{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:04:15Z","timestamp":1790615055558,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","journals.elsevierhealth.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.neo.2018.10.001","type":"journal-article","created":{"date-parts":[[2018,11,4]],"date-time":"2018-11-04T09:57:44Z","timestamp":1541325464000},"page":"1198-1208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Inhibition of mTORC2\/RICTOR Impairs Melanoma Hepatic Metastasis"],"prefix":"10.1016","volume":"20","author":[{"given":"Katharina M.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Hackl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Guenzle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bronsert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Fichtner-Feigl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Schlitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward K.","family":"Geissler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Hellerbrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven A.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neo.2018.10.001_bb0005","first-page":"120","article-title":"Epidemiology of skin cancer","volume":"810","author":"Leiter","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.neo.2018.10.001_bb0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/CMR.0000000000000332","article-title":"Recurrence behavior in early-stage cutaneous melanoma: pattern, timing, survival, and influencing factors","volume":"27","author":"Tas","year":"2017","journal-title":"Melanoma Res"},{"key":"10.1016\/j.neo.2018.10.001_bb0015","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1003466","article-title":"Improved survival with ipilimumab in patients with metastatic melanoma","volume":"363","author":"Hodi","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neo.2018.10.001_bb0020","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2147\/CMAR.S49494","article-title":"Treating advanced melanoma: current insights and opportunities","volume":"6","author":"Tronnier","year":"2014","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.neo.2018.10.001_bb0025","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/bjs.9189","article-title":"Systematic review and meta-analysis of liver resection for metastatic melanoma","volume":"100","author":"Aubin","year":"2013","journal-title":"Br J Surg"},{"key":"10.1016\/j.neo.2018.10.001_bb0030","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/jso.20079","article-title":"The natural course of cutaneous melanoma","volume":"86","author":"Leiter","year":"2004","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.neo.2018.10.001_bb0035","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cell.2017.03.035","article-title":"mTOR Signaling in Growth, Metabolism, and Disease","volume":"169","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neo.2018.10.001_bb0040","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.semcancer.2017.04.011","article-title":"Inhibition of Akt and other AGC kinases: A target for clinical cancer therapy?","volume":"48","author":"Pretre","year":"2017","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.neo.2018.10.001_bb0045","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cub.2004.06.054","article-title":"Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton","volume":"14","author":"Sarbassov","year":"2004","journal-title":"Curr Biol"},{"key":"10.1016\/j.neo.2018.10.001_bb0050","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s10620-014-3417-7","article-title":"Influence of Rictor and Raptor Expression of mTOR Signaling on Long-Term Outcomes of Patients with Hepatocellular Carcinoma","volume":"60","author":"Kaibori","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.neo.2018.10.001_bb0055","doi-asserted-by":"crossref","first-page":"24491","DOI":"10.18632\/oncotarget.15524","article-title":"Inhibition of mTORC2 component RICTOR impairs tumor growth in pancreatic cancer models","volume":"8","author":"Schmidt","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.neo.2018.10.001_bb0060","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1136\/jclinpath-2016-203913","article-title":"mTOR activity and its prognostic significance in human colorectal carcinoma depending on C1 and C2 complex-related protein expression","volume":"70","author":"Sticz","year":"2017","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.neo.2018.10.001_bb0065","doi-asserted-by":"crossref","first-page":"28120","DOI":"10.18632\/oncotarget.4866","article-title":"RICTOR involvement in the PI3K\/AKT pathway regulation in melanocytes and melanoma","volume":"6","author":"Laugier","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.neo.2018.10.001_bb0070","doi-asserted-by":"crossref","first-page":"34565","DOI":"10.18632\/oncotarget.16655","article-title":"Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3beta signaling","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.neo.2018.10.001_bb0075","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1111\/jcmm.13268","article-title":"Rictor regulates the vasculogenic mimicry of melanoma via the AKT-MMP-2\/9 pathway","volume":"21","author":"Liang","year":"2017","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.neo.2018.10.001_bb0080","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1158\/0008-5472.CAN-12-3931","article-title":"The multifaceted role of the microenvironment in liver metastasis: biology and clinical implications","volume":"73","author":"Van den Eynden","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.neo.2018.10.001_bb0085","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1158\/1078-0432.CCR-16-0460","article-title":"Role of the Microenvironment in Liver Metastasis: From Pre- to Prometastatic Niches","volume":"22","author":"Brodt","year":"2016","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.neo.2018.10.001_bb0090","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12307-008-0011-6","article-title":"The prometastatic microenvironment of the liver","volume":"1","author":"Vidal-Vanaclocha","year":"2008","journal-title":"Cancer