"Bone mineral density in hypercalciuric children: a 5 year follow-up","volume":"9","author":"Perrone","year":"1995","journal-title":"Pediatr Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0750","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s004670050341","article-title":"Bone mineral density in pediatric patients with idiopathic hypercalciuria","volume":"11","author":"Garc\u00eda-Nieto","year":"1997","journal-title":"Pediatr Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0755","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1056\/NEJM197404182901601","article-title":"Bone-resorbing activity in supernatants from lymphoid cell lines","volume":"290","author":"Mundy","year":"1974","journal-title":"N Engl J Med."},{"key":"10.1016\/j.nefro.2019.02.011_bib0760","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1172\/JCI108106","article-title":"Effect of osteoclast activating factor from human leukocytes on bone metabolism","volume":"56","author":"Raisz","year":"1975","journal-title":"J Clin Invest."},{"key":"10.1016\/j.nefro.2019.02.011_bib0765","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1210\/jcem-71-1-138","article-title":"Increased monocyte interleukin-1 activity and decreased vertebral bone density in patients with fasting idiopathic hypercalciuria","volume":"71","author":"Pacifici","year":"1990","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib0770","first-page":"32","article-title":"Low bone mineral density and peripheral blood monocyte activation profile in calcium stone formers with idiopathic hypercalciuria","volume":"82","author":"Ghazali","year":"1997","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib0775","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5414\/CNP57183","article-title":"Bone involvement in idiopathic hypercalciuria","volume":"57","author":"Misael da Silva","year":"2002","journal-title":"Clin Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0780","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/ki.1996.210","article-title":"New insights into the pathogenesis of idiopathic hypercalciuria: the role of bone","volume":"49","author":"Weisinger","year":"1996","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0785","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0014-5793(81)80149-4","article-title":"Purification of a factor from human blood monocyte-macrophages which stimulates the production of collagenase and prostaglandin E2 by cells cultured from rheumatoid synovial tissues","volume":"124","author":"Dayer","year":"1981","journal-title":"FEBS Lett."},{"key":"10.1016\/j.nefro.2019.02.011_bib0790","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0090-6980(84)90203-X","article-title":"Biphasic action of prostaglandin E2 on conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 in chick renal tubules","volume":"27","author":"Wark","year":"1984","journal-title":"Prostaglandins."},{"key":"10.1016\/j.nefro.2019.02.011_bib0795","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ki.1983.193","article-title":"Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men","volume":"24","author":"Maierhofer","year":"1983","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0800","doi-asserted-by":"crossref","first-page":"8213","DOI":"10.1073\/pnas.82.23.8213","article-title":"1,25-dihydroxyvitamin D3 causes formation of multinucleated cells with several osteoclast characteristics in cultures of primate marrow","volume":"82","author":"Roodman","year":"1985","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1016\/j.nefro.2019.02.011_bib0805","series-title":"Renal stone disease. Crystallization process, pathophysiology, metabolic disorders and prevention","first-page":"99","article-title":"Differences in renal handling of sodium after hyposaline loading between children and adults with idiopathic hypercalciuria","author":"Garc\u00eda-Nieto","year":"1997"},{"key":"10.1016\/j.nefro.2019.02.011_bib0810","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/ki.1988.111","article-title":"Interleukin-1 induces natriuresis in conscious rats: role of renal prostaglandins","volume":"33","author":"Beasley","year":"1988","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0815","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1089\/107999002760624279","article-title":"Interleukin-1beta increases urine flow rate and inhibits protein expression of Na(+)\/K(+)-ATPase in the rat jejunum and kidney","volume":"22","author":"Kreydiyyeh","year":"2002","journal-title":"J Interferon Cytokine Res."},{"key":"10.1016\/j.nefro.2019.02.011_bib0820","first-page":"150","article-title":"Evidence for spontaneous hypercalciuria in the rat","volume":"2","author":"Favus","year":"1979","journal-title":"Miner Electrol Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib0825","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1172\/JCI113770","article-title":"Mechanism of hypercalciuria in genetic hypercalciuric rats. Inherited defect in intestinal calcium transport","volume":"82","author":"Bushinsky","year":"1988","journal-title":"J Clin Invest."