{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:59:46Z","timestamp":1777895986079,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006484","name":"Vifor Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nefrolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.nefroe.2026.501418","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:17:00Z","timestamp":1772266620000},"page":"501418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of intravenous ferric carboxymaltose on physical performance and patient-reported outcomes in elderly patients with non-dialysis CKD, mild anemia, and iron deficiency: A pilot study"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6927-071X","authenticated-orcid":false,"given":"Maria Jes\u00fas","family":"Puchades","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Casas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Nu\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Gimenez-Civera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Montomoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"de la Espriella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Gonzalez-Rico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidro","family":"Torregrosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos J.","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleix","family":"Cases","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Gorriz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nefroe.2026.501418_bib0155","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1185\/030079904X2763","article-title":"The prevalence of anemia in patients with chronic kidney disease","volume":"20","author":"McClellan","year":"2004","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.nefroe.2026.501418_bib0160","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.nefro.2022.04.001","article-title":"Epidemiology and treatment of renal anaemia in Spain: RIKAS retrospective study","volume":"42","author":"Cases","year":"2023","journal-title":"Nefrologia"},{"key":"10.1016\/j.nefroe.2026.501418_bib0165","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/ckj\/sfz091","article-title":"Anemia and iron deficiency among chronic kidney disease Stages 3-5ND patients in the Chronic Kidney Disease Outcomes and Practice Patterns Study: often unmeasured, variably treated","volume":"13","author":"Wong","year":"2019","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.nefroe.2026.501418_bib0170","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1093\/ndt\/gft033","volume":"28","author":"Locatelli","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nefroe.2026.501418_bib0175","first-page":"279","article-title":"KDIGO clinical practice guideline for anemia in chronic kidney disease","volume":"2","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.nefroe.2026.501418_bib0180","series-title":"Clinical Guideline for Chronic kidney disease. Early identifications and management of chronic kidney disease in adults in primary and secondary care","year":"2015"},{"key":"10.1016\/j.nefroe.2026.501418_bib0185","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1016\/j.ekir.2021.07.032","article-title":"Iron deficiency in CKD without concomitant anemia","volume":"6","author":"Wish","year":"2021","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.nefroe.2026.501418_bib0190","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.kint.2019.04.029","article-title":"An increased mortality risk is associated with abnormal iron status in diabetic and non-diabetic Veterans with predialysis chronic kidney disease","volume":"96","author":"Cho","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2026.501418_bib0195","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1681\/ASN.2020101531","article-title":"Serum biomarkers of iron stores are associated with increased risk of all-cause mortality and cardiovascular events in nondialysis CKD patients, with or without anemia","volume":"32","author":"Guedes","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2026.501418_bib0200","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/ndt\/gfab050","article-title":"Serum biomarkers of iron stores are associated with worse physical health-related quality of life in nondialysis-dependent chronic kidney disease patients with or without anemia","volume":"36","author":"Guedes","year":"2021","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nefroe.2026.501418_bib0205","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","article-title":"Ferric carboxymaltose in patients with heart failure and iron deficiency","volume":"361","author":"Anker","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nefroe.2026.501418_bib0210","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/eurheartj\/ehu385","article-title":"Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency","volume":"36","author":"Ponikowski","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.nefroe.2026.501418_bib0215","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-025-03671-1","article-title":"Systematic review and meta-analysis of intravenous iron therapy for patients with heart failure and iron deficiency","author":"Anker","year":"2025","journal-title":"Nat Med"},{"key":"10.1016\/j.nefroe.2026.501418_bib0220","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/ejhf.2810","article-title":"Intravenous iron in patients with heart failure and iron deficiency: an updated meta-analysis","volume":"25","author":"Graham","year":"2023","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.nefroe.2026.501418_bib0225","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12882-021-02308-y","article-title":"A multicentre prospective double blinded randomised controlled trial of intravenous iron (ferric Derisomaltose (FDI)) in