{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:45:35Z","timestamp":1790210735246,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nefrolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.nefroe.2021.12.009","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T18:10:05Z","timestamp":1641406205000},"page":"612-619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mesoamerican nephropathy: A not so unknown chronic kidney disease"],"prefix":"10.1016","volume":"41","author":[{"given":"Mariel Fabiola","family":"Valdivia Mazeyra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mu\u00f1oz Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Alonso Ria\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohana","family":"Gil Giraldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"Quiroga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nefroe.2021.12.009_bib0005","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1053\/j.ajkd.2013.10.062","article-title":"CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy","volume":"63","author":"Correa-Rotter","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0010","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1590\/S1020-49892002000900009","article-title":"Nefropat\u00eda terminal en pacientes de un hospital de referencia en El Salvador","volume":"12","author":"Garc\u00eda-Trabanino","year":"2002","journal-title":"Rev Panam Salud Publica"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0015","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.semnephrol.2019.02.005","article-title":"Chronic kidney disease of unknown etiology: hotspots in india and other Asian countries","volume":"39","author":"Abraham","year":"2019","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0020","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.semnephrol.2019.02.006","article-title":"Chronic interstitial nephritis in agricultural communities (CINAC) in Sri Lanka","volume":"39","author":"Jayasumana","year":"2019","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0025","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.semnephrol.2019.02.004","article-title":"Mesoamerican nephropathy","volume":"39","author":"Correa-Rotter","year":"2019","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0030","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.nefro.2016.03.018","article-title":"Incidence, mortality, and prevalence of end-stage chronic renal disease in the Bajo Lempa region of El Salvador: a ten-year community registry","volume":"36","author":"Garc\u00eda-Trabanino","year":"2016","journal-title":"Nefrologia"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0035","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5414\/CN110186","article-title":"The unresolved epidemic of chronic kidney disease of uncertain origin (CKDu) around the world: a review and new insights","volume":"95","author":"Campese","year":"2021","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0040","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2147\/IJNRD.S270709","article-title":"Mesoamerican nephropathy (MeN): what we know so far","volume":"13","author":"Sanchez Polo","year":"2020","journal-title":"Int J Nephrol Renovasc Dis"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0045","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/ki.2014.306","article-title":"Burnt sugarcane harvesting is associated with acute renal dysfunction","volume":"87","author":"Paula Santos","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0050","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1152\/ajpregu.00354.2015","article-title":"Rehydration with soft drink-like beverages exacerbates dehydration and worsens dehydration-associated renal injury","volume":"311","author":"Garc\u00eda-Arroyo","year":"2016","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0055","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1681\/ASN.2008060576","article-title":"Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells","volume":"20","author":"Cirillo","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0060","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/ndt\/gfx033","article-title":"Con: Mesoamerican nephropathy: is the problem dehydration or rehydration?","volume":"32","author":"Campese","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0065","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1053\/j.ajkd.2015.08.021","article-title":"Heat stress nephropathy from exercise-induced uric acid crystalluria: a perspective on mesoamerican nephropathy","volume":"67","author":"Roncal-Jimenez","year":"2016","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0070","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/ndt\/gfw346","article-title":"Chronic interstitial nephritis in agricultural communities: a worldwide epidemic with social, occupational and environmental determinants","volume":"32","author":"Jayasumana","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0075","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/ckj\/sfx136","article-title":"What do epidemiological studies tell us about chronic kidney disease of undetermined cause in Meso-America? A systematic review and meta-analysis","volume":"11","author":"Gonz\u00e1lez-Quiroz","year":"2018","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0080","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12940-017-0254-0","article-title":"Pesticide exposures and chronic kidney disease of unknown etiology: an epidemiologic review","volume":"16","author":"Valcke","year":"2017","journal-title":"Environ Health"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0085","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3109\/0886022X.2011.623496","article-title":"Occupational silica exposure and chronic kidney disease","volume":"34","author":"Vupputuri","year":"2012","journal-title":"Ren Fail"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0090","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000480691","article-title":"Leptospirosis renal disease: emerging culprit of chronic kidney disease unknown etiology","volume":"138","author":"Yang","year":"2018","journal-title":"Nephron"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0095","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.envres.2016.02.002","article-title":"Kidney function in sugarcane cutters in Nicaragua \u2014 a longitudinal study of workers at risk of Mesoamerican nephropathy","volume":"147","author":"Wesseling","year":"2016","journal-title":"Environ Res"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0100","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/ndt\/gfv292","article-title":"Urine biomarkers of kidney injury among adolescents in Nicaragua, a region affected by an epidemic of chronic kidney disease of unknown aetiology","volume":"31","author":"Ram\u00edrez-Rubio","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0105","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00467-020-04595-3","article-title":"Biomarkers of kidney injury among children in a high-risk region for chronic kidney disease of uncertain etiology","volume":"36","author":"Leibler","year":"2021","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0110","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/MNH.0000000000000331","article-title":"Pathophysiologic