{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:39:04Z","timestamp":1790404744596,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.neo.2015.12.003","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:15:15Z","timestamp":1456704915000},"page":"90-99","source":"Crossref","is-referenced-by-count":25,"title":["Activation-Induced Cytidine Deaminase Links Ovulation-Induced Inflammation and Serous Carcinogenesis"],"prefix":"10.1016","volume":"18","author":[{"given":"Stav","family":"Sapoznik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Bahar-Shany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadar","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishay","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orshay","family":"Gabay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Glick-Saar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Dor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oranit","family":"Zadok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Barshack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Zundelevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einav Nili","family":"Gal-Yam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Yung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Hourvitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Korach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Beiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erez Y.","family":"Levanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Barak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarit","family":"Aviel-Ronen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Levanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neo.2015.12.003_bb0005","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ijc.10927","article-title":"Ovulation and risk of epithelial ovarian cancer","volume":"104","author":"Purdie","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1016\/j.neo.2015.12.003_bb0010","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0140-6736(71)92335-X","article-title":"Incessant ovulation\u2014a factor in ovarian neoplasia?","volume":"2","author":"Fathalla","year":"1971","journal-title":"Lancet"},{"key":"10.1016\/j.neo.2015.12.003_bb0015","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mce.2005.09.014","article-title":"Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: revisiting old hypotheses","volume":"247","author":"Fleming","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.neo.2015.12.003_bb0020","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jprot.2013.05.017","article-title":"Proteomic analysis of human follicular fluid: A new perspective towards understanding folliculogenesis","volume":"87","author":"Ambekar","year":"2013","journal-title":"J Proteomics"},{"key":"10.1016\/j.neo.2015.12.003_bb0025","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/humrep\/14.1.162","article-title":"Cytokines in the follicular fluid of stimulated and non-stimulated human ovaries; is ovulation a suppressed inflammatory reaction?","volume":"14","author":"Buscher","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.neo.2015.12.003_bb0030","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.neo.2015.12.003_bb0035","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neo.2015.12.003_bb0040","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/IGC.0b013e318199009c","article-title":"The fallopian tube: primary site of most pelvic high-grade serous carcinomas","volume":"19","author":"Salvador","year":"2009","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.neo.2015.12.003_bb0045","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1200\/JCO.2008.18.1107","article-title":"New insights into the pathogenesis of serous ovarian cancer and its clinical impact","volume":"26","author":"Levanon","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.neo.2015.12.003_bb0050","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/onc.2009.402","article-title":"Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis","volume":"29","author":"Levanon","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2015.12.003_bb0055","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.1073\/pnas.1017300108","article-title":"Modeling high-grade serous ovarian carcinogenesis from the fallopian tube","volume":"108","author":"Karst","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neo.2015.12.003_bb0060","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/nprot.2012.097","article-title":"Primary culture and immortalization of human fallopian tube secretory epithelial cells","volume":"7","author":"Karst","year":"2012","journal-title":"Nat Protoc"},{"key":"10.1016\/j.neo.2015.12.003_bb0065","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ygyno.2013.12.015","article-title":"Exposure of fallopian tube epithelium to follicular fluid mimics carcinogenic changes in precursor lesions of serous papillary carcinoma","volume":"132","author":"Bahar-Shany","year":"2014","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.neo.2015.12.003_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-387663-8.00005-3","article-title":"AID targeting in antibody diversity","volume":"110","author":"Pavri","year":"2011","journal-title":"Adv Immunol"},{"key":"10.1016\/j.neo.2015.12.003_bb0075","doi-asserted-by":"crossref","first-page":"8629","DOI":"10.1073\/pnas.0903803106","article-title":"V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment","volume":"106","author":"MacCarthy","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neo.2015.12.003_bb0080","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.cell.2014.11.014","article-title":"Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability","volume":"159","author":"Meng","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neo.2015.12.003_bb0085","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.cell.2014.11.013","article-title":"B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity","volume":"159","author":"Qian","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neo.2015.12.003_bb0090","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nri1896","article-title":"Targeting of somatic hypermutation","volume":"6","author":"Odegard","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.neo.2015.12.003_bb0095","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cell.2004.08.006","article-title":"AID is required for c-myc\/IgH chromosome translocations in vivo","volume":"118","author":"Ramiro","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.neo.2015.12.003_bb0100","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.molcel.2009.11.007","article-title":"AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations","volume":"36","author":"Robbiani","year":"2009","journal-title":"Mol Cell"},{"key":"10.1016\/j.neo.2015.12.003_bb0105","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1101\/gad.1963010","article-title":"Cytidine deaminases: AIDing DNA demethylation?","volume":"24","author":"Fritz","year":"2010","journal-title":"Genes Dev"},{"key":"10.1016\/j.neo.2015.12.003_bb0110","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/nature08752","article-title":"Reprogramming towards pluripotency requires AID-dependent DNA demethylation","volume":"463","author":"Bhutani","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.neo.2015.12.003_bb0115","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tibs.2015.01.006","article-title":"Activation-induced cytidine deaminase and active cytidine demethylation","volume":"40","author":"Ramiro","year":"2015","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.neo.2015.12.003_bb0120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev-pathol-020712-164004","article-title":"Chromosome translocation, B cell lymphoma, and activation-induced cytidine deaminase","volume":"8","author":"Robbiani","year":"2013","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.neo.2015.12.003_bb0125","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature06547","article-title":"Two