Microenviron"},{"key":"10.1016\/j.neo.2018.10.001_bb0095","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12307-011-0084-5","article-title":"The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation","volume":"4","author":"Vidal-Vanaclocha","year":"2011","journal-title":"Cancer Microenviron"},{"key":"10.1016\/j.neo.2018.10.001_bb0100","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/hep.24384","article-title":"Hepatic stellate cells: partners in crime for liver metastases?","volume":"54","author":"Kang","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.neo.2018.10.001_bb0105","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1053\/jhep.2003.50068","article-title":"Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasis","volume":"37","author":"Olaso","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.neo.2018.10.001_bb0110","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/hep.21379","article-title":"In vivo immune modulatory activity of hepatic stellate cells in mice","volume":"44","author":"Chen","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.neo.2018.10.001_bb0115","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1349-7006.2009.01087.x","article-title":"Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma","volume":"100","author":"Amann","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1016\/j.neo.2018.10.001_bb0120","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1349-7006.2000.tb00916.x","article-title":"In vivo and in vitro interactions between human colon carcinoma cells and hepatic stellate cells","volume":"91","author":"Shimizu","year":"2000","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.neo.2018.10.001_bb0125","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.prp.2016.12.014","article-title":"Effect of melanoma cells on proliferation and migration of activated hepatic stellate cells in vitro","volume":"213","author":"Meyer","year":"2017","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.neo.2018.10.001_bb0130","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","volume":"54","author":"Xu","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.neo.2018.10.001_bb0135","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/labinvest.3780426","article-title":"Immortal activated human hepatic stellate cells generated by ectopic telomerase expression","volume":"82","author":"Schnabl","year":"2002","journal-title":"Lab Investig"},{"key":"10.1016\/j.neo.2018.10.001_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037941","article-title":"Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition","volume":"7","author":"Schmidt","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neo.2018.10.001_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004293","article-title":"Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFkappaB Signaling in Hepatocellular Carcinoma","volume":"11","author":"Engelmann","year":"2015","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.neo.2018.10.001_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1476-5586(04)80047-2","article-title":"ONCOMINE: a cancer microarray database and integrated data-mining platform","volume":"6","author":"Rhodes","year":"2004","journal-title":"Neoplasia"},{"key":"10.1016\/j.neo.2018.10.001_bb0155","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/bjc.2014.638","article-title":"mTOR inhibition improves fibroblast growth factor receptor targeting in hepatocellular carcinoma","volume":"112","author":"Scheller","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1016\/j.neo.2018.10.001_bb0160","doi-asserted-by":"crossref","first-page":"17006","DOI":"10.1038\/cddiscovery.2017.6","article-title":"ATF3 reduces migration capacity by regulation of matrix metalloproteinases via NFkappaB and STAT3 inhibition in glioblastoma","volume":"3","author":"Guenzle","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.neo.2018.10.001_bb0165","doi-asserted-by":"crossref","first-page":"32748","DOI":"10.18632\/oncotarget.4977","article-title":"Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells","volume":"6","author":"Koch","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.neo.2018.10.001_bb0170","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1055\/s-0041-111838","article-title":"Improved Detection of preclinical Colorectal Liver Metastases by High Resolution Ultrasound including Molecular Ultrasound Imaging using the targeted Contrast Agent BR55","volume":"37","author":"Hackl","year":"2016","journal-title":"Ultraschall Med"},{"key":"10.1016\/j.neo.2018.10.001_bb0175","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12885-015-1064-9","article-title":"Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model","volume":"15","author":"Brandes","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.neo.2018.10.001_bb0180","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.27209","article-title":"Cylindromatosis gene CYLD regulates hepatocyte growth factor expression in hepatic stellate cells through interaction with histone deacetylase 7","volume":"60","author":"Pannem","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.neo.2018.10.001_bb0185","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00008390-200310000-00009","article-title":"Discrimination between gene expression patterns in the invasive margin and the tumour core of malignant melanomas","volume":"13","author":"Roesch","year":"2003","journal-title":"Melanoma Res"},{"key":"10.1016\/j.neo.2018.10.001_bb0190","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.4161\/cbt.4.9.2165","article-title":"Whole-genome expression profiling of the melanoma progression pathway reveals marked molecular differences between nevi\/melanoma in situ and advanced-stage melanomas","volume":"4","author":"Smith","year":"2005","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.neo.2018.10.001_bb0195","doi-asserted-by":"crossref","first-page":"20429","DOI":"10.1073\/pnas.0905139106","article-title":"Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival","volume":"106","author":"Bogunovic","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neo.2018.10.001_bb0200","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.1073\/pnas.0501564102","article-title":"The