{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:36:45Z","timestamp":1793403405792,"version":"4.5.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000888","name":"W. M. Keck Foundation","doi-asserted-by":"publisher","award":["5-T32-NS007205-33"],"award-info":[{"award-number":["5-T32-NS007205-33"]}],"id":[{"id":"10.13039\/100000888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000888","name":"W. M. Keck Foundation","doi-asserted-by":"publisher","award":["5-T32-EY13360"],"award-info":[{"award-number":["5-T32-EY13360"]}],"id":[{"id":"10.13039\/100000888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000913","name":"James S. McDonnell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01-CA141549"],"award-info":[{"award-number":["U01-CA141549"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01-CA160882"],"award-info":[{"award-number":["U01-CA160882"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["30 CA91842"],"award-info":[{"award-number":["30 CA91842"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RC4 NS072916"],"award-info":[{"award-number":["RC4 NS072916"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.neo.2015.10.002","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T04:19:03Z","timestamp":1447733943000},"page":"776-788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth"],"prefix":"10.1016","volume":"17","author":[{"given":"Anne C.","family":"Solga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie W.","family":"Pong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Cimino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Toonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Wylie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Magrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malachi","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obi L.","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Ellisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine R.","family":"Mardis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Gutmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neo.2015.10.002_bb0005","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0014-4800(79)90026-1","article-title":"Stromal aspects of breast carcinoma","volume":"31","author":"Tremblay","year":"1979","journal-title":"Exp Mol Pathol"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0010","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00000658-197203000-00014","article-title":"Anti-angiogenesis: new concept for therapy of solid tumors","volume":"175","author":"Folkman","year":"1972","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nm988","article-title":"Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer","volume":"10","author":"Willett","year":"2004","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.neo.2015.10.002_bb0020","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/mrm.23315","article-title":"Evaluation of combined bevacizumab plus irinotecan therapy in brain tumors using magnetic resonance imaging measures of relative cerebral blood volume","volume":"68","author":"Pechman","year":"2012","journal-title":"Magn Reson Med"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0025","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1101\/gr.142604.112","article-title":"Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma","volume":"23","author":"Gutmann","year":"2013","journal-title":"Genome Res"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0030","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3171\/jns.1979.50.3.0305","article-title":"Macrophages in experimental and human brain tumors. Part 2: studies of the macrophage content of human brain tumors","volume":"50","author":"Morantz","year":"1979","journal-title":"J Neurosurg"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0035","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00688191","article-title":"Immunohistological study of mononuclear cell infiltrate in malignant gliomas","volume":"74","author":"Rossi","year":"1987","journal-title":"Acta Neuropathol"},{"issue":"1","key":"10.1016\/j.neo.2015.10.002_bb0040","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/NEN.0b013e3182032d37","article-title":"Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth","volume":"70","author":"Simmons","year":"2011","journal-title":"J Neuropathol Exp Neurol"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0045","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s004010050520","article-title":"Distribution and characterization of microglia\/macrophages in human brain tumors","volume":"92","author":"Roggendorf","year":"1996","journal-title":"Acta Neuropathol"},{"issue":"4","key":"10.1016\/j.neo.2015.10.002_bb0050","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00401-001-0472-x","article-title":"Microglia promote glioma migration","volume":"103","author":"Bettinger","year":"2002","journal-title":"Acta