Iron deficient but not anaemic patients with chronic kidney disease on functional status","volume":"22","author":"Bhandari","year":"2021","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.nefroe.2026.501418_bib0230","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12882-022-02896-3","article-title":"The effect of intravenous iron supplementation on exercise capacity in iron-deficient but not anaemic patients with chronic kidney disease: study design and baseline data for a multicentre prospective double-blind randomised controlled trial","volume":"23","author":"Greenwood","year":"2022","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.nefroe.2026.501418_bib0235","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s41100-023-00460-9","article-title":"Six-minute walk test may be a reliable predictor of peak oxygen uptake in patients undergoing hemodialysis","volume":"9","author":"Andrade","year":"2023","journal-title":"Ren Replace Ther"},{"key":"10.1016\/j.nefroe.2026.501418_bib0240","first-page":"677","article-title":"The revised Piper Fatigue Scale: psychometric evaluation in women with breast cancer","volume":"25","author":"Piper","year":"1998","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.nefroe.2026.501418_bib0245","first-page":"301","article-title":"Eisen-Dextran intraven\u00f6s: therapeutische und experimentelle M\u00f6glichkeiten","volume":"100","author":"Ganzoni","year":"1970","journal-title":"Schweiz Med Wochenschr"},{"key":"10.1016\/j.nefroe.2026.501418_bib0250","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B"},{"key":"10.1016\/j.nefroe.2026.501418_bib0255","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/ki.2008.414","article-title":"Interpretation and review of health-related quality of life data in CKD patients receiving treatment for anemia","volume":"75","author":"Leaf","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2026.501418_bib0260","article-title":"Minimal clinically important differences in 6-minute walk test in patients with HFrEF and iron deficiency","author":"Khan","year":"2022","journal-title":"J Card Fail"},{"key":"10.1016\/j.nefroe.2026.501418_bib0265","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/jep.12629","article-title":"Minimal clinically important difference for change in 6-minute walk test distance of adults with pathology: a systematic review","volume":"23","author":"Bohannon","year":"2017","journal-title":"J Eval Clin Pract"},{"key":"10.1016\/j.nefroe.2026.501418_bib0270","doi-asserted-by":"crossref","first-page":"e27601","DOI":"10.1097\/MD.0000000000027601","article-title":"Erythropoietin therapy improves endothelial function in patients with non-dialysis chronic kidney disease and anemia (EARNEST-CKD): a clinical study","volume":"100","author":"Lim","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.nefroe.2026.501418_bib0275","doi-asserted-by":"crossref","first-page":"642296","DOI":"10.3389\/fmed.2021.642296","article-title":"Anemia in chronic kidney disease: from pathophysiology and current treatments, to future agents","volume":"8","author":"Portol\u00e9s","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.nefroe.2026.501418_bib0280","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2215\/CJN.15360920","article-title":"Heart failure hospitalization risk associated with iron status in veterans with CKD","volume":"16","author":"Cho","year":"2021","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2026.501418_bib0285","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1136\/bjsports-2014-093624","article-title":"Is iron treatment beneficial in, iron-deficient but non-anaemic (IDNA) endurance athletes? A systematic review and meta-analysis","volume":"49","author":"Burden","year":"2015","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.nefroe.2026.501418_bib0290","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1161\/CIRCULATIONAHA.118.038516","article-title":"Effects of Iron isomaltoside on skeletal muscle energetics in patients with chronic heart failure and iron deficiency (FERRIC-HF II)","volume":"139","author":"Charles-Edwards","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.nefroe.2026.501418_bib0295","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1159\/000096174","article-title":"A randomized controlled trial of oral versus intravenous iron in chronic kidney disease","volume":"26","author":"Agarwal","year":"2006","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.nefroe.2026.501418_bib0300","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2147\/TCRM.S243462","article-title":"Hypophosphatemia associated with intravenous iron therapies for iron deficiency anemia: a systematic literature review","volume":"16","author":"Glaspy","year":"2020","journal-title":"Ther Clin Risk Manag"}],"container-title":["Nefrolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251426000428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251426000428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:11:17Z","timestamp":1777623077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2013251426000428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2013251426000428"],"URL":"https:\/\/doi.org\/10.1016\/j.nefroe.2026.501418","relation":{},"ISSN":["2013-2514"],"issn-type":[{"value":"2013-2514","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of intravenous ferric carboxymaltose on physical performance and patient-reported outcomes in elderly patients with non-dialysis CKD, mild anemia, and iron deficiency: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Nefrolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nefroe.2026.501418","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedad Espa\u00f1ola de Nefrolog\u00eda.","name":"copyright","label":"Copyright"}],"article-number":"501418"}}