{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:04:00Z","timestamp":1783929840928,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nefrolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.nefroe.2025.02.009","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:31:37Z","timestamp":1741710697000},"page":"238-248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe"],"prefix":"10.1016","volume":"45","author":[{"given":"Sebasti\u00e1n","family":"Mas-Fontao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Civantos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-531X","authenticated-orcid":false,"given":"Nisa","family":"Boukichou-Abdelkader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Soto-Catalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Romeo-Colas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3027-2400","authenticated-orcid":false,"given":"Arantxa","family":"Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-5414","authenticated-orcid":false,"given":"Carmen","family":"Gomez-Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-2871","authenticated-orcid":false,"given":"Juan Antonio","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-0745","authenticated-orcid":false,"given":"Jaakko","family":"Tuomilehto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Egido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nefroe.2025.02.009_bib0195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41591-020-1116-9","article-title":"Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes","volume":"27","author":"Wagner","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0200","unstructured":"World Health Organization, International Diabetes Federation. Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO\/IDF consultation. 2006. Available from: https:\/\/iris.who.int\/handle\/10665\/43588 [cited 2.2.24]."},{"key":"10.1016\/j.nefroe.2025.02.009_bib0205","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.diabres.2007.05.004","article-title":"Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies","volume":"78","author":"Gerstein","year":"2007","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0210","doi-asserted-by":"crossref","unstructured":"Diabetes Prevention Program Research Group. 10-Year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet 2009;374:1677\u201386.","DOI":"10.1016\/S0140-6736(09)61457-4"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0215","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S2213-8587(16)00082-6","article-title":"Phenotypes of prediabetes and stratification of cardiometabolic risk","volume":"4","author":"Stefan","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0220","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejim.2018.07.001","article-title":"Prediabetes and macrovascular disease: review of the association, influence on outcome and effect of treatment","volume":"55","author":"Kleinherenbrink","year":"2018","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0225","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/CIRCULATIONAHA.106.685628","article-title":"Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)","volume":"116","author":"Barr","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0230","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1161\/CIRCULATIONAHA.116.023446","article-title":"Prediabetes and type 2 diabetes are associated with generalized microvascular dysfunction: the Maastricht study","volume":"134","author":"S\u00f6rensen","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0235","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S2213-8587(17)30234-6","article-title":"Prediabetes: moving away from a glucocentric definition","volume":"5","author":"Vas","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0240","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0245","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0250","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1111\/dme.13113","article-title":"Association between prediabetes and risk of chronic kidney disease: a systematic review and meta-analysis","volume":"33","author":"Echouffo-Tcheugui","year":"2016","journal-title":"Diabet Med"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0255","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12882-019-1307-0","article-title":"Association between prediabetes (defined by HbA1C, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study","volume":"20","author":"Kim","year":"2019","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0260","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1038\/s41467-020-18386-9","article-title":"An investigation of causal relationships between prediabetes and vascular complications","volume":"11","author":"Mutie","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0265","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/S0140-6736(12)60283-9","article-title":"Prediabetes: a high-risk state for diabetes development","volume":"379","author":"Tab\u00e1k","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0270","doi-asserted-by":"crossref","DOI":"10.1177\/14791641211058856","article-title":"Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: a review of the literature","volume":"18","author":"Thipsawat","year":"2021","journal-title":"Diab Vasc Dis Res"},{"issue":"Suppl.","key":"10.1016\/j.nefroe.2025.02.009_bib0275","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1016\/j.molmet.2019.06.016","article-title":"Biomarkers for type 2 diabetes","volume":"27S","author":"Laakso","year":"2019","journal-title":"Mol Metab"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0280","doi-asserted-by":"crossref","first-page":"854","DOI":"10.2337\/dc06-1693","article-title":"Sex differences in the prediction of type 2 diabetes by inflammatory markers: results from the MONICA\/KORA Augsburg case-cohort study, 1984\u20132002","volume":"30","author":"Thorand","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0285","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12902-017-0159-5","article-title":"High-sensitive C-reactive protein and risk of incident type 2 diabetes: a case\u2013control study nested within the Singapore Chinese Health Study","volume":"17","author":"Pan","year":"2017","journal-title":"BMC Endocr