Neuropathol"},{"issue":"1\u20132","key":"10.1016\/j.neo.2015.10.002_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2013.04.020","article-title":"Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression","volume":"260","author":"Yongjun","year":"2013","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neo.2015.10.002_bb0060","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neuroscience.2011.10.025","article-title":"Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells","volume":"200","author":"Fonseca","year":"2012","journal-title":"Neuroscience"},{"issue":"30","key":"10.1016\/j.neo.2015.10.002_bb0065","doi-asserted-by":"crossref","first-page":"12530","DOI":"10.1073\/pnas.0804273106","article-title":"Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion","volume":"106","author":"Markovic","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.neo.2015.10.002_bb0070","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1002\/ijc.29095","article-title":"Inhibition of glioma progression by a newly discovered CD38 inhibitor","volume":"136","author":"Blacher","year":"2015","journal-title":"Int J Cancer"},{"issue":"10","key":"10.1016\/j.neo.2015.10.002_bb0075","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/nm.3337","article-title":"CSF-1R inhibition alters macrophage polarization and blocks glioma progression","volume":"19","author":"Pyonteck","year":"2013","journal-title":"Nat Med"},{"issue":"Pt 1","key":"10.1016\/j.neo.2015.10.002_bb0080","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/brain\/awg016","article-title":"Prognostic factors of CNS tumours in neurofibromatosis 1 (NF1): a retrospective study of 104 patients","volume":"126","author":"Guillamo","year":"2003","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0085","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/ng0293-122","article-title":"Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis","volume":"3","author":"Legius","year":"1993","journal-title":"Nat Genet"},{"issue":"24","key":"10.1016\/j.neo.2015.10.002_bb0090","first-page":"8573","article-title":"Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity","volume":"63","author":"Bajenaru","year":"2003","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.neo.2015.10.002_bb0095","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuroscience.2010.06.017","article-title":"Ultrastructural characterization of the optic pathway in a mouse model of neurofibromatosis-1 optic glioma","volume":"170","author":"Kim","year":"2010","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.neo.2015.10.002_bb0100","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/j.celrep.2015.02.041","article-title":"Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties","volume":"10","author":"Chen","year":"2015","journal-title":"Cell Rep"},{"issue":"24","key":"10.1016\/j.neo.2015.10.002_bb0105","doi-asserted-by":"crossref","first-page":"10358","DOI":"10.1158\/0008-5472.CAN-08-2506","article-title":"Increased c-Jun-NH2-kinase signaling in neurofibromatosis-1 heterozygous microglia drives microglia activation and promotes optic glioma proliferation","volume":"68","author":"Daginakatte","year":"2008","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.neo.2015.10.002_bb0110","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/hmg\/ddm059","article-title":"Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth","volume":"16","author":"Daginakatte","year":"2007","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0115","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/ana.23813","article-title":"Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation","volume":"73","author":"Pong","year":"2013","journal-title":"Ann Neurol"},{"issue":"10","key":"10.1016\/j.neo.2015.10.002_bb0120","doi-asserted-by":"crossref","first-page":"e77571","DOI":"10.1371\/journal.pone.0077571","article-title":"F11R is a novel monocyte prognostic biomarker for malignant glioma","volume":"8","author":"Pong","year":"2013","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.neo.2015.10.002_bb0125","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1093\/nar\/gkr547","article-title":"Whole-transcriptome RNAseq analysis from minute amount of total RNA","volume":"39","author":"Tariq","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.neo.2015.10.002_bb0130","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jmoldx.2014.03.004","article-title":"cDNA hybrid capture improves transcriptome analysis on low-input and archived samples","volume":"16","author":"Cabanski","year":"2014","journal-title":"J Mol Diagn"},{"issue":"4","key":"10.1016\/j.neo.2015.10.002_bb0135","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/glia.22754","article-title":"RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease","volume":"63","author":"Solga","year":"2014","journal-title":"Glia"},{"issue":"7","key":"10.1016\/j.neo.2015.10.002_bb0140","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1101\/gad.862101","article-title":"Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain","volume":"15","author":"Zhu","year":"2001","journal-title":"Genes