{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:32:06Z","timestamp":1784046726819,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nefrolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.nefroe.2026.501443","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:17:00Z","timestamp":1772266620000},"page":"501443","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Irisin and the kidney: Key points to know?"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3661-2124","authenticated-orcid":false,"given":"Danilo Candido","family":"de Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4123-6741","authenticated-orcid":false,"given":"Juan Sebastian Henao","family":"Agudelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nefroe.2026.501443_bib0130","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.kint.2019.07.012","article-title":"A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases","volume":"96","author":"Jager","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.nefroe.2026.501443_bib0135","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostr\u00f6m","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nefroe.2026.501443_bib0140","doi-asserted-by":"crossref","first-page":"117756","DOI":"10.1016\/j.cca.2023.117756","article-title":"The role of irisin in kidney diseases","volume":"554","author":"Li","year":"2024","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.nefroe.2026.501443_bib0145","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nrendo.2016.221","article-title":"Physiology and role of irisin in glucose homeostasis","volume":"13","author":"Perakakis","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.nefroe.2026.501443_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101193","article-title":"Corrigendum to \u201cIrisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress\u201d [Redox Biol 20 (2019) 296\u2013306]","volume":"26","author":"Bi","year":"2019","journal-title":"Redox Biol"},{"key":"10.1016\/j.nefroe.2026.501443_bib0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064025","article-title":"Decrease in irisin in patients with chronic kidney disease","volume":"8","author":"Wen","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.nefroe.2026.501443_bib0160","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s11255-021-03000-8","article-title":"Circulating irisin level in chronic kidney disease patients: a systematic review and meta-analysis","volume":"54","author":"Gan","year":"2022","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.nefroe.2026.501443_bib0165","first-page":"11532","article-title":"Indoxyl sulfate induced frailty in patients with end-stage renal disease by disrupting the PGC-1\u03b1-FNDC5 axis","volume":"15","author":"Hou","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.nefroe.2026.501443_bib0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165792","article-title":"Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53","volume":"1866","author":"Liu","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.nefroe.2026.501443_bib0175","doi-asserted-by":"crossref","first-page":"857067","DOI":"10.3389\/fphar.2022.857067","article-title":"Post-treatment with irisin attenuates acute kidney injury in sepsis mice through anti-ferroptosis via the SIRT1\/Nrf2 pathway","volume":"13","author":"Qiongyue","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.nefroe.2026.501443_bib0180","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300420R","article-title":"Irisin ameliorates diabetic kidney disease by restoring autophagy in podocytes","volume":"37","author":"Lai","year":"2023","journal-title":"FASEB J"},{"key":"10.1016\/j.nefroe.2026.501443_bib0185","first-page":"6470","article-title":"Irisin alleviates renal injury caused by sepsis via the NF-\u03baB signaling pathway","volume":"24","author":"Jin","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.nefroe.2026.501443_bib0190","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2021.35.S1.03859","article-title":"Exercise-linked FNDC5\/Irisin attenuates macrophage-mediated renal inflammation in type 1 diabetes in aged mice","volume":"35","author":"Pushpakumar","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.nefroe.2026.501443_bib0195","article-title":"Effect of xanthenone versus irisin in alleviating renal ischemic reperfusion injury through modifying the PI3K\/AKT\/eNOS and TLR-4\/NFkB pathways","author":"Kolieb","year":"2024","journal-title":"Bull Egypt Soc Physiol Sci"},{"key":"10.1016\/j.nefroe.2026.501443_bib0200","doi-asserted-by":"crossref","first-page":"6537371","DOI":"10.1155\/2020\/6537371","article-title":"Irisin pretreatment protects kidneys against acute kidney injury induced by ischemia\/reperfusion via upregulating the expression of uncoupling protein 2","volume":"2020","author":"Zhang","year":"2020","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.nefroe.2026.501443_bib0205","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/jcp.29903","article-title":"Involvement of GPX4 in irisin's protection against ischemia reperfusion-induced acute kidney injury","volume":"236","author":"Zhang","year":"2021","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.nefroe.2026.501443_bib0210","article-title":"Irisin ameliorates UUO-induced renal interstitial fibrosis through TGF-\u03b21\/periostin\/MMP-2 signaling pathway","volume":"19","author":"Wang","year":"2024","journal-title":"PLOS ONE"},{"key":"10.1016\/j.nefroe.2026.501443_bib0215","doi-asserted-by":"crossref","first-page":"153393","DOI":"10.1016\/j.phymed.2020.153393","article-title":"Dojuksan ameliorates tubulointerstitial fibrosis through irisin-mediated muscle-kidney crosstalk","volume":"80","author":"Jiang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.nefroe.2026.501443_bib0220","doi-asserted-by":"crossref","first-page":"54","DOI":"10.25259\/Cytojournal_62_2024","article-title":"Fibronectin type III domain containing protein 5\/irisin alleviated sepsis-induced acute kidney injury by abating ferroptosis through the adenosine 5\u2032-monophosphate-activated protein kinase\/nuclear factor erythroid-2-related factor 2 signaling pathway","volume":"21","author":"Gui","year":"2024","journal-title":"Cytojournal"},{"key":"10.1016\/j.nefroe.2026.501443_bib0225","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.jrn.2021.05.007","article-title":"Serum irisin may predict cardiovascular events in elderly patients with chronic kidney disease stage 3\u20135","volume":"32","author":"Arcidiacono","year":"2022","journal-title":"J Ren Nutr"},{"key":"10.1016\/j.nefroe.2026.501443_bib0230","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000535582","article-title":"Relationship between serum irisin level, all-cause mortality, and cardiovascular mortality in peritoneal dialysis patients","volume":"49","author":"Zhou","year":"2024","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.nefroe.2026.501443_bib0235","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1139\/apnm-2021-0409","article-title":"Metabolic and hormonal responses to chronic blood-flow restricted resistance training in chronic kidney disease: a randomized trial","volume":"47","author":"Deus","year":"2022","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.nefroe.2026.501443_bib0240","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1007\/s11255-023-03475-7","article-title":"Serum irisin levels and osteoporosis in patients with advanced chronic kidney disease and renal transplant recipients","volume":"55","author":"Demir","year":"2023","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.nefroe.2026.501443_bib0245","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jdiacomp.2013.09.011","article-title":"Relationship between circulating irisin, renal function and body composition in type 2 diabetes","volume":"28","author":"Liu","year":"2014","journal-title":"J Diabetes Complicat"},{"key":"10.1016\/j.nefroe.2026.501443_bib0250","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/j.bbrc.2018.07.005","article-title":"Excessive irisin increases oxidative stress and apoptosis in murine heart","volume":"503","author":"Ho","year":"2018","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Nefrolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251426000465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251426000465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:11:20Z","timestamp":1777623080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2013251426000465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2013251426000465"],"URL":"https:\/\/doi.org\/10.1016\/j.nefroe.2026.501443","relation":{},"ISSN":["2013-2514"],"issn-type":[{"value":"2013-2514","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Irisin and the kidney: Key points to know?","name":"articletitle","label":"Article Title"},{"value":"Nefrolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nefroe.2026.501443","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Sociedad Espa\u00f1ola de Nefrolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"501443"}}