{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:50:45Z","timestamp":1791568245046,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nefrolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.nefroe.2026.501589","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:50:55Z","timestamp":1783943455000},"page":"501589","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Testosterone and anabolic androgenic steroids: Impact on acute kidney injury"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-4394","authenticated-orcid":false,"given":"Manuel","family":"Heras Benito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Rodr\u00edguez Tudero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.nefroe.2026.501589_bib0005","first-page":"160","article-title":"Implicaciones androl\u00f3gicas del abuso de esteroides androg\u00e9nicos anabolizantes","volume":"9","author":"Garc\u00eda","year":"2011","journal-title":"Rev Int Androl"},{"issue":"45","key":"10.1016\/j.nefroe.2026.501589_bib0010","first-page":"1499","article-title":"Severe renal insufficiency treated with anabolic 19-nor-steroids","volume":"120","author":"Gjorup","year":"1958","journal-title":"Ugeskr Laeger"},{"key":"10.1016\/j.nefroe.2026.501589_bib0015","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.0954-6820.1960.tb03542.x","article-title":"The effect of anabolic steroid (durabolin) in the conservative management of acute renal failure","volume":"167","author":"Gjorup","year":"1960","journal-title":"Acta Med Scand"},{"issue":"5","key":"10.1016\/j.nefroe.2026.501589_bib0020","first-page":"309","article-title":"Current use and abuse of anabolic steroids","volume":"44","author":"Reyes Vallejo","year":"2020","journal-title":"Actas Urol Esp (Engl Ed)"},{"key":"10.1016\/j.nefroe.2026.501589_bib0025","first-page":"100","article-title":"AKI(Acute kidney Injury):AQU\u00cd la nomenclatura tambi\u00e9n es importante","volume":"44","author":"Bover","year":"2024","journal-title":"Nefrologia"},{"issue":"7","key":"10.1016\/j.nefroe.2026.501589_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19074288","article-title":"Nutritional and non-nutritional strategies in bodybuilding: impact on kidney function","volume":"19","author":"Tidmas","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.nefroe.2026.501589_bib0035","article-title":"Testosterone deficiency and chronic kidney disease","volume":"37","author":"Zitzmann","year":"2024","journal-title":"J Clin Transl Endocrinol"},{"issue":"11","key":"10.1016\/j.nefroe.2026.501589_bib0040","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s40266-019-00716-2","article-title":"Is testosterone replacement therapy in older men effective and safe?","volume":"36","author":"Yabluchanskiy","year":"2019","journal-title":"Drugs Aging"},{"issue":"2-3","key":"10.1016\/j.nefroe.2026.501589_bib0045","first-page":"61","article-title":"Testosterone--effects, metabolism and genetic determination","volume":"57","author":"Schmidtov\u00e1","year":"2008","journal-title":"Cesk Fysiol"},{"issue":"2","key":"10.1016\/j.nefroe.2026.501589_bib0050","doi-asserted-by":"crossref","first-page":"F395","DOI":"10.1152\/ajprenal.00454.2015","article-title":"Low-dose testosterone protects against renal ischemia-reperfusion injury by increasing renal IL-10-to-TNF-\u03b1 ratio and attenuating T-cell infiltration","volume":"311","author":"Patil","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"10.1016\/j.nefroe.2026.501589_bib0055","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.genm.2012.02.003","article-title":"The vasodilatory effect of testosterone on renal afferent arterioles","volume":"9","author":"Lu","year":"2012","journal-title":"Gend Med"},{"issue":"9","key":"10.1016\/j.nefroe.2026.501589_bib0060","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.21873\/anticanres.15252","article-title":"Renal function improves after the discontinuation of androgen deprivation therapy in Japanese patients with prostate cancer","volume":"41","author":"Masuda","year":"2021","journal-title":"Anticancer Res"},{"key":"10.1016\/j.nefroe.2026.501589_bib0065","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41391-021-00415-3","article-title":"Androgen deprivation therapy and acute kidney injury in patients with prostate cancer undergoing definitive radiotherapy","volume":"26","author":"Sherer","year":"2023","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.nefroe.2026.501589_bib0070","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/jama.2013.8638","article-title":"Androgen deprivation therapy and risk of acute kidney injury in patients with prostate c\u00e1ncer","volume":"310","author":"Lapi","year":"2013","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.nefroe.2026.501589_bib0075","doi-asserted-by":"crossref","first-page":"E435","DOI":"10.1152\/ajpendo.00704.2006","article-title":"Testosterone exacerbates obstructive renal injury by stimulating TNF-alpha production and increasing proapoptotic and profibrotic signaling","volume":"294","author":"Metcalfe","year":"2008","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"10.1016\/j.nefroe.2026.501589_bib0080","doi-asserted-by":"crossref","first-page":"429","DOI":"10.5534\/wjmh.230110","article-title":"Is there a two-way risk between decreased testosterone levels and the progression and prognosis of chronic kidney disease? A cohort study based on the national health and nutrition examination survey database","volume":"42","author":"Pan","year":"2024","journal-title":"World J Mens Health"},{"key":"10.1016\/j.nefroe.2026.501589_bib0085","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1093\/ndt\/gfac278","article-title":"Serum