Dev"},{"issue":"14","key":"10.1016\/j.neo.2015.10.002_bb0145","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1128\/MCB.22.14.5100-5113.2002","article-title":"Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation","volume":"22","author":"Bajenaru","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"24","key":"10.1016\/j.neo.2015.10.002_bb0150","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1242\/dev.02162","article-title":"Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation","volume":"132","author":"Zhu","year":"2005","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.neo.2015.10.002_bb0155","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1158\/0008-5472.CAN-07-5916","article-title":"Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma","volume":"68","author":"Hegedus","year":"2008","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.neo.2015.10.002_bb0160","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/NEN.0b013e3182656ef8","article-title":"BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper","volume":"71","author":"Rodriguez","year":"2012","journal-title":"J Neuropathol Exp Neurol"},{"issue":"5","key":"10.1016\/j.neo.2015.10.002_bb0165","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/neuonc\/nou287","article-title":"The impact of coexisting genetic mutations on murine optic glioma biology","volume":"17","author":"Kaul","year":"2014","journal-title":"Neuro-Oncology"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0170","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/gene.10036","article-title":"Cre\/loxP-mediated inactivation of the murine Pten tumor suppressor gene","volume":"32","author":"Lesche","year":"2002","journal-title":"Genesis"},{"issue":"11","key":"10.1016\/j.neo.2015.10.002_bb0175","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/glia.20845","article-title":"Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)\u2013regulated glial proliferation","volume":"57","author":"Yeh","year":"2009","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.neo.2015.10.002_bb0180","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.stem.2007.07.008","article-title":"Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms","volume":"1","author":"Hegedus","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neo.2015.10.002_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1435s104","article-title":"Isolation and analysis of mouse microglial cells","volume":"104","author":"Garcia","year":"2014","journal-title":"Curr Protoc Immunol"},{"issue":"6","key":"10.1016\/j.neo.2015.10.002_bb0190","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2012.08.024","article-title":"Genomic landscape of non\u2013small cell lung cancer in smokers and never-smokers","volume":"150","author":"Govindan","year":"2012","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.neo.2015.10.002_bb0195","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJMoa0903840","article-title":"Recurring mutations found by sequencing an acute myeloid leukemia genome","volume":"361","author":"Mardis","year":"2009","journal-title":"N Engl J Med"},{"issue":"7385","key":"10.1016\/j.neo.2015.10.002_bb0200","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature10755","article-title":"Cancer exome analysis reveals a T-cell\u2013dependent mechanism of cancer immunoediting","volume":"482","author":"Matsushita","year":"2012","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.neo.2015.10.002_bb0205","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-Seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"issue":"17","key":"10.1016\/j.neo.2015.10.002_bb0210","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1093\/bioinformatics\/btr355","article-title":"Identification of novel transcripts in annotated genomes using RNA-Seq","volume":"27","author":"Roberts","year":"2011","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0215","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/gb-2011-12-3-r22","article-title":"Improving RNA-Seq expression estimates by correcting for fragment bias","volume":"12","author":"Roberts","year":"2011","journal-title":"Genome Biol"},{"issue":"5","key":"10.1016\/j.neo.2015.10.002_bb0220","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"6","key":"10.1016\/j.neo.2015.10.002_bb0225","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/neuonc\/nou329","article-title":"The impact of coexisting genetic mutations on murine optic glioma biology","volume":"17","author":"Kaul","year":"2014","journal-title":"Neuro Oncol"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0230","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00401-010-0784-9","article-title":"PI3K\/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma","volume":"121","author":"Rodriguez","year":"2011","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neo.2015.10.002_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2013.12.010","article-title":"Dynamic structural remodelling of microglia in health and disease: a review of the models, the signals and the mechanisms","volume":"37","author":"Walker","year":"2014","journal-title":"Brain Behav Immun"},{"issue":"5726","key":"10.1016\/j.neo.2015.10.002_bb0240","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0245","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/bpa.12088","article-title":"Increased amoeboid microglial density in the olfactory bulb of Parkinson's and Alzheimer's patients","volume":"24","author":"Doorn","year":"2014","journal-title":"Brain