{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T22:31:10Z","timestamp":1776465070537,"version":"3.51.2"},"reference-count":34,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.neo.2021.06.003","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T23:27:13Z","timestamp":1626823633000},"page":"870-878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genomic landscape and evolution of arm aneuploidy in lung adenocarcinoma"],"prefix":"10.1016","volume":"23","author":[{"given":"Beili","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neo.2021.06.003_bib0001","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41576-019-0171-x","article-title":"Context is everything: aneuploidy in cancer","volume":"21","author":"Ben-David","year":"2020","journal-title":"Nat Rev Genet"},{"issue":"5","key":"10.1016\/j.neo.2021.06.003_bib0002","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nrclinonc.2015.208","article-title":"Revisiting tumor aneuploidy-the place of ploidy assessment in the molecular era","volume":"13","author":"Danielsen","year":"2016","journal-title":"Nat Rev Clin Oncol"},{"issue":"5","key":"10.1016\/j.neo.2021.06.003_bib0003","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ccell.2016.03.025","article-title":"Integrated genomics for pinpointing survival loci within arm-level somatic copy number alterations","volume":"29","author":"Roy","year":"2016","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.neo.2021.06.003_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-14286-0","article-title":"Chromosome arm aneuploidies shape tumor evolution and drug response","volume":"11","author":"Shukla","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.neo.2021.06.003_bib0005","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ccell.2018.03.007","article-title":"Genomic and functional approaches to understanding cancer aneuploidy","volume":"33","author":"Taylor","year":"2018","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.neo.2021.06.003_bib0006","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"#cr-split#-10.1016\/j.neo.2021.06.003_bib0007.1","unstructured":"Myers DJ, Wallen JM. Lung Adenocarcinoma. [Updated 2020 Jun 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing"},{"key":"#cr-split#-10.1016\/j.neo.2021.06.003_bib0007.2","doi-asserted-by":"crossref","unstructured":"2020 Jan. Retrieved July 10, 2013, from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519578\/. doi:10.1016\/j.mayocp.2018.05.012","DOI":"10.1016\/j.mayocp.2018.05.012"},{"issue":"3","key":"10.1016\/j.neo.2021.06.003_bib0008","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.athoracsur.2011.04.052","article-title":"Prognostic value of chromosomal imbalances in squamous cell carcinoma and adenocarcinoma of the lung","volume":"92","author":"Danner","year":"2011","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.neo.2021.06.003_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13039-016-0297-x","article-title":"Inherent variability of cancer-specific aneuploidy generates metastases","volume":"9","author":"Bloomfield","year":"2016","journal-title":"Mol Cytogenet"},{"issue":"22","key":"10.1016\/j.neo.2021.06.003_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225762","article-title":"Defining signatures of arm-wise copy number change and their associated drivers in kidney cancers","volume":"20","author":"Benstead-Hume","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.neo.2021.06.003_bib0011","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cell.2018.03.043","article-title":"Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal","volume":"173","author":"Turajlic","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neo.2021.06.003_bib0012","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14093","article-title":"DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer","volume":"8","author":"Mamlouk","year":"2017","journal-title":"Nat Commun"},{"issue":"15","key":"10.1016\/j.neo.2021.06.003_bib0013","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"18","key":"10.1016\/j.neo.2021.06.003_bib0014","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/bioinformatics\/bts378","article-title":"DELLY: Structural variant discovery by integrated paired-end and split-read analysis","volume":"28","author":"Rausch","year":"2012","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.neo.2021.06.003_bib0015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/annonc\/mdu479","article-title":"Sequenza: Allele-specific copy number and mutation profiles from tumor sequencing data","volume":"26","author":"Favero","year":"2015","journal-title":"Ann Oncol"},{"issue":"1","key":"10.1016\/j.neo.2021.06.003_bib0016","first-page":"1","article-title":"Cooccur: Probabilistic species co-occurrence analysis in R","volume":"69","author":"Griffith","year":"2016","journal-title":"J Stat Softw"},{"issue":"12","key":"10.1016\/j.neo.2021.06.003_bib0017","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/bioinformatics\/btw035","article-title":"TRONCO: An R package for the inference of cancer progression models from heterogeneous genomic data","volume":"32","author":"De