testosterone concentrations and outcomes in hemodialysis patients enrolled in the EVOLVE trial","volume":"38","author":"Nilsson","year":"2023","journal-title":"Nephrol Dial Transplant"},{"issue":"12","key":"10.1016\/j.nefroe.2026.501589_bib0090","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/jsxmed\/qdae138","article-title":"Association of testosterone replacement therapy with atrial fibrillation and acute kidney injury","volume":"21","author":"Greenberg","year":"2024","journal-title":"J Sex Med"},{"issue":"1","key":"10.1016\/j.nefroe.2026.501589_bib0095","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/s12933-025-02930-2","article-title":"Testosterone therapy is associated with reduced risk of acute kidney injury, kidney failure with renal replacement therapy, and cardiovascular events in men with diabetes and hypogonadism","volume":"24","author":"Bonnet","year":"2025","journal-title":"Cardiovasc Diabetol"},{"issue":"3","key":"10.1016\/j.nefroe.2026.501589_bib0100","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11154-015-9320-5","article-title":"Doping with anabolic androgenic steroids (AAS): Adverse effects on non-reproductive organs and functions","volume":"16","author":"Nieschlag","year":"2015","journal-title":"Rev Endocr Metab Disord"},{"issue":"5","key":"10.1016\/j.nefroe.2026.501589_bib0105","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.annepidem.2014.01.009","article-title":"The global epidemiology of anabolic-androgenic steroid use: a meta-analysis and meta-regression analysis","volume":"24","author":"Sagoe","year":"2014","journal-title":"Ann Epidemiol"},{"issue":"12","key":"10.1016\/j.nefroe.2026.501589_bib0110","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1111\/add.16643","article-title":"What is the prevalence of anabolic-androgenic steroid use among women? A systematic review","volume":"119","author":"Piatkowski","year":"2024","journal-title":"Addiction"},{"key":"10.1016\/j.nefroe.2026.501589_bib0115","article-title":"Anabolic-androgenic steroids at supraphysiological doses: Cardiovascular impacts and pathophysiological mechanisms","volume":"258","author":"Souza Nascimento","year":"2026","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.nefroe.2026.501589_bib0120","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1059473","article-title":"Anabolic-androgenic steroids: how do they work and what are the risks?","volume":"13","author":"Bond","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"12","key":"10.1016\/j.nefroe.2026.501589_bib0125","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1161\/CIRCULATIONAHA.124.071117","article-title":"Cardiovascular disease in anabolic androgenic steroid users","volume":"151","author":"Windfeld-Mathiasen","year":"2025","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.nefroe.2026.501589_bib0130","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/joim.12850","article-title":"Health consequences of androgenic anabolic steroid use","volume":"285","author":"Horwitz","year":"2019","journal-title":"J Intern Med"},{"issue":"14","key":"10.1016\/j.nefroe.2026.501589_bib0135","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1001\/jama.2024.3180","article-title":"Mortality among users of anabolic steroids","volume":"331","author":"Windfeld-Mathiasen","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.nefroe.2026.501589_bib0140","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1053\/j.ackd.2016.09.008","article-title":"Tubulointerstitial injury and drugs of abuse","volume":"24","author":"Nanavati","year":"2017","journal-title":"Adv Chronic Kidney Dis"},{"issue":"1","key":"10.1016\/j.nefroe.2026.501589_bib0145","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/apt.13023","article-title":"Distinct phenotype of hepatotoxicity associated with illicit use of anabolic androgenic steroids","volume":"41","author":"Robles-Diaz","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.nefroe.2026.501589_bib0150","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/01.CSMR.0000306529.74500.f6","article-title":"The effect of anabolic steroids on the gastrointestinal system, kidneys, and adrenal glands","volume":"5","author":"Modlinski","year":"2006","journal-title":"Curr Sports Med Rep"},{"key":"10.1016\/j.nefroe.2026.501589_bib0155","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.2215\/CJN.00360114","article-title":"Nephrotoxic effects of common and emerging drugs of abuse","volume":"9","author":"Pendergraft","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.nefroe.2026.501589_bib0160","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1681\/ASN.2009040450","article-title":"Development of focal segmental glomerulosclerosis after anabolic steroid abuse","volume":"21","author":"Herlitz","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.nefroe.2026.501589_bib0165","doi-asserted-by":"crossref","first-page":"160","DOI":"10.34067\/KID.0000000000000321","article-title":"Sex and gender differences in AKI","volume":"5","author":"Curtis","year":"2024","journal-title":"Kidney360"},{"issue":"3","key":"10.1016\/j.nefroe.2026.501589_bib0170","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/nep.13806","article-title":"Understanding the opposite effects of sex hormones in mediating renal injury","volume":"26","author":"Lima-Posada","year":"2021","journal-title":"Nephrology (Carlton)"},{"issue":"8","key":"10.1016\/j.nefroe.2026.501589_bib0175","doi-asserted-by":"crossref","first-page":"e652","DOI":"10.1016\/j.amjmed.2019.02.052","volume":"132","author":"Gnanapandithan","year":"2019","journal-title":"Am