{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:41:36Z","timestamp":1781538096829,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":87,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nefrolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.nefroe.2023.03.012","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T07:42:55Z","timestamp":1681544575000},"page":"102-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Perception of Spanish nephrologists on an old unsolved problem: Pruritus associated with chronic kidney disease (CKD-aP)"],"prefix":"10.1016","volume":"43","author":[{"given":"Marian","family":"Goicoechea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Arenas-Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Areste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Elena","family":"Perez-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicens","family":"Esteve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Sanchez-Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Alcalde Bezhold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Sanchez-Villanueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Ojeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Prieto-Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Manuel Buades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nefroe.2023.03.012_bib0005","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2340\/00015555-2494","article-title":"Dynamic pruritus score: evaluation of the validity and reliability of a new instrument to assess the course of pruritus","volume":"97","author":"St\u00e4nder","year":"2017","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0010","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2340\/00015555-3164","article-title":"European S2K guideline in chronic pruritus","volume":"99","author":"Weisshaar","year":"2019","journal-title":"Acta Dermatol Venereol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0015","first-page":"1","article-title":"Chronic kidney disease-associated pruritus: a review","volume":"7","author":"Makar","year":"2021","journal-title":"Kidney Blood Pres Res"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0020","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/toxins13080527","article-title":"Chronic kidney disease-associated pruritus","volume":"28","author":"Agarwal","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0025","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/sj.ki.5000251","article-title":"Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients","volume":"69","author":"Narita","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0030","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1093\/ndt\/gfl461","article-title":"Pruritus in haemodialysis patients: international results from the Dialysis Outcomes and Practice Patterns Study (DOPPS)","volume":"21","author":"Pisoni","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0035","first-page":"1","article-title":"Clinical characteristics and outcomes of end-stage renal disease patients with self-reported pruritus symptoms","volume":"7","author":"Ramakrishnan","year":"2013","journal-title":"Int J Nephrol Renovasc Dis."},{"key":"10.1016\/j.nefroe.2023.03.012_bib0040","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.2215\/CJN.03280317","article-title":"International comparisons of prevalence, awareness, and treatment of pruritus in people on hemodialysis","volume":"12","author":"Rayner","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0045","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1053\/j.ajkd.2017.05.018","article-title":"Treatment of uremic pruritus: a systematic review","volume":"7","author":"Simonsen","year":"2017","journal-title":"Am J Kidney Dis"},{"issue":"12","key":"10.1016\/j.nefroe.2023.03.012_bib0050","first-page":"CD011393","article-title":"Interventions for itch in people with advance chronic kidney disease","volume":"12","author":"Hercz","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0055","first-page":"136","article-title":"Uremic pruritus in patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The role of plasma histamine and skin mast cells","volume":"34","author":"Mettang","year":"1990","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0060","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1525-1594.2001.025006441.x","article-title":"Polymethylmethacrylate eJicacy in reduction of renal itching in hemodialysis patients: crossover study and role of tumor necrosis factor-alpha","volume":"25","author":"Kato","year":"2001","journal-title":"Artif Organs"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0065","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1056\/NEJM196809262791308","article-title":"Intractable pruritus as a manifestation of secondary hyperparathyroidism in uremia. Disappearance of itching after subtotal parathyroidectomy","volume":"279","author":"Massry","year":"1968","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0070","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S0140-6736(96)04176-1","article-title":"Randomised crossover trial of naltrexone in uraemic pruritus","volume":"348","author":"Peer","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0075","doi-asserted-by":"crossref","first-page":"e0241088","DOI":"10.1371\/journal.pone.0241088","article-title":"Uremic pruritus and long-term morbidities in the dialysis population","volume":"15","author":"Ting","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0080","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1159\/000490689","article-title":"Uremic