},{"key":"10.1016\/j.nefro.2019.02.011_bib0830","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ki.1993.31","article-title":"Response of genetic hypercalciuric rats to a low calcium diet","volume":"43","author":"Kim","year":"1993","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0835","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1172\/JCI116246","article-title":"Increased intestinal vitamin D receptor in genetic hypercalciuric rats. A cause of intestinal calcium hyperabsorption","volume":"91","author":"Li","year":"1993","journal-title":"J Clin Invest."},{"key":"10.1016\/j.nefro.2019.02.011_bib0840","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1172\/JCI1164","article-title":"Hyperresponsiveness of vitamin D receptor gene expression to 1,25-dihydroxyvitamin D3. A new characteristic of genetic hypercalciuric stone-forming rats","volume":"101","author":"Yao","year":"1998","journal-title":"J Clin Invest."},{"key":"10.1016\/j.nefro.2019.02.011_bib0845","doi-asserted-by":"crossref","first-page":"C130","DOI":"10.1152\/ajpcell.1996.271.1.C130","article-title":"Increased sensitivity to 1,25(OH)2D3 in bone from genetic hypercalciuric rats","volume":"271","author":"Krieger","year":"1996","journal-title":"Am J Physiol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0850","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1046\/j.1523-1755.1999.00247.x","article-title":"Alendronate decreases urine calcium and supersaturation in genetic hypercalciuric rats","volume":"55","author":"Bushinsky","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0855","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/ki.1997.212","article-title":"Defective renal calcium reabsorption in genetic hypercalciuric rats","volume":"51","author":"Tsuruoka","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0860","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1681\/ASN.2004110991","article-title":"Regulation of renal calcium receptor gene expression by 1,25-dihydroxyvitamin D3 in genetic hypercalciuric stone-forming rats","volume":"16","author":"Yao","year":"2005","journal-title":"J Am Soc Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0865","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0140-6736(02)09842-2","article-title":"Association between activating mutations of calcium-sensing receptor and Bartter syndrome","volume":"360","author":"Watanabe","year":"2002","journal-title":"Lancet."},{"key":"10.1016\/j.nefro.2019.02.011_bib0870","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1210\/jc.2004-0412","article-title":"Peripheral blood monocyte vitamin D receptor levels are elevated in patients with idiopathic hypercalciuria","volume":"89","author":"Favus","year":"2004","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib0875","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000057388","article-title":"Normal vitamin D receptor concentration and responsiveness to 1,25-dihydroxyvitamin D3 in skin fibroblasts from patients with absorptive hypercalciuria","volume":"24","author":"Zerwekh","year":"1998","journal-title":"Miner Electrolyte Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib0880","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1159\/000369833","article-title":"Idiopathic calcium nephrolithiasis: a review of pathogenic mechanisms in the light of genetic studies","volume":"40","author":"Arcidiacono","year":"2014","journal-title":"Am J Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0885","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/ng.404","article-title":"Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density","volume":"412","author":"Thorleifsson","year":"2009","journal-title":"Nat Genet."},{"key":"10.1016\/j.nefro.2019.02.011_bib0890","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/ndt\/gfh754","article-title":"Mapping a new suggestive gene locus for autosomal dominant nephrolithiasis to chromosome 9q33.2-q34.2 by total genome search for linkage","volume":"20","author":"Wolf","year":"2005","journal-title":"Nephrol Dial Transplant."},{"key":"10.1016\/j.nefro.2019.02.011_bib0895","first-page":"510","article-title":"Herencia y prevalencia de hipercalciuria en la poblaci\u00f3n infantil de la isla de La Gomera","volume":"20","author":"Meli\u00e1n","year":"2000","journal-title":"Nefrolog\u00eda."},{"year":"2005","series-title":"La toponimia de La Gomera. Un estudio sobre los nombres de lugar, las voces ind\u00edgenas y los nombres de plantas, animales y hongos de La Gomera","author":"Perera L\u00f3pez","key":"10.1016\/j.nefro.2019.02.011_bib0900"},{"key":"10.1016\/j.nefro.2019.02.011_bib0905","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00467-006-0136-0","article-title":"Urolithiasis, idiopathic hypercalciuria and insularity","volume":"21","author":"Garc\u00eda-Nieto","year":"2006","journal-title":"Pediatr Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0910","first-page":"277","article-title":"The immunological functions of the vitamin D endocrine system","volume":"49","author":"Hayes","year":"2003","journal-title":"Cell Mol Biol (Noisy-le-grand)."