J Med"},{"issue":"3","key":"10.1016\/j.nefroe.2026.501589_bib0180","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s11255-009-9571-8","article-title":"Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review","volume":"41","author":"Daher","year":"2009","journal-title":"Int Urol Nephrol"},{"issue":"6","key":"10.1016\/j.nefroe.2026.501589_bib0185","first-page":"791","article-title":"At what price, glory? Severe cholestasis and acute renal failure in an athlete abusing stanozolol","volume":"151","author":"Yoshida","year":"1994","journal-title":"CMAJ"},{"issue":"36","key":"10.1016\/j.nefroe.2026.501589_bib0190","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1055\/s-2007-1024477","article-title":"Severe cholestasis with kidney failure from anabolic steroids in a body builder","volume":"124","author":"Habscheid","year":"1999","journal-title":"Dtsch Med Wochenschr"},{"issue":"3","key":"10.1016\/j.nefroe.2026.501589_bib0195","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1053\/j.ajkd.2014.05.010","article-title":"Bile acid nephropathy in a bodybuilder abusing an anabolic androgenic steroid","volume":"64","author":"Luciano","year":"2014","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1016\/j.nefroe.2026.501589_bib0200","doi-asserted-by":"crossref","first-page":"133","DOI":"10.14309\/crj.2016.24","article-title":"Severe cholestasis and bile acid nephropathy from anabolic steroids successfully treated with plasmapheresis","volume":"3","author":"Flores","year":"2016","journal-title":"ACG Case Rep J"},{"key":"10.1016\/j.nefroe.2026.501589_bib0205","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/00005373-200210000-00024","article-title":"Renal failure and exercise-induced rhabdomyolysis in patients taking performance-enhancing compounds","volume":"53","author":"Sandhu","year":"2002","journal-title":"J Trauma"},{"issue":"1","key":"10.1016\/j.nefroe.2026.501589_bib0210","first-page":"135","article-title":"Nephrocalcinosis associated with the use of anabolic steroid","volume":"37","author":"Machado Luchi","year":"2015","journal-title":"J Bras Nefrol"},{"issue":"6","key":"10.1016\/j.nefroe.2026.501589_bib0215","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.nefro.2015.09.005","article-title":"Lots of steroids and vitamins, tons of complications. Hypercalcemia and nephrocalcinosis as important complications of performance-enhancing drugs","volume":"35","author":"Bento","year":"2015","journal-title":"Nefrolog\u00eda"},{"key":"10.1016\/j.nefroe.2026.501589_bib0220","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19042122","article-title":"When bodibuilding goes wrong-bilateral renal artery thrombosis in a long-term misuser of anabolic steroids treated with Angiojet Rheolytic Trombectom","volume":"19","author":"Leminski","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"7","key":"10.1016\/j.nefroe.2026.501589_bib0225","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00101-002-0335-4","article-title":"A thirty-year old bodybuilder with septic shock and ARDS from abuse of anabolic steroids","volume":"51","author":"Herr","year":"2002","journal-title":"Anaesthesist"},{"issue":"12","key":"10.1016\/j.nefroe.2026.501589_bib0230","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.4187\/respcare.02338","article-title":"Caution for anabolic androgenic steroid use: a case report of multiple organ dysfunction s\u00edndrome","volume":"58","author":"Unai","year":"2013","journal-title":"Respir Care"},{"issue":"8","key":"10.1016\/j.nefroe.2026.501589_bib0235","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/1354750X.2021.1976837","article-title":"The effects of anabolic-androgenic steroids on DNA damage in bodybuilders\u2019 blood lymphocytes","volume":"26","author":"Abbasnezhad","year":"2021","journal-title":"Biomarkers"},{"issue":"5","key":"10.1016\/j.nefroe.2026.501589_bib0240","doi-asserted-by":"crossref","first-page":"438","DOI":"10.2174\/138955711795445907","article-title":"Is there a potential immune dysfunction with anabolic androgenic steroid use?: A review","volume":"11","author":"Brenu","year":"2011","journal-title":"Mini Rev Med Chem"},{"issue":"10","key":"10.1016\/j.nefroe.2026.501589_bib0245","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1002\/art.1780401027","article-title":"Systemic lupus erythematosus with membranous glomerulonephritis and transverse myelitis associated with anabolic steroid use","volume":"40","author":"Radis","year":"1997","journal-title":"Arthritis Rheum"}],"container-title":["Nefrolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251426001537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2013251426001537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:55:59Z","timestamp":1791564959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2013251426001537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2013251426001537"],"URL":"https:\/\/doi.org\/10.1016\/j.nefroe.2026.501589","relation":{},"ISSN":["2013-2514"],"issn-type":[{"value":"2013-2514","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Testosterone and anabolic androgenic steroids: Impact on acute kidney injury","name":"articletitle","label":"Article Title"},{"value":"Nefrolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nefroe.2026.501589","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.nefro.2026.501589","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Sociedad Espa\u00f1ola de Nefrolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"501589"}}