{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:58:36Z","timestamp":1793228316424,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,4]],"date-time":"2017-06-04T00:00:00Z","timestamp":1496534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","journals.elsevierhealth.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.neo.2017.08.004","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T21:00:45Z","timestamp":1505509245000},"page":"848-855","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":656,"title":["Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients"],"prefix":"10.1016","volume":"19","author":[{"given":"Arthur E.","family":"Frankel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Coughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwoong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Froehlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene P.","family":"Frenkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Y.","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neo.2017.08.004_bb0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJMoa1504030","article-title":"Combined nivolumab and ipilimumab or monotherapy in untreated melanoma","volume":"373","author":"Larkin","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neo.2017.08.004_bb0010","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1200\/JCO.2015.60.8448","article-title":"Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at Memorial Sloan Kettering Cancer Center","volume":"33","author":"Horvat","year":"2015","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"10.1016\/j.neo.2017.08.004_bb0015","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4172\/1948-5956.1000437","article-title":"Melanoma metamorphoses: advances in biology and therapy","volume":"9","author":"Frankel","year":"2017","journal-title":"J Cancer Sci Ther"},{"key":"10.1016\/j.neo.2017.08.004_bb0020","doi-asserted-by":"crossref","first-page":"e542","DOI":"10.1016\/S1470-2045(16)30406-5","article-title":"Predictive biomarkers for checkpoint inhibitor-based immunotherapy","volume":"17","author":"Gibney","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.neo.2017.08.004_bb0025","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccell.2016.06.003","article-title":"Critical role for CD103(+)\/CD141(+) dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma","volume":"30","author":"Roberts","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2017.08.004_bb0030","doi-asserted-by":"crossref","first-page":"e1240857","DOI":"10.1080\/2162402X.2016.1240857","article-title":"Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk","volume":"5","author":"Salerno","year":"2016","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.neo.2017.08.004_bb0035","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1126\/science.1223490","article-title":"Interactions between the microbiota and the immune system","volume":"336","author":"Hooper","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.neo.2017.08.004_bb0040","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.1240527","article-title":"Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment","volume":"342","author":"Iida","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neo.2017.08.004_bb0045","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.aac4255","article-title":"Commensal Bifidobacterium promotes antitumor immunity and facilitates anti\u2013PD-L1 efficacy","volume":"350","author":"Sivan","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.neo.2017.08.004_bb0050","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.aad1329","article-title":"Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota","volume":"350","author":"Vetizou","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.neo.2017.08.004_bb0055","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.neo.2017.08.004_bb0060","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nm.3871","article-title":"Activation of HIF-1alpha and LL-37 by commensal bacteria inhibits Candida albicans colonization","volume":"21","author":"Fan","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.neo.2017.08.004_bb0065","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.bbmt.2017.02.004","article-title":"Antibiotic-induced depletion of anti-inflammatory Clostridia is associated with the development of graft-versus-host disease in pediatric stem cell transplantation patients","volume":"23","author":"Simms-Waldrip","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.neo.2017.08.004_bb0070","doi-asserted-by":"crossref","DOI":"10.1177\/0148607116658762","article-title":"Severe gut microbiota dysbiosis is associated with poor growth in patients with short bowel syndrome","author":"Piper","year":"2016","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.neo.2017.08.004_bb0075","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nmeth.2066","article-title":"Metagenomic microbial community profiling using unique clade-specific marker genes","volume":"9","author":"Segata","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.neo.2017.08.004_bb0080","doi-asserted-by":"crossref","first-page":"e1002358","DOI":"10.1371\/journal.pcbi.1002358","article-title":"Metabolic reconstruction for metagenomic data and its application to the human microbiome","volume":"8","author":"Abubucker","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.neo.2017.08.004_bb0085","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1186\/s12859-016-1278-0","article-title":"FMAP: functional mapping and analysis pipeline for metagenomics and metatranscriptomics studies","volume":"17","author":"Kim","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.neo.2017.08.004_bb0090","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"10.1016\/j.neo.2017.08.004_bb0095","doi-asserted-by":"crossref","first-page":"e0152126","DOI":"10.1371\/journal.pone.0152126","article-title":"Fecal microbiota, fecal metabolome, and colorectal cancer interrelations","volume":"11","author":"Sinha","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neo.2017.08.004_bb0100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1758-2946-2-9","article-title":"Organization of GC\/MS and LC\/MS metabolomics data into chemical libraries","volume":"2","author":"Dehaven","year":"2010","journal-title":"J Chem"},{"key":"10.1016\/j.neo.2017.08.004_bb0105","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/S1470-2045(16)30366-7","article-title":"Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial","volume":"17","author":"Hodi","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.neo.2017.08.004_bb0110","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1056\/NEJMoa1302369","article-title":"Nivolumab plus ipilimumab in advanced melanoma","volume":"369","author":"Wolchok","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neo.2017.08.004_bb0115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12866-016-0738-z","article-title":"16S rRNA gene sequencing of mock microbial populations- impact of DNA extraction method, primer choice and sequencing