Pathol"},{"issue":"1\u20132","key":"10.1016\/j.neo.2015.10.002_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2003.11.012","article-title":"Differential expression of chemokines and chemokine receptors during microglial activation and inhibition","volume":"149","author":"Kremlev","year":"2004","journal-title":"J Neuroimmunol"},{"issue":"5A","key":"10.1016\/j.neo.2015.10.002_bb0255","first-page":"3217","article-title":"Interleukin 10 is expressed in human gliomas in vivo and increases glioma cell proliferation and motility in vitro","volume":"17","author":"Huettner","year":"1997","journal-title":"Anticancer Res"},{"issue":"5","key":"10.1016\/j.neo.2015.10.002_bb0260","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1046\/j.1471-4159.1998.71051837.x","article-title":"Interleukin-6\u2013mediated autocrine growth promotion in human glioblastoma multiforme cell line U87MG","volume":"71","author":"Goswami","year":"1998","journal-title":"J Neurochem"},{"issue":"12","key":"10.1016\/j.neo.2015.10.002_bb0265","first-page":"3498","article-title":"Recombinant human stem cell factor stimulates growth of a human glioblastoma cell line expressing c-kit protooncogene","volume":"52","author":"Berdel","year":"1992","journal-title":"Cancer Res"},{"issue":"8","key":"10.1016\/j.neo.2015.10.002_bb0270","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1093\/neuonc\/nos116","article-title":"The molecular profile of microglia under the influence of glioma","volume":"14","author":"Li","year":"2012","journal-title":"Neuro Oncol"},{"issue":"23","key":"10.1016\/j.neo.2015.10.002_bb0275","first-page":"5391","article-title":"Met and hepatocyte growth factor\/scatter factor expression in human gliomas","volume":"57","author":"Koochekpour","year":"1997","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0280","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/hs0202.103399","article-title":"Flow cytometric analysis of inflammatory cells in ischemic rat brain","volume":"33","author":"Campanella","year":"2002","journal-title":"Stroke"},{"issue":"18","key":"10.1016\/j.neo.2015.10.002_bb0285","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.1158\/0008-5472.CAN-13-1299","article-title":"Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro","volume":"73","author":"Henriquez","year":"2013","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0290","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00401-013-1124-7","article-title":"Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma","volume":"126","author":"Lambert","year":"2013","journal-title":"Acta Neuropathol"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0295","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/onc.2012.580","article-title":"NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma","volume":"33","author":"Solga","year":"2014","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.neo.2015.10.002_bb0300","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1074\/jbc.271.5.2599","article-title":"Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist","volume":"271","author":"Proudfoot","year":"1996","journal-title":"J Biol Chem"},{"issue":"45","key":"10.1016\/j.neo.2015.10.002_bb0305","doi-asserted-by":"crossref","first-page":"32478","DOI":"10.1074\/jbc.274.45.32478","article-title":"Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors","volume":"274","author":"Proudfoot","year":"1999","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.neo.2015.10.002_bb0310","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12974-014-0146-y","article-title":"Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection","volume":"11","author":"Huang","year":"2014","journal-title":"J Neuroinflammation"},{"issue":"1\u20133","key":"10.1016\/j.neo.2015.10.002_bb0315","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0165-2478(97)00075-8","article-title":"Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA\/1 mice","volume":"57","author":"Plater-Zyberk","year":"1997","journal-title":"Immunol Lett"},{"issue":"6","key":"10.1016\/j.neo.2015.10.002_bb0320","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/art.21033","article-title":"Amelioration of rat adjuvant-induced arthritis by Met-RANTES","volume":"52","author":"Shahrara","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"14","key":"10.1016\/j.neo.2015.10.002_bb0325","doi-asserted-by":"crossref","first-page":"11427","DOI":"10.1074\/jbc.M010750200","article-title":"Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells","volume":"276","author":"Wong","year":"2001","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0330","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/cr.2012.178","article-title":"A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells","volume":"23","author":"Zhang","year":"2013","journal-title":"Cell Res"},{"issue":"12","key":"10.1016\/j.neo.2015.10.002_bb0335","doi-asserted-by":"crossref","first-page":"e28842","DOI":"10.1371\/journal.pone.0028842","article-title":"CCL5 neutralization restricts cancer growth and potentiates the targeting of PDGFRbeta in colorectal