{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:05:35Z","timestamp":1781787935494,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.neo.2019.12.004","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T18:45:33Z","timestamp":1579718733000},"page":"129-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["AGO2 phosphorylation by c-Src kinase promotes tumorigenesis"],"prefix":"10.1016","volume":"22","author":[{"given":"Tianqi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neo.2019.12.004_b0005","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/35073094","article-title":"The hunting of the Src","volume":"2","author":"Martin","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.neo.2019.12.004_b0010","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1242\/jcs.01111","article-title":"Newest findings on the oldest oncogene; how activated src does it","volume":"117","author":"Frame","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1016\/j.neo.2019.12.004_b0015","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1093\/annonc\/mdm086","article-title":"The role of Src in prostate cancer","volume":"18","author":"Fizazi","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1016\/j.neo.2019.12.004_b0020","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1158\/0008-5472.CAN-05-4620","article-title":"Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival","volume":"66","author":"Song","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.neo.2019.12.004_b0025","first-page":"1696","article-title":"Expression of pp60c-src protein kinase in adult and fetal human tissue: high activities in some sarcomas and mammary carcinomas","volume":"43","author":"Jacobs","year":"1983","journal-title":"Cancer Res"},{"key":"10.1016\/j.neo.2019.12.004_b0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1172\/JCI116200","article-title":"Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer","volume":"91","author":"Talamonti","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neo.2019.12.004_b0035","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000111670","article-title":"Nonreceptor protein tyrosine kinases associated with neuronal development","volume":"14","author":"Maness","year":"1992","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.neo.2019.12.004_b0040","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1038\/onc.2009.278","article-title":"Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration","volume":"28","author":"Li","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2019.12.004_b0045","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1126\/science.1221551","article-title":"The crystal structure of human Argonaute2","volume":"336","author":"Schirle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.neo.2019.12.004_b0050","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nature03868","article-title":"TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing","volume":"436","author":"Chendrimada","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neo.2019.12.004_b0055","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/35005107","article-title":"An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells","volume":"404","author":"Hammond","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neo.2019.12.004_b0060","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0092-8674(02)00908-X","article-title":"Single-stranded antisense siRNAs guide target RNA cleavage in RNAi","volume":"110","author":"Martinez","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.neo.2019.12.004_b0065","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1126\/science.1073827","article-title":"A microRNA in a multiple-turnover RNAi enzyme complex","volume":"297","author":"Hutvagner","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neo.2019.12.004_b0070","doi-asserted-by":"crossref","first-page":"877","DOI":"10.7150\/jca.11735","article-title":"Argonaute 2: A Novel Rising Star in Cancer Research","volume":"6","author":"Ye","year":"2015","journal-title":"J Cancer"},{"key":"10.1016\/j.neo.2019.12.004_b0075","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature07186","article-title":"Prolyl 4-hydroxylation regulates Argonaute 2 stability","volume":"455","author":"Qi","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neo.2019.12.004_b0080","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/ncb1987","article-title":"The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2","volume":"11","author":"Rybak","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.neo.2019.12.004_b0085","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/s41388-018-0530-7","article-title":"Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis","volume":"38","author":"Zhang","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2019.12.004_b0090","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nature12080","article-title":"EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2","volume":"497","author":"Shen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neo.2019.12.004_b0095","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1111\/febs.13314","article-title":"Regulation of RPTPalpha-c-Src signalling pathway by miR-218","volume":"282","author":"Lai","year":"2015","journal-title":"FEBS J"},{"key":"10.1016\/j.neo.2019.12.004_b0100","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.neo.2017.09.001","article-title":"Src SUMOylation inhibits tumor growth via decreasing FAK Y925 phosphorylation","volume":"19","author":"Wang","year":"2017","journal-title":"Neoplasia"},{"key":"10.1016\/j.neo.2019.12.004_b0105","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.imlet.2012.02.014","article-title":"Identification of microRNA transcriptome involved in human natural killer cell activation","volume":"143","author":"Liu","year":"2012","journal-title":"Immunol Lett"},{"key":"10.1016\/j.neo.2019.12.004_b0110","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gni178","article-title":"Real-time quantification of microRNAs by stem-loop RT-PCR","volume":"33","author":"Chen","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neo.2019.12.004_b0115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1476-4598-13-95","article-title":"SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1","volume":"13","author":"Qu","year":"2014","journal-title":"Mol Cancer"},{"key":"10.1016\/j.neo.2019.12.004_b0120","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.neo.2019.04.010","article-title":"SUMOylation of Csk negatively modulates its tumor suppressor function","volume":"21","author":"Cui","year":"2019","journal-title":"Neoplasia"},{"key":"10.1016\/j.neo.2019.12.004_b0125","doi-asserted-by":"crossref","first-page":"13732","DOI":"10.1038\/ncomms13732","article-title":"c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.neo.2019.12.004_b0130","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neo.2019.12.004_b0135","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/1471-2407-9-366","article-title":"Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells","volume":"9","author":"Li","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.neo.2019.12.004_b0140","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1093\/nar\/gkq1032","article-title":"Phosphorylation of human Argonaute proteins affects small RNA binding","volume":"39","author":"Rudel","year":"2011","journal-title":"Nucleic Acids Research"},{"issue":"Suppl 1","key":"10.1016\/j.neo.2019.12.004_b0145","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/gb-2008-9-s1-s4","article-title":"GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function","volume":"9","author":"Mostafavi","year":"2008","journal-title":"Genome Biol"},{"key":"10.1016\/j.neo.2019.12.004_b0150","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses","volume":"45","author":"Tang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neo.2019.12.004_b0155","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/bcr55","article-title":"Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer","volume":"2","author":"Biscardi","year":"2000","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.neo.2019.12.004_b0160","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ccr.2004.09.001","article-title":"c-Src and cooperating partners in human cancer","volume":"6","author":"Ishizawar","year":"2004","journal-title":"Cancer cell"},{"key":"10.1016\/j.neo.2019.12.004_b0165","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1158\/0008-5472.CAN-06-2580","article-title":"Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior","volume":"67","author":"Dimri","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.neo.2019.12.004_b0170","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1158\/0008-5472.CAN-10-1432","article-title":"An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion","volume":"71","author":"Mader","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.neo.2019.12.004_b0175","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1359\/jbmr.090830","article-title":"Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: a randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial","volume":"25","author":"Hannon","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.neo.2019.12.004_b0180","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1038\/bjc.2013.646","article-title":"Strong reduction of AGO2 expression in melanoma and cellular consequences","volume":"109","author":"Voller","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.neo.2019.12.004_b0185","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/j.bbagen.2012.11.013","article-title":"Overexpression of human Argonaute2 inhibits cell and tumor growth","volume":"1830","author":"Zhang","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neo.2019.12.004_b0190","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cmet.2013.11.015","article-title":"Argonaute2 mediates compensatory expansion of the pancreatic beta cell","volume":"19","author":"Tattikota","year":"2014","journal-title":"Cell Metab"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558619303914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558619303914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:06:34Z","timestamp":1761483994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558619303914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1476558619303914"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2019.12.004","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AGO2 phosphorylation by c-Src kinase promotes tumorigenesis","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2019.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc.","name":"copyright","label":"Copyright"}]}}