platform","volume":"16","author":"Fouhy","year":"2016","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.neo.2017.08.004_bb0120","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1128\/AEM.01451-14","article-title":"Evaluating bias of illumina-based bacterial 16S rRNA gene profiles","volume":"80","author":"Kennedy","year":"2014","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.neo.2017.08.004_bb0125","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3389\/fmicb.2015.00771","article-title":"Primer and platform effects on 16S rRNA tag sequencing","volume":"6","author":"Tremblay","year":"2015","journal-title":"Front Microbiol"},{"key":"10.1016\/j.neo.2017.08.004_bb0130","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nature13828","article-title":"Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile","volume":"517","author":"Buffie","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neo.2017.08.004_bb0135","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4161\/gmic.21288","article-title":"Collateral effects of antibiotics on mammalian gut microbiomes","volume":"3","author":"Looft","year":"2012","journal-title":"Gut Microbes"},{"key":"10.1016\/j.neo.2017.08.004_bb0140","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neo.2017.08.004_bb0145","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1207\/s15327914nc5502_1","article-title":"Protection against cancer by dietary IP6 and inositol","volume":"55","author":"Vucenik","year":"2006","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.neo.2017.08.004_bb0150","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/rcm.3923","article-title":"Simultaneous determination of inositol and inositol phosphates in complex biological matrices: Quantitative ion-exchange chromatography\/tandem mass spectrometry","volume":"23","author":"Liu","year":"2009","journal-title":"Rapid Commun Mass Spectrom"},{"issue":"1","key":"10.1016\/j.neo.2017.08.004_bb0155","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/ph10010031","article-title":"Anacardic acid constituents from cashew nut shell liquid: NMR characterization and the effect of unsaturation on its biological activities","volume":"10","author":"Morais","year":"2017","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.neo.2017.08.004_bb0160","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.intimp.2015.08.038","article-title":"The anacardic 6-pentadecyl salicylic acid induces macrophage activation via the phosphorylation of ERK1\/2, JNK, P38 kinases and NF-kappaB","volume":"29","author":"Gnanaprakasam","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.neo.2017.08.004_bb0165","doi-asserted-by":"crossref","first-page":"13964","DOI":"10.1074\/jbc.M115.695866","article-title":"Natural product anacardic acid from cashew nut shells stimulates neutrophil extracellular trap production and bactericidal activity","volume":"291","author":"Hollands","year":"2016","journal-title":"J Biol Chem"},{"issue":"15","key":"10.1016\/j.neo.2017.08.004_bb0170","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1200\/JCO.2016.70.3348","article-title":"Intestinal microbiota and relapse after hematopoietic-cell transplantation","volume":"35","author":"Peled","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.neo.2017.08.004_bb0175","article-title":"Association of diversity and composition of the gut microbiome with differential responses to PD-1 based therapy in patients with metastatic melanoma. 2017 ASCO-SITC Clinical Immuno-Oncology Symposium; Orlando, FL, USA","volume":"35","author":"Gopalakrishnan","year":"2017","journal-title":"J Clin Oncol"},{"issue":"6","key":"10.1016\/j.neo.2017.08.004_bb0180","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/annonc\/mdx108","article-title":"Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab","volume":"28","author":"Chaput","year":"2017","journal-title":"Ann Oncol"},{"issue":"Suppl. 1","key":"10.1016\/j.neo.2017.08.004_bb0185","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1073\/pnas.1000087107","article-title":"Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation","volume":"108","author":"Dethlefsen","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neo.2017.08.004_bb0190","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neo.2017.08.004_bb0195","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.chom.2015.04.002","article-title":"Colitogenic Bacteroides thetaiotaomicron antigens access host immune cells in a sulfatase-dependent manner via outer membrane vesicles","volume":"17","author":"Hickey","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.neo.2017.08.004_bb0200","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.micpath.2009.04.015","article-title":"The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses","volume":"47","author":"Berezow","year":"2009","journal-title":"Microb Pathog"},{"key":"10.1016\/j.neo.2017.08.004_bb0205","doi-asserted-by":"crossref","first-page":"e0161779","DOI":"10.1371\/journal.pone.0161779","article-title":"Preclinical development of ipilimumab and nivolumab combination immunotherapy: mouse tumor models, in vitro functional studies, and cynomolgus macaque toxicology","volume":"11","author":"Selby","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neo.2017.08.004_bb0210","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1073\/pnas.1621363114","article-title":"cGAS is essential for the antitumor effect of immune checkpoint blockade","volume":"114","author":"Wang","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neo.2017.08.004_bb0215","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.tim.2015.03.002","article-title":"Fate, activity, and impact of ingested bacteria within the human gut microbiota","volume":"23","author":"Derrien","year":"2015","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.neo.2017.08.004_bb0220","doi-asserted-by":"crossref","first-page":"106ra106","DOI":"10.1126\/scitranslmed.3002701","article-title":"The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins","volume":"3","author":"McNulty","year":"2011","journal-title":"Sci Transl Med"},{"issue":"2","key":"10.1016\/j.neo.2017.08.004_bb0225","doi-asserted-by":"crossref","first-page":"149","DOI":"10.15252\/embr.201439466","article-title":"Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils","volume":"16","author":"Lou","year":"2015","journal-title":"EMBO Reports"},{"key":"10.1016\/j.neo.2017.08.004_bb0230","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1742-7843.2011.00833.x","article-title":"M Sebastin Santhosh, K Kemparaju and KS Girish, Emerging roles of anacardic acid and its derivatives: a pharmacological overview","volume":"110","author":"Hemshekhar","year":"2012","journal-title":"Basic Clin Pharmacol Toxicol"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558617302385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558617302385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T13:05:36Z","timestamp":1535375136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558617302385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1476558617302385"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2017.08.004","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2017.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc.","name":"copyright","label":"Copyright"}]}}