carcinoma","volume":"6","author":"Cambien","year":"2011","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.neo.2015.10.002_bb0340","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.4049\/jimmunol.172.7.4018","article-title":"Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis","volume":"172","author":"Glass","year":"2004","journal-title":"J Immunol"},{"issue":"1\u20132","key":"10.1016\/j.neo.2015.10.002_bb0345","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jneuroim.2005.01.020","article-title":"CCL2 and CCL5 mediate leukocyte adhesion in experimental autoimmune encephalomyelitis\u2014an intravital microscopy study","volume":"162","author":"dos Santos","year":"2005","journal-title":"J Neuroimmunol"},{"issue":"7","key":"10.1016\/j.neo.2015.10.002_bb0350","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/stem.1125","article-title":"Soluble CCL5 derived from bone marrow\u2013derived mesenchymal stem cells and activated by amyloid beta ameliorates Alzheimer's disease in mice by recruiting bone marrow\u2013induced microglia immune responses","volume":"30","author":"Lee","year":"2012","journal-title":"Stem Cells"},{"issue":"6294","key":"10.1016\/j.neo.2015.10.002_bb0355","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/347669a0","article-title":"Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES","volume":"347","author":"Schall","year":"1990","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0360","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cellimm.2011.05.001","article-title":"CCL5 induces a pro-inflammatory profile in microglia in vitro","volume":"270","author":"Skuljec","year":"2011","journal-title":"Cell Immunol"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0365","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ana.21107","article-title":"Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations","volume":"61","author":"Listernick","year":"2007","journal-title":"Ann Neurol"},{"issue":"2 Pt 1","key":"10.1016\/j.neo.2015.10.002_bb0370","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1164\/ajrccm.162.2.9907014","article-title":"CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus. Potential implication in eosinophil recruitment","volume":"162","author":"Tillie-Leblond","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"29","key":"10.1016\/j.neo.2015.10.002_bb0375","doi-asserted-by":"crossref","first-page":"17161","DOI":"10.1074\/jbc.271.29.17161","article-title":"Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha","volume":"271","author":"Raport","year":"1996","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0380","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1172\/JCI119145","article-title":"Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody","volume":"99","author":"Heath","year":"1997","journal-title":"J Clin Invest"},{"issue":"32","key":"10.1016\/j.neo.2015.10.002_bb0385","doi-asserted-by":"crossref","first-page":"9642","DOI":"10.1021\/bi970593z","article-title":"Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5","volume":"36","author":"Pakianathan","year":"1997","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.neo.2015.10.002_bb0390","first-page":"139","article-title":"Rantes distribution and cellular localization in the brain of HIV-infected patients","volume":"20","author":"Vago","year":"2001","journal-title":"Clin Neuropathol"},{"issue":"13","key":"10.1016\/j.neo.2015.10.002_bb0395","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/glia.21035","article-title":"Morphine induces the release of CCL5 from astrocytes: potential neuroprotective mechanism against the HIV protein gp120","volume":"58","author":"Avdoshina","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.neo.2015.10.002_bb0400","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1742-2094-5-50","article-title":"Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection","volume":"5","author":"Ovanesov","year":"2008","journal-title":"J Neuroinflammation"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0405","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1080\/13550280152403254","article-title":"Robust expression of TNF-alpha, IL-1beta, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus","volume":"7","author":"Lokensgard","year":"2001","journal-title":"J Neurovirol"},{"key":"10.1016\/j.neo.2015.10.002_bb0410","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1749-6632.2008.03959.x","article-title":"The chemokine CCL5 is essential for leukocyte recruitment in a model of severe Herpes simplex encephalitis","volume":"1153","author":"Vilela","year":"2009","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"10.1016\/j.neo.2015.10.002_bb0415","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.4049\/jimmunol.1302915","article-title":"CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120","volume":"193","author":"Maung","year":"2014","journal-title":"J Immunol"},{"issue":"1\u20132","key":"10.1016\/j.neo.2015.10.002_bb0420","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jneuroim.2012.02.009","article-title":"CCL5, CCR1 and CCR5 in murine glioblastoma: immune cell infiltration and survival rates are not dependent on individual expression of either CCR1 or CCR5","volume":"246","author":"Pham","year":"2012","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neo.2015.10.002_bb0425","article-title":"PRDX6 