{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:04:29Z","timestamp":1782983069833,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nefrolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.nefroe.2026.501470","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:37:21Z","timestamp":1776267441000},"page":"501470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between neutrophil-to-platelet ratio and acute kidney injury among patients undergoing cardiac surgery: An analysis based on Medical Information Mart for Intensive Care"],"prefix":"10.1016","volume":"46","author":[{"given":"Mingwu","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nefroe.2026.501470_bib0200","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990\u20132019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nefroe.2026.501470_bib0205","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.athoracsur.2020.05.181","article-title":"Cardiac surgery in low- and middle-income countries: a state-of-the-art review","volume":"111","author":"Vervoort","year":"2021","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.nefroe.2026.501470_bib0210","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrneph.2017.119","article-title":"Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment","volume":"13","author":"Wang","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.nefroe.2026.501470_bib0215","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/j.jvca.2015.06.017","article-title":"Global incidence and outcomes of adult patients with acute kidney injury after cardiac surgery: a systematic review and meta-analysis","volume":"30","author":"Hu","year":"2016","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.nefroe.2026.501470_bib0220","doi-asserted-by":"crossref","first-page":"613","DOI":"10.21470\/1678-9741-2022-0108","article-title":"Cardiac surgery-associated acute kidney injury in patients with preserved baseline renal function","volume":"37","author":"Marco","year":"2022","journal-title":"Braz J Cardiovasc Surg"},{"key":"10.1016\/j.nefroe.2026.501470_bib0225","doi-asserted-by":"crossref","first-page":"567","DOI":"10.20344\/amp.18755","article-title":"Kidney injury after cardiac surgery: prevention-associated cost reduction","volume":"36","author":"Maia","year":"2023","journal-title":"Acta Med Port"},{"key":"10.1016\/j.nefroe.2026.501470_bib0230","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10157-022-02313-x","article-title":"Increased numbers of pre-operative circulating monocytes predict risk of developing cardiac surgery-associated acute kidney injury in conditions requiring cardio pulmonary bypass","volume":"27","author":"Okadome","year":"2023","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.nefroe.2026.501470_bib0235","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/ALN.0000000000000959","article-title":"Platelet counts, acute kidney injury, and mortality after coronary artery bypass grafting surgery","volume":"124","author":"Kertai","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nefroe.2026.501470_bib0240","article-title":"The prognostic value of the combined neutrophil-to-lymphocyte ratio (NLR) and neutrophil-to-platelet ratio (NPR) in sepsis","volume":"14","author":"Zhang","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.nefroe.2026.501470_bib0245","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5402507","article-title":"High neutrophil-to-platelet ratio is associated with poor survival in patients with acute aortic dissection","volume":"2022","author":"Pang","year":"2022","journal-title":"Dis Markers"},{"key":"10.1016\/j.nefroe.2026.501470_bib0250","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.2217\/bmm-2021-0085","article-title":"Nomogram based on neutrophil-to-platelet ratio to predict in-hospital mortality in infective endocarditis","volume":"15","author":"Li","year":"2021","journal-title":"Biomark Med"},{"key":"10.1016\/j.nefroe.2026.501470_bib0255","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1011048","article-title":"Neutrophil-to-platelet ratio predicts mortality following percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction","volume":"13","author":"Lin","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.nefroe.2026.501470_bib0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41597-022-01899-x","article-title":"MIMIC-IV, a freely accessible electronic health record dataset","volume":"10","author":"Johnson","year":"2023","journal-title":"Sci Data"},{"key":"10.1016\/j.nefroe.2026.501470_bib0265","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14762","article-title":"Association between modified frailty index and postoperative delirium in patients after cardiac surgery: a cohort study of 2080 older adults","volume":"30","author":"Cheng","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.nefroe.2026.501470_bib0270","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/cc11454","article-title":"Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)","volume":"17","author":"Kellum","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.nefroe.2026.501470_bib0275","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1430776","article-title":"Elevated postoperative systemic immune-inflammation index associates with acute kidney injury after cardiac surgery: a large-scale cohort study","volume":"11","author":"Li","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.nefroe.2026.501470_bib0280","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1053\/j.jvca.2021.02.027","article-title":"Prognostic utility of KDIGO urine output criteria after cardiac surgery","volume":"35","author":"Katabi","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.nefroe.2026.501470_bib0285","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000040053","article-title":"Neutrophil-platelet ratio as a predictor of acute kidney injury in severe COVID-19","volume":"103","author":"Sayan","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.nefroe.2026.501470_bib0290","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.831930","article-title":"Inflammation and oxidative stress in the context of extracorporeal cardiac and pulmonary support","volume":"13","author":"Hatami","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.nefroe.2026.501470_bib0295","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1590\/S0102-76382010000400023","article-title":"Leukocytes and the inflammatory response in ischemia\u2013reperfusion injury","volume":"25","author":"Francischetti","year":"2010","journal-title":"Rev Bras Cir Cardiovasc"},{"key":"10.1016\/j.nefroe.2026.501470_bib0300","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.athoracsur.2005.05.069","article-title":"Oxygen delivery during cardiopulmonary bypass and acute renal failure after coronary