pruritus is associated with two-year cardiovascular mortality in long term hemodialysis patients","volume":"43","author":"Weng","year":"2018","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0085","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.ekir.2020.04.027","article-title":"CKD-associated pruritus: new insights into diagnosis, pathogenesis, and management","volume":"5","author":"Verduzco","year":"2020","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0090","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/j.ajkd.2007.03.010","article-title":"An update on pruritus associated with CKD","volume":"50","author":"Patel","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2147\/IJNRD.S108045","article-title":"Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges","volume":"10","author":"Shirazian","year":"2017","journal-title":"Int J Nephrol Renov Dis"},{"issue":"Suppl 3","key":"10.1016\/j.nefroe.2023.03.012_bib0100","doi-asserted-by":"crossref","first-page":"i8","DOI":"10.1093\/ckj\/sfab143","article-title":"Do you feel itchy? A guide towards diagnosis and measurement of chronic kidney disease-associated pruritus in dialysis patients","volume":"14","author":"Manenti","year":"2021","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0105","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.2215\/CJN.00100110","article-title":"ITCH National Registry Investigators. A longitudinal study of uremic pruritus in hemodialysis patients","volume":"5","author":"Mathur","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.krcp.2016.02.002","article-title":"Comparison of uremic pruritus between patients undergoing hemodialysis and peritoneal dialysis","volume":"35","author":"Min","year":"2016","journal-title":"Kidney Res Clin Pract"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0115","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2340\/00015555-1265","article-title":"Visual analogue Scale: evaluation of the instrument for the assessment of pruritus","volume":"92","author":"Reich","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0120","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/ndt\/gfi204","article-title":"The role of micro-inflammation in the pathogenesis of uraemic pruritus in haemodialysis patients","volume":"21","author":"Kimmel","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0125","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1093\/ndt\/17.12.2164","article-title":"Inflammation and pruritus in haemodialysis patients","volume":"17","author":"Virga","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0130","article-title":"Pruritus-reducing effects of omega-3 fatty acids in hemodialysis patients: a cross-over randomized clinical trial","volume":"3","author":"Forouhari","year":"2022","journal-title":"Hemodial Int"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0135","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1111\/jdv.16360","article-title":"Opioid receptors expression in the skin of haemodialysis patients suffering from uraemic pruritus","volume":"34","author":"Wieczorek","year":"2020","journal-title":"J Eur Acad Dermatology Venereol"},{"issue":"Abstract Suppl","key":"10.1016\/j.nefroe.2023.03.012_bib0140","first-page":"338A","article-title":"Improvement of quality of life in hemodialysis patients with uremic pruritus as measured by the skindex-10 questionnaire: effect of a novel kappa opiod receptor agonist, CR845 [abstract no: TH-PO1040]","volume":"27","author":"Mathur","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0145","first-page":"321","article-title":"Efficacy of topical hydrating and emollient lotion containing 10% urea ISDIN\u00ae plus dexpanthenol (Ureadin Rx 10) in the treatment of skin xerosis and pruritus in hemodialyzed patients: An open prospective pilot trial","volume":"146","author":"Castello","year":"2011","journal-title":"G Ital Dermatol Venereol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0150","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1526-0968.2004.00175.x","article-title":"Effect of skin care with an emollient containing a high water content on mild Uremic Pruritus","volume":"8","author":"Okada","year":"2004","journal-title":"Ther Apher Dial"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0155","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1365-4632.2010.04537.x","article-title":"Systematic review of topical capsaicin in the treatment of pruritus","volume":"49","author":"Gooding","year":"2010","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0160","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1080\/09546630802441218","article-title":"A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients","volume":"20","author":"Young","year":"2009","journal-title":"J Dermatol Treat"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0165","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/MNH.0000000000000567","article-title":"Charcoal for the management of pruritus and uremic toxins in patients with chronic kidney disease","volume":"29","author":"Cupisti","year":"2020","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"Suppl 5","key":"10.1016\/j.nefroe.2023.03.012_bib0170","doi-asserted-by":"crossref","first-page":"v8","DOI":"10.1093\/ndt\/gfm293","article-title":"Uraemic itching: do polymethylmethacrylate dialysis membranes play a role?","volume":"22","author":"Aucella","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0175","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1525-1594.2001.025006441.x","article-title":"Polymethylmethacrylate