Sano","year":"2016","journal-title":"Bioinformatics"},{"issue":"16","key":"10.1016\/j.neo.2021.06.003_bib0018","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1093\/bioinformatics\/bty186","article-title":"pyNBS: a Python implementation for network-based stratification of tumor mutations","volume":"34","author":"Huang","year":"2018","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.neo.2021.06.003_bib0019","first-page":"2825","article-title":"Scikit-learn: machine learning in python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J ofMachine Learn Res"},{"issue":"12","key":"10.1016\/j.neo.2021.06.003_bib0020","first-page":"2331","article-title":"Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung","volume":"57","author":"Petersen","year":"1997","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.neo.2021.06.003_bib0021","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/bjc.1998.42","article-title":"Comparison of DNA copy number changes in malignant mesothelioma, adenocarcinoma and large-cell anaplastic carcinoma of the lung","volume":"77","author":"Bj\u00f6rkqvist","year":"1998","journal-title":"Br J Cancer"},{"issue":"3","key":"10.1016\/j.neo.2021.06.003_bib0022","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/gcc.1145","article-title":"Genomic imbalances in human lung adenocarcinomas and squamous cell carcinomas","volume":"31","author":"Pei","year":"2001","journal-title":"Genes Chromosom Cancer"},{"issue":"2","key":"10.1016\/j.neo.2021.06.003_bib0023","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0165-4608(00)00363-0","article-title":"Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization","volume":"125","author":"Luk","year":"2001","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.neo.2021.06.003_bib0024","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1038\/sj.onc.1205836","article-title":"Chromosomal imbalances in human lung cancer","volume":"21","author":"Balsara","year":"2002","journal-title":"Oncogene"},{"issue":"7171","key":"10.1016\/j.neo.2021.06.003_bib0025","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nature06358","article-title":"Characterizing the cancer genome in lung adenocarcinoma","volume":"450","author":"Weir","year":"2007","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.neo.2021.06.003_bib0026","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/sj.bjc.6601569","article-title":"Chromosomal analysis of non-small-cell lung cancer by multicolour fluorescent in situ hybridisation","volume":"90","author":"Berrieman","year":"2004","journal-title":"Br J Cancer"},{"issue":"9","key":"10.1016\/j.neo.2021.06.003_bib0027","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/ijc.27879","article-title":"Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma","volume":"132","author":"Staaf","year":"2013","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.neo.2021.06.003_bib0028","doi-asserted-by":"crossref","first-page":"416","DOI":"10.21037\/tlcr.2018.05.01","article-title":"Genome-wide copy number analyses of samples from LACE-Bio project identify novel prognostic and predictive markers in early stage non-small cell lung cancer","volume":"7","author":"Rotolo","year":"2018","journal-title":"Transl Lung Cancer Res"},{"issue":"13","key":"10.1016\/j.neo.2021.06.003_bib0029","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1158\/0008-5472.CAN-04-4603","article-title":"Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis","volume":"65","author":"Zhao","year":"2005","journal-title":"Cancer Res"},{"issue":"31","key":"10.1016\/j.neo.2021.06.003_bib0030","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1038\/onc.2009.135","article-title":"An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors","volume":"28","author":"Chitale","year":"2009","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.neo.2021.06.003_bib0031","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1470-2045(10)70087-5","article-title":"New driver mutations in non-small-cell lung cancer","volume":"12","author":"Pao","year":"2011","journal-title":"Lancet Oncol"},{"issue":"6","key":"10.1016\/j.neo.2021.06.003_bib0032","first-page":"1021","article-title":"Pleural involvement in lung cancer","volume":"7","author":"Agalioti","year":"2015","journal-title":"J Thorac Dis"},{"issue":"3","key":"10.1016\/j.neo.2021.06.003_bib0033","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nrc3216","article-title":"RB: mitotic implications of a tumour suppressor","volume":"12","author":"Manning","year":"2012","journal-title":"Nat Rev Cancer"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558621000440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558621000440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:09:44Z","timestamp":1761484184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558621000440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1476558621000440"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2021.06.003","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic landscape and evolution of arm aneuploidy in lung adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2021.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}