promotes tumor development via the JAK2\/STAT3 pathway in a urethane-induced lung tumor model","volume":"10","author":"Yun","year":"2015","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.neo.2015.10.002_bb0430","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cellsig.2014.10.010","article-title":"Regulation of prostate stromal fibroblasts by the PIM1 protein kinase","volume":"27","author":"Zemskova","year":"2015","journal-title":"Cell Signal"},{"issue":"8","key":"10.1016\/j.neo.2015.10.002_bb0435","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.1167\/iovs.14-14394","article-title":"Inflammation-induced chemokine expression in uveal melanoma cell lines stimulates monocyte chemotaxis","volume":"55","author":"Jehs","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.neo.2015.10.002_bb0440","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.3892\/or.2014.3479","article-title":"Tunicamycin-induced ER stress regulates chemokine CCL5 expression and secretion via STAT3 followed by decreased transmigration of MCF-7 breast cancer cells","volume":"32","author":"Zhang","year":"2014","journal-title":"Oncol Rep"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0445","first-page":"285","article-title":"Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer","volume":"7","author":"Niwa","year":"2001","journal-title":"Clin Cancer Res"},{"issue":"18","key":"10.1016\/j.neo.2015.10.002_bb0450","first-page":"4681","article-title":"Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma","volume":"59","author":"Luboshits","year":"1999","journal-title":"Cancer Res"},{"issue":"7\u20138","key":"10.1016\/j.neo.2015.10.002_bb0455","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/sj.bjc.6690164","article-title":"The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice","volume":"79","author":"Mrowietz","year":"1999","journal-title":"Br J Cancer"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0460","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bbrc.2009.07.035","article-title":"CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation","volume":"387","author":"Murooka","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0465","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.4049\/jimmunol.182.3.1746","article-title":"Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer","volume":"182","author":"Tan","year":"2009","journal-title":"J Immunol"},{"issue":"11","key":"10.1016\/j.neo.2015.10.002_bb0470","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1002\/ijc.23401","article-title":"Gastric cancer cells exploit CD4+ cell-derived CCL5 for their growth and prevention of CD8+ cell-involved tumor elimination","volume":"122","author":"Sugasawa","year":"2008","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.neo.2015.10.002_bb0475","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pros.20306","article-title":"Expression of CCL5 (RANTES) and CCR5 in prostate cancer","volume":"66","author":"Vaday","year":"2006","journal-title":"Prostate"},{"issue":"6","key":"10.1016\/j.neo.2015.10.002_bb0480","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1593\/tlo.13499","article-title":"CCR5 antagonism by maraviroc reduces the potential for gastric cancer cell dissemination","volume":"6","author":"Mencarelli","year":"2013","journal-title":"Transl Oncol"},{"issue":"1","key":"10.1016\/j.neo.2015.10.002_bb0485","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3892\/or.2014.3214","article-title":"Chemokine expression profile of freshly isolated human glioblastoma-associated macrophages\/microglia","volume":"32","author":"Hattermann","year":"2014","journal-title":"Oncol Rep"},{"issue":"3","key":"10.1016\/j.neo.2015.10.002_bb0490","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/B:NEON.0000024241.05346.24","article-title":"CXCL12 in malignant glial tumors: a possible role in angiogenesis and cross-talk between endothelial and tumoral cells","volume":"67","author":"Salmaggi","year":"2004","journal-title":"J Neurooncol"},{"issue":"1","key":"10.1016\/j.neo.2015.10.002_bb0495","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.canlet.2009.07.014","article-title":"Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9","volume":"289","author":"Kenig","year":"2010","journal-title":"Cancer Lett"},{"key":"10.1016\/j.neo.2015.10.002_bb0500","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2119\/molmed.2011.00217","article-title":"Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling","volume":"18","author":"Coniglio","year":"2012","journal-title":"Mol Med"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558615001281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558615001281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:00:07Z","timestamp":1778616007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558615001281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":100,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1476558615001281"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2015.10.002","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2015.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}