insight into MesoAmerican nephropathy","volume":"26","author":"Madero","year":"2017","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0115","doi-asserted-by":"crossref","first-page":"49","DOI":"10.37757\/MR2014.V16.N2.8","article-title":"Histopathology of chronic kidney disease of unknown etiology in Salvadoran agricultural communities","volume":"16","author":"L\u00f3pez-Mar\u00edn","year":"2014","journal-title":"MEDICC Rev"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0120","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.ekir.2020.06.032","article-title":"Creatinine fluctuations forecast cross-harvest kidney function decline among sugarcane workers in guatemala","volume":"5","author":"Dally","year":"2020","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0125","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1053\/j.ajkd.2013.05.019","article-title":"Clinical and pathological characterization of Mesoamerican nephropathy: a new kidney disease in Central America","volume":"62","author":"Wijkstr\u00f6m","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0130","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.4269\/ajtmh.17-0260","article-title":"Clinical evidence of acute Mesoamerican nephropathy","volume":"97","author":"Fischer","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0135","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1053\/j.ajkd.2016.10.036","article-title":"Renal morphology, clinical findings, and progression rate in Mesoamerican nephropathy","volume":"69","author":"Wijkstr\u00f6m","year":"2017","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0140","unstructured":"Elinder CG, Wernerson AO. Mesoamerican nephropaty. UptoDate: [Accessed 11 March 2021] Available from: https:\/\/www.uptodate.com\/home."},{"key":"10.1016\/j.nefroe.2021.12.009_bib0145","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1053\/j.ajkd.2018.04.014","article-title":"Acute kidney injury in sugarcane workers at risk for Mesoamerican nephropathy","volume":"72","author":"Kupferman","year":"2018","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0150","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.kint.2019.11.009","article-title":"Chronic interstitial nephritis in agricultural communities is a toxin-induced proximal tubular nephropathy","volume":"97","author":"Vervaet","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0155","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000500373","article-title":"Hydration status and kidney health of factory workers exposed to heat stress: a pilot feasibility study","volume":"74 Suppl 3","author":"Nerbass","year":"2019","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0160","series-title":"Report from the third international workshop on chronic kidney diseases of uncertain\/non-traditional etiology in Mesoamerica and other regions","year":"2020"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0165","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.3389\/fphar.2020.01160","article-title":"Traditional herbal medicine in Mesoamerica: toward its evidence base for improving universal health coverage","volume":"11","author":"Geck","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0170","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.3390\/nu12061639","article-title":"Pathophysiological mechanisms by which heat stress potentially induces kidney inflammation and chronic kidney disease in sugarcane workers","volume":"12","author":"Hansson","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0175","unstructured":"Garc\u00eda-Trabanino R, Correa-Rotter R. Nefropat\u00eda End\u00e9mica Mesoamericana. Nefrolog\u00eda al d\u00eda. [Accessed 31 May 2021] Available from: https:\/\/www.nefrologiaaldia.org\/319."},{"key":"10.1016\/j.nefroe.2021.12.009_bib0180","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000494663","article-title":"Kidney injury from recurrent heat stress and rhabdomyolysis: protective role of allopurinol and sodium bicarbonate","volume":"48","author":"S\u00e1nchez-Lozada","year":"2018","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0185","doi-asserted-by":"crossref","first-page":"F726","DOI":"10.1152\/ajprenal.00543.2017","article-title":"Experimental heat stress nephropathy and liver injury are improved by allopurinol","volume":"315","author":"Roncal-Jimenez","year":"2018","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0190","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1056\/NEJMra0801327","article-title":"Rhabdomyolysis and acute kidney injury","volume":"361","author":"Bosch","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0195","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/MNH.0000000000000491","article-title":"Clinical evidence that treatment of metabolic acidosis slows the progression of chronic kidney disease","volume":"28","author":"Goraya","year":"2019","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0200","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMoa011161","article-title":"Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy","volume":"345","author":"Brenner","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0205","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.kint.2018.08.020","article-title":"Clinical markers to predict progression from acute to chronic kidney disease in Mesoamerican nephropathy","volume":"94","author":"Fischer","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2020.110414","article-title":"Chronic interstitial nephritis in agricultural communities (CINAC) and lysosomal tubulopathy: is there a place for anti-oxidants?","volume":"146","author":"Rodrigo","year":"2021","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0215","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1681\/ASN.2018020151","article-title":"Decline in kidney function among apparently healthy young adults at risk of Mesoamerican nephropathy","volume":"29","author":"Gonzalez-Quiroz","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2021.12.009_bib0220","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.nefro.2016.01.015","article-title":"Prevalence of patients receiving renal replacement therapy in El Salvador in 2014","volume":"36","author":"Garc\u00eda-Trabanino","year":"2016","journal-title":"Nefrologia"}],"container-title":["Nefrolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S201325142100136X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S201325142100136X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T19:47:43Z","timestamp":1761853663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S201325142100136X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S201325142100136X"],"URL":"https:\/\/doi.org\/10.1016\/j.nefroe.2021.12.009","relation":{},"ISSN":["2013-2514"],"issn-type":[{"value":"2013-2514","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesoamerican nephropathy: A not so unknown chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Nefrolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nefroe.2021.12.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedad Espa\u00f1ola de Nefrolog\u00eda.","name":"copyright","label":"Copyright"}]}}