levels of protection for the B cell genome during somatic hypermutation","volume":"451","author":"Liu","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neo.2015.12.003_bb0130","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00109-009-0496-6","article-title":"DNA deaminases: AIDing hormones in immunity and cancer","volume":"87","author":"Petersen-Mahrt","year":"2009","journal-title":"J Mol Med"},{"key":"10.1016\/j.neo.2015.12.003_bb0135","first-page":"99","article-title":"Estrogen directly activates AID transcription and function","volume":"206","author":"Pauklin","year":"2009","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neo.2015.12.003_bb0140","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/B978-0-12-385991-4.00003-9","article-title":"Role of activation-induced cytidine deaminase in inflammation-associated cancer development","volume":"111","author":"Marusawa","year":"2011","journal-title":"Adv Immunol"},{"key":"10.1016\/j.neo.2015.12.003_bb0145","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00109-009-0527-3","article-title":"A novel mechanism for inflammation-associated carcinogenesis; an important role of activation-induced cytidine deaminase (AID) in mutation induction","volume":"87","author":"Chiba","year":"2009","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.neo.2015.12.003_bb0150","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1053\/j.gastro.2014.04.036","article-title":"Accumulation of somatic mutations in TP53 in gastric epithelium with Helicobacter pylori infection","volume":"147","author":"Shimizu","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neo.2015.12.003_bb0155","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nm1566","article-title":"Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium","volume":"13","author":"Matsumoto","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.neo.2015.12.003_bb0160","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/onc.2008.415","article-title":"A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations","volume":"28","author":"Takai","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2015.12.003_bb0165","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/ijc.22292","article-title":"Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis","volume":"120","author":"Kou","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.neo.2015.12.003_bb0170","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/hep.22125","article-title":"Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma","volume":"47","author":"Komori","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.neo.2015.12.003_bb0175","doi-asserted-by":"crossref","first-page":"E2977","DOI":"10.1073\/pnas.1301021110","article-title":"Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells","volume":"110","author":"Mu\u00f1oz","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neo.2015.12.003_bb0180","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/exd.12402","article-title":"Expression of AID in malignant melanoma with BRAF(V600E) mutation","volume":"23","author":"Okura","year":"2014","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.neo.2015.12.003_bb0185","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1111\/j.1440-1746.2012.07216.x","article-title":"Fhit, E-cadherin, p53, and activation-induced cytidine deaminase expression in endoscopically resected early stage esophageal squamous neoplasia","volume":"27","author":"Hayashi","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.neo.2015.12.003_bb0190","doi-asserted-by":"crossref","first-page":"e87679","DOI":"10.1371\/journal.pone.0087679","article-title":"Insights into the motif preference of APOBEC3 enzymes","volume":"9","author":"Ebrahimi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neo.2015.12.003_bb0195","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/ng.2702","article-title":"An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers","volume":"45","author":"Roberts","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.neo.2015.12.003_bb0200","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neo.2015.12.003_bb0205","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13058-014-0498-3","article-title":"Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer","volume":"17","author":"Harris","year":"2015","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.neo.2015.12.003_bb0210","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature11881","article-title":"APOBEC3B is an enzymatic source of mutation in breast cancer","volume":"494","author":"Burns","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neo.2015.12.003_bb0215","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.cell.2012.04.024","article-title":"Mutational processes molding the genomes of 21 breast cancers","volume":"149","author":"Nik-Zainal","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neo.2015.12.003_bb0220","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.celrep.2014.04.053","article-title":"Break-induced replication is a source of mutation clusters underlying kataegis","volume":"7","author":"Sakofsky","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.neo.2015.12.003_bb0225","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.1158\/0008-5472.CAN-13-1753","article-title":"APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma","volume":"73","author":"Leonard","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.neo.2015.12.003_bb0230","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1084\/jem.20030481","article-title":"AID mediates hypermutation by deaminating single stranded DNA","volume":"197","author":"Dickerson","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.neo.2015.12.003_bb0235","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neo.2015.12.003_bb0240","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.neo.2015.12.003_bb0245","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.it.2011.03.003","article-title":"Complex regulation and function of activation-induced cytidine deaminase","volume":"32","author":"Stavnezer","year":"2011","journal-title":"Trends Immunol"},{"key":"10.1016\/j.neo.2015.12.003_bb0250","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1016\/j.neo.2015.12.003_bb0255","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci Signal"},{"key":"10.1016\/j.neo.2015.12.003_bb0260","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1477-7827-7-40","article-title":"Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics","volume":"7","author":"Revelli","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.neo.2015.12.003_bb0265","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1745-6150-7-47","article-title":"AID\/APOBEC cytosine deaminase induces genome-wide kataegis","volume":"7","author":"Lada","year":"2012","journal-title":"Biol Direct"},{"key":"10.1016\/j.neo.2015.12.003_bb0270","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1053\/j.gastro.2011.12.004","article-title":"Field cancerization in the intestinal epithelium of patients with Crohn\u2019s ileocolitis","volume":"142","author":"Galandiuk","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neo.2015.12.003_bb0275","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.1121343109","article-title":"Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing","volume":"109","author":"Lohr","year":"2012","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558615001700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558615001700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T19:51:19Z","timestamp":1536954679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558615001700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1476558615001700"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2015.12.003","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}