Disord"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0290","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1515\/CCLM.2003.177","article-title":"Oxidative stress in diabetes","volume":"41","author":"Piconi","year":"2003","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0295","doi-asserted-by":"crossref","first-page":"378790","DOI":"10.1155\/2013\/378790","article-title":"Markers of oxidative stress during diabetes mellitus","volume":"2013","author":"Tiwari","year":"2013","journal-title":"J Biomark"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0300","article-title":"Oxidative stress and inflammatory markers in prediabetes and diabetes","volume":"70","author":"Luc","year":"2019","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0305","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1515\/CCLM.2005.050","article-title":"Advanced oxidation protein products (AOPP) for monitoring oxidative stress in critically ill patients: a simple, fast and inexpensive automated technique","volume":"43","author":"Selmeci","year":"2005","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0310","first-page":"452","article-title":"The relationship between advanced oxidation protein products, vascular calcifications and arterial stiffness in predialysis chronic kidney disease patients","volume":"57","author":"Vinereanu","year":"2021","journal-title":"Med Kaunas Lith"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0315","doi-asserted-by":"crossref","first-page":"e0231196","DOI":"10.1371\/journal.pone.0231196","article-title":"Early prevention of diabetes microvascular complications in people with hyperglycaemia in Europe. ePREDICE randomized trial. Study protocol, recruitment and selected baseline data","volume":"15","author":"Gabriel","year":"2020","journal-title":"PLOS ONE"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0320","doi-asserted-by":"crossref","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","article-title":"Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline","volume":"158","author":"Stevens","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0325","first-page":"302","article-title":"Spanish Society of Nephrology document on KDIGO guidelines for the assessment and treatment of chronic kidney disease","volume":"34","author":"Gorostidi","year":"2014","journal-title":"Nefrologia"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0330","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3109\/10715762.2011.602074","article-title":"Advanced oxidation protein products (AOPP): novel uremic toxins, or components of the non-enzymatic antioxidant system of the plasma proteome?","volume":"45","author":"Selmeci","year":"2011","journal-title":"Free Radic Res"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0335","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0340","doi-asserted-by":"crossref","unstructured":"National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143\u2013421.","DOI":"10.1161\/circ.106.25.3143"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0345","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.numecd.2017.12.005","article-title":"Prediabetes is associated with microalbuminuria, reduced kidney function and chronic kidney disease in the general population: the KORA (Cooperative Health Research in the Augsburg Region) F4-Study","volume":"28","author":"Markus","year":"2018","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0350","doi-asserted-by":"crossref","first-page":"e13497","DOI":"10.1111\/1753-0407.13497","article-title":"Lower urinary albumin-to-creatinine ratio predicted all-cause and cardiovascular mortality in Chinese population with diabetes and prediabetes \u2013 the Shanghai Changfeng cohort study","volume":"16","author":"Chen","year":"2024","journal-title":"J Diabetes"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0355","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/jhh.2013.55","article-title":"Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage","volume":"28","author":"Mennuni","year":"2014","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0360","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00041552-200401000-00013","article-title":"Roles of oxidative stress and antioxidant therapy in chronic kidney disease and hypertension","volume":"13","author":"Vaziri","year":"2004","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0365","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/sj.jhh.1001913","article-title":"Relationships of C-reactive protein, uric acid, and glomerular filtration rate to arterial stiffness in Japanese subjects","volume":"19","author":"Saijo","year":"2005","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0370","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1523-1755.2005.00398.x","article-title":"Biomarkers of inflammation and progression of chronic kidney disease","volume":"68","author":"Tonelli","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0375","doi-asserted-by":"crossref","first-page":"11196","DOI":"10.3390\/ijms231911196","article-title":"The influence of the severity of early chronic kidney disease on oxidative stress in patients with and without type 2 diabetes mellitus","volume":"23","author":"Andrade-Sierra","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nefroe.2025.02.009_bib0380","article-title":"All about albumin: biochemistry, genetics, and medical applications. Theodore Peters, Jr. San Diego, CA: Academic Press, 1996, 432 pp, $85.00. ISBN 0-12-552110-3","volume":"43","author":"Azzazy","year":"1997","journal-title":"Clin Chem"}],"container-title":["Nefrolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251425000343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251425000343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T03:29:52Z","timestamp":1741922992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2013251425000343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2013251425000343"],"URL":"https:\/\/doi.org\/10.1016\/j.nefroe.2025.02.009","relation":{},"ISSN":["2013-2514"],"issn-type":[{"value":"2013-2514","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe","name":"articletitle","label":"Article Title"},{"value":"Nefrolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nefroe.2025.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedad Espa\u00f1ola de Nefrolog\u00eda.","name":"copyright","label":"Copyright"}]}}