operations","volume":"80","author":"Ranucci","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.nefroe.2026.501470_bib0305","doi-asserted-by":"crossref","first-page":"17583","DOI":"10.3390\/ijms242417583","article-title":"How neutrophils shape the immune response: reassessing their multifaceted role in health and disease","volume":"24","author":"Shafqat","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nefroe.2026.501470_bib0310","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1681\/ASN.2016080925","article-title":"Histones and neutrophil extracellular traps enhance tubular necrosis and remote organ injury in ischemic AKI","volume":"28","author":"Nakazawa","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nefroe.2026.501470_bib0315","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.athoracsur.2019.10.039","article-title":"Thrombocytopenia after cardiopulmonary bypass is associated with increased morbidity and mortality","volume":"110","author":"Griffin","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.nefroe.2026.501470_bib0320","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/ACO.0000000000000412","article-title":"Epidemiology and pathophysiology of cardiac surgery-associated acute kidney injury","volume":"30","author":"Fuhrman","year":"2017","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1016\/j.nefroe.2026.501470_bib0325","doi-asserted-by":"crossref","DOI":"10.1111\/apha.12995","article-title":"Renal haemodynamics and oxygenation during and after cardiac surgery and cardiopulmonary bypass","volume":"222","author":"Evans","year":"2018","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.nefroe.2026.501470_bib0330","doi-asserted-by":"crossref","first-page":"e437","DOI":"10.1097\/CCM.0000000000003710","article-title":"Acute kidney injury in critically ill patients after noncardiac major surgery: early versus late onset","volume":"47","author":"Li","year":"2019","journal-title":"Crit Care Med"},{"key":"10.1016\/j.nefroe.2026.501470_bib0335","doi-asserted-by":"crossref","first-page":"e00067-19","DOI":"10.1128\/AAC.00067-19","article-title":"Revising pediatric vancomycin dosing accounting for nephrotoxicity in a pharmacokinetic\u2013pharmacodynamic model","volume":"63","author":"Kloprogge","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.nefroe.2026.501470_bib0340","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2147\/CIA.S455588","article-title":"Neutrophil percentage as a potential biomarker of acute kidney injury risk and short-term prognosis in patients with acute myocardial infarction in the elderly","volume":"19","author":"Chen","year":"2024","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.nefroe.2026.501470_bib0345","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.ejcts.2010.11.034","article-title":"Risk of acute kidney injury after minimally invasive transapical aortic valve implantation in 270 patients","volume":"39","author":"Van Linden","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.nefroe.2026.501470_bib0350","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2023.2281653","article-title":"Postoperative thrombocytopenia and subsequent consequences in acute type A aortic dissection","volume":"55","author":"Tang","year":"2023","journal-title":"Ann Med"},{"key":"10.1016\/j.nefroe.2026.501470_bib0355","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/pan.13063","article-title":"Natural history of nonimmune-mediated thrombocytopenia and acute kidney injury in pediatric open-heart surgery","volume":"27","author":"Tew","year":"2017","journal-title":"Paediatr Anaesth"},{"key":"10.1016\/j.nefroe.2026.501470_bib0360","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1177\/2047487319894103","article-title":"Neutrophil to platelet ratio: a novel prognostic biomarker in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention","volume":"27","author":"Somaschini","year":"2020","journal-title":"Eur J Prevent Cardiol"},{"key":"10.1016\/j.nefroe.2026.501470_bib0365","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1007\/s11010-023-04901-1","article-title":"The predictive value of the neutrophil\/platelet ratio on in-hospital adverse events and long-term prognosis in patients with coronary artery disease after percutaneous coronary intervention and its possible internal mechanism","volume":"479","author":"Xiang","year":"2024","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.nefroe.2026.501470_bib0370","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/MOH.0000000000000608","article-title":"Platelet transfusion for patients with platelet dysfunction: effectiveness, mechanisms, and unanswered questions","volume":"27","author":"Lee","year":"2020","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.nefroe.2026.501470_bib0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijscr.2021.106589","article-title":"The role of monitoring platelet function perioperatively and platelet transfusion for operated spontaneous intracerebral hemorrhage patients with long-term oral antiplatelet therapy: a case report","volume":"89","author":"Wang","year":"2021","journal-title":"Int J Surg Case Rep"},{"key":"10.1016\/j.nefroe.2026.501470_bib0380","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41581-018-0015-5","article-title":"The role of platelets in acute kidney injury","volume":"14","author":"Jansen","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.nefroe.2026.501470_bib0385","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.celrep.2019.06.062","article-title":"Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice","volume":"28","author":"Carestia","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.nefroe.2026.501470_bib0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152742","article-title":"Bisphenol AF elevates procoagulant platelets by inducing necroptosis via RIPK1-inflammasome axis","volume":"454","author":"Vishalakshi","year":"2021","journal-title":"Toxicology"}],"container-title":["Nefrolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251426000672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251426000672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:37:47Z","timestamp":1776267467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2013251426000672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2013251426000672"],"URL":"https:\/\/doi.org\/10.1016\/j.nefroe.2026.501470","relation":{},"ISSN":["2013-2514"],"issn-type":[{"value":"2013-2514","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between neutrophil-to-platelet ratio and acute kidney injury among patients undergoing cardiac surgery: An analysis based on Medical Information Mart for Intensive Care","name":"articletitle","label":"Article Title"},{"value":"Nefrolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nefroe.2026.501470","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Sociedad Espa\u00f1ola de Nefrolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"501470"}}