{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:02:56Z","timestamp":1784206976470,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nefrolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.nefroe.2022.02.012","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T12:38:15Z","timestamp":1671194295000},"page":"458-466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bone mineral density and growth changes in patients with distal renal tubular acidosis after two-years treatment with a new alkalizing drug (ADV7103)"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4207-824X","authenticated-orcid":false,"given":"Aur\u00e9lia","family":"Bertholet-Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-9065","authenticated-orcid":false,"given":"Maria A.","family":"Manso-Silv\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-3828","authenticated-orcid":false,"given":"Victor","family":"Navas-Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Guittet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Joukoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Bacchetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3957-1359","authenticated-orcid":false,"given":"Olivia","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Rodriguez Portillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4174-2487","authenticated-orcid":false,"given":"Luc-Andr\u00e9","family":"Granier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nefroe.2022.02.012_bib0200","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1097\/01.ASN.0000023430.92674.E5","article-title":"Renal tubular acidosis: the clinical entity","volume":"13","author":"Rodriguez Soriano","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0205","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000478781","article-title":"New findings on the pathogenesis of distal renal tubular acidosis","volume":"3","author":"Trepiccione","year":"2017","journal-title":"Kidney Dis"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0210","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1681\/ASN.2005070732","article-title":"Acid\u2013Base status determines the renal expression of Ca2+ and Mg2+ transport proteins","volume":"17","author":"Nijenhuis","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0215","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1172\/JCI108962","article-title":"Attainment and maintenance of normal stature with alkali therapy in infants and children with classic renal tubular acidosis","volume":"61","author":"McSherry","year":"1978","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0220","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1046\/j.1523-1755.2001.0590031086.x","article-title":"Bone mineral density and histology in distal renal tubular acidosis","volume":"59","author":"Domrongkitchaiporn","year":"2001","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0225","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00041552-200007000-00008","article-title":"The effects of acid on bone","volume":"9","author":"Bushinsky","year":"2000","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0230","doi-asserted-by":"crossref","first-page":"F532","DOI":"10.1152\/ajprenal.00128.2003","article-title":"Chronic acidosis-induced alteration in bone bicarbonate and phosphate","volume":"285","author":"Bushinsky","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0235","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S1073-4449(12)80070-7","article-title":"The role of metabolic acidosis in the pathogenesis of renal osteodystrophy","volume":"2","author":"Kraut","year":"1995","journal-title":"Adv Ren Replace Ther"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0240","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1079\/PNS2003268","article-title":"Regulation of bone cell function by acid-base balance","volume":"62","author":"Arnett","year":"2003","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0245","series-title":"Acid\u2013base disorders: clinical evaluation and management","first-page":"127","article-title":"Renal tubular acidosis","author":"Reddi","year":"2020"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0250","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1046\/j.1523-1755.2000.00086.x","article-title":"Effect of metabolic acidosis on the growth hormone\/IGF-I endocrine axis in skeletal growth centers","volume":"57","author":"Green","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0255","first-page":"261","article-title":"Clinical profile of distal renal tubular acidosis","volume":"22","author":"Jha","year":"2011","journal-title":"Saudi J Kidney Dis Transplant"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0260","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.kint.2016.12.017","article-title":"The genetic and clinical spectrum of a large cohort of patients with distal renal tubular acidosis","volume":"91","author":"Palazzo","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0265","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2174\/1874312901408010103","article-title":"Sj\u00f6gren's, renal tubular acidosis and osteomalacia \u2013 an Asian Indian series","volume":"8","author":"Sandhya","year":"2014","journal-title":"Open Rheumatol J"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0270","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1136\/ard.46.10.768","article-title":"Clinical studies of renal disease in Sj\u00f6gren's syndrome","volume":"46","author":"Shiozawa","year":"1987","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0275","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2169\/internalmedicine.54.9421","article-title":"Clinical evaluation of Chinese patients with primary distal renal tubular acidosis","volume":"54","author":"Zhang","year":"2015","journal-title":"Intern Med"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0280","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1053\/ajkd.2002.30560","article-title":"Dosage of potassium citrate in the correction of urinary abnormalities in pediatric distal renal tubular acidosis patients","volume":"39","author":"Domrongkitchaiporn","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0285","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1046\/j.1523-1755.2002.00656.x","article-title":"Bone histology and bone mineral density after correction of acidosis in distal renal tubular acidosis","volume":"62","author":"Domrongkitchaiporn","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0290","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1007\/s00467-020-04685-2","article-title":"Evaluation of phenotypic and genotypic features of children with distal kidney tubular acidosis","volume":"35","author":"Atmis","year":"2020","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0295","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/ndt\/gfy409","article-title":"Treatment