efficacy in reduction of renal itching in hemodialysis patients: crossover study and role of tumor necrosis factor-alpha","volume":"25","author":"Kato","year":"2001","journal-title":"Artif Organs"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0180","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40697-016-0107-8","article-title":"Gabapentin for uremic pruritus in hemodialysis patients: a qualitative systematic review","volume":"3","author":"Lau","year":"2016","journal-title":"Can J Kidney Health Dis"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0185","first-page":"75","article-title":"Uraemic pruritus: relief of itching by gabapentin and pregabalin","volume":"122","author":"Rayner","year":"2012","journal-title":"Nephron"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0190","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jaad.2004.12.052","article-title":"Treatment of uremic pruritus with narrowband ultraviolet B phototherapy: an open pilot study","volume":"53","author":"Ada","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0195","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0272-6386(85)80115-3","article-title":"Uremic pruritus: skin divalent ion content and response to ultraviolet phototherapy","volume":"5","author":"Blachley","year":"1985","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0200","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s11255-020-02473-3","article-title":"Effect of mirtazapine on pruritus in patients on hemodialysis: a cross-over pilot study","volume":"52","author":"Gholyaf","year":"2020","journal-title":"Int Urol Nephrol [Internet]"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0205","first-page":"1","article-title":"Effect of sertraline on uremic pruritus improvement in ESRD patients","volume":"12","author":"Shakiba","year":"2012","journal-title":"Int J Nephrol [Internet]"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0210","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1681\/ASN.V113514","article-title":"Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo controlled crossover study","volume":"11","author":"Pauli-Magnus","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0215","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/jcpt.12404","article-title":"Will peripherally restricted kappa-opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential?","author":"Albert-Vartanian","year":"2016","journal-title":"J Clin Pharmacol Ther"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0220","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1056\/NEJMoa1912770","article-title":"A phase 3 trial of difelikefalin in hemodialysis patients with pruritus","volume":"382","author":"Fishbane","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0225","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1681\/ASN.2005020152","article-title":"Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies","volume":"16","author":"Wikstrom","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0230","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/ndt\/gfp588","article-title":"Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a Phase III, randomized, double-blind, placebo-controlled study","volume":"25","author":"Kumagai","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0235","unstructured":"Retirada de la solicitud de autorizaci\u00f3n de comercializaci\u00f3n de Winfuran (nalfurafina). 24 de enero de 2014 EMA\/33514\/2014."},{"key":"10.1016\/j.nefroe.2023.03.012_bib0240","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1159\/000484573","article-title":"A multicenter, randomized, double-blind, placebo-controlled trial of nalbuphine ER tablets for uremic pruritus","volume":"46","author":"Mathur","year":"2017","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0245","doi-asserted-by":"crossref","DOI":"10.1177\/2054358120954024","article-title":"Have we just scratched the surface? A narrative review of uremic pruritus in 2020","volume":"7","author":"Martin","year":"2020","journal-title":"Can J Kidney Health Dis"},{"key":"10.1016\/j.nefroe.2023.03.012_bib0250","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s10157-021-02047-2","article-title":"Anti-pruritic effect of nemolizumab in hemodialysis patients with uremic pruritus: a phase II, randomized, double-blind, placebo-controlled clinical study","volume":"25","author":"Kinugasa","year":"2021","journal-title":"Clin Exp Nephrol"}],"container-title":["Nefrolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251423000664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251423000664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T19:50:33Z","timestamp":1761853833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2013251423000664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S2013251423000664"],"URL":"https:\/\/doi.org\/10.1016\/j.nefroe.2023.03.012","relation":{},"ISSN":["2013-2514"],"issn-type":[{"value":"2013-2514","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perception of Spanish nephrologists on an old unsolved problem: Pruritus associated with chronic kidney disease (CKD-aP)","name":"articletitle","label":"Article Title"},{"value":"Nefrolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nefroe.2023.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.nefro.2022.04.009","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Sociedad Espa\u00f1ola de Nefrolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}