{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:55:53Z","timestamp":1780570553840,"version":"3.54.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,2]],"date-time":"2017-04-02T00:00:00Z","timestamp":1491091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","journals.elsevierhealth.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.neo.2017.06.005","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T23:01:33Z","timestamp":1504134093000},"page":"781-790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence"],"prefix":"10.1016","volume":"19","author":[{"given":"Nicola","family":"Alessio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Ferone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Di Bernardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Cipollaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorina","family":"Casale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Galderisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neo.2017.06.005_bb0005","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/bib\/bbr031","article-title":"When orthologs diverge between human and mouse","volume":"12","author":"Gharib","year":"2011","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.neo.2017.06.005_bb0010","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.neo.2017.06.005_bb0015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/excr.2000.5135","article-title":"p107 and p130: versatile proteins with interesting pockets","volume":"264","author":"Classon","year":"2001","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.neo.2017.06.005_bb0020","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.1038\/sj.onc.1209736","article-title":"The retinoblastoma gene is involved in multiple aspects of stem cell biology","volume":"25","author":"Galderisi","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2017.06.005_bb0025","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1128\/MCB.18.12.7455","article-title":"Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene","volume":"18","author":"LeCouter","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neo.2017.06.005_bb0030","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1242\/dev.125.23.4669","article-title":"Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene","volume":"125","author":"LeCouter","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.neo.2017.06.005_bb0035","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature01764","article-title":"Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry","volume":"424","author":"Sage","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.neo.2017.06.005_bb0040","first-page":"5556","article-title":"p130\/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107","volume":"54","author":"Claudio","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.neo.2017.06.005_bb0045","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1038\/sj.onc.1206558","article-title":"Cell cycle regulation and neural differentiation","volume":"22","author":"Galderisi","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2017.06.005_bb0050","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1074\/jbc.M509053200","article-title":"The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium","volume":"281","author":"Haigis","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neo.2017.06.005_bb0055","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1128\/MCB.16.5.2402","article-title":"Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts","volume":"16","author":"Herrera","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neo.2017.06.005_bb0060","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1128\/MCB.23.3.1044-1053.2003","article-title":"Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system","volume":"23","author":"MacPherson","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neo.2017.06.005_bb0065","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1101\/gad.1203304","article-title":"Cell type\u2013specific effects of Rb deletion in the murine retina","volume":"18","author":"MacPherson","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.neo.2017.06.005_bb0070","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1258\/jrsm.2008.08k033","article-title":"Why animal studies are often poor predictors of human reactions to exposure","volume":"102","author":"Bracken","year":"2009","journal-title":"J R Soc Med"},{"key":"10.1016\/j.neo.2017.06.005_bb0075","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1002\/med.21322","article-title":"The gap between the physiological and therapeutic roles of mesenchymal stem cells","volume":"34","author":"Galderisi","year":"2014","journal-title":"Med Res Rev"},{"key":"10.1016\/j.neo.2017.06.005_bb0080","doi-asserted-by":"crossref","first-page":"39457","DOI":"10.18632\/oncotarget.6277","article-title":"Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells","volume":"6","author":"Capasso","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.neo.2017.06.005_bb0085","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/nprot.2009.191","article-title":"Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo","volume":"4","author":"Debacq-Chainiaux","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.neo.2017.06.005_bb0090","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-62703-239-1_12","article-title":"Detection of senescence-associated heterochromatin foci (SAHF)","volume":"965","author":"Aird","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.neo.2017.06.005_bb0095","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/jcp.22786","article-title":"The switch from pRb\/p105 to Rb2\/p130 in DNA damage and cellular senescence","volume":"227","author":"Helmbold","year":"2012","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.neo.2017.06.005_bb0100","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1038\/onc.2009.222","article-title":"Rb2\/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence","volume":"28","author":"Helmbold","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2017.06.005_bb0105","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1128\/MCB.26.7.2501-2510.2006","article-title":"Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells","volume":"26","author":"Jackson","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neo.2017.06.005_bb0110","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0531-5565(00)00083-8","article-title":"Tumor suppressors and oncogenes in cellular senescence","volume":"35","author":"Bringold","year":"2000","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.neo.2017.06.005_bb0115","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0960-9822(98)70137-X","article-title":"Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts","volume":"8","author":"McConnell","year":"1998","journal-title":"Curr Biol"},{"key":"10.1016\/j.neo.2017.06.005_bb0120","doi-asserted-by":"crossref","first-page":"13719","DOI":"10.1038\/ncomms13719","article-title":"Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence","volume":"7","author":"Revandkar","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.neo.2017.06.005_bb0125","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1128\/MCB.25.6.2486-2497.2005","article-title":"Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb","volume":"25","author":"MacLellan","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neo.2017.06.005_bb0130","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.1002\/j.1460-2075.1996.tb01006.x","article-title":"Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system","volume":"15","author":"Macleod","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.neo.2017.06.005_bb0135","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1101\/gad.1296405","article-title":"Regulation of neuron survival and death by p130 and associated chromatin modifiers","volume":"19","author":"Liu","year":"2005","journal-title":"Genes Dev"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558617301495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558617301495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:05:16Z","timestamp":1659398716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558617301495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1476558617301495"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2017.06.005","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2017.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc.","name":"copyright","label":"Copyright"}]}}