and long-term outcome in primary distal renal tubular acidosis","volume":"34","author":"Lopez-Garcia","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0300","doi-asserted-by":"crossref","first-page":"13960","DOI":"10.1038\/s41598-020-70549-2","article-title":"Innovative prolonged-release oral alkalising formulation allowing sustained urine pH increase with twice daily administration: randomised trial in healthy adults","volume":"10","author":"Guittet","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0305","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00467-020-04693-2","article-title":"Efficacy and safety of an innovative prolonged-release combination drug in patients with distal renal tubular acidosis: an open-label comparative trial versus standard of care treatments","volume":"36","author":"Bertholet-Thomas","year":"2021","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0310","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00467-020-04873-0","article-title":"Safety, efficacy, and acceptability of ADV7103 during 24 months of treatment: an open-label study in pediatric and adult patients with distal renal tubular acidosis","volume":"36","author":"Bertholet-Thomas","year":"2021","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0315","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jocd.2013.08.004","article-title":"Executive summary of the 2013 International Society for Clinical Densitometry Position Development Conference on bone densitometry","volume":"16","author":"Schousboe","year":"2013","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0320","doi-asserted-by":"crossref","unstructured":"WHO MGRSG, de Onis M. WHO Child Growth Standards based on length\/height, weight and age. Acta Paediatr. Suppl. 2006;450:76\u201385. https:\/\/doi.org\/10.1111\/j.1651-2227.2006.tb02378.x.","DOI":"10.1111\/j.1651-2227.2006.tb02378.x"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0325","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2471\/BLT.07.043497","article-title":"Development of a WHO growth reference for school-aged children and adolescents","volume":"85","author":"de Onis","year":"2007","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0330","series-title":"Auxologie: m\u00e9thode et s\u00e9quences","author":"Semp\u00e9","year":"1979"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0335","series-title":"Handbook of growth and growth monitoring in health and disease","first-page":"2999","article-title":"Growth velocity curves: what they are and how to use them","author":"Bozzola","year":"2012"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0340","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/ajcn\/43.5.711","article-title":"Incremental growth tables: supplementary to previously published charts","volume":"43","author":"Baumgartner","year":"1986","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0345","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/GIM.0b013e3181a7e8f8","article-title":"ACMG practice guideline: genetic evaluation of short stature","volume":"11","author":"Seaver","year":"2009","journal-title":"Genet Med"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0350","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jcf.2010.01.003","article-title":"Incorporating genetic potential when evaluating stature in children with cystic fibrosis","volume":"9","author":"Zhang","year":"2010","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0355","first-page":"321","article-title":"Long-term outcome in children with primary distal renal tubular acidosis","volume":"42","author":"Bajpai","year":"2005","journal-title":"Indian Pediatrics"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0360","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bone.2004.04.028","article-title":"Alteration of noncollagenous bone matrix proteins in distal renal tubular acidosis","volume":"35","author":"Disthabanchong","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0365","doi-asserted-by":"crossref","first-page":"e233350","DOI":"10.1136\/bcr-2019-233350","article-title":"Rickets with hypophosphatemia, hypokalemia and normal anion gap metabolic acidosis: not always an easy diagnosis","volume":"13","author":"Agrawal","year":"2020","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0370","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0022-3476(05)81194-1","article-title":"Primary distal tubular acidosis in childhood: clinical study and long-term follow-up of 28 patients","volume":"121","author":"Caldas","year":"1992","journal-title":"J Pediatr"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0375","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00467-009-1169-y","article-title":"Bicarbonate therapy improves growth in children with incomplete distal renal tubular acidosis","volume":"24","author":"Sharma","year":"2009","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0380","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.2215\/CJN.02360409","article-title":"Bone disease in medullary sponge kidney and effect of potassium citrate treatment","volume":"4","author":"Fabris","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0385","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00240-016-0906-5","article-title":"Abnormal distal renal tubular acidification in patients with low bone mass: prevalence and impact of alkali treatment","volume":"45","author":"Sromicki","year":"2017","journal-title":"Urolithiasis"},{"key":"10.1016\/j.nefroe.2022.02.012_bib0390","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00467-016-3573-4","article-title":"Clinical and molecular aspects of distal renal tubular acidosis in children","volume":"32","author":"Besouw","year":"2017","journal-title":"Pediatr Nephrol"}],"container-title":["Nefrolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251422001717?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251422001717?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T15:26:34Z","timestamp":1748532394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2013251422001717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S2013251422001717"],"URL":"https:\/\/doi.org\/10.1016\/j.nefroe.2022.02.012","relation":{},"ISSN":["2013-2514"],"issn-type":[{"value":"2013-2514","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone mineral density and growth changes in patients with distal renal tubular acidosis after two-years treatment with a new alkalizing drug (ADV7103)","name":"articletitle","label":"Article Title"},{"value":"Nefrolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nefroe.2022.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Sociedad Espa\u00f1ola de Nefrolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}