},{"key":"10.1016\/j.nefro.2019.02.011_bib0915","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.coph.2010.04.001","article-title":"Vitamin D: modulator of the immune system","volume":"10","author":"Baeke","year":"2010","journal-title":"Curr Opin Pharmacol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0920","doi-asserted-by":"crossref","first-page":"755","DOI":"10.5694\/j.1326-5377.1971.tb92527.x","article-title":"Urinary calculi in Fiji Indians. The curry kidney","volume":"2","author":"Holmes","year":"1971","journal-title":"Med J Aust."},{"key":"10.1016\/j.nefro.2019.02.011_bib0925","first-page":"1481","article-title":"Hospital morbidity in the Fiji islands with special reference to the saccharine disease","volume":"49","author":"Sorokin","year":"1975","journal-title":"S Afr Med J."},{"key":"10.1016\/j.nefro.2019.02.011_bib0930","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/bmj.2.6027.69-a","article-title":"Curry kidney","volume":"2","author":"An\u00f3nimo","year":"1976","journal-title":"Br Med J."},{"key":"10.1016\/j.nefro.2019.02.011_bib0935","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/ki.1994.347","article-title":"Demographic and geographic variability of kidney stones in the United States","volume":"46","author":"Soucie","year":"1994","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib0940","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s00467-005-1861-5","article-title":"High incidence of kidney stones in Icelandic children","volume":"20","author":"Edvardsson","year":"2005","journal-title":"Pediatr Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0945","first-page":"11","article-title":"Inbreeding and nephrolithiasis in Croatian island isolates","volume":"26","author":"Rudan","year":"2002","journal-title":"Coll Antropol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0950","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0026-0495(86)90002-8","article-title":"Bone resorption and hypercalciuria in calcium stone formers","volume":"35","author":"Sutton","year":"1986","journal-title":"Metabolism."},{"key":"10.1016\/j.nefro.2019.02.011_bib0955","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1699-0463.1989.tb00793.x","article-title":"A histomorphometric determination of iliac bone remodeling in patients with recurrent renal stone formation and idiopathic hypercalciuria","volume":"97","author":"Steiniche","year":"1989","journal-title":"APMIS."},{"key":"10.1016\/j.nefro.2019.02.011_bib0960","first-page":"175","article-title":"Bone disease in calcium stone forming patients","volume":"42","author":"Heilberg","year":"1994","journal-title":"Clin Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0965","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2215\/CJN.00240108","article-title":"RANKL is a mediator of bone resorption in idiopathic hypercalciuria","volume":"3","author":"Gomes","year":"2008","journal-title":"Clin J Am Soc Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0970","doi-asserted-by":"crossref","first-page":"c89","DOI":"10.1159\/000072491","article-title":"Bone mineral density in girls and their mothers with idiopathic hypercalciuria","volume":"94","author":"Garc\u00eda-Nieto","year":"2003","journal-title":"Nephron Clin Pract."},{"key":"10.1016\/j.nefro.2019.02.011_bib0975","series-title":"Eurolithiasis","first-page":"31","article-title":"Biochemical markers of bone activity in children with idiopathic hypercalciuria","author":"Garc\u00eda-Nieto","year":"2001"},{"key":"10.1016\/j.nefro.2019.02.011_bib0980","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s004670050133","article-title":"Urinary inhibitors of crystallization in hypercalciuric children with hematuria and nephrolithiasis","volume":"10","author":"Perrone","year":"1996","journal-title":"Pediatr Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib0985","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s00467-005-2035-1","article-title":"Hypocitraturia: A risk factor for reduced bone mineral density in idiopathic hypercalciuria?","volume":"21","author":"Penido","year":"2006","journal-title":"Pediatr Nephrol."},{"issue":"Supl. 1","key":"10.1016\/j.nefro.2019.02.011_bib0990","first-page":"144","article-title":"Estudio longitudinal de la densidad mineral \u00f3sea en pacientes con hipercalciuria idiop\u00e1tica. M\u00e1s de dos d\u00e9cadas de seguimiento","volume":"37","author":"P\u00e9rez Su\u00e1rez","year":"2017","journal-title":"Nefrologia."},{"key":"10.1016\/j.nefro.2019.02.011_bib0995","first-page":"2083","article-title":"Longitudinal study, bone mineral density in children diagnosed with idiopathic hypercalciuria","volume":"24","author":"Garc\u00eda Nieto","year":"2009","journal-title":"Pediatr Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib1000","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF02017547","article-title":"Determination of hydroxyl content of calcified tissue mineral","volume":"5","author":"Vatassery","year":"1970","journal-title":"Calcif Tissue Res."},{"key":"10.1016\/j.nefro.2019.02.011_bib1005","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0034-5687(75)90053-5","article-title":"The bone CO2 compartment: evidence for a bicarbonate pool","volume":"25","author":"Poyart","year":"1975","journal-title":"Respir Physiol."},{"key":"10.1016\/j.nefro.2019.02.011_bib1010","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1056\/NEJM196806132782403","article-title":"Genetic predisposition to formation of calcium oxalate renal calculi","volume":"278","author":"Resnick","year":"1968","journal-title":"N Engl J Med."