gene expression signatures of melanoma progression","volume":"102","author":"Haqq","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neo.2018.10.001_bb0205","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1080\/15384101.2016.1152428","article-title":"Hepatic stellate cell promoted hepatoma cell invasion via the HGF\/c-Met signaling pathway regulated by p53","volume":"15","author":"Liu","year":"2016","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neo.2018.10.001_bb0210","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/hep.510260315","article-title":"Tumor-dependent activation of rodent hepatic stellate cells during experimental melanoma metastasis","volume":"26","author":"Olaso","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.neo.2018.10.001_bb0215","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1007\/s00464-017-5834-0","article-title":"Laparoscopic liver resection for metastatic melanoma","volume":"32","author":"Aghayan","year":"2018","journal-title":"Surg Endosc"},{"key":"10.1016\/j.neo.2018.10.001_bb0220","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1200\/JCO.2001.19.16.3622","article-title":"Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system","volume":"19","author":"Balch","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.neo.2018.10.001_bb0225","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.bbrc.2015.07.001","article-title":"Elevated Rictor expression is associated with tumor progression and poor prognosis in patients with gastric cancer","volume":"464","author":"Bian","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neo.2018.10.001_bb0230","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1476-4598-9-57","article-title":"Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo","volume":"9","author":"Roulin","year":"2010","journal-title":"Mol Cancer"},{"key":"10.1016\/j.neo.2018.10.001_bb0235","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ejca.2016.12.010","article-title":"The mitogen-activated protein kinase pathway in melanoma part I - Activation and primary resistance mechanisms to BRAF inhibition","volume":"73","author":"Amaral","year":"2017","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.neo.2018.10.001_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctrv.2016.06.009","article-title":"Wnt\/beta-catenin signaling in melanoma: Preclinical rationale and novel therapeutic insights","volume":"49","author":"Xue","year":"2016","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.neo.2018.10.001_bb0245","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1158\/0008-5472.CAN-10-4058","article-title":"mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways","volume":"71","author":"Gulhati","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.neo.2018.10.001_bb0250","doi-asserted-by":"crossref","first-page":"9360","DOI":"10.1158\/0008-5472.CAN-10-0207","article-title":"mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis","volume":"70","author":"Zhang","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.neo.2018.10.001_bb0255","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.devcel.2016.04.011","article-title":"PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2","volume":"37","author":"Daulat","year":"2016","journal-title":"Dev Cell"},{"key":"10.1016\/j.neo.2018.10.001_bb0260","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13058-017-0868-8","article-title":"Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis","volume":"19","author":"Morrison Joly","year":"2017","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.neo.2018.10.001_bb0265","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1172\/JCI91144","article-title":"AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis","volume":"127","author":"Li","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neo.2018.10.001_bb0270","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1007\/s13277-015-4296-z","article-title":"Upregulation of RICTOR gene transcription by the proinflammatory cytokines through NF-kappaB pathway contributes to the metastasis of renal cell carcinoma","volume":"37","author":"Sun","year":"2016","journal-title":"Tumour Biol"},{"key":"10.1016\/j.neo.2018.10.001_bb0275","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.canlet.2016.01.048","article-title":"Animal models of colorectal cancer with liver metastasis","volume":"387","author":"Oh","year":"2017","journal-title":"Cancer Lett"},{"key":"10.1016\/j.neo.2018.10.001_bb0280","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrc3001","article-title":"Mouse models of advanced spontaneous metastasis for experimental therapeutics","volume":"11","author":"Francia","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.neo.2018.10.001_bb0285","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1172\/JCI63836","article-title":"IQGAP1 suppresses TbetaRII-mediated myofibroblastic activation and metastatic growth in liver","volume":"123","author":"Liu","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neo.2018.10.001_bb0290","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1245\/s10434-009-0599-x","article-title":"Hepatic stellate cells promote liver metastasis of colon cancer cells by the action of SDF-1\/CXCR4 axis","volume":"16","author":"Matsusue","year":"2009","journal-title":"Ann Surg Oncol"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558618303609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558618303609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T16:57:14Z","timestamp":1605373034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558618303609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S1476558618303609"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2018.10.001","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of mTORC2\/RICTOR Impairs Melanoma Hepatic Metastasis","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2018.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc.","name":"copyright","label":"Copyright"}]}}