},{"key":"10.1016\/j.nefro.2019.02.011_bib1015","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1056\/NEJM197902153000703","article-title":"Familial idiopathic hypercalciuria","volume":"300","author":"Coe","year":"1979","journal-title":"N Engl J Med"},{"issue":"3 Pt 2","key":"10.1016\/j.nefro.2019.02.011_bib1020","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0022-5347(17)40994-3","article-title":"Familial forms of hypercalciuria","volume":"141","author":"Favus","year":"1989","journal-title":"J Urol."},{"key":"10.1016\/j.nefro.2019.02.011_bib1025","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1053\/j.ajkd.2004.06.030","article-title":"Genetics of hypercalciuria and calcium nephrolithiasis: from the rare monogenic to the common polygenic forms","volume":"44","author":"Gambaro","year":"2004","journal-title":"Am J Kidney Dis."},{"key":"10.1016\/j.nefro.2019.02.011_bib1030","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1681\/ASN.2004100888","article-title":"Genetic hypercalciuria","volume":"16","author":"Moe","year":"2005","journal-title":"J Am Soc Nephrol."},{"key":"10.1016\/j.nefro.2019.02.011_bib1035","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/(SICI)1096-8628(19980616)78:1<52::AID-AJMG10>3.0.CO;2-N","article-title":"4q33-qter deletion and absorptive hypercalciuria: report of two unrelated girls","volume":"78","author":"Imamura","year":"1998","journal-title":"Am J Med Genet."},{"key":"10.1016\/j.nefro.2019.02.011_bib1040","first-page":"3907","article-title":"Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24","volume":"84","author":"Reed","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib1045","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1210\/jcem.87.4.8300","article-title":"Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density","volume":"87","author":"Reed","year":"2002","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.nefro.2019.02.011_bib1050","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1046\/j.1523-1755.2000.00774.x","article-title":"Isolated hypercalciuria with mutation in CLCN5: relevance to idiopathic hypercalciuria","volume":"57","author":"Scheinman","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib1055","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1046\/j.1523-1755.2000.00138.x","article-title":"Evaluation of the calcium-sensing receptor gene in idiopathic hypercalciuria and calcium nephrolithiasis","volume":"58","author":"Petrucci","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.nefro.2019.02.011_bib1060","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1093\/ndt\/17.9.1614","article-title":"Epithelial Ca(2+) channel (ECAC1) in autosomal dominant idiopathic hypercalciuria","volume":"17","author":"M\u00fcller","year":"2002","journal-title":"Nephrol Dial Transplant."},{"key":"10.1016\/j.nefro.2019.02.011_bib1065","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.nefro.2017.07.004","article-title":"Quantification of the risk of urinary calcium stone formation in the urine collected at two times of the day in a group of children studied to rule out prelithiasis","volume":"38","author":"Garc\u00eda Nieto","year":"2018","journal-title":"Nefrologia."},{"key":"10.1016\/j.nefro.2019.02.011_bib1070","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/pgmj.40.461.130","article-title":"The aetiology and treatment of urinary calculus","volume":"40","author":"Hodgkinson","year":"1964","journal-title":"Postgrad Med J."},{"key":"10.1016\/j.nefro.2019.02.011_bib1075","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0009-8981(97)06554-6","article-title":"Simple test to evaluate the risk of urinary calcium stone formation","volume":"263","author":"Grases","year":"1997","journal-title":"Clin Chim Acta."},{"key":"10.1016\/j.nefro.2019.02.011_bib1080","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00467-011-1987-6","article-title":"Effect of thiazides on bone mineral density in children with idiopathic hypercalciuria","volume":"27","author":"Garc\u00eda-Nieto","year":"2012","journal-title":"Pediatr Nephrol."}],"container-title":["Nefrolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0211699519300918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0211699519300918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T12:54:20Z","timestamp":1759323260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0211699519300918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":108,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0211699519300918"],"URL":"https:\/\/doi.org\/10.1016\/j.nefro.2019.02.011","relation":{},"ISSN":["0211-6995"],"issn-type":[{"type":"print","value":"0211-6995"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"La hipercalciuria idiop\u00e1tica revisada. \u00bfAnomal\u00eda metab\u00f3lica o enfermedad?","name":"articletitle","label":"Article Title"},{"value":"Nefrolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nefro.2019.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Sociedad Espa\u00f1ola de Nefrolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}